Dark Matter Sub-Halo Counts via Star Stream Crossings

Dark matter sub-halos create gaps in the stellar streams orbiting in the halos of galaxies. We evaluate the sub-halo stream crossing integral with the guidance of simulations to find that the linear rate of gap creation, R_gap, in a typical Cold Dark Matter (CDM) galactic halo at 100 kpc is R_gap = 0.0066 M_8^-0.35 kpc^-1 Gyr^-1$, where M_8 = M/10^8 M_sun, is the minimum mass halo that creates a visible gap. The relation can be recast entirely in terms of observables, as R_gap= 0.059 w^-0.85 kpc^-1 Gyr^-1, for w in kpc, normalized at 100 kpc. Using published data, the density of gaps is estimated for M31's NW stream and the Milky Way Pal 5 stream, Orphan stream, and Eastern Banded Structure. The estimated rates of gap creation all have errors of 50% or more due to uncertain dynamical ages and the relatively noisy stream density measurements. The gap rate-width data are in good agreement with the CDM predicted relation. The high density of gaps in the narrow streams require a total halo population of 10^5 sub-halos above a minimum mass of 10^5 M_sun.Comment: ApJ accepted and copy-edite

Les nouveaux patrimoines en Pays de la Loire

Richement illustré et doté de nombreuses cartes inédites, cet ouvrage interroge la signification de l’importance croissante des « nouveaux patrimoines ». Contribuant à promouvoir le respect de la diversité culturelle et la promotion de la créativité humaine, ils présentent aussi un versant économique non négligeable. Ce livre, centré sur les Pays de la Loire, rassemble une cinquantaine de contributeurs, universitaires et professionnels du patrimoine, du tourisme et de la médiation culturelle

From Research to Operational Biomonitoring of Freshwaters: A Suggested Conceptual Framework and Practical Solutions

International audienceThe contradictory demands of managers (quick relevant operational responses) and ecologists (need time for in-depth research) involved in freshwater biomonitoring are still relevant today. To contribute to solving this dilemma, we are proposing a novel biomonitoring approach, which among many others, could be used in this field and further developed in the future. Biomonitoring actions are integrated in conceptual schemes, in which hydrology, chemistry, hydrogeology and geomorphology bear as much importance as biology. Among biomonitoring tools, a harmonization system allows end-users to use a set of qualitative indicators (various biotic indices) and integrate the information given by individual biotic indices. Functional traits and calculation of an ecological potential in porous aquatic habitats (surficial coarse sediments and the hyporheic system) are regarded as a basis for assessing ecological functioning of streams and rivers. This last methodology takes into account the dynamics of water exchanges between surface water and groundwater. Objectives of ecological quality, ecological potentials and resilience capacity that need to be preserved or rehabilitated in aquatic habitats are established. In lakes, a similar approach was followed and a general typology of lake functioning was proposed, including that for urban lakes. All those biomonitoring tools are transferred to end-users and subject to further research. The final purpose is to promote practical high-tech tools which are continually and interactively connected with ongoing research

Shp-2 Is Dispensable for Establishing T Cell Exhaustion and for PD-1 Signaling In Vivo.

In chronic infection and cancer, T cells acquire a dysfunctional state characterized by the expression of inhibitory receptors. In vitro studies implicated the phosphatase Shp-2 downstream of these receptors, including PD-1. However, whether Shp-2 is responsible in vivo for such dysfunctional responses remains elusive. To address this, we generated T cell-specific Shp-2-deficient mice. These mice did not show differences in controlling chronic viral infections. In this context, Shp-2-deleted CD8 <sup>+</sup> T lymphocytes expanded moderately better but were less polyfunctional than control cells. Mice with Shp-2-deficient T cells also showed no significant improvement in controlling immunogenic tumors and responded similarly to controls to α-PD-1 treatment. We therefore showed that Shp-2 is dispensable in T cells for globally establishing exhaustion and for PD-1 signaling in vivo. These results reveal the existence of redundant mechanisms downstream of inhibitory receptors and represent the foundation for defining these relevant molecular events