Feeding Ecology of Asiatic Wild Ass \u3ci\u3eEquus hemionus\u3c/i\u3e

The Mongolian wild ass or khulan (Equus hemionus) is a potential competitor for forage to reintroduced Przewalski’s horses. To evaluate the major foraging plants of khulan we chose the alkane method that was first described by Mayes in 1984. Different plant species contain varying amounts and proportions of n-alkanes. This fact allows the determination of diet composition by comparing the plant alkane to the fecal alkane pattern. The major advantage is that the method is non-invasive and has been shown to be a reliable method in captive trials. Fecal and plant samples were collected simultaneously and preserved by drying. The alkane content was determined gas chromatographically after chemical extraction. The diet composition was calculated according to Dove and Moore (1995). The results showed that in autumn 2003 beside some grass like species herbs like Allium mongolicum and Zygophyllum pterocarpum were the major foraging pants in Gobi B Strictly Protected Area in southwestern Mongolia

Feeding Ecology of Asiatic Wild Ass \u3ci\u3eEquus hemionus\u3c/i\u3e

The Mongolian wild ass or khulan (Equus hemionus) is a potential competitor for forage to reintroduced Przewalski’s horses. To evaluate the major foraging plants of khulan we chose the alkane method that was first described by Mayes in 1984. Different plant species contain varying amounts and proportions of n-alkanes. This fact allows the determination of diet composition by comparing the plant alkane to the fecal alkane pattern. The major advantage is that the method is non-invasive and has been shown to be a reliable method in captive trials. Fecal and plant samples were collected simultaneously and preserved by drying. The alkane content was determined gas chromatographically after chemical extraction. The diet composition was calculated according to Dove and Moore (1995). The results showed that in autumn 2003 beside some grass like species herbs like Allium mongolicum and Zygophyllum pterocarpum were the major foraging pants in Gobi B Strictly Protected Area in southwestern Mongolia

Identification of Herder-Wild Equid Conflicts in the Great Gobi B Strictly Protected Area in SW Mongolia

In protected areas of Mongolian overgrazing, competition with wild ungulates and poaching are important management concerns. The Great Gobi B Strictly Protected Area (SPA) in SW Mongolia is a re-introduction site for the Przewalski’s horse (Equus ferus przewalskii), a stronghold of the Asiatic wild ass (Equus hemionus), and remains an important grazing area for seminomadic herders. We show the power of simple inventory and monitoring methods to assess herder-wildlife conflicts, by combining data of: (1) human and livestock demographic data, (2) migration patterns, of semi-nomadic herders, (3) monthly surveys of wild- and domestic ungulates, and (4) observations of re-introduced, free-ranging Przewalski’s horses. A total of 111 semi-nomadic families with 57,657 head of livestock use the park, mainly in winter. Grazing impact of small stock affects 33% of the park area and is virtually absent in the core area. However, due to the unequal distribution of open water, livestock is present at almost all water points. Seasonal wild horse and wild ass distribution seems to be positively linked to water availability and negatively to herder presence. We documented several cases of wild ungulate poaching, but the magnitude of the problem remains unknown. There are still many knowledge gaps and local people need to be more actively involvement in park management. As this is a rather new approach in Mongolia, we suggest park management to move towards adaptive co-management, accompanied by simple, but sound monitoring and evaluation schemes

Identification of Herder-Wild Equid Conflicts in the Great Gobi B Strictly Protected Area in SW Mongolia

In protected areas of Mongolian overgrazing, competition with wild ungulates and poaching are important management concerns. The Great Gobi B Strictly Protected Area (SPA) in SW Mongolia is a re-introduction site for the Przewalski’s horse (Equus ferus przewalskii), a stronghold of the Asiatic wild ass (Equus hemionus), and remains an important grazing area for seminomadic herders. We show the power of simple inventory and monitoring methods to assess herder-wildlife conflicts, by combining data of: (1) human and livestock demographic data, (2) migration patterns, of semi-nomadic herders, (3) monthly surveys of wild- and domestic ungulates, and (4) observations of re-introduced, free-ranging Przewalski’s horses. A total of 111 semi-nomadic families with 57,657 head of livestock use the park, mainly in winter. Grazing impact of small stock affects 33% of the park area and is virtually absent in the core area. However, due to the unequal distribution of open water, livestock is present at almost all water points. Seasonal wild horse and wild ass distribution seems to be positively linked to water availability and negatively to herder presence. We documented several cases of wild ungulate poaching, but the magnitude of the problem remains unknown. There are still many knowledge gaps and local people need to be more actively involvement in park management. As this is a rather new approach in Mongolia, we suggest park management to move towards adaptive co-management, accompanied by simple, but sound monitoring and evaluation schemes

A cost-effectiveness analysis of a hydration response technology dressing in the treatment of venous leg ulcers in the UK

Introduction: Venous leg ulceration causes significant pain and suffering for patients, additionally it places considerable financial and service burden on the National Health Service (NHS). A large proportion of venous leg ulceration do not heal within the standard time frames of 16 – 24 weeks, resulting in static wounds which commonly have issues with increasing exudate production. Static wounds can have significant negative impact on the patients quality of life, the wound bed and periwound skin, increased risk of infection all of which results in delayed wound healing and increased health service costs. As the NHS continues to face times of austerity, services need to find solutions to be able to reduce cost and release nursing time whilst maintaining standards of care. Cutimed® Sorbion® Sachet S is a treatment option for the management of patients with a venous leg ulceration. The objective of this study was to provide an update of the health economic analysis of Cutimed® Sorbion® Sachet S in comparison to relevant comparators in the UK with current cost data. Methods: Cutimed® Sorbion® Sachet S was compared against Zetuvit Plus, DryMax extra, KerraMax Care and Eclypse from a cost effectiveness perspective. Clinical data were derived from literature and expert opinion. Cost input was utilized based on publicly available data and literature. The average patient in the model is assumed to be 65 years with a diagnosed venous leg ulcer. It is assumed that patients in the different treatment arms have the same background mortality, hence the endpoint mortality is not included in the model. The analysis is based on a deterministic Markov model derived from Harding et al. with weekly cycles. The following assumptions are made: First, all patients start in a static health state with a non-healed but non-progressing venous leg ulcer. It is assumed in the model that patients can transition to a deteriorating health state where a wound is improving or the wound could progress. Additionally, venous leg ulcers could be healed from a progressed wound (i.e. improved wound), they could develop into a severe wound with complications (infections) to be treated in hospitals. The time frame for the analysis was fixed for one year and no re-occurence after healing was assumed to happen. Results: The cost-effectiveness analysis demonstrates health economic dominance of Cutimed® Sorbion® Sachet S being more effective and cost-saving against all analysed comparators. When using literature-based input values the incrementally higher healing rates for Cutimed® Sorbion® Sachet S are 11.04 months (versus Zetuvit Plus), 29.04 months (versus DryMax extra), 1.68 months (versus KerraMax Care) and 11.04 months (versus Eclypse). Cost savings per patient were 37.60£ (versus Zetuvit Plus), 171.68£ (versus DryMax extra), 3.13£ (versus KerraMax Care) and 43.63£ (versus Eclypse). Clinical benefits and cost savings are increasing when real life practice assumptions based on expert opinion are included. Conclusions: Based on the underlying health economic model, Cutimed® Sorbion® Sachet S is more effective and less costly than other comparative products in venous leg ulcers in the UK

IL-7 and IL-15 independently program the differentiation of intestinal CD3−NKp46+ cell subsets from Id2-dependent precursors

The natural cytotoxicity receptor NKp46 (encoded by Ncr1) was recently shown to identify a subset of noncytotoxic, Rag-independent gut lymphocytes that express the transcription factor Rorc, produce interleukin (IL)-22, and provide innate immune protection at the intestinal mucosa. Intestinal CD3−NKp46+ cells are phenotypically heterogeneous, comprising a minority subset that resembles classical mature splenic natural killer (NK) cells (NK1.1+, Ly49+) but also a large CD127+NK1.1− subset of lymphoid tissue inducer (LTi)–like Rorc+ cells that has been proposed to include NK cell precursors. We investigated the developmental relationships between these intestinal CD3−NKp46+ subsets. Gut CD3−NKp46+ cells were related to LTi and NK cells in requiring the transcriptional inhibitor Id2 for normal development. Overexpression of IL-15 in intestinal epithelial cells expanded NK1.1+ cells within the gut but had no effect on absolute numbers of the CD127+NK1.1−Rorc+ subset of CD3−NKp46+ cells. In contrast, IL-7 deficiency strongly reduced the overall numbers of CD3−NKp46+NK1.1− cells that express Rorc and produce IL-22 but failed to restrict homeostasis of classical intestinal NK1.1+ cells. Finally, in vivo fate-mapping experiments demonstrated that intestinal NK1.1+CD127− cells are not the progeny of Rorc-expressing progenitors, indicating that CD127+NK1.1−Rorc+ cells are not canonical NK cell precursors. These studies highlight the independent cytokine regulation of functionally diverse intestinal NKp46+ cell subsets

The Danger of Having All Your Eggs in One Basket—Winter Crash of the Re-Introduced Przewalski's Horses in the Mongolian Gobi

Large mammals re-introduced into harsh and unpredictable environments are vulnerable to stochastic effects, particularly in times of global climate change. The Mongolian Gobi is home to several rare large ungulates such as re-introduced Przewalski's horses (Equus ferus przewalskii) and Asiatic wild asses (Equus hemionus), but also to a millennium-old semi-nomadic livestock herding culture