293 research outputs found
Domain modeling and grid generation for multi-block structured grids with application to aerodynamic and hydrodynamic configurations
About five years ago, a joint development was started of a flow simulation system for engine-airframe integration studies on propeller as well as jet aircraft. The initial system was based on the Euler equations and made operational for industrial aerodynamic design work. The system consists of three major components: a domain modeller, for the graphical interactive subdivision of flow domains into an unstructured collection of blocks; a grid generator, for the graphical interactive computation of structured grids in blocks; and a flow solver, for the computation of flows on multi-block grids. The industrial partners of the collaboration and NLR have demonstrated that the domain modeller, grid generator and flow solver can be applied to simulate Euler flows around complete aircraft, including propulsion system simulation. Extension to Navier-Stokes flows is in progress. Delft Hydraulics has shown that both the domain modeller and grid generator can also be applied successfully for hydrodynamic configurations. An overview is given about the main aspects of both domain modelling and grid generation
New perspectives in physics and astrophysics from the theoretical understanding of Gamma-Ray Bursts
If due attention is given in formulating the basic equations for the
Gamma-Ray Burst (GRB) phenomenon and in performing the corresponding
quantitative analysis, GRBs open a main avenue of inquiring on totally new
physical and astrophysical regimes. This program is one of the greatest
computational efforts in physics and astrophysics and cannot be actuated using
shortcuts. A systematic approach has been highlighted in three paradigms: the
relative space-time transformation (RSTT) paradigm, the interpretation of the
burst structure (IBS) paradigm, the GRB-supernova time sequence (GSTS)
paradigm. In fundamental physics new regimes are explored: (1) the process of
energy extraction from black holes; (2) the quantum and general relativistic
effects of matter-antimatter creation near the black hole horizon; (3) the
physics of ultrarelativisitc shock waves with Lorentz gamma factor . In astronomy and astrophysics also new regimes are explored: (i) the
occurrence of gravitational collapse to a black hole from a critical mass core
of mass M\agt 10M_\odot, which clearly differs from the values of the
critical mass encountered in the study of stars ``catalyzed at the endpoint of
thermonuclear evolution" (white dwarfs and neutron stars); (ii) the extremely
high efficiency of the spherical collapse to a black hole, where almost 99.99%
of the core mass collapses leaving negligible remnant; (iii) the necessity of
developing a fine tuning in the final phases of thermonuclear evolution of the
stars, both for the star collapsing to the black hole and the surrounding ones,
in order to explain the possible occurrence of the "induced gravitational
collapse". A new class of space missions to acquire information on such extreme
new regimes are urgently needed.Comment: RevTeX4, 93 pages, 50 figures, to appear in the "Proceedings of the
Xth Brazilian School of Cosmology and Gravitation", M. Novello, editor, AIP,
in pres
Is the treatment of the tear trough deformity with hyaluronic acid injections a safe procedure? A systematic review
Among the various therapeutic options for the treatment of tear trough deformities, the use of hyaluronic acid-based fillers has constantly been increasing. The aim of this research is to conduct a systematic review of the published literature related to the use of hyaluronic acid-based dermal fillers for the treatment of tear trough deformities and possible related complications. A search of the published literature was conducted following the PRISMA guidelines, including PubMed, Cochrane Library, and Ovid databases. Text words and Medical Search Headings (MeSH terms) were used to identify nine articles included in our analysis. The most used filler was Restylane (Galderma). The injection technique was performed through the use of a cannula or, more frequently, with a needle, through the execution of boluses or retrograde release. The injection plane was predominantly the supra-periosteal layer. The most observed side effects were mild and included redness, edema, contour irregularities, bruising, and blue-gray dyschromia. The degree of patient satisfaction was high, with an optimal aesthetic result that was maintained for 6 to 12 months. Although the duration of treatment of tear trough deformities with HA fillers is not comparable to surgical treatment, this is a minimally invasive, safe procedure, quick to perform, and with a high degree of patient satisfaction
Higher-order Mechanics: Variational Principles and other topics
After reviewing the Lagrangian-Hamiltonian unified formalism (i.e, the
Skinner-Rusk formalism) for higher-order (non-autonomous) dynamical systems, we
state a unified geometrical version of the Variational Principles which allows
us to derive the Lagrangian and Hamiltonian equations for these kinds of
systems. Then, the standard Lagrangian and Hamiltonian formulations of these
principles and the corresponding dynamical equations are recovered from this
unified framework.Comment: New version of the paper "Variational principles for higher-order
dynamical systems", which was presented in the "III Iberoamerican Meeting on
Geometry, Mechanics and Control" (Salamanca, 2012). The title is changed. A
detailed review is added. Sections containing results about variational
principles are enlarged with additional comments, diagrams and summarizing
results. Bibliography is update
Parametrization for the Scale Dependent Growth in Modified Gravity
We propose a scale dependent analytic approximation to the exact linear
growth of density perturbations in Scalar-Tensor (ST) cosmologies. In
particular, we show that on large subhorizon scales, in the Newtonian gauge,
the usual scale independent subhorizon growth equation does not describe the
growth of perturbations accurately, as a result of scale-dependent relativistic
corrections to the Poisson equation. A comparison with exact linear numerical
analysis indicates that our approximation is a significant improvement over the
standard subhorizon scale independent result on large subhorizon scales. A
comparison with the corresponding results in the Synchronous gauge demonstrates
the validity and consistency of our analysis.Comment: 10 pages, 5 figures. Minor modifications and references added to
match published versio
From Atiyah Classes to Homotopy Leibniz Algebras
A celebrated theorem of Kapranov states that the Atiyah class of the tangent
bundle of a complex manifold makes into a Lie algebra object in
, the bounded below derived category of coherent sheaves on .
Furthermore Kapranov proved that, for a K\"ahler manifold , the Dolbeault
resolution of is an
algebra. In this paper, we prove that Kapranov's theorem holds in much wider
generality for vector bundles over Lie pairs. Given a Lie pair , i.e. a
Lie algebroid together with a Lie subalgebroid , we define the Atiyah
class of an -module (relative to ) as the obstruction to
the existence of an -compatible -connection on . We prove that the
Atiyah classes and respectively make and
into a Lie algebra and a Lie algebra module in the bounded below
derived category , where is the abelian
category of left -modules and is the universal
enveloping algebra of . Moreover, we produce a homotopy Leibniz algebra and
a homotopy Leibniz module stemming from the Atiyah classes of and ,
and inducing the aforesaid Lie structures in .Comment: 36 page
Averaging inhomogeneities in scalar-tensor cosmology
The backreaction of inhomogeneities on the cosmic dynamics is studied in the
context of scalar-tensor gravity. Due to terms of indefinite sign in the
non-canonical effective energy tensor of the Brans-Dicke-like scalar field,
extra contributions to the cosmic acceleration can arise. Brans-Dicke and
metric f(R) gravity are presented as specific examples. Certain representation
problems of the formalism peculiar to these theories are pointed out.Comment: Comments and references added. 14 page
The correlation of RNase A enzymatic activity with the changes in the distance between Nepsilon2-His12 and N delta1-His119 upon addition of stabilizing and destabilizing salts.
The effect of stabilizing and destabilizing salts on the catalytic behavior of ribonuclease A (RNase A) was investigated at pH 7.5 and 25 degrees C, using spectrophotometric, viscometric and molecular dynamic methods. The changes in the distance between N(epsilon2) of His(12) and N(delta1) of His(119) at the catalytic center of RNase A upon the addition of sodium sulfate, sodium hydrogen sulfate and sodium thiocyanate were evaluated by molecular dynamic methods. The compactness and expansion in terms of Stokes radius of RNase A upon the addition of sulfate ions as kosmotropic salts, and thiocyanate ion as a chaotropic salt, were estimated by viscometric measurements. Enzyme activity was measured using cytidine 2', 3'-cyclic monophosphate as a substrate. The results from the measurements of distances between N(epsilon2) of His(12) and N(delta1) of His(119) and Stokes radius suggest (i) that the presence of sulfate ions decreases the distance between the catalytic His residues and increases the globular compactness, and (ii) that there is an expansion of the enzyme surface as well as elongation of the catalytic center in the presence of thiocyanate ion. These findings are in agreement with activity measurements
Efficacy of idelalisib and rituximab in relapsed/refractory chronic lymphocytic leukemia treated outside of clinical trials. A report of the Gimema Working Group
Because the efficacy of new drugs reported in trials may not translate into similar results when used in the real-life, we analyzed the efficacy of idelalisib and rituximab (IR) in 149 patients with relapsed/refractory chronic lymphocytic leukemia treated at 34 GIMEMA centers. Median progression-free survival (PFS) and overall survival were 22.9 and 44.5 months, respectively; performance status (PS) ≥2 and ≥3 previous lines of therapy were associated with shorter PFS and overall survival (OS). 48% of patients were on treatment at 12 months; the experience of the centers (≥5 treated patients) and PS 0-1 were associated with a significantly longer treatment duration (p = 0.015 and p = 0.002, respectively). TP53 disruption had no prognostic significance. The overall response rate to subsequent treatment was 49.2%, with median OS of 15.5 months and not reached in patients who discontinued, respectively, for progression and for toxicity (p < 0.01). Treatment breaks ≥14 days were recorded in 96% of patients and adverse events mirrored those reported in trials. In conclusion, this real-life analysis showed that IR treatment duration was longer at experienced centers, that the ECOG PS and ≥3 lines of previous therapy are strong prognostic factor and that the overall outcome with this regimen was superimposable to that reported in a randomized trial
Filtering out the cosmological constant in the Palatini formalism of modified gravity
According to theoretical physics the cosmological constant (CC) is expected
to be much larger in magnitude than other energy densities in the universe,
which is in stark contrast to the observed Big Bang evolution. We address this
old CC problem not by introducing an extremely fine-tuned counterterm, but in
the context of modified gravity in the Palatini formalism. In our model the
large CC term is filtered out, and it does not prevent a standard cosmological
evolution. We discuss the filter effect in the epochs of radiation and matter
domination as well as in the asymptotic de Sitter future. The final expansion
rate can be much lower than inferred from the large CC without using a
fine-tuned counterterm. Finally, we show that the CC filter works also in the
Kottler (Schwarzschild-de Sitter) metric describing a black hole environment
with a CC compatible to the future de Sitter cosmos.Comment: 22 pages, 1 figure, discussion extended, references added, accepted
by Gen.Rel.Gra
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