90 research outputs found

    Pengukuran Tingkat Kapabilitas pada PT Sentral Electric Menggunakan Framework Cobit 5

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    PT.Sentral Elektrik adalah perusahaan yang terletak di Jakarta utara dan bergerak di bidang distribusi barang elektronik. Assesment atau pengukuran dilakukan untuk mengetahui kondisi perusahaan yang bertujuan untuk memberikan rekomendasi terhadap kekurangan. Permasalahan yang dialami oleh perusahaan adalah terkait dengan sumber daya manusia, aset, dan monitoring oleh karena itu 3 masalah ini yang dijadikan bahasan utama dalam melakukan audit. Kerangka kerja (framework) yang dijadikan dasar untuk melakukan penilaian kapabilitas perusahaan adalah Control Objective for Information and Related Technology 5 (COBIT 5). Pada COBIT 5 terdapat 5 domain dan 37 total proses, untuk proses pengukuran kapabilitas dipilih 5 proses yang ada pada 5 domain dan melakukan analisa terhadap subproses dan aktifitas didalamnya. Lima proses yang dipilih adalah APO07, BAI09, EDM01, MEA01, dan DSS03. Metode pengumpulan data yang digunakan pada penelitian ini adalah observasi dan wawancara terhadap proses bisnis perusahaan dan narasumber untuk menilai aktifitas terkait dengan 5 proses terpilih. Dari pengukuran yang dilakukan, diketahui bahwa PT.Sentral elektrik mendapatkan tingkat kapabilitas pada level 1 yaitu performed process pada 5 proses terpilih.Dari hasil penilaian perusahaan sudah memiliki kondisi yang cukup ideal namun ada beberapa aktifitas yang masih bisa ditingkatkan. Untuk meningkatkan kondisi perusahaan juga terdapat rekomendasi dan follow-up terkait aktifitas COBIT 5 yang bertujuan meningkatkan kondisi perusahaa

    Expanding the functional proteome of Mycoplasma pneumoniae

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    University of Technology Sydney. Faculty of Science.The growing incidence of antibiotic resistance globally is a significant public health issue and as previously susceptible bacteria continue to develop resistance, we need to develop novel strategies to counter this trend. Mycoplasma pneumoniae is a genome reduced bacteria that is one of the major causes of bacterial pneumonia in close contact settings such as schools and hospitals. Children, the elderly, and the immuno-suppressed are commonly infected due to an under developed or impaired immune system. A successful vaccine against this respiratory pathogen is yet to be developed and treatment options are limited. Additionally, children are limited to one class of antibiotics due to the permanent side effects of other agents. Antibiotic resistance within M. pneumoniae was detected over a decade ago and has now spread to most of the Northern Hemisphere. Though infections are not typically fatal, M. pneumoniae can cause secondary co-infections; some of which can be fatal. The work presented within this thesis expands the functional proteome of M. pneumoniae, with the goal of discovering potential novel therapeutic or vaccine targets. This was initially achieved by examining the full repertoire of proteins exposed on the surface of M. pneumoniae. This thesis then addresses which host antigens these proteins potentially interact with during infection. Although a single protein was not chosen as a vaccine target, the result of the work presented here report a list of potential targets that participate in the colonisation of the respiratory epithelium. This thesis highlights that the interactions between M. pneumoniae and host epithelium are complex, and involve a wide range of diverse proteins. This thesis begins with an introduction to M. pneumoniae and what is currently known about the proteins involved during the interaction with the human host

    Studi Keakuratan dan Kekonvergenan Metode Elemen Hingga Berbasis Kriging dan Konvensional

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    Metode elemen hingga (MEH) saat ini merupakan metode numerik yang digunakan secara luas dalam bidang teknik dan ilmu pengetahuan. Sebagai alternatif MEH konvensional, akhir-akhir ini terdapat usulan MEH jenis baru yang dinamakan metode elemen hingga berbasis Kriging (MEH-K). Dengan MEH-K, seorang analis struktur dapat menggunakan mesh yang tersusun dari elemen yang paling sederhana, yaitu elemen segitiga tiga node, namun tetap dapat memperoleh hasil yang akurat dan halus distribusi gradiennya. Dalam makalah ini disajikan studi keakuratan dan kekonvergenan metode baru ini dibandingkan dengan MEH konvensional. Studi dilakukan dalam konteks masalah linier-elastik tegangan bidang. Elemen yang ditinjau adalah elemen segitiga dengan basis polinom linier, kuadratik, dan kubik. Studi dilakukan secara numerik dengan melakukan pengujian pada dua masalah, yaitu balok kantilever dan pelat siku yang memiliki titik singularitas tegangan. Ukuran yang dipakai dalam menilai keakuratan dan kekonvergenan adalah energi regangan struktur. Hasil studi menunjukkan bahwa untuk elemen dengan basis linier, keakuratan MEH-K lebih baik daripada MEH konvensional, namun untuk elemen kuadratik dan kubik, hasil-hasil MEH konvensional lebih baik daripada MEH-K

    Engaging students in scenario-based assessment for final exams

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    We present our approaches to enhancing the authenticity of final exams across large first-year first semester biology units of cohort sizes between 300-1200 students. Historically exams were primarily used as an instrument that mainly assessed knowledge retention with limited provision of feedback to students. The necessity to shift to online learning during the height of the COVID-19 pandemic provided us with a challenging, yet opportune moment to transform our final examinations into an authentic learning experience for undergraduate biology students. We placed a large focus on integrating scenario-based questions in the final exam thereby assessing students’ ability to apply knowledge to real-world contexts. To enhance engagement with the assessment, we also provided personalised feedback for each student. With additional challenges around access to artificial intelligence and academic integrity, we share our experiences returning to in-person final examinations and evaluate the relevancy and benefits of scenario-based questions for student assessment and learning. We also share our approaches to feedforwarding initiatives to prepare students for examinations that is different to what most students would have experienced in their secondary schooling

    Pengaruh Perbedaan Suhu Curing dan pH Cairan Pembersih Terhadap Ceramic Coating

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    Penelitian ini menginvestigasi pengaruh variasi jenis spray gun terhadap ketebalan cat pada panel yang diuji. Parameter utama yang diperhatikan adalah perbedaan jarak penyemprotan dan variasi gerakan penyemprotan. Setelah proses pengecatan, panel tersebut melanjutkan tahap ceramic coating. Fokus dilanjutkan pada pengujian perbedaan pH pada permukaan lapisan ceramic coating, menggambarkan interaksi antara jenis spray gun dan kualitas lapisan pelindung yang dihasilkan. Selain itu, penelitian juga mempertimbangkan pengaruh perbedaan suhu curing terhadap lapisan ceramic coating, mengevaluasi stabilitas dan performa material pada berbagai kondisi suhu. Hasil penelitian ini dapat memberikan wawasan mendalam mengenai optimalisasi teknik penyemprotan dan proses ceramic coating, memperkaya pemahaman dalam industri pengecatan dan perlapisan pelindung. Dari penelitian yang ada didapati bahwa pH asam dan pH basa memiliki sifat abrasif yang paling tinggi dan sangat dianjurkan untuk menghindari pemakaian pH yang tidak netral pada permukaan lapisan coating

    Management of an Elderly Patient with Orthostatic Hypotension in Endodontic Retreatment: A Case Report

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    Orthostatic hypotension occurs when cardiovascular adaptive mechanisms fail to compensate the reduction in venous return that normally occurs on the upright position. A patient with orthostatic hypotension can be a challenging case for a dentist. A 78-year-old male came with idiopatic orthostatic hypotension and felt uncomfortable with his old crown restoration and discoloration on his upper teeth. Management of orthostatic hypotension can be handled by manipulating the dental chair interval movement position

    Elongation factor Tu is a multifunctional and processed moonlighting protein

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    Many bacterial moonlighting proteins were originally described in medically, agriculturally, and commercially important members of the low G + C Firmicutes. We show Elongation factor Tu (Ef-Tu) moonlights on the surface of the human pathogens Staphylococcus aureus (SaEf-Tu) and Mycoplasma pneumoniae (MpnEf-Tu), and the porcine pathogen Mycoplasma hyopneumoniae (MhpEf-Tu). Ef-Tu is also a target of multiple processing events on the cell surface and these were characterised using an N-terminomics pipeline. Recombinant MpnEf-Tu bound strongly to a diverse range of host molecules, and when bound to plasminogen, was able to convert plasminogen to plasmin in the presence of plasminogen activators. Fragments of Ef-Tu retain binding capabilities to host proteins. Bioinformatics and structural modelling studies indicate that the accumulation of positively charged amino acids in short linear motifs (SLiMs), and protein processing promote multifunctional behaviour. Codon bias engendered by an A + T rich genome may influence how positively-charged residues accumulate in SLiMs
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