Lymfocytär tyroidit hos hund (clt)

Hypotyreoidism är en vanlig endokrin sjukdom hos hundar. Den orsakar nedsatt livskvalitet i form av utbredda symptom från flera olika organsystem och sjukdomen kräver livslång medicinering. En orsak till hypotyreoidism är Canine Lymphocytic Thyroiditis (CLT), en autoimmun sjukdom som står för ett stort antal av sjukdomsfallen hos hund. Mycket talar för att utvecklandet av sjukdomen har en ärftlighetskomponent eftersom den uppträder i mycket hög frekvens inom vissa raser medan det är en tämligen ovanlig åkomma inom andra raser. Studier av hundpopulationer har visat på en genetisk koppling mellan CLT och gener för Dog Leukocyte Antigen II (DLA II) hos vissa raser. DLA II, även kallat Major Histocompatibility Complex II (MHC II), kan vara en predisponerande faktor för autoimmun sjukdom hos inavlade populationer som rashundar. Patogenesen är hos hund ännu inte säkerställd men studier visar att B-celler samt CD8+- och CD4+ T-celler är involverade och ger upphov till immunoglobulin G (IgG) autoantikroppar och ett cellmedierat svar. I CLT kan autoantikroppar uppstå mot flera strukturer i tyroidea. Autoantikroppar mot tyroglobulin är det vanligaste serologiska fyndet hos hundar med CLT medan autoantikroppar mot tyroidperoxidas, tyroxin (T4) och triiodotyronin (T3) är mindre vanligt. Autoantikroppar mot tyroglobulin ses som en tidig indikation på CLT då de avtar i ett senare stadie av sjukdomen. Histologiskt kan man se att CLT är en inflammatorisk och progressiv sjukdom som slutligen leder till en fibrös omvandling av tyroidea med endast ett fåtal inflammatoriska celler.Hypothyroidism is a common endocrine disorder in dogs. The lack of thyroid hormone causes a diversity of symptoms from different organ systems, which will lead to a decreased quality of life as well as lifelong medical treatment. Canine Lymphocytic Thyroiditis (CLT) is an autoimmune cause of hypothyroidism and it represents a large part of the total cases in dogs. There is a belief that the cause of CLT might have a genetic component, since the disease occurs in high frequency in some breeds while it is rare in others. Studies of different breeds has connected CLT with the gene for Dog Leukocyte Antigen II (DLA II). DLA II, also known as Major Histocompatibility Complex II is a protein complex that can be a predisposing factor among inbred populations such as pure-bred dogs. The pathology in dogs is still uncertain but studies have shown that CD4+- and CD8+ T-cells are involved and the immune response leads to both immunoglobulin G (IgG) autoantibodies and a cellmediated answer. Autoantibodies are generated against several thyroid structures, the most common findings are autoantibodies against thyroglobulin while autoantibodies against thyroidperoxidase, thyroxine (T4) and triiodothyronine (T3) are more uncommon. Autoantibodies against thyroglobulin is seen as an early sign of CLT, but the levels of autoantibodies is not constant and will decrease in the end-stage of the disease. The histological appearance of the thyroid reveals an inflammatoric and progressive disease that eventually will lead to a fibrous change of the thyroid with only a few scattered inflammatory cells

Impact of Gaps on Resource Efficiency in Heavy Welding Industry.

This paper describes a study investigating the current situation concerning plate gaps in welding operations at a company producing welded products. A varying gap between the plates has been identified as a root cause for quality issues and unnecessary costly welds, hence affecting resource efficiency. The result showed signs of vast variations of gaps, both concerning the size of gaps and presence of an extra weld. The investigation indicates a large potential, possible to achieve without heavy investments

Yrkesval och det personliga intressets betydelse

I studie- och yrkesvägledning framhålls ofta individens intresse som centralt för yrkesvalet. Trots kunskap om att individens intressen och preferenser påverkas av sociala strukturer, så är detta fokus på intresse inget som problematiserats i någon högre utsträckning. Utifrån intervjuer med vägledare och gymnasieelever om hur de uppfattar och använder sig av yrkesvägledande material diskuteras i artikeln olika förståelser av ”intresse” och vilken betydelse detta ges för traditionella och otraditionella yrkesval

Ärligt talat så har jag det som krävs för att vara en bra förälder! : En studie om hur föräldrars generella hälsotillstånd påverkar den upplevda föräldrakompetensen

Background: Good health at community and individual levels are key policy priorities. These priorities can be shown through supporting parents about various different healthy lifestyle choices. In order to know where interventions are needed, it is of interest to study how parents generally feel and how they perceive their parenting. Aim: To study how parents rate their own health and parenting skills, and examine whether there is any correlation between perceived general health and perceived parental competence.  Further, this study will show whether there is a correlation between rate of perceived general health and rate of perceived parental competence when it comes to gender. Method: 64 questionnaires were collected at strategic open kindergartens in the municipality of Uppsala. The questionnaires were distributed to the parents present and who chose to participate in this study. Main result: The result of this study shows that parents have a high rate of general health. A weak correlation between rate of perceived general health and rate of perceived parental competence were found. However a clear correlation between rate of perceived general health and rate of perceived parental competence could be seen of fathers, while the mothers are unrelated. Conclusion:  Parents in Uppsala seems to feel generally well and believe they are capable parents. It also appears that these two factors are interrelated so that parents who are doing well also generally feel better in their parenting. More and major studies are needed to obtain a general and trustworthy result

Ärligt talat så har jag det som krävs för att vara en bra förälder! : En studie om hur föräldrars generella hälsotillstånd påverkar den upplevda föräldrakompetensen

Background: Good health at community and individual levels are key policy priorities. These priorities can be shown through supporting parents about various different healthy lifestyle choices. In order to know where interventions are needed, it is of interest to study how parents generally feel and how they perceive their parenting. Aim: To study how parents rate their own health and parenting skills, and examine whether there is any correlation between perceived general health and perceived parental competence.  Further, this study will show whether there is a correlation between rate of perceived general health and rate of perceived parental competence when it comes to gender. Method: 64 questionnaires were collected at strategic open kindergartens in the municipality of Uppsala. The questionnaires were distributed to the parents present and who chose to participate in this study. Main result: The result of this study shows that parents have a high rate of general health. A weak correlation between rate of perceived general health and rate of perceived parental competence were found. However a clear correlation between rate of perceived general health and rate of perceived parental competence could be seen of fathers, while the mothers are unrelated. Conclusion:  Parents in Uppsala seems to feel generally well and believe they are capable parents. It also appears that these two factors are interrelated so that parents who are doing well also generally feel better in their parenting. More and major studies are needed to obtain a general and trustworthy result

Ärligt talat så har jag det som krävs för att vara en bra förälder! : En studie om hur föräldrars generella hälsotillstånd påverkar den upplevda föräldrakompetensen

Background: Good health at community and individual levels are key policy priorities. These priorities can be shown through supporting parents about various different healthy lifestyle choices. In order to know where interventions are needed, it is of interest to study how parents generally feel and how they perceive their parenting. Aim: To study how parents rate their own health and parenting skills, and examine whether there is any correlation between perceived general health and perceived parental competence.  Further, this study will show whether there is a correlation between rate of perceived general health and rate of perceived parental competence when it comes to gender. Method: 64 questionnaires were collected at strategic open kindergartens in the municipality of Uppsala. The questionnaires were distributed to the parents present and who chose to participate in this study. Main result: The result of this study shows that parents have a high rate of general health. A weak correlation between rate of perceived general health and rate of perceived parental competence were found. However a clear correlation between rate of perceived general health and rate of perceived parental competence could be seen of fathers, while the mothers are unrelated. Conclusion:  Parents in Uppsala seems to feel generally well and believe they are capable parents. It also appears that these two factors are interrelated so that parents who are doing well also generally feel better in their parenting. More and major studies are needed to obtain a general and trustworthy result

Maternal and neonatal factors associated with poor early weight gain and later retinopathy of prematurity

Aim: To identify factors associated with poor early weight gain as reflected in an alarm system, WINROP, and risk of later proliferative retinopathy of prematurity (ROP) in infants with gestational age (GA) < 28 weeks

WINROP identifies severe retinopathy of prematurity at an early stage in a nation-based cohort of extremely preterm infants

OBJECTIVE: To evaluate the ability of a postnatal weight-gain algorithm (WINROP) to identify sight-threatening retinopathy of prematurity (ROP type 1) in a nation-based extremely preterm infant cohort. METHODS: This study enrolled all 707 live-born extremely preterm (gestational age [GA] &lt;27 weeks) infants, born 2004-2007 in Sweden; the Extremely preterm Infants in Sweden Study (EXPRESS). WINROP analysis was performed retrospectively in 407 of the infants using weekly weight gain to assess the preterm infant's risk of developing ROP type 1 requiring treatment. GA, birthweight (BW), and weekly postnatal weight measurements were entered into WINROP. WINROP signals with an alarm to indicate if the preterm infant is at risk for ROP type 1. RESULTS: In this extremely preterm population, WINROP correctly identified 96% (45/47) of the infants who required treatment for ROP type 1. The median time from alarm to treatment was 9 weeks (range, 4-20 weeks). CONCLUSIONS: WINROP, an online surveillance system using weekly weight gain, identified extremely preterm infants at risk for ROP type 1 requiring treatment at an early stage and with high sensitivity in a Swedish nation-based cohort