Quantum Chaos Versus Classical Chaos: Why is Quantum Chaos Weaker?

We discuss the questions: How to compare quantitatively classical chaos with quantum chaos? Which one is stronger? What are the underlying physical reasons

Cosmological parameters from SDSS and WMAP

We measure cosmological parameters using the three-dimensional power spectrum P(k) from over 200,000 galaxies in the Sloan Digital Sky Survey (SDSS) in combination with WMAP and other data. Our results are consistent with a ``vanilla'' flat adiabatic Lambda-CDM model without tilt (n=1), running tilt, tensor modes or massive neutrinos. Adding SDSS information more than halves the WMAP-only error bars on some parameters, tightening 1 sigma constraints on the Hubble parameter from h~0.74+0.18-0.07 to h~0.70+0.04-0.03, on the matter density from Omega_m~0.25+/-0.10 to Omega_m~0.30+/-0.04 (1 sigma) and on neutrino masses from <11 eV to <0.6 eV (95%). SDSS helps even more when dropping prior assumptions about curvature, neutrinos, tensor modes and the equation of state. Our results are in substantial agreement with the joint analysis of WMAP and the 2dF Galaxy Redshift Survey, which is an impressive consistency check with independent redshift survey data and analysis techniques. In this paper, we place particular emphasis on clarifying the physical origin of the constraints, i.e., what we do and do not know when using different data sets and prior assumptions. For instance, dropping the assumption that space is perfectly flat, the WMAP-only constraint on the measured age of the Universe tightens from t0~16.3+2.3-1.8 Gyr to t0~14.1+1.0-0.9 Gyr by adding SDSS and SN Ia data. Including tensors, running tilt, neutrino mass and equation of state in the list of free parameters, many constraints are still quite weak, but future cosmological measurements from SDSS and other sources should allow these to be substantially tightened.Comment: Minor revisions to match accepted PRD version. SDSS data and ppt figures available at http://www.hep.upenn.edu/~max/sdsspars.htm

MAOA-Dependent Activation of Shh-IL6-RANKL Signaling Network Promotes Prostate Cancer Metastasis by Engaging Tumor-Stromal Cell Interactions

Metastasis is a predominant cause of death for prostate cancer (PCa) patients; however, the underlying mechanisms are poorly understood. We report that monoamine oxidase A (MAOA) is a clinically and functionally important mediator of PCa bone and visceral metastases, activating paracrine Shh signaling in tumor-stromal interactions. MAOA provides tumor cell growth advantages in the bone microenvironment by stimulating interleukin-6 (IL6) release from osteoblasts, and triggers skeletal colonization by activating osteoclastogenesis through osteoblast production of RANKL and IL6. MAOA inhibitor treatment effectively reduces metastasis and prolongs mouse survival by disengaging the Shh-IL6-RANKL signaling network in stromal cells in the tumor microenvironment. These findings provide a rationale for targeting MAOA and its associated molecules to treat PCa metastasis.[Display omitted]•MAOA is associated with prostate cancer metastasis in clinical specimens•MAOA promotes metastasis by activating the paracrine Shh-IL6-RANKL signaling•MAOA drives tumor-stromal cell interactions in a vicious-cycle manner•MAOA inhibitor treatment reduces metastasis and prolongs survival in miceWu et al. show that monoamine oxidase A (MAOA) is an important mediator of prostate cancer bone and visceral metastases by activating paracrine Shh-IL6-RANKL signaling in tumor-stromal interactions. Pharmacological inhibition of MAOA restricts metastasis and extends survival in a mouse prostate cancer model

The SCUBA half-degree extragalactic survey - II. Submillimetre maps, catalogue and number counts

We present maps, source catalogue and number counts of the largest, most complete and unbiased extragalactic submillimetre survey: the 850-μm SCUBA Half-Degree Extragalactic Survey (SHADES). Using the Submillimetre Common-User Bolometer Array (SCUBA) on the James Clerk Maxwell Telescope (JCMT), SHADES mapped two separate regions of sky: the Subaru/XMM–Newton Deep Field (SXDF) and the Lockman Hole East (LH). Encompassing 93 per cent of the overall acquired data (i.e. data taken up to 2004 February 1), these SCUBA maps cover 720 arcmin2 with a rms noise level of about 2 mJy and have uncovered >100 submillimetre galaxies. In order to ensure the utmost robustness of the resulting source catalogue, data reduction was independently carried out by four subgroups within the SHADES team, providing an unprecedented degree of reliability with respect to other SCUBA catalogues available from the literature. Individual source lists from the four groups were combined to produce a robust 120-object SHADES catalogue; an invaluable resource for follow-up campaigns aiming to study the properties of a complete and consistent sample of submillimetre galaxies. For the first time, we present deboosted flux densities for each submillimetre galaxy found in a large survey. Extensive simulations and tests were performed separately by each group in order to confirm the robustness of the source candidates and to evaluate the effects of false detections, completeness and flux density boosting. Corrections for these effects were then applied to the data to derive the submillimetre galaxy source counts. SHADES has a high enough number of detected sources that meaningful differential counts can be estimated, unlike most submillimetre surveys which have to consider integral counts. We present differential and integral source number counts and find that the differential counts are better fit with a broken power law or a Schechter function than with a single power law; the SHADES data alone significantly show that a break is required at several mJy, although the precise position of the break is not well constrained. We also find that a 850-μm survey complete down to 2 mJy would resolve 20–30 per cent of the far-infrared background into point sources

The SCUBA Half-Degree Extragalactic Survey — I. Survey motivation, design and data processing.

The Submillimetre Common-User Bolometer Array (SCUBA) Half-Degree Extragalactic Survey (SHADES) is a major new blank-field extragalactic submillimetre (submm) survey currently underway at the James Clerk Maxwell Telescope (JCMT). Ultimately, SHADES aims to cover half a square degree at 450 and 850 μm to a 4σ depth of ≃ 8 mJy at 850 μm. Two fields are being observed, the Subaru/XMM—Newton Deep Field (SXDF) (02h18m−05°) and the Lockman Hole East (10h52m+ 57°). The survey has three main aims: (i) to investigate the population of high-redshift submm galaxies and the cosmic history of massive dust-enshrouded star formation activity; (ii) to investigate the clustering properties of submm-selected galaxies in order to determine whether these objects could be progenitors of present-day massive ellipticals; and (iii) to investigate the fraction of submm-selected sources that harbour active galactic nuclei. To achieve these aims requires that the submm data be combined with co-spatial information spanning the radio-to-X-ray frequency range. Accordingly, SHADES has been designed to benefit from ultra-deep radio imaging obtained with the Very Large Array (VLA), deep mid-infrared observations from the Spitzer Space Telescope, submm mapping by the Balloon-borne Large Aperture Submillimetre Telescope (BLAST), deep near-infrared imaging with the United Kingdom Infrared Telescope, deep optical imaging with the Subaru Telescope and deep X-ray observations with the XMM—Newton observatory. It is expected that the resulting extensive multiwavelength data set will provide complete photometric redshift information accurate to graphic as well as detailed spectral energy distributions for the vast majority of the submm-selected sources. In this paper, the first of a series on SHADES, we present an overview of the motivation for the survey, describe the SHADES survey strategy, provide a detailed description of the primary data-analysis pipeline and demonstrate the superiority of our adopted matched-filter source-extraction technique over, for example, Emerson-II style methods. We also report on the progress of the survey. As of 2004 February, 720 arcmin2 had been mapped with SCUBA (about 40 per cent of the anticipated final total area) to a median 1σ depth of 2.2 mJy per beam at 850 μm (25 mJy per beam at 450 μm), and the source-extraction routines give a source density of 650 ± 50 sources deg−2 > 3σ at 850 μm. Although uncorrected for Eddington bias, this source density is more than sufficient for providing enough sources to answer the science goals of SHADES, once half a square degree is observed. A refined reanalysis of the original 8-mJy survey Lockman hole data was carried out in order to evaluate the new data-reduction pipeline. Of the 17 most secure sources in the original sample, 12 have been reconfirmed, including 10 of the 11 for which radio identifications were previously secured