Facilitating Group Work: a Guide to Good Practice

Oakley et al. (2004) and Gibbs (2009) observe that owing to the extensive literature on group work, lecturers searching for a succinct guide on how to facilitate this activity effectively would find it challenging to digest such a large corpus. We extensively reviewed the literature in order to produce a quick and accessible guide for lecturers to use. It is our aspiration that this could be referred to when planning and facilitating group work projects with insights and recommendations informed by our research. Moreover, as this work draws on publications from educators in a wide range of disciplines, we expect this guide to be universally applicable. Recommendations: We recommend that lecturers new to group work should consider implementing the following key steps when carrying out group work: Produce and distribute a Group Work Policy document, Ask students to produce Team Expectations Agreements, Establish a transparent group formation mechanism (e.g. ‘Pair and Share’), Choose assessment methods to align with learning outcomes as related to Person, Process, or Product, Manage emergent conflict and discipline issues using a series of measures of increasing consequence for the student Future work Our group report and artefact could be condensed and edited into a short pamphlet or flyer, which could be distributed to lecturers in different departments as a practical aid for facilitating group projects. In addition, our ‘guide to good practice’ could be further developed in the form of a mobile, or web application for rapid accessibility and convenience

Spotlight on: Humanities in speech and language therapy

In this ‘Spotlight on: Humanities in speech and language therapy’, we argue the case for the arts and humanities to find its way into speech and language therapy (SLT) course curricula, clinical practicum, and other areas related to SLT professional practice. We have a long-held belief that the arts and humanities have much to offer the discipline of speech and language therapy. This review begins with a consideration of what is meant by health humanities, within the more traditionally termed ‘medical humanities’. Considerations for curricular inclusion are also presented. An example from a literary autobiographical work is used to illustrate the possibility and potential of integrating a humanities’ approach to a speech and language therapy curriculum in order to better understand and appreciate communication and communication breakdown. Finally, although the case is made in this review for the discipline of speech and language therapy to embrace the humanities, by implication, there is no reason why other healthcare programmes cannot consider the possibility, where better understanding of the human condition of health and illness is core to teaching and learning

Using evidence to influence policy: Oxfam's experience

Policymaking is rarely 'evidence-based'. Rather, policy can only be strongly evidence-informed if its advocates act effectively. Policy theories suggest that they can do so by learning the rules of political systems, and by forming relationships and networks with key actors to build up enough knowledge of their environment and trust from their audience. This knowledge allows them to craft effective influencing strategies, such as to tell a persuasive and timely story about an urgent policy problem and its most feasible solution. Empirical case studies help explain when, how, and why such strategies work in context. If analysed carefully, they can provide transferable lessons for researchers and advocates that are seeking to inform or influence policymaking. Oxfam Great Britain has become an experienced and effective advocate of evidence-informed policy change, offering lessons for building effective action. In this article, we combine insights from policy studies with specific case studies of Oxfam campaigns to describe four ways to promote the uptake of research evidence in policy: (1) learn how policymaking works, (2) design evidence to maximise its influence on specific audiences, (3) design and use additional influencing strategies such as insider persuasion or outsider pressure, and adapt the presentation of evidence and influencing strategies to the changing context, and (4) embrace trial and error. The supply of evidence is one important but insufficient part of this story

Attitudes to Interprofessional Education Among Health Science Students Engaging in a Multidisciplinary Workshop Series

Introduction: Interprofessional education (IPE) provides an opportunity for students from single-professions to interact with other disciplines. Student attitude to IPE can impact engagement and change in attitude may provide an indicator of the impact of IPE. This study examines pre-workshop attitudes to IPE and change in attitude following a series of three IPE workshops. Methods: Preworkshop attitudes were examined using the Readiness for Interprofessional Learning Scale (RIPLS) and the Interprofessional Education Perception Scale (IEPS). The IEPS was repeated at the start of Workshop 1 and at the end of Workshop 3. Data were analyzed using linear regression analysis and linear mixed methods for repeated measures. Results: 405 students participated (pre-workshop n=122; workshop 1 n=244; workshop 3 n=236). Pre-workshop attitudinal scores were high. While male gender and studying medicine negatively predicted attitude across some domains, previous experience of a joint patient treatment session on clinical placement positively predicted attitude in the domain of Perception of Actual Cooperation (standardised Beta 0.283, p=0.005). Attitude to IPE improved across all domains of the IEPS from online preparation to the end of workshop 3 (pCompetency and Autonomy, and in the domain of Perceived Need for Cooperation improved only following online preparation, while the domain of Perception of Actual Cooperation improved following both online preparation and participation in the workshops. Discussion: The results presented reflect positively on student readiness for IPE. Attitudes were further improved following engagement in a structured series of IPE workshops

Evidence for perceptual hypercorrection in American r-dissimilation: A pilot study

We tested Ohala's (1993) theory that dissimilation results from perceptual hypercorrection for assimilation. We created nonce words by splicing syllables containing /r/ to continuations that either did or did not contain another /r/. When listeners were asked to type these nonce words, they were significantly more likely to omit the first /r/ if there was a later /r/. This is consistent with Ohala's claim that one rhotic can perceptually mask the presence of another rhotic. The patterns of r-dropping mimics the characteristics of real English r-dissimilation, in which speakers tend to drop the first /r/ from words like surprise. We argue that perceptual errors are a plausible cause of the actuation of r-dissimilation, although other articulatory or processing constraints may contribute to its persistence

MAD data collection – current trends

The multi-wavelength anomalous diffraction, or MAD, method of determining protein structure is becoming routine in protein crystallography. An increase in the number of tuneable synchrotrons beamlines coupled with the widespread availability position-sensitive X-ray detectors based on charged-coupled devices and having fast readout raised MAD structure determination to a new and exciting level. Ultra-fast MAD data collection is now possible. Recognition of the value of selenium for phasing protein structures and improvement of methods for incorporating selenium into proteins in the form of selenomethionine have attracted greater interest in the MAD method. Recent developments in crystallographic software are complimenting the above advances, paving the way for rapid protein structure determination. An overview of a typical MAD experiment is described here, with emphasis on the rates and quality of data acquisition now achievable at beamlines developed at third-generation synchrotrons sources

Highly versatile cell-penetrating peptide loaded scaffold for efficient and localised gene delivery to multiple cell types: From development to application in tissue engineering

Gene therapy has recently come of age with seven viral vector-based therapies gaining regulatory approval in recent years. In tissue engineering, non-viral vectors are preferred over viral vectors, however, lower transfection efficiencies and difficulties with delivery remain major limitations hampering clinical translation. This study describes the development of a novel multi-domain cell-penetrating peptide, GET, designed to enhance cell interaction and intracellular translocation of nucleic acids; combined with a series of porous collagen-based scaffolds with proven regenerative potential for different indications. GET was capable of transfecting cell types from all three germ layers, including stem cells, with an efficiency comparable to Lipofectamine® 3000, without inducing cytotoxicity. When implanted in vivo, GET gene-activated scaffolds allowed for host cell infiltration, transfection localized to the implantation site and sustained, but transient, changes in gene expression – demonstrating both the efficacy and safety of the approach. Finally, GET carrying osteogenic (pBMP-2) and angiogenic (pVEGF) genes were incorporated into collagen-hydroxyapatite scaffolds and with a single 2μg dose of therapeutic pDNA, induced complete repair of critical-sized bone defects within 4 weeks. GET represents an exciting development in gene therapy and by combining it with a scaffold-based delivery system offers tissue engineering solutions for a myriad of regenerative indications

Formyl Peptide Receptor as a Novel Therapeutic Target for Anxiety-Related Disorders

Formyl peptide receptors (FPR) belong to a family of sensors of the immune system that detect microbe-associated molecules and inform various cellular and sensorial mechanisms to the presence of pathogens in the host. Here we demonstrate that Fpr2/3-deficient mice show a distinct profile of behaviour characterised by reduced anxiety in the marble burying and light-dark box paradigms, increased exploratory behaviour in an open-field, together with superior performance on a novel object recognition test. Pharmacological blockade with a formyl peptide receptor antagonist, Boc2, in wild type mice reproduced most of the behavioural changes observed in the Fpr2/3(-/-) mice, including a significant improvement in novel object discrimination and reduced anxiety in a light/dark shuttle test. These effects were associated with reduced FPR signalling in the gut as shown by the significant reduction in the levels of p-p38. Collectively, these findings suggest that homeostatic FPR signalling exerts a modulatory effect on anxiety-like behaviours. These findings thus suggest that therapies targeting FPRs may be a novel approach to ameliorate behavioural abnormalities present in neuropsychiatric disorders at the cognitive-emotional interface

Dimensionality of Carbon Nanomaterials Determines the Binding and Dynamics of Amyloidogenic Peptides: Multiscale Theoretical Simulations

Experimental studies have demonstrated that nanoparticles can affect the rate of protein self-assembly, possibly interfering with the development of protein misfolding diseases such as Alzheimer's, Parkinson's and prion disease caused by aggregation and fibril formation of amyloid-prone proteins. We employ classical molecular dynamics simulations and large-scale density functional theory calculations to investigate the effects of nanomaterials on the structure, dynamics and binding of an amyloidogenic peptide apoC-II(60-70). We show that the binding affinity of this peptide to carbonaceous nanomaterials such as C60, nanotubes and graphene decreases with increasing nanoparticle curvature. Strong binding is facilitated by the large contact area available for π-stacking between the aromatic residues of the peptide and the extended surfaces of graphene and the nanotube. The highly curved fullerene surface exhibits reduced efficiency for π-stacking but promotes increased peptide dynamics. We postulate that the increase in conformational dynamics of the amyloid peptide can be unfavorable for the formation of fibril competent structures. In contrast, extended fibril forming peptide conformations are promoted by the nanotube and graphene surfaces which can provide a template for fibril-growth

Antibiotic residues in final effluents of European wastewater treatment plants and their impact on the aquatic environment

A comprehensive monitoring of a broad set of antibiotics in the final effluent of wastewater treatment plants (WWTPs) of 7 European countries (Portugal, Spain, Ireland, Cyprus, Germany, Finland, and Norway) was carried out in two consecutive years (2015 and 2016). This is the first study of this kind performed at an international level. Within the 53 antibiotics monitored 17 were detected at least once in the final effluent of the WWTPs, i.e.: ciprofloxacin, ofloxacin, enrofloxacin, orbifloxacin, azithromycin, clarithromycin, sulfapyridine, sulfamethoxazole, trimethoprim, nalidixic acid, pipemidic acid, oxolinic acid, cefalexin, clindamycin, metronidazole, ampicillin, and tetracycline. The countries exhibiting the highest effluent average concentrations of antibiotics were Ireland and the southern countries Portugal and Spain, whereas the northern countries (Norway, Finland and Germany) and Cyprus exhibited lower total concentration. The antibiotic occurrence data in the final effluents were used for the assessment of their impact on the aquatic environment. Both, environmental predicted no effect concentration (PNEC-ENVs) and the PNECs based on minimal inhibitory concentrations (PNEC-MICs) were considered for the evaluation of the impact on microbial communities in aquatic systems and on the evolution of antibiotic resistance, respectively. Based on this analysis, three compounds, ciprofloxacin, azithromycin and cefalexin are proposed as markers of antibiotic pollution, as they could occasionally pose a risk to the environment. Integrated studies like this are crucial to map the impact of antibiotic pollution and to provide the basis for designing water quality and environmental risk in regular water monitoring programs.Peer reviewe