Life-threatening laryngeal attacks in hereditary angioedema patients

Background: Hereditary angioedema due to C1-inhibitor deficiency (HAE-C1INH) is a rare genetic disease that runs in the family. As a result of the disease, acute swellings of the subcutaneous tissue and mucous membranes of the digestive and respiratory systems, including the larynx, occur. Any attack of the disease involving the throat and larynx is particularly dangerous and requires knowledge of clinical determinants of the disease and its proper management. Materials and methods: The study included adult consecutive HAE-C1INH patients having follow-up visits in our centre. The group was examined with a structured clinical questionnaire, concerning the last 6 months and focusing particularly on laryngeal swelling attacks. Results: 55 subjects (F/M – 35/20, age range – 18–76) were included in the study. Laryngeal attacks occurred in 19 individuals (34.5%): 1–3, 4–6, and ≥7 attacks in 9, 8 and 2 patients, respectively, two of whom required intubation. In comparison to other patients, subjects with laryngeal attacks were characterised by significantly more frequent: (1) facial attacks, (2) severe disease activity, (3) the occurrence of female patients, (4) mental stress as a trigger of attacks. All patients with laryngeal attacks had a rescue medication at home and 15/19 (78%) patients could use it at home. Most of them used plasma-derived C1-inhibitor 17/19 (89.5%) and icatibant, 8/19 (42.1%). Discussion: HAE-C1INH patients with laryngeal attacks require particular attention. Proper training regarding the identification of these patients, adequate management, access to emergency services and emergency drugs are essential to ensure the safety of subjects with this localization of HAE-C1INH attacks

Spojrzenie na Bawarską Republikę Rad w Revolutionstagebuch 1919 Victora Klemperera

Victor Klemperer beschreibt in seinem Revolutionstagebuch 1919 die Ereignisse der Münchener Räterepublik als Tragikomödie – eine Mischung aus Lächerlichkeit, Verbrechen sowie Bitterkeit – und übt zugleich Kritik an dem konservativen Münchener Bürgertum. In anschaulichen Momentaufnahmen aus der belagerten Stadt schildert er das Scheitern der Revolution 1918/1919, einen der entscheidenden Wendepunkte der deutschen Geschichte.In his book Revolutionstagebuch 1919, Victor Klemperer presents events taking place during the time of the Bavarian Soviet Republic as a tragicomedy – a mixture of ridiculousness, bitterness and crime, while fiercely criticising the mentality of the conservative bourgeoisie of Munich. In his vivid descriptions of successive events as they unfold in the besieged city, the author depicts the defeat of the 1918-1919 Revolution – one of the most decisive moments in German history.Victor Klemperer opisuje w swoim pamiętniku Revolutionstagebuch 1919 wydarzenia w Bawarskiej Republice Rad jako tragikomedię – mieszankę śmieszności, zbrodni i goryczy, krytykując jednocześnie konserwatywne monachijskie mieszczaństwo. W obrazowych wycinkach rzeczywistości z oblężonego miasta ukazuje klęskę rewolucji 1918/1919 roku, jednego z decydujących momentów w historii Niemiec

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"Badania i obserwacje kliniczne prowadzone intensywnie od kilku dekad pokazują, jak ważną rolę w procesie chorowania, zdrowienia i utrzymywania zdrowia odgrywa rodzina. Przekonania rodzinne dotyczące zdrowia i choroby, doświadczenia rodzinne związane z chorowaniem, przeżywaniem kryzysów i utrat, założenia dotyczące przyczyn i przebiegu choroby, znaczenie przypisywane poszczególnym objawom i jednostkom chorobowym, a wreszcie przekonania dotyczące kompetencji rodzinnych w stosunku do działań leczniczych w dużej mierze warunkują sposób chorowania jej członków oraz możliwość zaakceptowania przez rodzinę proponowanego sposobu leczenia."(...

The problem of divers, aviators and paratroopers - barotrauma of the paranasal sinuses

Barotrauma of the paranasal sinuses is a trauma caused by a large difference in air pressure between the sinuses and the environment. It concerns essentially divers, aviators, as well as paratroopers. A characteristic symptom is sudden and piercing pain in the sinus area. The pain begins while the ambient's pressure is changing or an instant later. The result of a pressure injury may be an epistaxis. Sinusitis may be also an effect of sinuses' mucosal damage. Drugs used primarily in patients with pressure-related injury are vasoconstructive medicaments and analgesics. Antibiotics are also applied in some situations. Because the incidence of barotrauma increases in predisposed people, e.g. with anatomical abnormalities, nose surgery, including correction of the nasal septum or paranasal sinuses, i.e. conchotomy, is used to prevent injury

The use of .NET Core in web applications development

The article presents the use of .NET Core in web applications development. The analysis covers tests performed on a test application based on the .NET Core framework. The following benchmarking criteria were selected for the framework analysis: pattern search in text, counting parsing time, rendering operations on graphical files, adding files to archives, CRUD operation speed. These criteria were compared on two different operating systems - Windows, Linux. Additionally, the paper presents results obtained after the tests and their analysis. The hypothesis that tests will be executed faster on Windows than on Linux has only been partially confirmed

The problem of divers, aviators and paratroopers - barotrauma of the paranasal sinuses

Adamczyk Katarzyna, Adamczyk Dorota, Wójcik Rafał. The problem of divers, aviators and paratroopers - barotrauma of the paranasal sinuses. Journal of Education, Health and Sport. 2018;8(9):786-793 eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1414170 http://ojs.ukw.edu.pl/index.php/johs/article/view/5937 https://pbn.nauka.gov.pl/sedno-webapp/works/876946 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part b item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eissn 2391-8306 7 © The Authors 2018; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 02.08.2018. Revised: 18.08.2018. Accepted: 12.09.2018. The problem of divers, aviators and paratroopers - barotrauma of the paranasal sinuses Katarzyna Adamczyk1, Dorota Adamczyk1, Rafał Wójcik2 1Student, Medical University of Lublin 2Department of Human Anatomy, Medical University of Lublin Abstract Barotrauma of the paranasal sinuses is a trauma caused by a large difference in air pressure between the sinuses and the environment. It concerns essentially divers, aviators, as well as paratroopers. A characteristic symptom is sudden and piercing pain in the sinus area. The pain begins while the ambient pressure is changing or an instant later. The result of a pressure injury may be an epistaxis. Sinusitis may be also an effect of sinuses' mucosal damage. Drugs used primarily in patients with pressure-related injury are vasoconstrictive medicaments and analgesics. Antibiotics are also applied in some situations. Because the incidence of barotrauma increases in predisposed people, e.g. with anatomical abnormalities, nose surgery, including correction of the nasal septum or paranasal sinuses, i.e. canthotomy, is used to prevent injury. Keywords: barotrauma, paranasal sinuses, ascend injury, descend injury, divin

Demony kobiece w literaturze bizantyńskiej

The thesis’ aim is to demonstrate not only the evolution, but also means of representation and various functions of Byzantine female demons. The thesis discusses a selection of texts (from antiquity to late Byzantine times) concerning female demons, notorious for killing newborn babies and harming women during pregnancy, labour or immediately after it, as well as demonesses, whose main task was to tempt men. Although these female demons had originated from beliefs in different cultures, had different names, they possessed identical attributes, e.g. they appeared in similar situations, had also common traits of appearance and skills: polymorphism or flying. The first chapter serves as a background for the next two chapters. It is a presentation of the female demons of the ancient world: Mesopotamia, Israel, Greece and Rome. The second chapter is an analysis of a late antique text, the so called Testament of Solomon. The third chapter is dedicated to Gello – a demoness, whose origins may be traced back to no less than VII century BC (where her name was mentioned for the first time in a poem by Sappho), and who enjoyed great popularity in Byzantium, remains well-known and is still present in tchem folklore of many countries, whose culture is genealogically connected with the Byzantine/Orthodox tradition