Role of natural phenolics in hepatoprotection: A mechanistic review and analysis of regulatory network of associated genes

The liver is not only involved in metabolism and detoxification, but also participate in innate immune function and thus exposed to frequent target Thus, they are the frequent target of physical injury. Interestingly, liver has the unique ability to regenerate and completely recoup from most acute, non-iterative situation. However, multiple conditions, including viral hepatitis, non-alcoholic fatty liver disease, long term alcohol abuse and chronic use of medications can cause persistent injury in which regenerative capacity eventually becomes dysfunctional resulting in hepatic scaring and cirrhosis. Despite the recent therapeutic advances and significant development of modern medicine, hepatic diseases remain a health problem worldwide. Thus, the search for the new therapeutic agents to treat liver disease is still in demand. Many synthetic drugs have been demonstrated to be strong radical scavengers, but they are also carcinogenic and cause liver damage. Present day various hepatic problems are encountered with number of synthetic and plant based drugs. Nexavar (sorafenib) is a chemotherapeutic medication used to treat advanced renal cell carcinoma associated with several side effects. There are a few effective varieties of herbal preparation like Liv-52, silymarin and Stronger neomin phages (SNMC) against hepatic complications. Plants are the huge repository of bioactive secondary metabolites viz; phenol, flavonoid, alkaloid etc. In this review we will try to present exclusive study on phenolics with its mode of action mitigating liver associated complications. And also its future prospects as new drug lead

FLOATING HABITATION : RE-INVENTION OF SPATIAL RELATIONSHIP WITH WATER THROUGH ADVANCEMENT OF TECHNOLOGY

Master'sMASTER OF ARCHITECTURE (M.ARCH

A novel cabin air distribution strategy for automotive applications

This report looks at the current state of the art for air distribution methods in particular, personalized ventilation (PV) type of air distribution. PV systems have been widely used in the buildings applications and lately, in the development of new aircraft cabin air distributions. Air distribution in vehicles has had a few new cooling methods like spot cooling being researched on. PV systems have the aim of providing effective cooling with increased comfort providing better quality air to the occupant. The solar heat load on a vehicle was studied. It was shown that the peak heat load in the vehicle does not occur when the sun is at its peak, but only when the sunlight is able to penetrate most of the windows at about 2 pm. There are also various methods to lower the direct solar radiation coming into the vehicle and one of them is via geometry. The best geometrical compromise to minimise solar radiation, and yet not affect the aerodynamics of the vehicle too drastically, is to position the windscreen at an angle of 40o from the vertical plane. This gives a reduction of about 15% in terms of solar loading compared to an angle of a conventional car at 57o. The most effective way of heat reduction is to prevent the solar radiation from entering the vehicle directly. If the peak cooling load and the energy usage for cooling were to be reduced from the cooling down phase after parking, some effective methods would be to allow for natural or forced ventilation of the ambient air during parking or lowering the thermal capacity of the materials in the cabin. Both methods can lead to a decrease in energy requirement by 27%. A PV system for vehicles was introduced. This design was developed from prior designs which had various issues with airflow being affected by the warm air in the vehicle. The PV seat allowed for the individual cooling of a passenger. A series of simulations were conducted using StarCCM and Theseus FE. Three cases were ran, one being the full conventional air conditioning system with a mass flow rate of 0.1 kg/s, the next is a conventional air conditioning system but only with mass flow rate of 0.025 kg/s and focused entirely on the driver, and lastly the PV seat with the driver seated inside. The same mass flow rate was used for the PV seat case. All cases used an inlet air temperature of 8℃. Comparing to latter 2 cases, the PV seat was able to produce a better comfort index score compared to the conventional seat with an improvement of about 0.7% to 50%. This was done with a reduction of air inlet velocity of 110%. The streamlines also showed that the airflow was more effective and much of the air did not flow into the back seat area reducing the cross contamination between passengers. Taking reference from breathing region at the back seat, measuring the spread of contaminants from the front, the PV seat case had 32% less contaminants compared to the convention air conditioning layout. Most importantly, although not proven via simulations, it can be deduced that potential energy savings are possible for a comparable comfort between the 2 types of cooling systems.MASTER OF ENGINEERING (MAE

Factors Determining Sandwich Generation Household’s Asset Allocation in Taiwan

「三明治世代」一詞形容著家庭的中間世代─父母，他們承擔著對上一代老人的照顧責任以及撫養下一代子女的義務，就像是三明治一樣夾在上下兩代的壓力之間，在不同國家皆佔有不小的比例。而台灣在各種社會與經濟變化如人口高齡化、學歷貶值、物價上漲與薪資漲幅有限的情勢下，三明治世代家庭除了本身的家庭所得外，會希望透過資產投資來獲取額外的報酬以應付支出。為了瞭解這類型家庭對於家庭資產選擇的情形與影響決策的主因，本研究建立三明治世代家庭資產選擇模型，依據三明治世代範圍的不同，先從三代同堂家庭開始分析，再延伸到不同類型家庭但是有撫養與照顧上下代老人小孩的廣義三明治世代家庭，所用資料來自於中央研究院的華人動態資料庫，並以Probit模型分析其資產選擇的行為，實證結果為：三代同堂家庭在上下兩代影響因素中以小孩層面影響為主，小孩年教育費用與家庭儲蓄機率呈現負向關係；對廣義三明治世代家庭而言，上下代影響因素中則以老人層面影響資產選擇，給老人月生活費和股票參與機率呈現正向關係。此外，受到上下代因素影響，部分家庭會將額外的房屋或店面出租，老人層面變數和子女教育費用皆會顯著正面影響出租機率。不論是三代同堂或是廣義三明治世代家庭，家庭所得、父母年齡與教育程度皆會顯著正向影響所有資產參與機率。因此未來政府制定福利政策時，能以小孩教育和老人照護方面為主，來幫助台灣三明治世代家庭。第一章 緒論 1 第一節 研究動機與目的 1 第二節 研究流程 5 第三節 研究範圍與限制 6 第二章 文獻探討 7 第一節 家庭資產選擇因素 7 第二節 三明治世代相關文獻 10 第三章 研究方法 12 第一節 Probit 模型 12 第二節 三明治世代家庭資產選擇迴歸模型 14 第四章 實證分析 18 第一節 資料處理與變數說明 18 第二節 敘述性統計 21 第三節 實證模型 24 第四節 實證結果與分析 25 第五章 結論與建議 35 第一節 結論 35 第二節 建議 37 第三節 未來研究方向 38 參考文獻 39 附錄 4

Rhizoctonia spp. isolated from turfgrass

Rhizoctonia spp. 在地基部穿剌接種，會引起感染病勢快速發展， 造成莖部褐化 乾枯，或葉鞘、葉片褐腐。接種在種子或幼苗則幼苗根部褐化，嚴重時全株枯萎。 在七種測試草種中， 小糠草、百慕達草 U-3 和韓國草之幼苗較容易被感染危害。 化學藥劑以 Vitavax-200 （ carboxin+thiram ）和貝芬普寧（ carbendaxim+mepronil ）二種防治效果較佳。 生物防治試驗中，無論是對種子或 草莖之防治，Chaetomium sp. 之效果均較 Trichoderma sp. 和 Bacillus sp. 之 效果佳。 #9313413 #931341

Prevalence of female smoking among local undergraduates.

To understand the smoking behaviour of local female undergraduates and investigate the initiation and continuation

Learning logic, search and cracking through a number guessing game

This paper describes the development of a number guessing game aimed at playful learning of logic, search and cracking for the young. It can also be used to train memory and intelligent guessing for seniors. Theories and models utilized are Goals, Operators, Methods and Selection (GOMS), Norman’s 7 stages, and Schneiderman et. al’s design principles for user interface design. Findings among students indicate that the number guessing game is easy to use, and useful and that history and feedback are the most important design factors. This paper has managed to come out with an expected result where multitasking is required and player has to read and understand the meaning from the output to complete the game. We look forward to possibly designing for both children and seniors in the future by improving the game features without making the game become more complicated