Methodology for staff management assessment efficiency in the medical institutions

This paper considers human resources to be important for the effective functioning and development of the organization in current socio-economic conditions. Corporate management involves the impact on people (corporate staff) primarily. The authors noted that the staff management assessment is a powerful instrument to increase the management process’s effectiveness. The normative documents of the Ministry of Health of Ukraine define the following methods of quality control of medical services: clinical audit and monitoring

Результати трансформації логістичних професійних компетенцій під час глобальної пандемії

This study outlines the current changes in requirements of the labour market for logistics professionals through the prism of the changing business environment caused by industrial change and current crises. Proposals for the introduction of changes for the higher education and postgraduate professional development providers were given.У цьому дослідженні висвітлюються поточні зміни вимог ринку праці до фахівців з логістики через призму мінливого бізнес-середовища, спричиненого змінами промисловості та поточними кризами. Надано пропозиції щодо внесення змін до закладів вищої освіти та післядипломної кваліфікації

Speciality of Introduction of Competency-Based Approach in the Course of Practicum of Solving Mathematical Problem

У статті розглядається специфіка впровадження компетентнісного підходу в курсі практикуму з розв’язування математичних задач, виокремлено рівні математичної компетентності студентів, пов’язаної з раціональними рівняннями.The article deals with peculiarities of competentional approach implementation in the Practical Classes in Maths Problem Solution

An Investigation of the Effect of Thermoplastic Additives in Asphalt Concrete Mixtures on the Properties of Different Types of Asphalt Concrete

The effect of modification of asphalt concrete mixtures of different grain sizes with “Ric-Polycell” (Ukraine) and “Duroflex®-SMA” thermoplastic polymers (Germany), which were added directly to the asphalt mixer during their preparation, on the properties of asphalt concrete was studied. It is confirmed that it is more expedient to use stone mastic asphalt concretes with a larger size of mineral crushed stone grains on high-traffic roads, as they are more rutting-resistant compared to asphalt concretes with smaller size and content of crushed stone grains. The effect of the temperature of preparation and thermostating of asphalt concrete mixtures modified with the investigated thermoplastics on the compressive strength of asphalt concrete at a temperature of 50 °С, which were made of the studied mixtures, was investigated. It was found that the maximum possible temperatures of preparation and thermostating of asphalt concrete mixes provide a more complete modification. The effect of the content of thermoplastic polymers in the composition of asphalt concrete mixtures on the properties and rutting resistance of fine-grained asphalt concrete, as well as stone mastic asphalt concrete, was studied. It was found that adding the “Ric-Polycell” polymer in the amount of 1.5 % and 3 % by weight of bitumen in the composition of the studied asphalt mixtures in the asphalt mixer during their preparation increases the rutting resistance of asphalt concrete under the studied conditions by 2.52–3.86 times. Modification of asphalt concrete mixtures with the “Duroflex®-SMA” additive in the amount of 0.3 % and 0.6 % by weight of the aggregate by a similar technology also allows increasing the rutting resistance of the obtained asphalt concrete by 1.86–3.16 times. Using these modifiers in the future will have a positive effect on the service life of the entire pavement structur

An Investigation of the Effect of Thermoplastic Additives in Asphalt Concrete Mixtures on the Properties of Different Types of Asphalt Concrete

The effect of modification of asphalt concrete mixtures of different grain sizes with “Ric-Polycell” (Ukraine) and “Duroflex®-SMA” thermoplastic polymers (Germany), which were added directly to the asphalt mixer during their preparation, on the properties of asphalt concrete was studied. It is confirmed that it is more expedient to use stone mastic asphalt concretes with a larger size of mineral crushed stone grains on high-traffic roads, as they are more rutting-resistant compared to asphalt concretes with smaller size and content of crushed stone grains. The effect of the temperature of preparation and thermostating of asphalt concrete mixtures modified with the investigated thermoplastics on the compressive strength of asphalt concrete at a temperature of 50 °С, which were made of the studied mixtures, was investigated. It was found that the maximum possible temperatures of preparation and thermostating of asphalt concrete mixes provide a more complete modification. The effect of the content of thermoplastic polymers in the composition of asphalt concrete mixtures on the properties and rutting resistance of fine-grained asphalt concrete, as well as stone mastic asphalt concrete, was studied. It was found that adding the “Ric-Polycell” polymer in the amount of 1.5 % and 3 % by weight of bitumen in the composition of the studied asphalt mixtures in the asphalt mixer during their preparation increases the rutting resistance of asphalt concrete under the studied conditions by 2.52–3.86 times. Modification of asphalt concrete mixtures with the “Duroflex®-SMA” additive in the amount of 0.3 % and 0.6 % by weight of the aggregate by a similar technology also allows increasing the rutting resistance of the obtained asphalt concrete by 1.86–3.16 times. Using these modifiers in the future will have a positive effect on the service life of the entire pavement structur

ЩОДО КОНСТРУКТИВНО-ТЕХНОЛОГІЧНИХ ОСОБЛИВОСТЕЙ ГЕРМЕТИЗАЦІЇ ТРІЩИН В АСФАЛЬТОБЕТОННИХ ПОКРИТТЯХ

In Ukraine a significant part of motor roads with flexible pavement, especially local ones, serves with cracks in asphalt concrete layers during long period. Asphalt concrete spalling in the zone of open crack edges is a further stage of pavement layer deterioration during its long period of service. Costs for repair of these defects are much higher than for crack sealing. Monitoring of actual condition of flexible pavements in various regions of Ukraine indicates that cracks in asphalt concrete pavement appear in different locations, have different direction and pattern, width, depth and length. Number of cracks, their frequency of location on the pavement, length and width of opening at low temperatures depend on duration of the pavement exploitation. Today there are no exact regulations on structural and technological decisions in terms of crack preparation and sealing with regard to their width and activity in normative and technical documents. The topic of the paper is development of structural and technological decisions for crack preparation and sealing in asphalt concrete pavements with regard to their width and activity. It is noted that hot-applied bituminous sealing materials are the most popular in Ukraine for works on crack sealing in asphalt concrete road pavements. Based on the results of scientific and technical supervision of various crack sealing techniques in asphalt concrete road pavements it is shown that crack sealing can be performed with preliminary routing (rectangular rout) in zone of crack or without routing. It is noted that cracks with preliminary routing can be sealed with overband or without overband of sealing material on the surface of asphalt pavement. Technique of crack sealing by filling of the created rout with bitumen-polymer mastic or hot-applied sealant with overband on asphalt pavement surface provides the highest watertightness and durability of the sealed crack, in comparison with sealing by filling of the created rout flush with asphalt pavement, or without routing. Classification of cracks in asphalt concrete pavements is proposed and structural and technological decisions on crack preparation and sealing are described.Предложена классификация трещин в асфальтобетонных покрытиях и описаны конструктивные и технологические решения по подготовке и герметизации трещин.Запропоновано класифікацію тріщин в асфальтобетонних покриттях дорожніх одягів, описано конструктивно-технологічні особливості підготовки і герметизації тріщин

Development of an Advanced Strategy on the Assay Method Transfer

Aim. The paper intends to frame and pilot the optimised science-based principles of the assay transfer.Materials and methods. The research was performed on desloratadine film-coated tablets, using an analytical balance Mettler Toledo XP 205DR and Class A volumetric glassware. Absorbance readings were measured on a UV-Vis spectrophotometer Lambda 25.Results and discussion. The concept of method transfer that complements the conventional approach to validation with the lifecycle initiative and the metrological base of the State Pharmacopoeia of Ukraine was substantiated, following which the transfer of the spectrophotometric procedure for desloratadine assay was conducted. For the batch intended for the transfer, the budget of analytical and technological variability was balanced. The deviation of a single assay result from the grand mean was used as the criterion for accuracy in the transfer. The requirement for the one-sided confidence interval for assay result runs not to exceed the target uncertainty of the procedure was used as the criterion for precision. The control strategy requirements for variability sources and the analytical target profile requirements for precision and accuracy were met in the receiving unit.Conclusion. The paper discusses the premise and advocates an alternative approach to the method transfer. Precision is proposed not to study during the transfer (in the short-term experiment) but assess from the stability data (in the long-term experiment). Compliance with the normal analytical practice (the maximum permissible variability attributed to analysts and analytical instruments) allows narrowing down the transfer design to the confirmation in the minimal experiment that the amplitude of variability sources lies within the predefined rang

The Synthesis and Study of Profiles of the Ornidazole Impurities

Pharmacopoeial reference standards (PhRSs) provide the comparability of the test results of generic drugs. PhRSs of ornidazole impurities are not described in pharmacopoeias. Therefore, the establishment of PhRSs of the State Pharmacopeia of Ukraine (SPhU RSs) of ornidazole impurities is an essential task, the integral part of which is synthesis and characterisation of ornidazole impurities.Aim: To synthesise impurities of ornidazole as candidate materials for certification as SPhU RSs and study their profiles in the substance and infusion solution of ornidazole.Methods: Traditional methods of organic synthesis, 1Н NMR spectroscopy, IR absorption spectrophotometry, the capillary method for the melting point determination, liquid chromatography with a spectrophotometric detector. Results: Ornidazole-diol and ornidazole-epoxide were synthesized, and their structures were confirmed using 1Н NMR and IR spectra. Their chromatographic profiles in the substance and the infusion drug of ornidazole being under pharmaceutical development were studied. The problem with the ornidazole-diol determination by the manufacturer's procedure was found, and its correction was proposed. The purity of the compounds synthesized was approximately 99.5 %. In the substance, the content of ornidazole-epoxide exceeded 0.1 %, whereas the content of ornidazole-diol was negligible. In the drug, the content of ornidazole-epoxide reduced to zero with time, while the content of ornidazole-diol increased considerably (to approx. 3 %).Conclusions: The efficient methods for the synthesis of ornidazole-epoxide and ornidazole-diol were developed, and the synthesis was conducted. The profiles of the synthesized impurities in the substance and the infusion drug of ornidazole being under pharmaceutical development were studied. It was found that ornidazole-epoxide and ornidazole-diol are present in the substance and the drug at the level which requires their identification and quantitative determination. The proposed methods for synthesis provide obtaining ornidazole-diol and ornidazole-epoxide of high purity, which enables to use them as the candidate materials for certification as SPhU RS