Der elektronische Mutterpass

Zusammenfassung: Durch das Führen einer elektronischen Krankengeschichte für Schwangerschaft, Geburt und Wochenbett wurde es uns möglich, die elektronisch gespeicherten Daten im PDF-Format auf einen USB-Stick zu übertragen. In der Ambulanz der Klinik für Geburtshilfe am Universitätsspital Zürich erhalten seit Herbst 2005 alle Schwangeren einen mit Drittmitteln der Industrie finanzierten elektronischen Mutterpass. Er beinhaltet alle über die Schwangere gespeicherten Daten der Krankenakte einschließlich (Ultraschall-)Bildern. Der Stick wird nach jeder Kontrolluntersuchung neu synchronisiert. Die ersten Rückmeldungen der Schwangeren sind sehr positi

The sequelae of a missed Essex-Lopresti lesion

Radial head fractures are the most common type of elbow fracture in adults. Unrecognised disruption of the intraosseous membrane at the time of injury can lead to severe wrist pain from proximal radial migration especially if the radial head is excised. In this case, despite anatomical reduction and internal fixation of the radial head fracture, longitudinal forearm instability developed after delayed radial head resection was performed 7 months post-injury. A Suave-Kapandji procedure was performed due to ongoing wrist pain. Because of the previous radial head resection, this led to a floating forearm that could only be solved by creating a one-bone forearm, sacrificing all forearm rotation to achieve a stable lever arm between the elbow and wrist joint

In situ stress tensor measured in an Alaskan glacier

An experimental program at Worthington Glacier, Alaska, U.S.A., has yielded the first in situ measurements of the full stress tensor in glacier ice. Measurements were made with an array of stiff (low-compliance) normal-force sensors frozen into a borehole at 120 m depth. Freezing in temperate ice was accomplished by a down-hole heat exchanger which extracted heat at the rate of 15 W. Under slowly varying stress conditions, relaxation of stress anomalies by viscous creep following drilling of the hole and installation of the sensors allows for equilibration of measured stresses with far-field stresses. Equilibration of local and far-field stresses was confirmed and pressure sensor calibrated in laboratory experiments prior to the field program. Results of the stress measurements show principal axes of the stress tensor oriented in directions consistent with the geometry of the glacier and broadly consistent with measured englacial strain rate. The magnitudes of stress-tensor components are more error-prone and more sensitive to uncertainty in sensor magnitude than uncertainty in sensor orientation. Mean stress determined by pressure measurements agrees with estimated lithostatic overburden with within approximately 15%. Unexpected results include a stress perturbation lasted about 5 days that caused a rotation of the orientations of the principal stress axes of approximately 5 degrees about an axis pointing in the down-flow direction

Expression and delivery of an endolysin to combat Clostridium perfringens

Clostridium perfringens is a cause for increasing concern due to its responsibility for severe infections both in humans and animals, especially poultry. To find new control strategies to treat C. perfringens infection, we investigated the activity and delivery of a bacteriophage endolysin. We identified a new endolysin, designated CP25L, which shows similarity to an N-acetylmuramoyl-l-alanine amidase domain and is distinct from other C. perfringens endolysins whose activity has been demonstrated in vitro. The cp25l gene was cloned and expressed in Escherichia coli, and the gene product demonstrated lytic activity against all 25 C. perfringens strains tested. The probiotic strain Lactobacillus johnsonii FI9785 was engineered to deliver the endolysin to the gastrointestinal tract. The integration of the nisRK two-component regulatory system from the Lactococcus lactis nisin A biosynthesis operon into the chromosome of L. johnsonii allowed constitutive expression of the endolysin under the control of the nisA promoter (P(nisA)), while the use of a signal peptide (SLPmod) led to successful secretion of the active endolysin to the surrounding media. The high specificity and activity of the endolysin suggest that it may be developed as an effective tool to enhance the control of C. perfringens by L. johnsonii in the gastrointestinal tract

Spectral Analysis of the Chandra Comet Survey

We present results of the analysis of cometary X-ray spectra with an extended version of our charge exchange emission model (Bodewits et al. 2006). We have applied this model to the sample of 8 comets thus far observed with the Chandra X-ray observatory and ACIS spectrometer in the 300-1000 eV range. The surveyed comets are C/1999 S4 (LINEAR), C/1999 T1 (McNaught-Hartley), C/2000 WM1 (LINEAR), 153P/2002 (Ikeya-Zhang), 2P/2003 (Encke), C/2001 Q4 (NEAT), 9P/2005 (Tempel 1) and 73P/2006-B (Schwassmann-Wachmann 3) and the observations include a broad variety of comets, solar wind environments and observational conditions. The interaction model is based on state selective, velocity dependent charge exchange cross sections and is used to explore how cometary X-ray emission depend on cometary, observational and solar wind characteristics. It is further demonstrated that cometary X-ray spectra mainly reflect the state of the local solar wind. The current sample of Chandra observations was fit using the constrains of the charge exchange model, and relative solar wind abundances were derived from the X-ray spectra. Our analysis showed that spectral differences can be ascribed to different solar wind states, as such identifying comets interacting with (I) fast, cold wind, (II), slow, warm wind and (III) disturbed, fast, hot winds associated with interplanetary coronal mass ejections. We furthermore predict the existence of a fourth spectral class, associated with the cool, fast high latitude wind.Comment: 16 pages, 16 figures, and 7 Tables; accepted A&A (Due to space limits, this version has lower resolution jpeg images.

β-Glucan is a major growth substrate for human gut bacteria related to Coprococcus eutactus

A clone encoding carboxymethyl cellulase activity was isolated during functional screening of a human gut metagenomic library using Lactococcus lactis MG1363 as heterologous host. The insert carried a glycoside hydrolase family 9 (GH9) catalytic domain with sequence similarity to a gene from Coprococcus eutactus ART55/1. Genome surveys indicated a limited distribution of GH9 domains among dominant human colonic anaerobes. Genomes of C. eutactus-related strains harboured two GH9-encoding and four GH5-encoding genes, but the strains did not appear to degrade cellulose. Instead, they grew well on β-glucans and one of the strains also grew on galactomannan, galactan, glucomannan and starch. Coprococcus comes and Coprococcus catus strains did not harbour GH9 genes and were not able to grow on β-glucans. Gene expression and proteomic analysis of C. eutactus ART55/1 grown on cellobiose, β-glucan and lichenan revealed similar changes in expression in comparison to glucose. On β-glucan and lichenan only, one of the four GH5 genes was strongly upregulated. Growth on glucomannan led to a transcriptional response of many genes, in particular a strong upregulation of glycoside hydrolases involved in mannan degradation. Thus, β-glucans are a major growth substrate for species related to C. eutactus, with glucomannan and galactans alternative substrates for some strains

Simultaneous Swift X-ray and UV views of comet C/2007 N3 (Lulin)

We present an analysis of simultaneous X-Ray and UV observations ofcomet C/2007 N3 (Lulin) taken on three days between January 2009 and March 2009 using the Swift observatory. For our X-ray observations, we used basic transforms to account for the movement of the comet to allow the combination of all available data to produce an exposure-corrected image. We fit a simple model to the extracted spectrum and measured an X-ray flux of 4.3+/-1.3 * 10^-13 ergs cm-2 s-1 in the 0.3 to 1.0 keV band. In the UV, we acquired large-aperture photometry and used a coma model to derive water production rates given assumptions regarding the distribution of water and its dissociation into OH molecules about the comet's nucleus. We compare and discuss the X-ray and UV morphology of the comet. We show that the peak of the cometary X-ray emission is offset sunward of the UV peak emission, assumed to be the nucleus, by approximately 35,000 km. The offset observed, the shape of X-ray emission and the decrease of the X-ray emission comet-side of the peak, suggested that the comet was indeed collisionally thick to charge exchange, as expected from our measurements of the comet's water production rate (6--8 10^28 mol. s-1). The X-ray spectrum is consistent with solar wind charge exchange emission, and the comet most likely interacted with a solar wind depleted of very highly ionised oxygen. We show that the measured X-ray lightcurve can be very well explained by variations in the comet's gas production rates, the observing geometry and variations in the solar wind flux.Comment: Paper accepted for publication in Astronomy and Astrophysics, 6 March 2012, 12 pages, 8 colour figures, one tabl

Exploring the Relationship Between Housing Downturns and Partisan Elections: Neighborhood-Level Evidence from Maricopa County, Arizona

An understudied outcome of foreclosure crises is how their aftershocks affect partisan elections. Two hypotheses are that partisan shifts may occur in neighborhoods with concentrated foreclosures because of (1) declines in turnout among liberal leaning voters or (2) swells of anti-incumbency among all voters. This research explores these hypotheses in Maricopa County, Arizona, by using econometric modeling to uncover associations among neighborhood foreclosures, voter turnout, and changes in the Republican vote share between the 2006 and the 2010 Arizona gubernatorial and U.S. Senate elections. Our results show evidence of (1) anti-incumbent voting behavior and more liberal shifts among neighborhoods harder hit by foreclosures and (2) conservative shifts in neighborhoods experiencing African-American and Latinx population growth. These findings are suggestive of a link between neighborhood housing market distress and neighborhood partisan shifts, which in aggregate may shape state and national policymaking and future neighborhood conditions