Caracterização geológica da porção centro-sul da Bacia Pernambuco com base na integração de modelo digital de elevação, dados magnetométricos e geológicos

Este trabalho descreve os principais aspectos geológicos, em escala de detalhe, observados para a porção centro-sul da Bacia Pernambuco, localizada em parte dos municípios de Ipojuca e Sirinhaém (PE). Seis unidades litoestratigráficas puderam ser individualizadas: o embasamento cristalino (rochas metamórficas intemperizadas), a Formação Cabo (conglomerados polimíticos), a Suíte Magmática Ipojuca (riolitos, basaltos e rochas piroclásticas), as formações Estiva (folhelhos verdes, calcíferos, com ausência de microfósseis) e Algodoais (argilitos e arenitos médios a finos, com fácies sedimentar vulcanogênica associada), e depósitos quaternários. Foram utilizadas ferramentas como o modelo digital de elevação (MDE) da Triangulated Irregular Network (TIN), derivado dos dados topográficos da Folha Sirinhaém (escala 1:25.000) e o mapa de amplitude do sinal analítico para auxiliar a cartografia geológica. Os lineamentos topográficos e magnéticos (trends NNW-ESE, NW-SE e NE-SW) correspondem à fase rifte. Esses lineamentos estão relacionados a falhas de borda (evento inicial) e, principalmente, à reativação dessas falhas, combinada à geração de novas falhas. Vinte e seis anomalias magnéticas positivas e circulares foram identificadas e podem refletir a assinatura de possíveis centros vulcânicos. Atentamos a ocorrência de dois possíveis grandes centros vulcânicos que se propagam em direção ao Platô de Pernambuco, sendo que um está localizado na porção leste da área (CV1), onde ocorre o maior volume de sedimentação quaternária, e o outro está inserido na porção sudoeste (CV2), e excede os limites da área estudada

COVID-19 x cardiovascular system: clinical evolution, risk factors and myocardial injury mechanism

SARS-CoV-2 has driven the COVID-19 epidemic around the world, making it one of the most significant medical challenges of the last century. This infectious agent infects host cells by binding to ACE2 receptors (an enzyme present in several tissues, such as the heart, lung and kidneys) and can lead to pneumonia, acute myocardial damage and chronic damage to the cardiovascular system. Pre-existing conditions such as diabetes, hypertension and obesity are related to greater severity and a significant increase in the fatality rate of COVID-19. The exacerbated production of inflammatory cytokines such as IL-6 and TNF-α leads to systemic inflammation, which can directly affect the cardiovascular system. Acute myocardial infarction (increased risk), myocarditis, arrhythmias, venous thromboembolism and takotsubo cardiomyopathy are some of the most prevalent complications of the cardiovascular system described in patients with COVID-19

Sound localization: the relevance of interaural differences in auditory thresholds

OBJETIVO: Esclarecer a relação das diferenças entre os limiares auditivos das orelhas direita e esquerda com o percentual de erros e acertos na localização de fontes sonoras em ambientes reverberantes. MÉTODOS: Foram examinados 56 voluntários, sendo 33 homens e 23 mulheres, média de idade de 26,6 anos, submetidos aos seguintes testes: otoscopia, audiometria tonal, imitanciometria e emissões otoacústicas. Todos os voluntários apresentaram audição dentro dos padrões de normalidade. Posteriormente, os indivíduos foram submetidos ao teste de localização sonora espacial, onde foram utilizadas ondas quadradas com freqüências fundamentais centradas em 500 Hz, 2000 Hz e 4000 Hz. Os estímulos foram apresentados quinze vezes em cada uma das treze posições espaciais do aparelho utilizado, em cada uma das freqüências escolhidas. Assim, foram apresentados 585 estímulos, no total, por pessoa. RESULTADOS: Na amostra estudada, encontrou-se como resultado, idade entre 18 e 50 anos, média da diferença dos limiares auditivos entre as orelhas de 6,81 dB e percentual de acertos na localização sonora dentro dos padrões normais. A correlação entre as diferenças interaurais e os acertos na localização, no entanto, não foi significativa. CONCLUSÕES: O presente estudo demonstrou que, em pessoas com audição normal, as variações dos limiares auditivos e as diferenças entre as orelhas até 10 dB não interferem na localização de fontes sonoras. _________________________________________________________________________________________ ABSTRACT: PURPOSE: To relate the differences between left and right ears' auditory thresholds and rate of correct/incorrect responses in sound localization tasks placed in reverberant environments. METHODS: The following tests were carried out: otoscopy, pure tone audiometry, impedanciometry and otoacoustic emissions. All 56 volunteers presented normal hearing results in all tests. After that, the volunteers were submitted to a sound localization test, in which square waves of 500 Hz, 2000 Hz and 4000 Hz were used. Stimuli were presented fifteen times in each one of the thirteen space positions of the device used, for each frequency tested. Therefore, a total number of 585 stimuli were presented for each subject. RESULTS: Data analysis showed that the sample had subjects with ages between 18 and 50 years, the average difference between right and left ears' auditory thresholds was 6,81 dB, and percentage of correct answers on the sound localization test was within normal values. No significant correlations were found between interaural differences and localization abilities. CONCLUSIONS: The present study showed that, for people with normal hearing, the auditory thresholds variations and interaural differences until 10 dB do not interfere on sound localization

Aedes aegypti breeding site in an underground rainwater reservoir: a warning

We describe the discovery of Aedes aegypti underground breeding site in the Pinheiros neighborhood of São Paulo, SP, during an entomological survey program performed in 2016. Even with intense surveillance and vector control, large numbers of mosquitoes were present in this area. A detailed investigation allowed for the detection of Ae. aegypti in an underground reservoir used for rainwater storage. After the implementation of protection screens in the accesses, the presence of the vector was no longer detected. In this study, we discuss the frequent use of this type of reservoir structure and its risk for mosquito production.Descreve-se o encontro de criadouro subterrâneo de Aedes aegypti no bairro de Pinheiros, São Paulo, SP, ocorrido durante um programa de levantamento entomológico, realizado em 2016. Mesmo com intensa vigilância e controle vetorial, grande quantidade de mosquitos estava presente nessa área. Investigação minuciosa permitiu a detecção de Ae. aegypti em reservatório subterrâneo para armazenamento de água pluvial. Após a implantação de telas de proteção nos acessos, não foi mais detectada a presença do vetor. O uso frequente desse tipo de estrutura e o seu risco para a produção de mosquitos é discutido

Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial

Background: Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). Methods/Design: ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with ARDS compared to conventional treatment (ARDSNet strategy). We will enroll adult patients with ARDS of less than 72 h duration. The intervention group will receive an alveolar recruitment maneuver, with stepwise increases of PEEP achieving 45 cmH(2)O and peak pressure of 60 cmH2O, followed by ventilation with optimal PEEP titrated according to the static compliance of the respiratory system. In the control group, mechanical ventilation will follow a conventional protocol (ARDSNet). In both groups, we will use controlled volume mode with low tidal volumes (4 to 6 mL/kg of predicted body weight) and targeting plateau pressure <= 30 cmH2O. The primary outcome is 28-day survival, and the secondary outcomes are: length of ICU stay; length of hospital stay; pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; mechanical ventilation-free days from days 1 to 28; ICU, in-hospital, and 6-month survival. ART is an event-guided trial planned to last until 520 events (deaths within 28 days) are observed. These events allow detection of a hazard ratio of 0.75, with 90% power and two-tailed type I error of 5%. All analysis will follow the intention-to-treat principle. Discussion: If the ART strategy with maximum recruitment and PEEP titration improves 28-day survival, this will represent a notable advance to the care of ARDS patients. Conversely, if the ART strategy is similar or inferior to the current evidence-based strategy (ARDSNet), this should also change current practice as many institutions routinely employ recruitment maneuvers and set PEEP levels according to some titration method.Hospital do Coracao (HCor) as part of the Program 'Hospitais de Excelencia a Servico do SUS (PROADI-SUS)'Brazilian Ministry of Healt

MLH1, MSH2, MSH3 and EXO1 polymorphisms and head and neck squamous cell carcinoma risk and prognosis

Sem informação3315Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO) / Clinical Science Symposium on Predicting and Improving Adverse Outcomes in Older Adults with Cance