99 research outputs found
A molecular characterization of breast cancer progression, including onset, tumor growth and metastasis
Molecular absorption lines toward star-forming regions : a comparative study of HCO+, HNC, HCN, and CN
Aims. The comparative study of several molecular species at the origin of the
gas phase chemistry in the diffuse interstellar medium (ISM) is a key input in
unraveling the coupled chemical and dynamical evolution of the ISM. Methods.
The lowest rotational lines of HCO+, HCN, HNC, and CN were observed at the
IRAM-30m telescope in absorption against the \lambda 3 mm and \lambda 1.3 mm
continuum emission of massive star-forming regions in the Galactic plane. The
absorption lines probe the gas over kiloparsecs along these lines of sight. The
excitation temperatures of HCO+ are inferred from the comparison of the
absorptions in the two lowest transitions. The spectra of all molecular species
on the same line of sight are decomposed into Gaussian velocity components.
Most appear in all the spectra of a given line of sight. For each component, we
derived the central opacity, the velocity dispersion, and computed the
molecular column density. We compared our results to the predictions of
UV-dominated chemical models of photodissociation regions (PDR models) and to
those of non-equilibrium models in which the chemistry is driven by the
dissipation of turbulent energy (TDR models). Results. The molecular column
densities of all the velocity components span up to two orders of magnitude.
Those of CN, HCN, and HNC are linearly correlated with each other with mean
ratios N(HCN)/N(HNC) = 4.8 1.3 and N(CN)/N(HNC) = 34 12, and more
loosely correlated with those of HCO+, N(HNC)/N(HCO+) = 0.5 0.3,
N(HCN)/N(HCO+) = 1.9 0.9, and N(CN)/N(HCO+) = 18 9. These ratios
are similar to those inferred from observations of high Galactic latitude lines
of sight, suggesting that the gas sampled by absorption lines in the Galactic
plane has the same chemical properties as that in the Solar neighbourhood. The
FWHM of the Gaussian velocity components span the range 0.3 to 3 km s-1 and
those of the HCO+ lines are found to be 30% broader than those of CN-bearing
molecules. The PDR models fail to reproduce simultaneously the observed
abundances of the CN-bearing species and HCO+, even for high-density material
(100 cm-3 < nH < 104 cm-3). The TDR models, in turn, are able to reproduce the
observed abundances and abundance ratios of all the analysed molecules for the
moderate gas densities (30 cm-3 < nH < 200 cm-3) and the turbulent energy
observed in the diffuse interstellar medium. Conclusions. Intermittent
turbulent dissipation appears to be a promising driver of the gas phase
chemistry of the diffuse and translucent gas throughout the Galaxy. The details
of the dissipation mechanisms still need to be investigated
Can Short-Range Interactions Mediate a Bose Metal Phase in 2D?
We show here based on a 1-loop scaling analysis that short-range interactions
are strongly irrelevant perturbations near the insulator-superconductor (IST)
quantum critical point. The lack of any proof that short-range interactions
mediate physics which is present only in strong coupling leads us to conclude
that short-range interactions are strictly irrelevant near the IST quantum
critical point. Hence, we argue that no new physics, such as the formation of a
uniform Bose metal phase can arise from an interplay between on-site and
nearest-neighbour interactions.Comment: 3 pages, 1 .eps file. SUbmitted to Phys. Rev.
On the Coexistence of Diagonal and off-Diagonal Long-Range Order, a Monte Carlo Study
The zero temperature properties of interacting 2 dimensional lattice bosons
are investigated. We present Monte Carlo data for soft-core bosons that
demonstrate the existence of a phase in which crystalline long-range order and
off-diagonal long-range order (superfluidity) coexist. We comment on the
difference between hard and soft-core bosons and compare our data to mean-field
results that predict a larger coexistence region. Furthermore, we determine the
critical exponents for the various phase transitions.Comment: 7 pages and 8 figures appended in postscript, KA-TFP-93-0
Interaction-induced Bose Metal in 2D
We show here that the regularization of the conductivity resulting from the
bosonic interactions on the `insulating' (quantum disordered) side of an
insulator-superconductor transition in 2D gives rise to a metal with a finite
conductivity, , as temperature tends to zero. The Bose
metal is stable to weak disorder and hence represents a concrete example of an
interaction-induced metallic phase. Phenomenological inclusion of dissipation
reinstates the anticipated insulating behaviour in the quantum-disordered
regime. Hence, we conclude that the traditionally-studied
insulator-superconductor transition, which is driven solely by quantum
fluctuations, corresponds to a superconductor-metal transition. The possible
relationship to experiments on superconducting thin films in which a
low-temperature metallic phase has been observed is discussed.Comment: A figure has been added and the physics has been clarified. To appear
in PR
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Soil structural analysis tools and properties for Hanford site waste tank evaluation
As Hanford Site contractors address future structural demands on nuclear waste tanks, built as early as 1943, it is necessary to address their current safety margins and ensure safe margins are maintained. Although the current civil engineering practice guidelines for soil modeling are suitable as preliminary design tools, future demands potentially result in loads and modifications to the tanks that are outside the original design basis and current code based structural capabilities. For example, waste removal may include cutting a large hole in a tank. This report addresses both spring modeling of site soils and finite-element modeling of soils. Additionally seismic dynamic modeling of Hanford Site soils is also included. Of new and special interest is Section 2.2 that Professor Robert D. Holtz of the University of Washington wrote on plane strain soil testing versus triaxial testing with Hanford Site application to large buried waste tanks
Functional profiling of single CRISPR/Cas9-edited human long-term hematopoietic stem cells.
In the human hematopoietic system, rare self-renewing multipotent long-term hematopoietic stem cells (LT-HSCs) are responsible for the lifelong production of mature blood cells and are the rational target for clinical regenerative therapies. However, the heterogeneity in the hematopoietic stem cell compartment and variable outcomes of CRISPR/Cas9 editing make functional interrogation of rare LT-HSCs challenging. Here, we report high efficiency LT-HSC editing at single-cell resolution using electroporation of modified synthetic gRNAs and Cas9 protein. Targeted short isoform expression of the GATA1 transcription factor elicit distinct differentiation and proliferation effects in single highly purified LT-HSC when analyzed with functional in vitro differentiation and long-term repopulation xenotransplantation assays. Our method represents a blueprint for systematic genetic analysis of complex tissue hierarchies at single-cell resolution
Vortex Fluctuations in High-Tc Films: Flux Noise Spectrum and Complex Impedance
The flux noise spectrum and complex impedance for a 500 {\AA} thick YBCO film
are measured and compared with predictions for two dimensional vortex
fluctuations. It is verified that the complex impedance and the flux noise
spectra are proportional to each other, that the logarithm of the flux noise
spectra for different temperatures has a common tangent with slope , and that the amplitude of the noise decreases as , where is
the height above the film at which the magnetic flux is measured. A crossover
from normal to anomalous vortex diffusion is indicated by the measurements and
is discussed in terms of a two-dimensional decoupling.Comment: 5 pages including 4 figures in two columns, to appear in Phys. Rev.
Let
Further Evidence for Chemical Fractionation from Ultraviolet Observations of Carbon Monoxide
Ultraviolet absorption from interstellar 12CO and 13CO was detected toward
rho Oph A and chi Oph. The measurements were obtained at medium resolution with
the Goddard High Resolution Spectrograph on the Hubble Space Telescope. Column
density ratios, N(12CO)/N(13CO), of 125 \pm 23 and 117 \pm 35 were derived for
the sight lines toward rho Oph A and chi Oph, respectively. A value of 1100 \pm
600 for the ratio N(12C16O)/N(12C18O) toward rho Oph A was also obtained.
Absorption from vibrationally excited H_2 (v" = 3) was clearly seen toward this
star as well.
The ratios are larger than the isotopic ratios for carbon and oxygen
appropriate for ambient interstellar material. Since for both carbon and oxygen
the more abundant isotopomer is enhanced, selective isotopic photodissociation
plays the key role in the fractionation process for these directions. The
enhancement arises because the more abundant isotopomer has lines that are more
optically thick, resulting in more self shielding from dissociating radiation.
A simple argument involving the amount of self shielding [from N(12CO)] and the
strength of the ultraviolet radiation field premeating the gas (from the amount
of vibrationally excited H_2) shows that selective isotopic photodissociation
controls the fractionation seen in these two sight lines, as well as the sight
line to zeta Oph.Comment: 40 pages, 8 figures, to appear in 10 July 2003 issue of Ap
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