2,888 research outputs found
Hot Gas in the Galactic Thick Disk and Halo Near the Draco Cloud
This paper examines the ultraviolet and X-ray photons generated by hot gas in
the Galactic thick disk or halo in the Draco region of the northern hemisphere.
Our analysis uses the intensities from four ions, C IV, O VI, O VII, and O
VIII, sampling temperatures of ~100,000 to ~3,000,000 K. We measured the O VI,
O VII and O VIII intensities from FUSE and XMM-Newton data and subtracted off
the local contributions in order to deduce the thick disk/halo contributions.
These were supplemented with published C IV intensity and O VI column density
measurements. Our estimate of the thermal pressure in the O VI-rich thick
disk/halo gas, p_{th}/k = 6500^{+2500}_{-2600} K cm^{-3}, suggests that the
thick disk/halo is more highly pressurized than would be expected from
theoretical analyses. The ratios of C IV to O VI to O VII to O VIII,
intensities were compared with those predicted by theoretical models. Gas which
was heated to 3,000,000 K then allowed to cool radiatively cannot produce
enough C IV or O VI-generated photons per O VII or O VIII-generated photon.
Producing enough C IV and O VI emission requires heating additional gas to
100,000 < T < 1,000,000 K. However, shock heating, which provides heating
across this temperature range, overproduces O VI relative to the others.
Obtaining the observed mix may require a combination of several processes,
including some amount of shock heating, heat conduction, and mixing, as well as
radiative cooling of very hot gas.Comment: 10 pages, 2 figures. Accepted for publication in the Astrophysical
Journa
Relationship of Sorghum kernel size to physiochemical, milling, pasting, and cooking properties
Effects of kernel size on grain sorghum [Sorghum bicolor (L.) Moench] quality were studied in an experiment designed to separate effects of kernel size from seedlot. The study utilized three sieve fractions of varying kernel diameter (\u3e3.35, \u3e2.80 and \u3e2.36 mm) from six seedlots. Chemical composition, physical characteristics, milling characteristics, pasting properties, and cooking qualities were determined for each kernel size fraction. Large kernels lost less relative mass during 1 min of decortication, were higher in protein concentration, and lower in ash. Milling yields were higher from large kernels, and flour from large kernels had higher water absorbance, brighter white color, and larger particle size. Kernel size effects on Rapid Visco Analyzer (RVA) properties were not consistent. These results suggest that within the sorghum seedlots studied, an increase in kernel size is associated with an increase in sorghum quality as defined by the parameters measured in this study
FUSE Detection of Galactic OVI Emission in the Halo above the Perseus Arm
Background observations obtained with the Far Ultraviolet Spectroscopic
Explorer (FUSE) toward l=95.4, b=36.1 show OVI 1032,1038 in emission. This
sight line probes a region of stronger-than-average soft X-ray emission in the
direction of high-velocity cloud Complex C above a part of the disk where
Halpha filaments rise into the halo. The OVI intensities, 1600+/-300
ph/s/cm^2/sr (1032A) and 800+/-300 ph/s/cm^2/sr (1038A), are the lowest
detected in emission in the Milky Way to date. A second sight line nearby
(l=99.3, b=43.3) also shows OVI 1032 emission, but with too low a
signal-to-noise ratio to obtain reliable measurements. The measured
intensities, velocities, and FWHMs of the OVI doublet and the CII* line at
1037A are consistent with a model in which the observed emission is produced in
the Galactic halo by hot gas ejected by supernovae in the Perseus arm. An
association of the observed gas with Complex C appears unlikely.Comment: accepted for publication in ApJL, 11 pages including 3 figure
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Uneven distribution of cobamide biosynthesis and dependence in bacteria predicted by comparative genomics.
The vitamin B12 family of cofactors known as cobamides are essential for a variety of microbial metabolisms. We used comparative genomics of 11,000 bacterial species to analyze the extent and distribution of cobamide production and use across bacteria. We find that 86% of bacteria in this data set have at least one of 15 cobamide-dependent enzyme families, but only 37% are predicted to synthesize cobamides de novo. The distribution of cobamide biosynthesis and use vary at the phylum level. While 57% of Actinobacteria are predicted to biosynthesize cobamides, only 0.6% of Bacteroidetes have the complete pathway, yet 96% of species in this phylum have cobamide-dependent enzymes. The form of cobamide produced by the bacteria could be predicted for 58% of cobamide-producing species, based on the presence of signature lower ligand biosynthesis and attachment genes. Our predictions also revealed that 17% of bacteria have partial biosynthetic pathways, yet have the potential to salvage cobamide precursors. Bacteria with a partial cobamide biosynthesis pathway include those in a newly defined, experimentally verified category of bacteria lacking the first step in the biosynthesis pathway. These predictions highlight the importance of cobamide and cobamide precursor salvaging as examples of nutritional dependencies in bacteria
Variability in H9N2 haemagglutinin receptor-binding preference and the pH of fusion
H9N2 avian influenza viruses are primarily a disease of poultry; however, they occasionally infect humans and are considered a potential pandemic threat. Little work has been performed to assess the intrinsic biochemical properties related to zoonotic potential of H9N2 viruses. The objective of this study, therefore, was to investigate H9N2 haemagglutinins (HAs) using two well-known correlates for human adaption: receptor-binding avidity and pH of fusion. Receptor binding was characterized using bio-layer interferometry to measure virus binding to human and avian-like receptor analogues and the pH of fusion was assayed by syncytium formation in virus-infected cells at different pHs. We characterized contemporary H9N2 viruses of the zoonotic G1 lineage, as well as representative viruses of the zoonotic BJ94 lineage. We found that most contemporary H9N2 viruses show a preference for sulphated avian-like receptor analogues. However, the ‘Eastern’ G1 H9N2 viruses displayed a consistent preference in binding to a human-like receptor analogue. We demonstrate that the presence of leucine at position 226 of the HA receptor-binding site correlated poorly with the ability to bind a human-like sialic acid receptor. H9N2 HAs also display variability in their pH of fusion, ranging between pH 5.4 and 5.85 which is similar to that of the first wave of human H1N1pdm09 viruses but lower than the pH of fusion seen in zoonotic H5N1 and H7N9 viruses. Our results suggest possible molecular mechanisms that may underlie the relatively high prevalence of human zoonotic infection by particular H9N2 virus lineages
An Effective Theory for Midgap States in Doped Spin Ladder and Spin-Peierls Systems: Liouville Quantum Mechanics
In gapped spin ladder and spin-Peierls systems the introduction of disorder,
for example by doping, leads to the appearance of low energy midgap states. The
fact that these strongly correlated systems can be mapped onto one dimensional
noninteracting fermions provides a rare opportunity to explore systems which
have both strong interactions and disorder. In this paper we show that the
statistics of the zero energy midgap wave functions in these models can be
effectively described by Liouville Quantum Mechanics. This enables us to
calculate the disorder averaged N-point correlation functions of these states
(the explicit calculation is performed for N=2,3). We find that whilst these
midgap states are typically weakly correlated, their disorder averaged
correlation are power law. This discrepancy arises because the correlations are
not self-averaging and averages of the wave functions are dominated by
anomalously strongly correlated configurations.Comment: 13 page latex fil
System for the measurement of ultra-low stray light levels
An apparatus is described for measuring the effectiveness of stray light suppression light shields and baffle arrangements used in optical space experiments and large space telescopes. The light shield and baffle arrangement and a telescope model are contained in a vacuum chamber. A source of short, high-powered light energy illuminates portions of the light shield and baffle arrangement and reflects a portion of same to a photomultiplier tube by virtue of multipath scattering. The resulting signal is transferred to time-channel electronics timed by the firing of the high energy light source allowing time discrimination of the signal thereby enabling the light scattered and suppressed by the model to be distinguished from the walls and holders around the apparatus
Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy
Mutations in the gene encoding dystrophin, a protein that maintains muscle integrity and function, cause Duchenne muscular dystrophy (DMD). The deltaE50-MD dog model of DMD harbors a mutation corresponding to a mutational “hotspot” in the human DMD gene. We used adeno-associated viruses to deliver CRISPR gene editing components to four dogs and examined dystrophin protein expression 6 weeks after intramuscular delivery (n = 2) or 8 weeks after systemic delivery (n = 2). After systemic delivery in skeletal muscle, dystrophin was restored to levels ranging from 3 to 90% of normal, depending on muscle type. In cardiac muscle, dystrophin levels in the dog receiving the highest dose reached 92% of normal. The treated dogs also showed improved muscle histology. These large-animal data support the concept that, with further development, gene editing approaches may prove clinically useful for the treatment of DMD
Competing magnetic states, disorder, and the magnetic character of Fe3Ga4
The physical properties of metamagnetic FeGa single crystals are
investigated to explore the sensitivity of the magnetic states to temperature,
magnetic field, and sample history. The data reveal a moderate anisotropy in
the magnetization and the metamagnetic critical field along with features in
the specific heat at the magnetic transitions K and K. Both
and are found to be sensitive to the annealing conditions of the
crystals suggesting that disorder affects the competition between the
ferromagnetic (FM) and antiferromagnetic (AFM) states. Resistivity measurements
reveal metallic transport with a sharp anomaly associated with the transition
at . The Hall effect is dominated by the anomalous contribution which
rivals that of magnetic semiconductors in magnitude ( cm at 2 T
and 350 K) and undergoes a change of sign upon cooling into the low temperature
FM state. The temperature and field dependence of the Hall effect indicate that
the magnetism is likely to be highly itinerant in character and that a
significant change in the electronic structure accompanies the magnetic
transitions. We observe a contribution from the topological Hall effect in the
AFM phase suggesting a non-coplanar contribution to the magnetism. Electronic
structure calculations predict an AFM ground state with a wavevector parallel
to the crystallographic -axis preferred over the experimentally measured FM
state by 50 meV per unit cell. However, supercell calculations with a
small density of Fe-antisite defects introduced tend to stabilize the FM over
the AFM state indicating that antisite defects may be the cause of the
sensitivity to sample synthesis conditions.Comment: 13 pages, 14 figures, and 4 supplementary table
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