Intraocular pressure and ocular pulse amplitude using dynamic contour tonometry and contact lens tonometry

BACKGROUND: The new Ocular Dynamic Contour Tonometer (DCT), investigational device supplied by SMT (Swiss Microtechnology AG, Switzerland) allows simultaneous recording of intraocular pressure (IOP) and ocular pulse amplitude (OPA). It was the aim of this study to compare the IOP results of this new device with Goldmann tonometry. Furthermore, IOP and OPA measured with the new slitlamp-mounted DCT were compared to the IOP and OPA measured with the hand-held SmartLens(®), a gonioscopic contact lens tonometer (ODC Ophthalmic Development Company AG, Switzerland). METHODS: Nineteen healthy subjects were included in this study. IOP was determined by three consecutive measurements with each of the DCT, SmartLens(®), and Goldmann tonometer. Furthermore, OPA was measured three times consecutively by DCT and SmartLens(®). RESULTS: No difference (P = 0.09) was found between the IOP values by means of DCT (mean: 16.6 mm Hg, median: 15.33 mm Hg, SD: +/- 4.04 mm Hg) and Goldmann tonometry (mean: 16.17 mm Hg, median: 15.33 mm Hg, SD: +/- 4.03 mm Hg). The IOP values of SmartLens(® )(mean: 20.25 mm Hg, median: 19.00 mm Hg, SD: +/- 4.96 mm Hg) were significantly higher (P = 0.0008) both from Goldmann tonometry and DCT. The OPA values of the DCT (mean: 3.08 mm Hg, SD: +/- 0.92 mm Hg) were significantly lower (P = 0.0003) than those obtained by SmartLens(® )(mean: 3.92 mm Hg, SD: +/- 0.83 mm Hg). CONCLUSIONS: DCT was equivalent to Goldmann applanation tonometry in measurement of IOP in a small group of normal subjects. In contrast, SmartLens(® )(contact lens tonometry) gave IOP readings that were significantly higher compared with Goldmann applanation tonometer readings. Both devices, DCT and SmartLens(® )provide the measurement of OPA which could be helpful e.g. for the management of glaucoma

Central corneal thickness among Aboriginal people attending eye clinics in remote South Australia

The definitive version is available at www.blackwell-synergy.comPurpose: To determine the central corneal thickness (CCT) and its demographic associations among Aboriginal people attending eye clinics in remote South Australia. Methods: A clinic-based cross-sectional study was conducted involving opportunistic sampling of patients. Eligible participants underwent measurement of CCT by ultrasound pachymetry. The results were compared with a group of Caucasian control patients. Results: All patients (189) who were invited to participate in the study had their CCT measured. The mean age was 44.8 ± 14.5 years, and women comprised 57.7% of the sample. The control group consisted of 115 Caucasian participants. The mean age was 47.1 ± 14.8 years, and women accounted for 55.7% of the sample. Mean CCT for Aboriginal participants was 514.9 ± 30.5 μm in the right eye and 515.6 ± 30.5 μm in the left eye (t = 1.1, P = 0.3). Mean right CCT for Caucasian participants was 544.6 ± 31.9 μm and mean left CCT in this group was 547.1 ± 32.2 μm (t = 4.6, P < 0.001). There was a significant difference between the right (t = 8.4, P < 0.001) and left (t = 8.8, P < 0.001) CCT of Aboriginal and Caucasian participants. Conclusions: The CCT among Aboriginal patients attending eye clinic in remote South Australia was significantly thinner than that of a Caucasian control group. Thinner corneas among this group of Aboriginal patients may indicate a need to adjust intraocular pressure according to CCT and to be more vigilant for glaucoma.Shane R Durkin, Edwin WH Tan, Robert J Casson, Dinesh Selva and Henry S Newlan

Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

Newly activated CD8(+) T cells reprogram their metabolism to meet the extraordinary biosynthetic demands of clonal expansion; however, the signals mediating metabolic reprogramming remain poorly defined. Herein, we demonstrate an essential role for sterol regulatory element binding proteins (SREBPs) in the acquisition of effector cell metabolism. Without SREBP signaling, CD8(+) T cells are unable to blast, resulting in markedly attenuated clonal expansion during viral infection. Mechanistic studies indicate that SREBPs are essential to meet the heightened lipid requirements of membrane synthesis during blastogenesis. SREBPs are dispensable for homeostatic proliferation, indicating a context-specific requirement for SREBPs in effector responses. These studies provide insights into the molecular signals underlying metabolic reprogramming of CD8(+) T cells during the transition from quiescence to activation