Proyecto de inversión para el diseño online, manufactura y comercialización de bolsos, mochilas, carteras y accesoríos en la ciudad de Guayaquil

El presente proyecto tiene como objetivo determinar la viabilidad de la inversión para el diseño online, manufactura y comercialización de carteras, mochilas, bolsos y accesorios en la ciudad de Guayaquil. La idea del proyecto nace como una alternativa que permite a las personas adquirir un artículo ajustado realmente a sus gustos, demostrando su individualidad en un mundo afectado por la producción en masa

¿Cómo acceder a las emociones básicas relacionadas a un aprendizaje matemático?

Este reporte tiene como objetivo mostrar una alternativa diferente de acceder a las emociones que expresan los estudiantes al enfrentarse a una tarea matemática, sobre la construcción de una caja en un software dinámico. Se accede a las emociones con un software especializado en detectar expresiones faciales asociadas a la emoción, FaceReader y bajo un marco teórico que considera a la emoción como multidimensional. Los actores fueron estudiantes de colegio, cuya edad oscilaba entre 14 y 17 años. Los resultados se muestran en mapa de calor, cuya variabilidad de intensidad de color representa la frecuencia absoluta de la emoción registrada y de la interpretación de los mismo se concluyó, que las dificultades de tazar ciertos signos geométricos, desencadenan emociones negativas con mayor frecuencia, tales como: la tristeza, enojo, miedo y disgusto. Estas inhiben la búsqueda de otras posibilidades de resolver la tarea, a tal punto que el estudiante la termina abandonando

Topological field theories in n-dimensional spacetimes and Cartan's equations

Action principles of the BF type for diffeomorphism invariant topological field theories living in n-dimensional spacetime manifolds are presented. Their construction is inspired by Cuesta and Montesinos' recent paper where Cartan's first and second structure equations together with first and second Bianchi identities are treated as the equations of motion for a field theory. In opposition to that paper, the current approach involves also auxiliary fields and holds for arbitrary n-dimensional spacetimes. Dirac's canonical analysis for the actions is detailedly carried out in the generic case and it is shown that these action principles define topological field theories, as mentioned. The current formalism is a generic framework to construct geometric theories with local degrees of freedom by introducing additional constraints on the various fields involved that destroy the topological character of the original theory. The latter idea is implemented in two-dimensional spacetimes where gravity coupled to matter fields is constructed out, which has indeed local excitations.Comment: LaTeX file, no figure

Dental erosion and hypersensitivity in adults, "Neodental" dental office

Introducción: las superficies del esmalte, la dentina y el cemento dental están sujetas a una variedad de procesos destructivos. La exposición de la dentina puede provocar sensibilidad, problemas estéticos y exposición de la pulpa.Objetivo: analizar la erosión dental y la hipersensibilidad en pacientes con edades entre 27 a 56 años que asistieron, al consultorio dental “Neodental”, Ecuador.Métodos: se realizó un estudio observacional, descriptivo de corte transversal en pacientes adultos de 20 a 56 años examinados en el consultorio dental “Neodental”, Ecuador, en el período septiembre-diciembre de 2022. El universo estuvo integrado por 42 pacientes, de ellos, mediante muestreo aleatorio simple, según los criterios de inclusión y exclusión, se obtuvo una muestra de 20 pacientes. Los datos fueron obtenidos de la historia clínica de los pacientes y una encuesta elaborada para tales fines. Las variables utilizadas fueron descritas estadísticamente mediante frecuencias relativas porcentuales.Resultados: el 40 % de la muestra se cepilla una vez al día mostrando una higiene bucal deficiente, solo el 20 % se cepilla tres ocasiones y apenas un 15 % de la población las cuatro veces reconocidas para determinar un cepillado e higiene bucal eficiente. El 60 % de la muestra desconocía sobre la erosión dental, mientras que el 40 % de la muestra restante conocía la patología. El 70 % de la muestra consume medicamentos que contienen vitamina C, y el 30 % restante consume con poca frecuencia o no lo consume.Conclusiones: los pacientes con hipersensibilidad y erosión dental generalmente son diagnosticados a tiempo cuando la pieza dental todavía tiene un buen pronóstico.Introduction: enamel, dentin and dental cement surfaces are subjected to a variety of destructive processes. Exposure of dentin can cause sensitivity, cosmetic problems, and exposure of the pulp.Objective: to analyze dental erosion and hypersensitivity in patients aged 27 to 56 who attended the "Neodental" dental office, Ecuador.Methods: an observational, descriptive cross-sectional study was carried out in adult patients from 20 to 56 years of age examined at the "Neodental"dental office, Ecuador, in the period September-December 2022. The universe consisted of 42 patients, of whom, using simple random sampling,according to the inclusion and exclusion criteria, a sample of 20 patientswas obtained. The data were obtained from the clinical history of the patients and a survey elaborated for such purposes. The variables used were statistically described by percentage relative frequencies.Results: 40 % of the sample brushes one time a day showing poor oral hygiene, only 20 % brushes three times and only 15 % of the populationthe four times recognized to determine efficient brushing and oral hygiene. 60 % of the sample was unaware of dental erosion, while theremaining 40 % of the sample knew about the pathology. 70 % of the sample consume medicines that contain vitamin C, and the remaining 30 % consume it infrequently or not at all.Conclusions: patients with hypersensitivity and dental erosion aregenerally diagnosed in time when the dental piece still has a good prognosis.

Simulation-based Inference for Exoplanet Atmospheric Retrieval: Insights from winning the Ariel Data Challenge 2023 using Normalizing Flows

Advancements in space telescopes have opened new avenues for gathering vast amounts of data on exoplanet atmosphere spectra. However, accurately extracting chemical and physical properties from these spectra poses significant challenges due to the non-linear nature of the underlying physics. This paper presents novel machine learning models developed by the AstroAI team for the Ariel Data Challenge 2023, where one of the models secured the top position among 293 competitors. Leveraging Normalizing Flows, our models predict the posterior probability distribution of atmospheric parameters under different atmospheric assumptions. Moreover, we introduce an alternative model that exhibits higher performance potential than the winning model, despite scoring lower in the challenge. These findings highlight the need to reevaluate the evaluation metric and prompt further exploration of more efficient and accurate approaches for exoplanet atmosphere spectra analysis. Finally, we present recommendations to enhance the challenge and models, providing valuable insights for future applications on real observational data. These advancements pave the way for more effective and timely analysis of exoplanet atmospheric properties, advancing our understanding of these distant worlds.Comment: Conference proceeding for the ECML PKDD 202

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.

Although several lung cancer susceptibility loci have been identified, much of the heritability for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European descent were genotyped on the OncoArray and combined with existing data for an aggregated genome-wide association study (GWAS) analysis of lung cancer in 29,266 cases and 56,450 controls. We identified 18 susceptibility loci achieving genome-wide significance, including 10 new loci. The new loci highlight the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer, with four loci associated with lung cancer overall and six loci associated with lung adenocarcinoma. Gene expression quantitative trait locus (eQTL) analysis in 1,425 normal lung tissue samples highlights RNASET2, SECISBP2L and NRG1 as candidate genes. Other loci include genes such as a cholinergic nicotinic receptor, CHRNA2, and the telomere-related genes OFBC1 and RTEL1. Further exploration of the target genes will continue to provide new insights into the etiology of lung cancer

Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020

We show the distribution of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three genomic nomenclature systems to all sequence data from the World Health Organization European Region available until 10 July 2020. We highlight the importance of real-time sequencing and data dissemination in a pandemic situation, compare the nomenclatures and lay a foundation for future European genomic surveillance of SARS-CoV-2

The deep, historical-roots of Cuban anti-imperialism

Colonialism, imperialism and anti-imperialism have been decisive in shaping Cuban political identity for 150 years. US determination to control Cuba, consistent with the Monroe Doctrine, had a strong economic rationale even before Spain was defeated in the War of Independence in 1898. Debate raged between Cubans who aspired to true independence and an annexationalist minority, who favoured union with the US. The Platt Amendment imposed on Cuba by the US in 1903 ‘reduced the independence and sovereignty of the Cuban republic to a myth’. Between then and the Revolution of 1959 Cuba was effectively first a protectorate and then neo-colony of the US, which dominated the Cuban economy, politics and foreign policy. Tackling the terrible socioeconomic and political effects of Cuba’s subjugation under the Spanish empire and then US imperialism necessitated a radical transformation of the Cuban economy, political institutions and power structures. The transition to socialism inevitably meant confronting US imperialism – and vice versa. Since 1959, US imperialism, with its powerful allies in the right-wing exile community based in Miami, have relentlessly tried to destroy the Revolution and Cuban socialism. The issue of imperialism remains key today, in the post-Fidel, President Trump era