Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.

Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

The present work was largely supported by a grant from the US National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (R01HL118305). The full list of acknowledgments appears in the Supplementary Notes 3 and 4.Peer reviewedPublisher PD

Innoveren voor zorg thuis: Deel 1 - Werkruimte als inspiratiebron

Hoeveel werkruimte heeft een zorgverlener nodig voor het uitvoeren van zijn werk? Welke verlichtingssterkte is nodig voor het geven van medicijnen en invullen van dossiers aan tafel? Hoeveel ruimte heeft een mantelzorger nodig voor het aan- en uittrekken van steunkousen bij de cliënt? Dat werd onderzocht in het Saxion-project Ontwerpen voor Zorgverleners. In dit artikel (eerste van vier) wordt de werkomgeving van thuiszorgmedewerkers en mantelzorgers onder de loep genomen en worden ervaringen gedeeld met de tools grounded theory, observatie en interview. De artikelenreeks is verschenen in vakblad Product. &nbsp

FabLab Enschede 3 jaar: Verleden, heden, toekomst

Na drie jaar wordt de eerste fase van FabLab Enschede succesvol afgesloten. Met dit fraaie boekje (ontwerp door Karin Voortman-Overbeek) wordt teruggeblikt op een stormachtige start die mede mogelijk is gemaakt door de gemeente Enschede, de provincie Overijssel en Saxion. Met interviews en voorbeelden wordt een beeld gegeven van wat het FabLab Enschede gedaan en bereikt heeft en hoe het na deze eerste fase verder wil

Zorg voor intimiteit en seksualiteit van ouderen in verpleeghuis en thuiszorg

Dit artikel is overgenomen uit het tijdschrift Geron, 2020, nr. 2 https://gerontijdschrift.nl/artikelen/zorg-voor-intimiteit-en-seksualiteit-van-ouderen-in-verpleeghuis-en-thuiszorg/  Afgelopen jaren is er veel aandacht geweest voor de zorg rond intimiteit en seksualiteit van ouderen in verpleeghuis en thuiszorg. Er zijn verschillende tools ontwikkeld op dit gebied. In de praktijk blijkt dat er nog veel winst is te behalen. Dit kan door de juiste tool te matchen met de juiste organisatie, zorgprofessional, cliënt en naaste. Het RAAK-project ‘intimiteit en seksualiteit in de ouderenzorg’ is hierover in gesprek geweest met cliënten, zorgprofessionals en naasten.&nbsp

n–6 fatty acid biomarkers and incident atrial fibrillation:an individual participant-level pooled analysis of 11 international prospective studies

Background: The presence of atrial fibrillation (AF) is associated with an over 2-fold increased risk of stroke, heart failure, and cardiovascular mortality. Long chain n–6 PUFAs have been suggested to have a variety of beneficial biologic effects that may reduce AF development; however, prior studies evaluating this relationship are limited. Objectives: We prospectively evaluated the association between circulating levels of linoleic acid (LA) and arachidonic acid (AA) with incident AF. Methods: We used participant-level data from a global consortium of 11 prospective cohort studies with measurements of LA and AA in adults (aged ≥18 y). Participating studies conducted de novo analyses using a prespecified analytical plan with harmonized definitions for exposures, outcomes, covariates, and subgroups. Associations were pooled using inverse-variance weighted meta-analysis. Results: Among 41,335 participants, 6173 incident cases of AF were ascertained, with median follow-up time of 14 y. In multivariable analysis, per interquintile range (difference between the 10th and 90th percentiles for each fatty acid), circulating n–6 levels were not associated with incident AF. For LA, the hazard ratio per interquintile range was 0.96 (95% confidence interval [CI]: 0.89, 1.04), and for AA, 1.02 (95% CI: 0.94, 1.10), with little evidence of heterogeneity between cohorts. Associations were similarly nonsignificant across subgroups of age, race, and biomarker fraction. Conclusions: Biomarkers of n–6 fatty acids including LA and AA are not associated with incident AF. These findings suggest that overall effects of n–6 PUFAs on influencing AF development are neutral.</p

Omega-3 Fatty Acid Biomarkers and Incident Atrial Fibrillation

Background: The relationship between omega-3 fatty acids and atrial fibrillation (AF) remains controversial. Objectives: This study aimed to determine the prospective associations of blood or adipose tissue levels of eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) with incident AF. Methods: We used participant-level data from a global consortium of 17 prospective cohort studies, each with baseline data on blood or adipose tissue omega-3 fatty acid levels and AF outcomes. Each participating study conducted a de novo analyses using a prespecified analytical plan with harmonized definitions for exposures, outcome, covariates, and subgroups. Associations were pooled using inverse-variance weighted meta-analysis. Results: Among 54,799 participants from 17 cohorts, 7,720 incident cases of AF were ascertained after a median 13.3 years of follow-up. In multivariable analysis, EPA levels were not associated with incident AF, HR per interquintile range (ie, the difference between the 90th and 10th percentiles) was 1.00 (95% CI: 0.95-1.05). HRs for higher levels of DPA, DHA, and EPA+DHA, were 0.89 (95% CI: 0.83-0.95), 0.90 (95% CI: 0.85-0.96), and 0.93 (95% CI: 0.87-0.99), respectively. Conclusions: In vivo levels of omega-3 fatty acids including EPA, DPA, DHA, and EPA+DHA were not associated with increased risk of incident AF. Our data suggest the safety of habitual dietary intakes of omega-3 fatty acids with respect to AF risk. Coupled with the known benefits of these fatty acids in the prevention of adverse coronary events, our study suggests that current dietary guidelines recommending fish/omega-3 fatty acid consumption can be maintained.</p

Omega-3 Blood Levels and Stroke Risk:A Pooled and Harmonized Analysis of 183 291 Participants from 29 Prospective Studies

BACKGROUND: The effect of marine omega-3 PUFAs on risk of stroke remains unclear. METHODS: We investigated the associations between circulating and tissue omega-3 PUFA levels and incident stroke (total, ischemic, and hemorrhagic) in 29 international prospective cohorts. Each site conducted a de novo individual-level analysis using a prespecified analytical protocol with defined exposures, covariates, analytical methods, and outcomes; the harmonized data from the studies were then centrally pooled. Multivariable-adjusted HRs and 95% CIs across omega-3 PUFA quintiles were computed for each stroke outcome. RESULTS: Among 183 291 study participants, there were 10 561 total strokes, 8220 ischemic strokes, and 1142 hemorrhagic strokes recorded over a median of 14.3 years follow-up. For eicosapentaenoic acid, comparing quintile 5 (Q5, highest) with quintile 1 (Q1, lowest), total stroke incidence was 17% lower (HR, 0.83 [CI, 0.76-0.91]; P&lt;0.0001), and ischemic stroke was 18% lower (HR, 0.82 [CI, 0.74-0.91]; P&lt;0.0001). For docosahexaenoic acid, comparing Q5 with Q1, there was a 12% lower incidence of total stroke (HR, 0.88 [CI, 0.81-0.96]; P=0.0001) and a 14% lower incidence of ischemic stroke (HR, 0.86 [CI, 0.78-0.95]; P=0.0001). Neither eicosapentaenoic acid nor docosahexaenoic acid was associated with a risk for hemorrhagic stroke. These associations were not modified by either baseline history of AF or prevalent CVD. CONCLUSIONS: Higher omega-3 PUFA levels are associated with lower risks of total and ischemic stroke but have no association with hemorrhagic stroke.</p