Revisiting the DARPA Communicator Data using Conversation Analysis

The state of the art in human computer conversation leaves something to be desired and, indeed, talking to a computer can be down-right annoying. This paper describes an approach to identifying ``opportunities for improvement'' in these systems by looking for abuse in the form of swear words. The premise is that humans swear at computers as a sanction and, as such, swear words represent a point of failure where the system did not behave as it should. Having identified where things went wrong, we can work backward through the transcripts and, using conversation analysis (CA) work out how things went wrong. Conversation analysis is a qualitative methodology and can appear quite alien - indeed unscientific - to those of us from a quantitative background. The paper starts with a description of Conversation analysis in its modern form, and then goes on to apply the methodology to transcripts of frustrated and annoyed users in the DARPA Communicator project. The conclusion is that there is at least one species of failure caused by the inability of the Communicator systems to handle mixed initiative at the discourse structure level. Along the way, I hope to demonstrate that there is an alternative future for computational linguistics that does not rely on larger and larger text corpora.Comment: 19 pages, 2 annotated transcripts, 24 reference

Research on Social Engagement with a Rabbitic User Interface

Companions as interfaces to smart rooms need not only to be easy to interact with, but also to maintain long-term relationships with their users. The FP7-funded project SERA (Social Engagement with Robots and Agents) contributes to knowledge about and modeling of such relationships. One focal activity is an iterative field study to collect real-life long-term interaction data with a robotic interface. The first stage of this study has been completed. This paper reports on the set-up and the first insights

Alaska-Canada Rail Link Economic Benefits

Construction of the 1,740 km Alaska-Canada Rail Link (ACRL) between Fort Nelson, BC and Delta Junction, Alaska to join the North American rail system to the Alaska Railroad will result in tremendous economic benefits for Canada and the US. The ACRL will provide valuable additional east-west rail capacity and tidewater access to the Pacific, hugely benefitting not only the Yukon and Eastern Alaska regions, into which it will introduce rail transport for the first time, but throughout both countries. The economic benefits of ACRL construction are consistent with Canadian government’s desire to promote Northern development and comparable in significance to those of Canadian Pacific Railway in the 1880’s and the St. Lawrence Seaway in the 1950’s. Construction of the ACRL alone will bring unprecedented economic stimulus to the region in terms of job creation, wages and income tax revenue over multiple years. Table 7-1 below summarizes the benefits from ACRL construction for the Yukon, BC and Canada as a whole. However, these estimates are conservative as they exclude benefits associated with pre-construction activities, railway operation post-construction, sales taxes and corporate taxes as well as all such benefits that will accrue to Alaska and the US

Chromatids segregate without centrosomes during Caenorhabditis elegans mitosis in a Ran- and CLASP-dependent manner

This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License.During mitosis, chromosomes are connected to a microtubule-based spindle. Current models propose that displacement of the spindle poles and/or the activity of kinetochore microtubules generate mechanical forces that segregate sister chromatids. Using laser destruction of the centrosomes during Caenorhabditis elegans mitosis, we show that neither of these mechanisms is necessary to achieve proper chromatid segregation. Our results strongly suggest that an outward force generated by the spindle midzone, independently of centrosomes, is sufficient to segregate chromosomes in mitotic cells. Using mutant and RNAi analysis, we show that the microtubule-bundling protein SPD-1/MAP-65 and BMK-1/kinesin-5 act as a brake opposing the force generated by the spindle midzone. Conversely, we identify a novel role for two microtubule-growth and nucleation agents, Ran and CLASP, in the establishment of the centrosome-independent force during anaphase. Their involvement raises the interesting possibility that microtubule polymerization of midzone microtubules is continuously required to sustain chromosome segregation during mitosis.This work was supported by an ATIP grant from Centre National de la Recherche Scientifique and Human Frontiers Science Program Grant RGP0034/2010 to M.D. W.N. is the recipient of a PhD fellowship from the French Government.Peer Reviewe

Seeing the world through others’ minds: inferring social context from behaviour

Past research tells us that individuals can infer information about a target’s emotional state and intentions from their facial expressions (Frith & Frith, 2012), a process known as mentalising. This extends to inferring the events that caused the facial reaction (e.g. Pillai, Sheppard, & Mitchell, 2012; Pillai et al., 2014), an ability known as retrodictive mindreading. Here, we enter new territory by investigating whether or not people (perceivers) can guess a target’s social context by observing their response to stimuli. In Experiment 1, perceivers viewed targets’ responses and were able to determine whether these targets were alone or observed by another person. In Experiment 2, another group of perceivers, without any knowledge of the social context or what the targets were watching, judged whether targets were hiding or exaggerating their facial expressions; and their judgments discriminated between conditions in which targets were observed and alone. Experiment 3 established that another group of perceivers’ judgments of social context were associated with estimations of target expressivity to some degree. In Experiments 1 and 2, the eye movements of perceivers also varied between conditions in which targets were observed and alone. Perceivers were thus able to infer a target’s social context from their visible response. The results demonstrate an ability to use other minds as a window onto a social context that could not be seen directly

The crystal structure of Pneumolysin at 2.0 Å resolution reveals the molecular packing of the pre-pore complex

Pneumolysin is a cholesterol-dependent cytolysin (CDC) and virulence factor of Streptococcus pneumoniae. It kills cells by forming pores assembled from oligomeric rings in cholesterol-containing membranes. Cryo-EM has revealed the structures of the membrane-surface bound pre-pore and inserted-pore oligomers, however the molecular contacts that mediate these oligomers are unknown because high-resolution information is not available. Here we have determined the crystal structure of full-length pneumolysin at 1.98 Å resolution. In the structure, crystal contacts demonstrate the likely interactions that enable polymerisation on the cell membrane and the molecular packing of the pre-pore complex. The hemolytic activity is abrogated in mutants that disrupt these intermolecular contacts, highlighting their importance during pore formation. An additional crystal structure of the membrane-binding domain alone suggests that changes in the conformation of a tryptophan rich-loop at the base of the toxin promote monomer-monomer interactions upon membrane binding by creating new contacts. Notably, residues at the interface are conserved in other members of the CDC family, suggesting a common mechanism for pore and pre-pore assembly

Psychometric and Behavioral Measures of Central Auditory Function: The Relationship between Dichotic Listening and Digit Span Tasks

We hypothesized that the Digit Span (DS) subtest and component tasks (Wechsler, 1991) would show strong relationships with a dichotic listening test (Musiek, 1983). In two sets of archival clinical data (N = 74 and N = 51) we demonstrated that: (a) individuals with central auditory deficits had lower DS scores, F(1, 72) = 7.34, p = .008; η2 = .09; and (b) left-ear dichotic deficits impacted forward span, F(2, 48) = 8.45, p = .001. Right-ear dichotic listening performance also accounted for significant vari-ance in digit forward span (R2 = 0.17, p = .003). While limited in scope, the studies conclude that forward but not reverse span performance is strongly related to dichotic listening, and can serve as a marker for possible central auditory deficits

Psychometric and Behavioral Measures of Central Auditory Function: The Relationship between Dichotic Listening and Digit Span Tasks

We hypothesized that the Digit Span (DS) subtest and component tasks (Wechsler, 1991) would show strong relationships with a dichotic listening test (Musiek, 1983). In two sets of archival clinical data (N = 74 and N = 51) we demonstrated that: (a) individuals with central auditory deficits had lower DS scores, F(1, 72) = 7.34, p = .008; η2 = .09; and (b) left-ear dichotic deficits impacted forward span, F(2, 48) = 8.45, p = .001. Right-ear dichotic listening performance also accounted for significant vari-ance in digit forward span (R2 = 0.17, p = .003). While limited in scope, the studies conclude that forward but not reverse span performance is strongly related to dichotic listening, and can serve as a marker for possible central auditory deficits

Identifying quality indicators for prehospital emergency care services in the low to middle income setting: The South African perspective

Introduction Historically, performance within the Prehospital Emergency Care (PEC) setting has been assessed primarily based on response times. While easy to measure and valued by the public, overall, response time targets are a poor predictor of quality of care and clinical outcomes. Over the last two decades however, significant progress has been made towards improving the assessment of PEC performance, largely in the form of the development of PEC-specific quality indicators (QIs). Despite this progress, there has been little to no development of similar systems within the low- to middle-income country setting. As a result, the aim of this study was to identify a set of QIs appropriate for use in the South African PEC setting. Methods A three-round modified online Delphi study design was conducted to identify, refine and review a list of QIs for potential use in the South African PEC setting. Operational definitions, data components and criteria for use were developed for 210 QIs for inclusion into the study. Results In total, 104 QIs reached consensus agreement including, 90 clinical QIs, across 15 subcategories, and 14 non-clinical QIs across two subcategories. Amongst the clinical category, airway management (n = 13 QIs; 14%); out-of-hospital cardiac arrest (n = 13 QIs; 14%); and acute coronary syndromes (n = 11 QIs; 12%) made up the majority. Within the non-clinical category, adverse events made up the significant majority with nine QIs (64%). Conclusion Within the South Africa setting, there are a multitude of QIs that are relevant and appropriate for use in PEC. This was evident in the number, variety and type of QIs reaching consensus agreement in our study. Furthermore, both the methodology employed, and findings of this study may be used to inform the development of PEC specific QIs within other LMIC settings.Peer reviewe