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4 research outputs found

Rare and Common Variants Conferring Risk of Tooth Agenesis

We present association results from a large genome-wide association study of tooth agenesis (TA) as well as selective TA, including 1,944 subjects with congenitally missing teeth, excluding third molars, and 338,554 controls, all of European ancestry. We also tested the association of previously identified risk variants, for timing of tooth eruption and orofacial clefts, with TA. We report associations between TA and 9 novel risk variants. Five of these variants associate with selective TA, including a variant conferring risk of orofacial clefts. These results contribute to a deeper understanding of the genetic architecture of tooth development and disease. The few variants previously associated with TA were uncovered through candidate gene studies guided by mouse knockouts. Knowing the etiology and clinical features of TA is important for planning oral rehabilitation that often involves an interdisciplinary approach

Erasmus University Digital Repository

Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits : A Multi-Ethnic Meta-Analysis of 45,891 Individuals

Author: Abecasis G.R.
Abecasis G.R.
Abecasis G.R.
Adair L.S.
Adair L.S.
Adrienne Cupples L.
Aihie Sayer A.
Allison M.A.
Altshuler D.
Altshuler D.
Altshuler D.
Amin N.
An P.
Ardlie K.
Ardlie K.
Ariyurek Y.
Assimes T.L.
Aulchenko Y.S.
Aulchenko Y.S.
Aulchenko Y.S.
Balkau B.
Balkau B.
Ballantyne C.M.
Ballantyne C.M.
Bandinelli S.
Bandinelli S.
Barbalic M.
Barroso I.
Barroso I.
Barroso I.
Barter P.
Beekman M.
Beilby J.P.
Ben-Shlomo Y.
Benediktsson R.
Benediktsson R.
Bengtsson Boström K.
Bennett A.J.
Bennett A.J.
Bergman R.N.
Bergman R.N.
Bergman R.N.
Bergmann S.
Bidulescu A.
Bis J.C.
Blagieva R.
Bochud M.
Boehm B.O.
Boehnke M.
Boehnke M.
Boehnke M.
Boerwinkle E.
Boerwinkle E.
Boerwinkle E.
Bonnefond A.
Bonnycastle L.L.
Bonnycastle L.L.
Bonnycastle L.L.
Boomsma D.I.
Boomsma D.I.
Borch-Johnsen K.
Borecki I.B.
Borecki I.B.
Borja J.B.
Bornstein S.R.
Bouatia-Naji N.
Bragi Walters G.
Bravenboer B.
Brody J.
Brunner E.
Buchanan T.A.
Bumpstead S.
Bumpstead S.J.
Burtt N.P.
Burtt N.P.
Buxbaum S.G.
Böhringer S.
Böttcher Y.
Campbell H.
Campbell H.
Campbell H.
Cao A.
Carlson O.D.
Cauchi S.
Caulfield M.J.
Cavalcanti-Proença C.
Chambers J.
Chambers J.
Charpentier G.
Charpentier G.
Chasman D.I.
Chen I.
Chen Y.-D.I.
Chines P.
Chines P.S.
Cho Y.S.
Clarke R.
Coassin S.
Coin L.J.M.
Collins F.S.
Collins F.S.
Collins F.S.
Cooper C.
Cooper M.N.
Cornelis M.
Cornelis M.
Couper D.J.
Couper D.J.
Crawford G.
Crawford G.
Crawford G.
Crisponi L.
Daly M.J.
Damien C.-C.
Dastani Z.
Day I.N.M.
de Faire U.
de Geus E.J.C.
de Geus E.J.C.
Dedoussis G.V.
Dedoussis G.V.
Dehghan A.
Deloukas P.
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Deloukas P.
Delplanque J.
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Publication date: 01/01/2012
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J. Kaprio, S. Ripatti ja M.-L. Lokki työryhmien jäseniä.Peer reviewe

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Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: A multi-ethnic meta-analysis of 45,891 individuals

Author: Abecasis G.R. (Goncalo R.)
Abecasis G.R. (Goncalo R.)
Abecasis G.R. (Gonçalo R.)
Abecasis G.R. (Gonçalo)
Adair L.S. (Linda)
Allison M.A. (Matthew)
Altshuler D. (David)
Altshuler D. (David)
Amin N. (Najaf)
An P. (Ping)
Ardlie K.G. (Kristin)
Ardlie K.G. (Kristin)
Ariyurek Y. (Yavuz)
Aulchenko Y.S. (Yurii S.)
Aulchenko Y.S. (Yurii S.)
Aulchenko Y.S. (Yurii)
Bacquer O.L. (Olivier)
Balkau B. (Beverley)
Balkau B. (Beverley)
Ballantyne C. (Christie)
Ballantyne C.M. (Christie M.)
Ballantyne C.M. (Christie M.)
Bandinelli S. (Stefania)
Bandinelli S. (Stefania)
Barbalic M. (maja)
Barroso I.
Barroso I.E. (Inês)
Barroso I.E. (Inês)
Barter P. (Phil)
Beekman M. (Marian)
Beilby J.P. (John)
Ben-Shlomo Y.
Benediktsson R. (Rafn)
Benediktsson R. (Rafn)
Bennett A.J. (Amanda)
Bennett A.J. (Amanda)
Bergman R.N. (Richard N.)
Bergman R.N. (Richard N.)
Bergman R.N. (Richard N.)
Bergmann S.M. (Sven)
Bidulescu A. (Aurelian)
Bis J.C. (Joshua)
Blagieva R. (Roza)
Bochud M. (Murielle)
Boehm B.O. (Bernhard)
Boehnke M. (Michael)
Boehnke M. (Michael)
Boehnke M. (Michael)
Boekholdt S.M. (Matthijs)
Boerwinkle E. (Eric)
Boerwinkle E. (Eric)
Boerwinkle E.A. (Eric)
Bonnefond A. (Amélie)
Bonnycastle L.L. (Lori L.)
Bonnycastle L.L. (Lori L.)
Bonnycastle L.L. (Lori)
Boomsma D.I. (Dorret I)
Boomsma D.I. (Dorret I.)
Boomsma D.I. (Dorret)
Borch-Johnsen K.
Borecki I.B. (Ingrid B)
Borja J.B. (Judith)
Boström K.B. (Kristina Bengtsson)
Bouatia-Naji N. (Nabila)
Bravenboer B. (Bert)
Brunner E. (Eric)
Buchanan T.A. (Thomas)
Bumpstead S. (Suzannah)
Bumpstead S. (Suzannah)
Burtt N.P. (Noël P.)
Burtt N.P. (Noël)
Buxbaum S.G. (Sarah)
Böhringer S. (Stefan)
Böttcher Y. (Yvonne)
Campbell H. (Harry)
Campbell H. (Harry)
Campbell H. (Harry)
Cao A. (Antonio)
Carlson O.D. (Olga)
Cauchi S. (Stephane)
Caulfield M. (Mark)
Caulfield M.J. (Mark J.)
Cavalcanti-Proença C. (Christine)
Chambers J. (John)
Chambers J.C. (John C.)
Charpentier G. (Guillaume)
Charpentier G. (Guillaume)
Chasman D.I. (Daniel)
Chen I. (Ida)
Chen Y.-D.I. (Yii-Der Ida)
Chen Y.D.I. (Yii-Der Ida)
Chines P.S. (Peter S.)
Chines P.S. (Peter)
Cho Y.S. (Yoon Shin)
Clarke R. (Robert)
Coassin S. (Stefan)
Coin L. (Lachlan)
Collins F.S. (Francis S.)
Collins F.S. (Francis S.)
Collins F.S. (Francis)
Cooper C. (Charles)
Cooper C. (Cyrus)
Cooper M.N. (Matthew)
Cornelis M. (Marilyn)
Cornelis M. (Marilyn)
Couper D.J. (David J.)
Couper D.J. (David)
Crawford G. (Gabe)
Crawford G. (Gabe)
Crawford G. (Gabriel)
Crisponi L. (Laura)
Croteau-Chonka D.C. (Damien)
Daly M.J. (Mark)
Dam R.M. (Rob) van
Dastani Z. (Zari)
Day I.N.M. (Ian)
Dedoussis G.V. (George)
Dehghan A. (Abbas)
Deloukas P. (Panagiotis)
Deloukas P. (Panagiotis)
Delplanque J. (Jerome)
DIAGRAM+ Consortium
Dina C. (Christian)
Dina C. (Christian)
Dominiczak A. (Anna)
Dominiczak A.F. (Anna F.)
Doney A.S.F. (Alex S. F.)
Doney A.S.F. (Alex)
Duijn C.M. (Cornelia) van
Duncan B.B. (Bruce)
Dupuis J. (Josée)
Dupuis J. (Josée)
Dupuis J. (Josée)
Döring A. (Angela)
Ebrahim S. (Shanil)
Egan J.M. (Josephine)
Egan J.M. (Josephine)
Ejebe K.G. (Kenechi)
Elliott A.L. (Amanda)
Elliott A.L. (Amanda)
Elliott K.S. (Katherine)
Elliott P. (Paul)
Erdmann J. (Jeanette)
Erdmann J. (Jeanette)
Erdos M.R. (Michael)
Erdos M.R. (Michael)
Evans D.M. (David)
Faire U. (Ulf) de
Fedson A.C. (Annette)
Feitosa M.F. (Mary Furlan)
Ferreira T. (Teresa)
Ferrucci L. (Luigi)
Ferrucci L. (Luigi)
Fischer-Rosinsky A. (Antje)
Florez J.C. (Jose C.)
Florez J.C. (Jose)
Florez J.C. (Jose)
Forouhi N.G. (Nita)
Fouchier S.W. (Sigrid)
Fox C.S. (Caroline)
Fox C.S. (Caroline)
Franklin C.S. (Christopher)
Franklin C.S. (Christopher)
Franks P.W. (Paul)
Frants R. (Rune)
Frants R.R. (Rune)
Franzosi M.
Frayling T.M. (Timothy M.)
Frayling T.M. (Timothy M.)
Frayling T.M. (Timothy M.)
Frayling T.M. (Timothy)
Froguel P. (Philippe)
Froguel P. (Philippe)
Fuchsberger C. (Christian)
Gabriel S.B. (Stacey)
Galan P. (Pilar)
Ganser M. (Martha)
Garcia M.E. (M.)
Geus E.J.C. (Eco) de
Gieger C. (Christian)
Gieger C. (Christian)
Gieger C. (Christian)
Gieger C. (Christian)
Glazer N.L. (Nicole)
GLGC Investigators
Gloyn A.L. (Anna L.)
Gloyn A.L. (Anna)
Go M.J. (Min Jin)
Goel A. (Anuj)
Gonzalez E. (Elena)
Goodarzi M. (Mark)
Graessler J. (Jürgen)
Grallert H. (Harald)
Grallert H. (Harald)
Grarup N. (Niels)
Grarup N. (Niels)
Green T. (Todd)
Greenwood C.M.T. (Celia)
Griffin S. (Simon)
Grimsby J. (Jonna)
Groop L. (Leif)
Groop L. (Leif)
Groop L. (Leif)
Groves C.J. (Christopher)
Groves C.J. (Christopher)
Grundy S.M. (Scott)
Gudnason V. (Vilmundur)
Guiducci C. (Candace)
Guiducci C. (Candace)
Guo X. (Xiuqing)
Guo X. (Xiuqing)
Gwilliam R. (Rhian)
Gyllensten U. (Ulf)
Gyllensten U. (Ulf)
Gyllensten U. (Ulf)
Hadjadj S. (Samy)
Hadjadj S. (Samy)
Haeften T.W. (Timon) van
Hagen K. (Knut)
Hall A.S. (Alistair)
Hallmans G. (Göran)
Hammond N. (Naomi)
Hamsten A. (Anders)
Han X. (Xijing)
Hansen T. (Torben)
Haritunians T. (Talin)
Harris T.B. (Tamara B.)
Harris T.B. (Tamara)
Hartikainen A.L.
Hassanali N. (Neelam)
Hassanali N. (Neelam)
Hastie N. (Nick)
Hattersley A.T. (Andrew)
Haun M. (Margot)
Havulinna A.S. (Aki)
Hayward C.
Hayward C. (Caroline)
Heath S.C. (Simon)
Heemst D. (Diana) van
Hegele R.A. (Robert)
Heid I.M. (Iris)
Heid I.M. (Iris)
Hengstenberg C. (Christian)
Henneman P. (Peter)
Henneman P. (Peter)
Hercberg S. (Serge)
Herder C. (Christian)
Herder C. (Christian)
Herpt T.W. (Thijs) van
Hicks A.A. (Andrew A.)
Hicks A.A. (Andrew)
Hide W.A. (Winston)
Hillman D.R. (David)
Hingorani A. (Aroon)
Hitman G.A. (Graham)
Hivert M.-F. (Marie-France)
Hoek M. (Mandy) van
Hofman A.
Hofman A. (Albert)
Hofman A. (Albert)
Hofman A. (Albert)
Hofmann O.M. (Oliver)
Holm H. (Hilma)
Hottenga J.J. (Jouke Jan)
Hottenga J.J. (Jouke Jan)
Hovingh G.K. (Kees)
Hu F.B. (Frank B)
Hu F.B. (Frank B.)
Hu F.B. (Frank)
Hui J. (Jennie)
Hung J. (Joe)
Hunter D.J. (David)
Huth C. (Cornelia)
Hveem K. (Kristian)
Igl W. (Wilmar)
Illig T. (Thomas)
Illig T. (Thomas)
Ingelsson E. (Erik)
Ingelsson E. (Erik)
Ingelsson E. (Erik)
Isaacs A. (Aaron)
Isaacs A.J. (Aaron)
Isomaa B. (Bo)
Isomaa B. (Bo)
Jackson A.U. (Anne)
Jackson A.U. (Anne)
Jarvelin M.-R. (Marjo-Riitta)
Jarvelin M.-R. (Marjo-Riitta)
Jarvelin M.-R. (Marjo-Riitta)
Johansen C.T. (Christopher)
Johansson A. (Åsa)
Johnson P.R.V. (Paul R. V.)
Johnson P.R.V. (Paul)
Johnson T. (Toby)
Johnson T. (Toby)
Johnson T. (Toby)
Jorgensen T. (Torben)
Jorgensen T. (Torben)
Jula A. (Antti)
Jula A. (Antti)
Kaakinen M. (Marika)
Kanaya A. (Alka)
Kanoni S. (Stavroula)
Kanoni S. (Stavroula)
Kao W.H.L. (W. H. Linda)
Kao W.H.L. (Wen H. L.)
Kao W.H.L. (Wen)
Kao W.H.L. (Wen)
Kaplan L. (Lee)
Kaprio J. (Jaakko)
Kapur K. (Karen)
Karpe F. (Fredrik)
Kastelein J.J.P. (John)
Katsareli E. (Efi)
Kedenko L. (Lyudmyla)
Kesaniemi Y.A. (Antero)
Khaw K.-T. (Kay-Tee)
Khaw K.T.
Kim Y-J. (Yong-Jin)
Kim Y.J.
Kivimaki M. (Mika)
Kizer J.R. (Jorge)
Klopp N. (Norman)
Klopp N. (Norman)
Kloppenburg M. (Margreet)
Knight B. (Beatrice)
Kong A. (Augustine)
Kong A. (Augustine)
Kooner J. (Jaspal)
Koseki M. (Masahiro)
Koskinen S. (Seppo)
Kovacs P. (Peter)
Kraft P. (Peter)
Kristiansson K. (Kati)
Kronenberg F. (Florian)
Kronenberg F. (Florian)
Kumari M. (Meena)
Kuusisto J. (Johanna)
Kuzawa C.W. (Christopher W.)
Kuzawa C.W. (Christopher)
Kyvik K.O. (Kirsten O.)
Kyvik K.O. (Kirsten Ohm)
Kähönen M. (Mika)
König I.R. (Inke)
Laakso M. (Markku)
Laakso M. (Markku)
Laakso M. (Markku)
Laaksonen R. (Reijo)
Ladouceur M. (Martin)
Lajunen T. (Taina)
Lakatta E.G. (Edward G.)
Lamina C. (Claudia)
Lamina C. (Claudia)
Lange L.A. (Leslie)
Lange L.A. (Leslie)
Langenberg C. (Claudia)
Langenberg C. (Claudia)
Langenberg C. (Claudia)
Langenberg C. (Claudia)
Lathrop G. (GMark)
Launer L.J. (Lenore J.)
Lauritzen T. (Torsten)
Lawlor D.A. (Debbie)
Lecoeur C. (Cécile)
Lee J.-Y. (Jong-Young)
Lehtimäki T. (Terho)
Lettre G. (Guillaume)
Li M. (Man)
Li M. (Man)
Li X. (Xiaohui)
Li X. (Xiaohui)
Li Y. (Yun)
Lieverse A.G. (Aloysius)
Lindgren C.M. (Cecilia M.)
Lindgren C.M. (Cecilia)
Liu C.-T. (Ching-Ti)
Liu Y. (YongMei)
Lohman K. (Kurt)
Lokki M.L.
Loo B.-M. (Britt-Marie)
Loos R.J.F. (Ruth)
Loos R.J.F. (Ruth)
Loos R.J.F. (Ruth)
Luan J. (Jian’an)
Luan J. (Jian’an)
Luben R.N. (Robert)
Lucas G. (Gavin)
Lyssenko V. (Valeriya)
Lyssenko V. (Valeriya)
Lyytikäinen L.-P. (Leo-Pekka)
MAGIC Consortium
Magnusson P.K. (Patrik)
Magnusson P.K.E. (Patrik K. E.)
Mahley R. (Robert)
Mangino M. (Massimo)
Mangino M. (Massimo)
Manning A.K. (Alisa K.)
Manning A.K. (Alisa)
Marmot M. (Michael)
Marre M. (Michel)
Marroni F. (Fabio)
Martin N.G. (Nicholas)
Martinez-Larrad M.T. (Maria Teresa)
Masson D. (David)
McArdle W.L. (Wendy)
McAteer J.B. (Jarred)
McCarroll S.A. (Steve)
McCarroll S.A. (Steven)
McCarthy M.I. (Mark I.)
McCarthy M.I. (Mark I.)
McCarthy M.I. (Mark)
McCulloch L.J. (Laura J.)
McCulloch L.J. (Laura)
McPherson R. (Ruth)
Meigs J.B. (James B.)
Meigs J.B. (James)
Meigs J.B. (James)
Meisinger C. (Christa)
Meitinger T. (Thomas)
Meitinger T. (Thomas)
Meitinger T. (Thomas)
Melander O. (Olle)
Melzer D. (David)
Meneton P. (Pierre)
Meulenbelt I. (Ingrid)
Meyre D. (David)
Midthjell K. (Kristian)
Mitchell B.D. (Braxton)
Mohlke K.L. (Karen L.)
Mohlke K.L. (Karen L.)
Mohlke K.L. (Karen L.)
Mohlke K.L. (Karen)
Mooser V. (Vincent)
Mooser V. (Vincent)
Mooser V.E. (Vincent E.)
Morken M.A. (Mario A.)
Morken M.A. (Mario)
Morris A.D. (Andrew D.)
Morris A.D. (Andrew)
Morris A.P. (Andrew P.)
Morris A.P. (Andrew P.)
Morris A.P. (Andrew)
Mukherjee S. (Sutapa)
Munroe P. (Patricia)
Musani S. (Solomon)
Musunuru K. (Kiran)
MuTHER Consortium
Mägi R. (Reedik)
Naitza S. (Silvia)
Narisu N. (Narisu)
Narisu N. (Narisu)
Nathan D.M. (David)
Navarro P. (Pau)
Navarro P. (Pau)
Neville M.J. (Matthew)
Nickerson D.A. (Deborah A.)
Nickerson D.A. (Deborah)
Nieminen M.S. (Markku)
Nilsson P. (Peter)
Nuotio M.-L. (Marja-Liisa)
Oostra B.A. (Ben A.)
Oostra B.A. (Ben)
Oostra B.A. (Ben)
Ordovas J.M. (Jose M.)
Ordovas J.M. (Jose)
Orho-Melander M. (Marju)
Orrù M. (Marco)
Owen K.R. (Katharine)
O’Connell J. (Jeffrey)
Pakyz R. (Ruth)
Palmer C. (Cameron)
Palmer C.N.A. (Colin N. A.)
Palmer C.N.A. (Colin)
Pankow J.S. (James S.)
Pankow J.S. (James)
Paolisso G. (Giuseppe)
Pare G. (Guillame)
Park T. (Taesung)
Parker A.N. (Alex)
Pattaro C. (Cristian)
Pattaro C. (Cristian)
Pattou F. (François)
Paulweber B. (Bernhard)
Payne F. (Felicity)
Payne F. (Felicity)
Pearson D. (Daniel)
Peden J. (John)
Pedersen N.L. (Nancy)
Pedersen O. (Oluf)
Pedersen O. (Oluf)
Peloso G.M. (Gina)
Peltonen L. (Leena Johanna)
Penninx B.W.J.H.
Penninx B.W.J.H. (Brenda W. J. H.)
Penninx B.W.J.H. (Brenda)
Perola M. (Markus)
Perola M. (Markus)
Perola M. (Markus)
Perry J.R.B. (John R. B.)
Perry J.R.B. (John R. B.)
Perry J.R.B. (John)
Petersen A.K.
Pfeiffer A.F.H. (Andreas)
Pichler I. (Irene)
Pichler I. (Irene)
Platou C.P. (Carl)
Polasek O. (Ozren)
Posthuma D. (Danielle)
Potter S.C. (Simon)
Pouta A. (Anneli)
Pramstaller P.P. (Peter P.)
Pramstaller P.P. (Peter P.)
Pramstaller P.P. (Peter Paul)
Pramstaller P.P. (Peter Paul)
Proença C. (Christine)
Prokopenko I. (Inga)
Prokopenko I. (Inga)
Province M.A. (Mike)
Psaty B.M. (Bruce M.)
Psaty B.M. (Bruce)
Qi L. (Lu)
Qi L. (Lu)
Quertermous T. (Thomas)
Quertermous T. (Thomas)
Rader D.J. (Daniel)
Raitakari O. (Olli)
Randall J.C. (Joshua)
Rasmussen-Torvik L.J. (Laura)
Rathmann W. (Wolfgang)
Rathmann W. (Wolfgang)
Raychaudhuri S. (Soumya)
Rayner N.W. (Nigel W.)
Rayner N.W. (Nigel William)
Redline S. (Susan)
Reilly M.P. (Muredach P.)
Rice K.M. (Kenneth)
Richards J.B. (J. Brent)
Ricketts S.L. (Sally)
Ridker P.M. (Paul)
Rieder M. (Mark)
Rieder M. (Mark)
Ripatti S. (Samuli)
Ripatti S. (Samuli)
Rivadeneira Ramirez F. (Fernando)
Roberts R. (Robert)
Robertson N.R. (Neil)
Roccasecca R.M.
Rocheleau G. (Ghislain)
Rocheleau G. (Ghislain)
Roden M. (Michael)
Roden M. (Michael)
Rolandsson O. (Olov)
Rose L.M. (Lynda)
Rotter J.I. (Jerome I)
Rudan I. (Igor)
Rudan I. (Igor)
Rudan I. (Igor)
Ruokonen A. (Aimo)
Ruokonen A. (Aimo)
Rybin D. (Denis)
Sabatti C. (Chiara)
Saharinen J. (Juha)
Salomaa V. (Veikko)
Salomaa V. (Veikko)
Salomaa V. (Veikko)
Samani N.J. (Nilesh)
Samani N.J. (Nilesh)
Sampson M.J. (Michael J)
Sampson M.J. (Michael)
Sandbaek A. (Annelli)
Sandhu M. (Manjinder)
Sandhu M.S. (Manjinder)
Sanna S. (Serena)
Sanna S. (Serena)
Sattar N. (Naveed)
Saxena R. (Richa)
Saxena R. (Richa)
Sayer A.A.
Schadt E.E. (Eric E.)
Schadt E.E. (Eric)
Scheet P. (Paul)
Schlessinger D. (David)
Schlessinger D. (David)
Schunkert H. (Heribert)
Schwarz P.E.H. (Peter)
Scott L.J. (Laura J.)
Scott L.J. (Laura)
Scott R.A. (Robert)
Scuteri A. (Angelo)
Scuteri A. (Angelo)
Scuteri A. (Angelo)
Seedorf U. (Udo)
Segrè A.V. (Ayellet)
Seielstad M. (Mark)
Semple R.K. (Robert K.)
Serrano-Ríos M. (Manuel)
Sethupathy P. (Praveen)
Sharp S.J. (Stephen)
Shields B.M. (Beverley)
Shields B.M. (Beverley)
Shrader P. (Peter)
Shrader P. (Peter)
Shuldiner A.R. (Alan)
Sigurdsson G. (Gunnar)
Sigursson G. (Gunnar)
Sijbrands E. (Eric)
Sijbrands E.J.G. (Eric J. G.)
Sijbrands E.J.G. (Eric)
Silander K. (Kaisa)
Silander K. (Kaisa)
Silveira A. (Angela)
Sim X. (Xueling)
Sim X. (Xueling)
Simpson L. (Laila)
Singleton A. (Andrew)
Sinisalo J. (Juha)
Siscovick D.S. (David)
Siscovick D.S. (David)
Sladek R. (Rob)
Sladek R. (Rob)
Slagboom P.E. (Eline)
Small K.S. (Kerrin)
Smith A.V. (Albert Vernon)
Smith A.V. (Albert)
Smith A.V. (Davey)
Smith A.V. (Davey)
Smith G.D. (George Davey)
Smith J.D. (Joshua D.)
Smith N.L. (Nicholas)
Song K. (Kijoung)
Soranzo N. (Nicole)
Soranzo N. (Nicole)
Sovio U. (Ulla)
Sparsø T. (Thomas)
Sparsø T. (Thomas)
Spector T.D. (Tim D.)
Spector T.D. (Timothy D.)
Spector T.D. (Timothy)
Spranger J. (Joachim)
St Pourcain B. (Beate)
Stefansson K. (Kari)
Stefansson K. (Kari)
Stein L.D. (Lincoln)
Steinthorsdottir V. (Valgerdur)
Steinthorsdottir V. (Valgerdur)
Strachan D.P. (David)
Strassburger K. (Klaus)
Stringham H.M. (Heather M.)
Stringham H.M. (Heather M.)
Stringham H.M. (Heather)
Stumvoll M. (Michael)
Stylianou I.M. (Ioannis M.)
Stylianou I.M. (Ioannis)
Sun Q. (Qi)
Surakka I. (Ida)
Swift A.J. (Amy)
Swift A.J. (Amy)
Syddall H. (Holly)
Syvänen A.C.
Tai E.-S. (E-Shyong)
Tai E.S. (Shyong)
Tall A.R. (Alan R.)
Tanaka T. (Toshiko)
Taylor H.A. (Herman A.)
Taylor H.A. (Herman)
Teslovich T.M. (Tanya M.)
Teslovich T.M. (Tanya M.)
Thompson J.R. (John)
Thompson J.R. (John)
Thorand B. (Barbara)
Thorand B. (Barbara)
Thorleifsson G. (Gudmar)
Thorleifsson G. (Gudmar)
Thorleifsson G. (Gudmar)
Thorsteinsdottir U. (Unnur)
Thorsteinsdottir U. (Unnur)
Thorsteinsdottir U. (Unnur)
Thorsteinsdottir U. (Unnur)
Tichet J. (Jean)
Tichet J. (Jean)
Timpson N.J. (Nicholas J.)
Timpson N.J. (Nicholas)
Tracy R.P. (Russell)
Tuomi T. (Tiinamaija)
Tuomi T. (Tiinamaija)
Tuomilehto J. (Jaakko)
Tuomilehto J. (Jaakko)
Tuomilehto J. (Jaakko)
Tönjes A. (Anke)
Uda M. (Manuela)
Uda M. (Manuela)
Uh H.-W. (Hae-Won)
Uitterlinden A. (Andre)
Uitterlinden A.G. (Andre G.)
Uitterlinden A.G. (André)
Valle T.T. (Timo T.)
van Duijn C. (Cornelia)
van Duijn C.M. (Cornelia M.)
van Duijn C.M. (Cornelia M.)
van Hoek M. (Mandy)
Varma D. (Dhiraj)
Viikari J. (Jorma)
Visvikis-Siest S. (Sophie)
Vitart V. (Veronique)
Vitart V. (Veronique)
Vliet-Ostaptchouk J.V. (Jana) van
Vogelzangs N. (Nicole)
Voight B.F. (Benjamin F.)
Voight B.F. (Benjamin F.)
Voight B.F. (Benjamin)
Vollenweider P. (Peter)
Vollenweider P. (Peter)
Vollenweider P. (Peter)
Waeber G. (Gérard)
Waeber G. (Gérard)
Wagner P.J. (Peter)
Walker M. (Mark)
Walley A. (Andrew)
Walters G. (GBragi)
Walters G.B. (Bragi)
Ward K.L. (Kim L.)
Wareham N.J. (Nick J.)
Wareham N.J. (Nick)
Wareham N.J. (Nick)
Watanabe R.M. (Richard M.)
Watanabe R.M. (Richard)
Waterworth D. (Dawn)
Waterworth D. (Dawn)
Waterworth D.M. (Dawn)
Watkins H. (Hugh)
Weedon M.N. (Michael)
Weedon M.N. (Michael)
Welch R.P. (Ryan)
Wheeler E. (Eleanor)
Whitfield J. (John)
Wichmann H.-E. (H.-Erich)
Wichmann H.E. (H. Erich)
Wichmann H.E. (Heinz Erich)
Wichmann H.E. (Heinz Erich)
Wijmenga C. (Cisca)
Wild S.H. (Sarah)
Willems van Dijk J.A.P. (Ko)
Willems S.M. (Sara)
Willems-vanDijk K. (Ko)
Willemsen G.
Willemsen G.A.H.M. (Gonneke)
Willer C.J. (Cristen J.)
Willer C.J. (Cristen)
Williams G.H. (Gordon)
Wilson J.F. (James F.)
Wilson J.F. (James)
Wilson J.G. (James G.)
Winkler T.W. (Thomas W.)
Witteman J. (Jacqueline)
Witteman J.C.M. (Jacqueline C. M.)
Witteman J.C.M. (Jacqueline)
Witteman J.C.M. (Jaqueline C. M.)
Wong T.Y. (Tien Y.)
Wood A.R. (Andrew)
Wright A.F. (Alan)
Wright A.F. (Alan)
Wu G. (Guanming)
Wu Y. (Ying)
Yarnell J.W.G. (John W.)
Yuan X. (Xin)
Zabena C. (Carina)
Zee R.Y.L. (Robert)
Zeggini E. (Eleftheria)
Zeggini E. (Eleftheria)
Zelenika D. (Diana)
Zethelius B. (Björn)
Zhai G. (Guangju)
Zhang W. (Weihua)
Zhao J.H. (Jing Hua)
Zhao J.H. (Jing Hua)
Zhao J.H. (Jing Hua)
Ziegler A. (Andreas)
Zillikens M.C. (Carola)
Zwart J-A. (John-Anker)
Ódonnell C.J. (Christopher)
Publication venue
Publication date: 01/01/2012
Field of study

Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P = 4.5×10−8- 1.2 ×10−43). Using a novel method to combine data across ethnicities (N = 4,232 African Americans, N = 1,776 Asians, and N = 29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adiponectin concentrations after accounting for multiple testing (p<3×10−4). We next developed a multi-SNP genotypic risk score to test the association of adiponectin decreasing risk alleles on metabolic traits and diseases using consortia-level meta-analytic data. This risk score was associated with increased risk of T2D (p = 4.3×10−3, n = 22,044), increased triglycerides (p = 2.6×10−14, n = 93,440), increased waist-to-hip ratio (p = 1.8×10−5, n = 77,167), increased glucose two hours post oral glucose tolerance testing (p = 4.4×10−3, n = 15,234), increased fasting insulin (p = 0.015, n = 48,238), but with lower in HDL- cholesterol concentrations (p = 4.5×10−13, n = 96,748) and decreased BMI (p = 1.4×10−4, n = 121,335). These findings identify novel genetic determinants of adiponectin levels, which, taken together, influence risk of T2D and markers of insulin resistance

Erasmus University Digital Repository

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

Author: Abecasis G. (Goncalo)
Abecasis G.R. (Gonçalo)
Abecasis G.R. (Gonçalo)
Aben K.K.H. (Katja)
Absher D. (Devin)
Absher D. (Devin)
Aherrahrou Z. (Zouhair)
Ahlqvist E. (Emma)
Ahmadi K.R. (Kourosh)
Ahmed N. (Nabeel)
Alavere H. (Helene)
Alibrandi M.T.S. (Maria)
Allayee H. (Hooman)
Allen H.L.
Almgren P. (Peter)
Altshuler D. (David)
Amin N. (Najaf)
Anand S.S. (Sonia)
Andersen K.K. (Karl)
Ardissino D. (Diego)
Ardlie K.G. (Kristin)
Armitage J. (Jane)
Arnold A.M. (Alice)
Aspelund T. (Thor)
Assimes T.L. (Themistocles)
Assmann G. (Gerd)
Aulchenko Y.S. (Yurii)
Azhar M. (Muhammad)
Balkau B. (Beverley)
Ball S.G. (Stephen G.)
Barbalic M. (maja)
Barker A.M. (Adam)
Barlassina C. (Christina)
Barlera S. (Simona)
Barnes D. (Daniel)
Barnes T.A. (Timothy)
Barrett A. (Angela)
Barroso I.E. (Inês)
Bataille V. (Veronique)
Becker D.M. (Diane)
Becker L.C. (Lewis)
Beckmann J.S. (Jacques)
Beckmann J.S. (Jacques)
Beilby J.P. (John)
Bell J.T. (Jordana)
Ben-Shlomo Y.
Ben-Shlomo Y. (Yoav)
Bennett A.J. (Amanda)
Berger K. (Klaus)
Bergman R.N. (Richard N.)
Bergmann S.M. (Sven)
Berndt S.I. (Sonja)
Biebermann H. (Heike)
Bis J.C. (Joshua)
Blagieva R. (Roza)
Blakemore A.I.F. (Alexandra)
Blankenberg S. (Stefan)
Boehm B.O. (Bernhard)
Boehm B.O. (Bernhard)
Boehnke M. (Michael)
Boeing H. (Heiner)
Boeing H. (Heiner)
Boekholdt S.M. (Matthijs)
Boerwinkle E.A. (Eric)
Boes T. (Tanja)
Bonnycastle L.L. (Lori)
Boomsma D.I. (Dorret)
Borecki I.B. (Ingrid)
Bornstein S.R. (Stefan R.)
Bornstein S.R. (Stefan)
Boström K.B. (Kristina Bengtsson)
Bouatia-Naji N. (Nabila)
Bowman L.
Braund P.S. (Peter)
Bravenboer B. (Bert)
Buchanan T.A. (Thomas)
Bumpstead S. (Suzannah)
Burnett M.S.
Burtt N.P. (Noël)
Busonero F.
Buysschaert I. (Ian)
Cambien F. (François)
Campbell H. (Harry)
Cappuccio F.P. (Francesco P.)
Cappuccio F.P. (Francesco)
Carlquist J.F. (John)
Cauchi S. (Stephane)
Caulfield M. (Mark)
Cavalcanti-Proença C. (Christine)
Chambers J.C. (John C.)
Chambers J.C. (John)
Chanock S.J. (Stephen)
Charpentier G. (Guillaume)
Chasman D.I. (Daniel)
Chatterjee N. (Nilanjan)
Chen C.-M. (Chih-Mei)
Chen H. (Han)
Chen L. (Li)
Chines P.S. (Peter)
Cichon S. (Sven)
Clarke R.
Clarke R. (Robert)
Codd V. (Veryan)
Coin L. (Lachlan)
Coin L. (Lachlan)
Collins F.S. (Francis S.)
Collins F.S. (Francis)
Collins F.S. (Francis)
Connell J. (John)
Cooper C. (Charles)
Cooper C.C. (Cyrus C.)
Cooper M.N. (Matthew N.)
Cooper M.N. (Matthew)
Cornelis M. (Marilyn)
Couper D.J. (David)
Crawford G. (Gabe)
Cupples L.A. (Adrienne)
Daly M.J. (Mark)
Dam R.M. (Rob) van
Danesh J. (John)
Davies R.W. (Robert)
Day I.N.M. (Ian N.M.)
Day I.N.M. (Ian)
Dedoussis G.V. (George)
Dedoussis G.V. (George)
Dedoussis G.V. (George)
Dehghan A. (Abbas)
Deloukas P. (Panagiotis)
Demissie S. (Serkalem)
Den Heijer M. (Martin)
Dennison E.M. (Elaine)
Dermitzakis E.T. (Emmanouil T.)
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Weyant R.J. (Robert)
Wheeler E. (Eleanor)
White C.C. (Charles)
Wichmann H.-E. (H-Erich)
Wichmann H.E. (Heinz Erich)
Widen E. (Elisabeth)
Wiegand S. (Susanna)
Wijmenga C. (Cisca)
Wiklund F. (Fredrik)
Wild P.S. (Philipp)
Wild S.H. (Sarah)
Wilk A. (Alicja)
Willemsen G.A.H.M. (Gonneke)
Willenborg C. (Christina)
Willer C.J. (Cristen)
Wilson J.F. (James F.)
Wingerden S. (Sophie) van
Winkler T.W. (Thomas W.)
Witte D.R. (Daniel R.)
Witte D.R. (Deniel)
Witteman J. (Jacqueline)
Witteman J.C.M. (Jacqueline)
Witteman J.C.M. (Jaqueline C.M.)
Wood A.R. (Andrew)
Workalemahu T. (Tsegaselassie)
Wright A.F. (Alan)
Wright B.J. (Benjamin)
Wu G. (Guanming)
Xie W. (Weijia)
Xu J. (Jianfeng)
Yang J. (Jian)
Yang J. (Joanna)
Yang T.-P. (Tsun-Po)
Ye S. (Shu)
Zabena C. (Carina)
Zaidi M.A. (Aghar)
Zaman K.S. (Khan Shah)
Zeggini E. (Eleftheria)
Zeller T. (Tanja)
Zethelius B. (Björn)
Zgaga L. (Lina)
Zhang Q. (Qunyuan)
Zhang W. (Weihua)
Zhao J.H. (Jing Hua)
Ziegler A. (Andreas)
Ziegler A. (Andreas)
Zillikens M.C. (Carola)
Zitting P. (Paavo)
Zondervan K.T. (Krina T.)
Zondervan K.T. (Krina)
Zwart J-A. (John-Anker)
Öhrvik J. (John)
Östenson C.-G. (Claes-Göran)
Publication venue
Publication date: 01/10/2011
Field of study

OBJECTIVE - Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired b-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS - We have conducted a meta-analysis of genome-wide association tests of ;2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS - Nine SNPs at eight loci were associated with proinsulin levels (P < 5 × 10-8). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/ C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 3 10-4), improved b-cell function (P = 1.1 × 10-5), and lower risk of T2D (odds ratio 0.88; P = 7.8 × 10-6). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS - We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis

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