Soldiers Two

https://digitalcommons.library.umaine.edu/mmb-me/1417/thumbnail.jp

Western nursery practice

Citation: Vinall, Henry N. Western nursery practice. Senior thesis, Kansas State Agricultural College, 1903.Morse Department of Special CollectionsIntroduction: I. Location. The chief point in choosing a location for a nursery is to secure the proper soil, and in this matter it is well to remember that all classes of fruit trees do not require the same kind of soil. In growing the apple, it is of paramount importance to plant the grafts on the best soil obtainable so that a strong healthy growth will be made high enough the first year to produce when headed back the body or trunk of you future tree. If two seasons are required for this growth, the tree is apt to be crooked when the second season’s growth commenced. Old nurserymen often avoid such result by cutting the first year’s growth back to the ground, if is too weak, and allowing the extra strength of the root produced by the previous season’s growth to be used in the production of this single shoot or whip; the prime object in growing apple trees for market, being to secure as large and stocky a tree as possible when it is two years old. With peach trees such is not the case, they as a rule attain to a marketable size in one year from the bud and there is a tendency to make too large a growth and nurserymen have found it advantageous to plant the seed on rather thin soil instead of rich loam, thus checking their growth and making their wood more hard and firm. With this exception however it is generally advisable to procure as good soil as possible and it should always be deep and . Never try to grow nursery stock over underlying hardpan. The best soil is a deep, rich, nearly level upland loam. II. Preparation of the Ground. This is an important consideration in the success of nursery work since in taking the crop of trees from the field it is often left in very poor condition for planting

Student use and instructor beliefs: Machine translation in language education

The use of machine translation (MT) tools remains controversial among language instructors, with limited integration into classroom practices. While much of the existing research into MT and language education has explored instructor perceptions, less is known about how students actually use MT or how student use compares to instructor beliefs and expectations. In response to this gap, the current article explores how students use MT while writing and how this use compares to instructor perceptions via two studies: a computer-tracking study of how 49 second semester-level language learners (French, Spanish) use MT and a qualitative survey of 165 US-based second language educators’ beliefs about MT. Findings highlight important areas of alignment (e.g., MT input at word level) and divergence (e.g., MT output analysis strategies) between student use and instructor perceptions as well as layered tensions in what mediates student use of MT tools. The article concludes with calls for more research on student use and an outline for how to approach MT tools in language education in ways that support existing student practices

"He was distraught, I was distraught.." Parents' experiences of accessing emergency care following an avulsion injury to their child

Objective To explore how parents access emergency care for their children following avulsion of a permanent tooth. Method Semi-structured qualitative interviews were undertaken with parents of children who had suffered a tooth avulsion injury in the previous two years. The interviews were recorded and transcribed verbatim. Framework analysis was used to analyse the data and interpret the core concepts from the interviews. Results Nine parents participated in the study. None of the children received the appropriate emergency dental care within the timeframe identified by national and international guidelines. The core themes that emerged following the analysis were knowledge, access and emotion. Discussion & Conclusions The parents who were interviewed for this study had poor knowledge of what to do in the event of a tooth avulsion injury. This lack of knowledge directly impaired their ability to navigate emergency dental care for their child. They described their upset and distress following their child's injury, but also feelings of frustration and disappointment in relation to the emergency care their child received. There is a need to develop appropriate support and clinical pathways to enable parents to rapidly access appropriate and timely care for their child following a complex dental trauma

1862-06-14 George Vinall solicits a promotion to a new regiment

https://digitalmaine.com/cw_me_2nd_regiment_corr/1292/thumbnail.jp

"I learn to seek solutions but without work I can't solve anything" : Youth Education and Community Development in Rural Honduras <Special Issue : Youth, Education, and Work>

This paper draws on a social capital framework to explore the complex relationship between youth education, their roles in community development, and their future opportunities as they transition from school to work against the backdrop of the social, economic, and political realities of rural Honduras. Data is from a three-year qualitative study that followed a cohort of 6th grade students as they progressed through the Sistema de Aprendizaje Tutorial (SAT), an alternative secondary education program that facilitates the development of capabilities so that youth can take charge of their intellectual and spiritual growth and contribute to the building of better communities. We focus on the youths' own words to understand how they conceptualize the resources that exist in their communities, their access to these resources, when and how these resources are successfully mobilized for community development, as well as how youth perceive their limitations to create future opportunities, particularly with regards to work

Remuneration of primary dental care in England: a qualitative framework analysis of perspectives of a new service delivery model incorporating incentives for improved access, quality and health outcomes

Objective: This study aimed to describe stakeholder perspectives of a new service delivery model in primary care dentistry incorporating incentives for access, quality and health outcomes. Design: Data were collected through observations, interviews and focus groups. Setting: This was conducted under six UK primary dental care practices, three working under the incentive-driven contract and three working under the traditional activity-based contract. Participants: Observations were made of 30 dental appointments. Eighteen lay people, 15 dental team staff and a member of a commissioning team took part in the interviews and focus groups. Results: Using a qualitative framework analysis informed by Andersen’s model of access, we found oral health assessments influenced patients’ perceptions of need, which led to changes in preventive behaviour. Dentists responded to the contract, with greater emphasis on prevention, use of the disease risk ratings in treatment planning, adherence to the pathways and the utilisation of skill-mix. Participants identified increases in the capacity of practices to deliver more care as a result. These changes were seen to improve evaluated and perceived health and patient satisfaction. These outcomes fed back to shape people’s predispositions to visit the dentist. Conclusion: The incentive-driven contract was perceived to increase access to dental care, determine dentists’ and patients’ perceptions of need, their behaviours, health outcomes and patient satisfaction. Dentists face challenges in refocusing care, perceptions of preventive dentistry, deployment of skill mix and use of the risk assessments and care pathways. Dentists may need support in these areas and to recognise the differences between caring for individual patients and the patient-base of a practice

XPO1 inhibition by selinexor induces potent cytotoxicity against high grade bladder malignancies.

Treatment options for high grade urothelial cancers are limited and have remained largely unchanged for several decades. Selinexor (KPT-330), a first in class small molecule that inhibits the nuclear export protein XPO1, has shown efficacy as a single agent treatment for numerous different malignancies, but its efficacy in limiting bladder malignancies has not been tested. In this study we assessed selinexor-dependent cytotoxicity in several bladder tumor cells and report that selinexor effectively reduced XPO1 expression and limited cell viability in a dose dependent manner. The decrease in cell viability was due to an induction of apoptosis and cell cycle arrest. These results were recapitulated in in vivo studies where selinexor decreased tumor growth. Tumors treated with selinexor expressed lower levels of XPO1, cyclin A, cyclin B, and CDK2 and increased levels of RB and CDK inhibitor p27, a result that is consistent with growth arrest. Cells expressing wildtype RB, a potent tumor suppressor that promotes growth arrest and apoptosis, were most susceptible to selinexor. Cell fractionation and immunofluorescence studies showed that selinexor treatment increased nuclear RB levels and mechanistic studies revealed that RB ablation curtailed the response to the drug. Conversely, limiting CDK4/6 dependent RB phosphorylation by palbociclib was additive with selinexor in reducing bladder tumor cell viability, confirming that RB activity has a role in the response to XPO1 inhibition. These results provide a rationale for XPO1 inhibition as a novel strategy for the treatment of bladder malignancies