Optical variability of the accretion disk around the intermediate mass black hole ESO 243-49 HLX-1 during the 2012 outburst

We present dedicated quasi-simultaneous X-ray (Swift) and optical (Very Large Telescope (VLT), V- and R-band) observations of the intermediate mass black hole candidate ESO 243-49 HLX-1 before and during the 2012 outburst. We show that the V-band magnitudes vary with time, thus proving that a portion of the observed emission originates in the accretion disk. Using the first quiescent optical observations of HLX-1, we show that the stellar population surrounding HLX-1 is fainter than V~25.1 and R~24.2. We show that the optical emission may increase before the X-ray emission consistent with the scenario proposed by Lasota et al. (2011) in which the regular outbursts could be related to the passage at periastron of a star circling the intermediate mass black hole in an eccentric orbit, which triggers mass transfer into a quasi-permanent accretion disk around the black hole. Further, if there is indeed a delay in the X-ray emission we estimate the mass-transfer delivery radius to be ~1e11 cm.Comment: 9 pages, 2 figures, accepted for publication in ApJ

Developmental changes in mu suppression to observed and executed actions in autism spectrum disorders

There has been debate over whether disruptions in the mirror neuron system (MNS) play a key role in the core social deficits observed in autism spectrum disorders (ASD). EEG mu suppression during the observation of biological actions is believed to reflect MNS functioning, but understanding of the developmental progression of the MNS and EEG mu rhythm in both typical and atypical development is lacking. To provide a more thorough and direct exploration of the development of mu suppression in individuals with ASD, a sample of 66 individuals with ASD and 51 typically developing individuals of 6-17 years old were pooled from four previously published studies employing similar EEG methodology. We found a significant correlation between age and mu suppression in response to the observation of actions, both for individuals with ASD and typical individuals. This relationship was not seen during the execution of actions. Additionally, the strength of the correlation during the observation of actions did not significantly differ between groups. The results provide evidence against the argument that mirror neuron dysfunction improves with age in individuals with ASD and suggest, instead, that a diagnosis-independent developmental change may be at the root of the correlation of age and mu suppression

Spectroscopy of the optical afterglow of GRB 021004: Origin of the blue-shifted hydrogen lines

We present spectra of the afterglow of GRB 021004 taken with WHT ISIS and VLT FORS1 at three epochs spanning 0.49–6.62 days after the burst. Alongside absorption lines from the host galaxy, we identify absorption in HI, SiIV and CIV with blueshifts of up to 2800 km s−1 from the explosion centre which we assume originates close to the progenitor. We investigate the origin of the outflowing material and evaluate various possible progenitor models, in particular a binary progenitor consisting of a Wolf-Rayet star and hydrogen-rich companion

Gamma-Ray Burst Afterglows as Probes of Environment and Blastwave Physics II: The Distribution of p and Structure of the Circumburst Medium

We constrain blastwave parameters and the circumburst media of a subsample of BeppoSAX Gamma-Ray Bursts. For this sample we derive the values of the injected electron energy distribution index, p, and the density structure index of the circumburst medium, k, from simultaneous spectral fits to their X-ray, optical and nIR afterglow data. The spectral fits have been done in count space and include the effects of metallicity, and are compared with the previously reported optical and X-ray temporal behaviour. Assuming the fireball model, we can find a mean value of p for the sample as a whole of 2.035. A statistical analysis Of the distribution demonstrates that the p values in this sample are inconsistent with a single universal value for p at the 3sigma level or greater. This approach provides us with a measured distribution of circumburst density structures rather than considering only the cases of k = 0 (homogeneous) and k = 2 (wind-like). We find five GRBs for which k can be well constrained, and in four of these cases the circumburst medium is clearly wind-like. The fifth source has a value of 0 less than or equal to k less than or equal to 1, consistent with a homogeneous circumburst medium

Characterization of AGN from the XMM–Newton Slew Survey

We present optical spectroscopy of candidate active galactic nuclei (AGN) pinpointed by a Swift follow-up campaign on unidentified transients in the XMM-Newton Slew Survey, increasing the completeness of the identifications of AGN in the Survey. Our Swift follow-up campaign identified 17 X-ray Telescope-detected candidate AGN, of which 9 were selected for optical follow-up and a further two were confirmed as AGN elsewhere. Using data obtained at the William Herschel Telescope, Very Large Telescope and New Technology Telescope, we find AGN features in seven of the candidates. We classify six as Seyfert types 1.0-1.5, with broad-line region velocities spanning 2000-12000 km s-1, and identify one as a possible type II AGN, consistent with the lack of a soft band X-ray detection in the Slew Survey. The virial black hole mass estimates for the sample lie between 1 × 108 and 3 × 109 M☉, with one source likely emitting close to its Eddington rate, LBol/LEdd ~ 0.9. We find a wide redshift range 0.08 < z < 0.9 for the nine now confirmed AGN drawn from the unidentified Slew Survey sample. One source remaining unclassified shows outbursts rarely seen before in AGN. We conclude that AGN discovered in this way are consistent with the largely non-varying, Slew-selected, known AGN population. We also find parallels with XMM-Newton Bright Serendipitous Survey AGN selected from pointed observations, and postulate that shallow X-ray surveys select AGN drawn from the same populations that have been characterized in deeper X-ray-selected samples

Gamma-Ray Burst Afterglows as Probes of Environment and Blastwave Physics

We use a new approach to obtain limits on the absorbing columns towards an initial sample of 10 long Gamma-Ray Bursts observed with BeppoSAX and selected on the basis of their good optical and nIR coverage, from simultaneous fits to nIR, optical and X-ray afterglow data, in count space and including the effects of metallicity. In no cases is a MIV-like ext,inction preferred, when testing MW, LMC and SMC extinction laws. The 2175A bump would in principle be detectable in all these afterglows, but is not present in the data. An SMC-like gas-to-dust ratio or lower value can be ruled out for 4 of the hosts analysed here (assuming Sh4C metallicity and extinction law) whilst the remainder of the sample have too large an error to discriminate. We provide a more accurate estimate of the line-of-sight extinction and improve upon the uncertainties for the majority of the extinction measurements made in previous studies of this sample. We discuss this method to determine extinction values in comparison with the most commonly employed existing methods

Robust photometric redshift determinations of gamma-ray burst afterglows at z > 2

Theory suggests that about 10% of Swift-detected gamma-ray bursts (GRBs) will originate at redshifts greater than 5 yet a number of high redshift candidates may be left unconfirmed due to the lack of measured redshifts. Here we introduce our code, GRBz, a method of simultaneous multi-parameter fitting of GRB afterglow optical and near infrared, spectral energy distributions. It allows for early determinations of the photometric redshift, spectral index and host extinction to be made. We assume that GRB afterglow spectra are well represented by a power-law decay and model the effects of absorption due to the Lyman forest and host extinction. We use a genetic algorithm-based routine to simultaneously fit the parameters of interest, and a Monte Carlo error analysis. We use GRBs of previously determined spectroscopic redshifts to prove our method, while also introducing new near infrared data of GRB 990510 which further constrains the value of the host extinction. Our method is effective in estimating the photometric redshift of GRBs, relatively unbiased by assumptions of the afterglow spectral index or the host galaxy extinction. Monte Carlo error analysis is required as the method of error estimate based on the optimum population of the genetic algorithm underestimates errors significantly.Comment: Accepted to A&A: 8 pages, 5 figure

Peribiliary glands are key in regeneration of the human biliary epithelium after severe bile duct injury

Peribiliary glands (PBG) are a source of stem/progenitor cells organized in a cellular network encircling large bile ducts. Severe cholangiopathy with loss of luminal biliary epithelium has been proposed to activate PBG, resulting in cell proliferation and differentiation to restore biliary epithelial integrity. However, formal evidence for this concept in human livers is lacking. We, therefore, developed a novel ex vivo model using precision-cut slices of extrahepatic human bile ducts obtained from discarded donor livers, providing an intact anatomical organization of cell structures, to study spatiotemporal differentiation and migration of PBG cells after severe biliary injury. Post-ischemic bile duct slices were incubated in oxygenated culture medium for up to a week. At baseline, severe tissue injury was evident with loss of luminal epithelial lining and mural stroma necrosis. In contrast, PBG remained relatively well preserved and different reactions of PBG were noted, including PBG dilatation, cell proliferation and maturation. Proliferation of PBG cells increased after 24 h of oxygenated incubation, reaching a peak after 72 h. Proliferation of PBG cells was paralleled by a reduction in PBG apoptosis and differentiation from a primitive and pluripotent (Nanog+/Sox9+) to a mature (CFTR+/secretin receptor+) and activated phenotype (increased expression of HIF-1α, Glut-1, and VEGF-A). Migration of proliferating PBG cells in our ex vivo model was unorganized, but resulted in generation of epithelial monolayers at stromal surfaces. CONCLUSION: Human PBG contain biliary progenitor cells and are able to respond to bile duct epithelial loss with proliferation, differentiation, and maturation to restore epithelial integrity. The ex vivo spatiotemporal behaviour of human PBG cells provides evidence for a pivotal role of PBG in biliary regeneration after severe injury. This article is protected by copyright. All rights reserved