Immunoglobulin A nephropathy and ischemic heart disease: a nationwide population-based cohort study

Background Chronic kidney disease has been linked to cardiovascular disease and specifically ischemic heart disease (IHD), but large-scale population data in patients with immunoglobulin A nephropathy (IgAN) are missing. Objective To examine absolute and relative risks for IHD in patients with IgAN. Methods Population-based register-based cohort study in Sweden. We identified 3945 patients with biopsy-verified IgAN, and 19,272 age- and sex-matched reference individuals from the general population. To reduce residual confounding from genetic factors and early environmental factors we carried out secondary analyses, where we compared 3039 IgAN patients with 6729 siblings, whereas a spousal analysis consisted of 2377 married couples where one of the spouses had IgAN. Data on IHD and end-stage renal disease (ESRD) were retrieved from the nationwide Patient Register. Cox regression estimated hazard ratios (HRs) adjusted for matching variables, education, country of birth, cancer, diabetes mellitus, and other systemic inflammatory diseases. Results During a follow-up of 55,527 person-years (py; mean follow-up 14.1 years), 371 patients (9.4%) with IgAN developed IHD (6.7/1000 py), compared with 1070 (5.6%) in 287,677 py in reference individuals (3.7/1000 py). The corresponding adjusted HR was 1.86 (95%CI = 1.63–2.13), equivalent to one extra case of IHD per 34 IgAN patients followed-up for 10 years. HRs were similar in men and women with IgAN, but higher in the first year after diagnosis and in patients born outside the Nordic countries. Patients with IgAN were at increased risk of IHD also compared to siblings (HR = 2.07; 95%CI = 1.62–2-64) and spouses (HR = 1.91; 95%CI = 1.40–2.61). Conclusions In this nationwide population-based study, patients with IgAN were at an 86% increased risk of future IHD

Eccentric and Isometric Shoulder Rotation Strength and Range of Motion: Normative Values for Adolescent Competitive Tennis Players

[EN] The aim of this cross-sectional study was to investigate isometric internal rotation (IR), external rotation (ER), abduction (ABD), and eccentric external rotation (eccER) shoulder strength and rotational range of motion (ROM) in adolescent male and female competitive tennis players. Additional aims of the study were to provide a tennis-specific normative database based on a large sample of players to deepen the knowledge regarding shoulder strength and ROM for adolescent competitive tennis players, and to discuss differences based on sex, age, and level of play. Shoulder strength and ROM was assessed in 301 adolescent competitive tennis players, 176 boys and 125 girls with a mean age of 14.6 and 14.4 years, respectively. Outcome variables of interest were isometric IR and ER strength, ABD strength, eccER shoulder strength, intermuscular strength ratios ER/IR and eccER/IR, IR ROM, ER ROM, and total range of motion (TROM). A General Linear Model two-way ANOVA was used to analyze differences in sex, age, and level of play. The findings of this study demonstrated age, side, and sex differences in the shoulder isometric strength, the eccER strength and ROM in adolescent competitive tennis players. Furthermore, when strength was expressed as ratios ER/IR and eccER/IR both sexes showed a lower ratio for eccER/IR in national players (0.95 ± 0.22 and 0.95 ± 0.23) compared to regional players (1.01 ± 0.32 and 1.07 ± 0.29) for male and female players, respectively. In conclusion, this paper presents a tennis-specific normative database for shoulder rotation strength and ROM in adolescent male and female competitive players. The key points in this evaluation are strength values normalized to body mass, intermuscular ratios, and TROM.SIThis study was funded by the Swedish Naprapathic AssociationThe authors thank the Swedish Tennis Association, and they also want to express their gratitude to all regional and national players who participated in the SMASH study. A special thank you to Cecilia Palmqvist for coordinating the team. Clara Onell for back-office support. Thank you also to Filip Allerkrans, Kristin Haugland, Gustav Knutas, Jonathan Kull, Linnea Lindberg, Daniel Sjödin, Emilie Kristine Slatleim, and David Tveit for assistance in data collection

Acute central nervous system toxicity during treatment of pediatric acute lymphoblastic leukemia : phenotypes, risk factors and genotypes

Publisher Copyright: © 2022 Ferrata Storti Foundation Published under a CC BY-NC license.Central nervous system (CNS) toxicity is common at diagnosis and during treatment of pediatric acute lymphoblastic leukemia (ALL). We studied CNS toxicity in 1, 464 children aged 1.0-17.9 years, diagnosed with ALL and treated according to the Nordic Society of Pediatric Hematology and Oncology ALL2008 protocol. Genome-wide association studies, and a candidate single-nucleotide polymorphism (SNP; n=19) study were performed in 1, 166 patients. Findings were validated in an independent Australian cohort of children with ALL (n=797) in whom two phenotypes were evaluated: diverse CNS toxicities (n=103) and methotrexate-related CNS toxicity (n=48). In total, 135/1, 464 (9.2%) patients experienced CNS toxicity for a cumulative incidence of 8.7% (95% confidence interval: 7.31-10.20) at 12 months from diagnosis. Patients aged ≥10 years had a higher risk of CNS toxicity than had younger patients (16.3% vs. 7.4%; P<0.001). The most common CNS toxicities were posterior reversible encephalopathy syndrome (n=52, 43 with seizures), sinus venous thrombosis (n=28, 9 with seizures), and isolated seizures (n=16). The most significant SNP identified by the genome-wide association studies did not reach genomic significance (lowest P-value: 1.11x10-6), but several were annotated in genes regulating neuronal functions. In candidate SNP analysis, ATXN1 rs68082256, related to epilepsy, was associated with seizures in patients <10 years (P=0.01). ATXN1 rs68082256 was validated in the Australian cohort with diverse CNS toxicities (P=0.04). The role of ATXN1 as well as the novel SNP in neurotoxicity in pediatric ALL should be further explored.Peer reviewe

Öppen översättning Lokalisering av programvara med öppen källkod

Den här uppsatsen handlar om översättning av dataprogram med öppen källkod. En bakgrundsstudie om öppen källkod med inriktning på problematiken kring översättning, terminologi och språkvård genomförs. Eftersom öppen källkod delvis är ideologiserad i ett samhällsperspektiv, uppmärksammas också den ställning som öppen källkod har i samhället. Som en del av arbetet översattes det fria översättningsverktyget OmegaT till svenska, för att få exempel på problem som kan förekomma. Studien visar att den användarbaserade översättningen av öppen källkod inte nödvändigtvis leder till sämre översättningar, som varit en vanlig uppfattning. Tvärtom fungerar de grundläggande funktionerna inom öppen källkod för att även upprätthålla välgjorda översättningar, i den mån en aktiv användarbas finns på målspråket

A Tide of Poetry : Collections of Poetry Published in Sweden 1976–1995

The subject of this dissertation is the publishing of poetry in Sweden 1976–1995. The purpose is to examine the position of poetry in the Swedish book market and in the literary process. It is an empirical and statistical study based primarily on an inventory of the published works. The study shows that the publication of Swedish poetry collections in 1976–1995 consisted of 3 848 titles (new works only), which was more than ever before. Publication was consistent over the period, partly due to the allocation of the literature grant introduced by the Swedish government in 1975, but also to the technical development which made it possible for small and private publishers to release collections of poetry at a lower cost. The main publishers were the general publishing houses of Bonniers, Norstedts and Wahlström &amp; Widstrand, but more than a third of the collections were published by vanity press and self publishers. Publication was strongly concentrated to the capital area. Regardless of the size of the publisher, poetry collections were printed in small numbers and generally sold poorly. Along with the technical development offset-printed books replaced duplicated publications, and more books were hardbound. The publishing houses made bigger efforts than ever before to publish female poets. The number increased over the period, but the men were still in a clear majority by 1995. The women were also largely responsible for rejuvenating the body of authors. The number of debutants was relatively constant during the period. The results in this dissertation indicate a hierarchic order among the publishing houses that determine the conditions for the authors and their works. This is verified through analyses of coverage in the national and regional daily papers, as well as three analyses of the authorships of Yngve Aldhagen, Else-Britt Kjellqvist and Bruno K. Öijer. The dissertation concludes that poetry exists on the publishing lists mainly for symbolical reasons; to publish poetry gives cultural capital to the publishers

A Tide of Poetry : Collections of Poetry Published in Sweden 1976–1995

The subject of this dissertation is the publishing of poetry in Sweden 1976–1995. The purpose is to examine the position of poetry in the Swedish book market and in the literary process. It is an empirical and statistical study based primarily on an inventory of the published works. The study shows that the publication of Swedish poetry collections in 1976–1995 consisted of 3 848 titles (new works only), which was more than ever before. Publication was consistent over the period, partly due to the allocation of the literature grant introduced by the Swedish government in 1975, but also to the technical development which made it possible for small and private publishers to release collections of poetry at a lower cost. The main publishers were the general publishing houses of Bonniers, Norstedts and Wahlström &amp; Widstrand, but more than a third of the collections were published by vanity press and self publishers. Publication was strongly concentrated to the capital area. Regardless of the size of the publisher, poetry collections were printed in small numbers and generally sold poorly. Along with the technical development offset-printed books replaced duplicated publications, and more books were hardbound. The publishing houses made bigger efforts than ever before to publish female poets. The number increased over the period, but the men were still in a clear majority by 1995. The women were also largely responsible for rejuvenating the body of authors. The number of debutants was relatively constant during the period. The results in this dissertation indicate a hierarchic order among the publishing houses that determine the conditions for the authors and their works. This is verified through analyses of coverage in the national and regional daily papers, as well as three analyses of the authorships of Yngve Aldhagen, Else-Britt Kjellqvist and Bruno K. Öijer. The dissertation concludes that poetry exists on the publishing lists mainly for symbolical reasons; to publish poetry gives cultural capital to the publishers