PARADIGMAS TECNOLÓGICOS: UMA VISÃO HISTÓRICA PARA A TRANSIÇÃO PRESENTE

O trabalho discute o conceito de paradigma tecno-econômico de Freeman e Pérez e mostra sua importância para o estudo de mudanças tecnológicas radicais, com efeitos amplos sobre a estrutura econômica e social. Em particular, compara-se o velho paradigma tecnoeconômico fordista com o novo paradigma baseado em tecnologias da informação (TI). Finalmente, discutem-se os desafios colocados pela transição entre paradigmas. Abstract The paper discusses the concept of techno-economic paradigm, as proposed by Freeman and Pérez, and shows its usefulness for studying radical technological change, which entails widespread effects on the economic and social structure. In particular, the old Fordist paradigm is compared to the new paradigm based on technologies intensive in information. Concurrently, it is discussed the challenge posed by the transition between paradigms

O Brasil e o novo paradigma tecnológico de desenvolvimento econômico mundial

The economic advantages that Brazil has obtained through its industrialization process in the Post-World War H period, the stabilization programs and structural changes adopted by neo-liberal policies as well as the changings that are taking place In the world economy are manifestations of the techno-economic paradigm of economic development based on the information technology. This is the thesis of this paper.The economic advantages that Brazil has obtained through its industrialization process in the Post-World War H period, the stabilization programs and structural changes adopted by neo-liberal policies as well as the changings that are taking place In the world economy are manifestations of the techno-economic paradigm of economic development based on the information technology. This is the thesis of this paper

BIM-Based method for the verification of building code compliance

Urban planning is a valuable tool for growth control and city development, both to maintain the local urban identity and provide life quality for inhabitants. To regulate it, local governments have defined standards for a proper city’s growth through municipal and detailed urban plans. Such instruments identify a set of rules which constructions and buildings must fulfil for a careful and smooth integration within the urban areas. New projects are required to comply with such rules, and designers must adapt and guarantee that their projects fulfil all the local urban requirements. However, the verification process of construction projects is still a manual procedure and often a time-consuming process, with high possibilities for inaccurate measures. Thus, this paper aims to streamline the verification procedure of construction projects’ code compliance to enhance project design efficiency and save designers time. To do so, the Building Information Modelling (BIM) method will be used through the Dynamo programming software. By creating a Dynamo routine to check the building code and urban plan compliance from Brazilian municipalities, specific BIM models will be automatically analysed to detect and evaluate if it is according to local urban legislation. Results have provided a real-time decision support tool, where designers can assess if their buildings are complying with local urban codes at any time of the design stage, making it easy to innovate and integrate innovative design options, as well as to precisely communicate their buildings’ code compliance. Such a method can also support municipality authorities to verify project compliance, reducing assessment and calculation errors, as well as the required time and bureaucracy for project appraisal.This research was funded by the Portuguese Foundation for Science and Technology, through the Regional Operation Programme of North (Grant number SFRH/BD/145735/2019)

Il funzionamento delle Camere durante l'emergenza sanitaria. Riflessioni sulla difficile praticabilità di un Parlamento "telematico"

This essay focuses on the functioning of Parliamentary institution during the ongoing health emergency. After analyzing the different measures the Italian Parliament applied to ensure the continuity of parliamentary work without threatening the health of its members, we explore the initiatives put in place by Parliaments of other main European countries involved in the Covid-19 pandemic. In particular, the purpose of this study is to verify the impact different solutions had on the functioning of Parliaments and the exercise of MPs\u2019 prerogatives in order to reflect on the legitimacy, as well as the opportunity, of electronic voting procedures, now and in the future

Desenvolvimento regional e biodiversidade: reflexões sobre as possibilidades do estado do Espírito Santo

O objetivo deste capítulo é refletir sobre as possibilidades de instrumentos que, considerando preservação e uso sustentável, aproveitem as biodiversidades terrestre e marinha capixabas para lançar o Espírito Santo aos níveis mais elevados de desenvolvimento econômico, uma vez que isso não foi possível com as estratégias de industrialização operacionalizadas até os dias de hoje. Além disso, o surgimento de demandas para produtos e serviços com características sustentáveis tem levado ao aumento da consciência local quanto aos benefícios da conservação da biodiversidade. Esses novos patamares, porém, só serão alcançados à medida que os eixos de definição de políticas e instrumentos para o progresso econômico e social passarem a considerar os serviços ambientais e a preservação da biodiversidade importantes canais de geração de emprego e renda ao longo do tempo.The purpose of this chapter is to reflect on the possibilities of the instruments that considering preservation and sustainable use will take advantage of land and marine biodiversity to catapult the state of Espírito Santo into the highest levels of economic development, since operationalized industrialization strategies have failed to work so far. Also, the rise in demands for products and services with sustainable characteristics has helped increase local awareness regarding the benefits from preserving biodiversity. However, these new milestones will only be achieved when those developing policies and instruments for social and economic progress start to envisage environmental services and preserving biodiversity as important channels to generate jobs and income in the long term

Comparative Study on (Dis)use of Heritage in Ouro Preto-Br and Oporto-Pt

Appropriation arrangements of a particular territory expose the contradictions inherent in life in society. Those contradictions, in turn, do not depend on the existence of laws and regulations, setting up the materialization of different evolutionary processes. For this investigation, urban dynamics are influenced and compelled to respond to the particular pressures of capitalism, a late capitalism in the case of Ouro Preto, in which patrimonialization incurs break hegemonic models of space uses and reuses. The state apparatus appears plastering latent transformations and confirms the role of the ‘heritage-person’ as a potential heritage aggressor. This research’s main objective is to compare the dynamics of the heritage’s appropriation and use in Ouro Preto, Minas Gerais, Brazil and Oporto, Portugal. More specifically, it searches to understand the historical perspective of historic centre appropriation, its heritage value and its value for the tourism; to compare the heritage conservation legislation in both cities; and to study the problems of public equipment rehabilitation. This article presents the first step results of comparisons between the legislation on the urban rights (real estate assets) in Portugal and Brazil. It also presents the statistical comparison of types of infringement and their penalties applied by the historic centres rehabilitation programmes in Oporto and Ouro Preto. Through a systematic survey, the researchers diagnosed the main infringements committed to heritage assets. The use of records allowed to understand and to classify the types of offenses. These data for both cities will be compared, as well as each country’s or international guidelines regarding urban rehabilitation

Análise fundamentalista para seleção de uma carteira de investimento em ações com baixa razão book-to-market

This study combines the data utilized in traditional fundamentalist analysis, such as net income and ROA, with measures developed to evaluate companies with low book-to-market ratios (LBM), such as stable earnings, research and development spending and stable sales growth, in an attempt to separate the winners from the losers among LBM companies listed on the São Paulo Stock Exchange (Bovespa) in the period from 1994 to 2006. We used the model proposed by Mohanram (2005), adapted to Brazilian reality. The results for the Brazilian market are similar to Mohanram’s findings (2005) for the American market: the abnormal return for 12 and 24 months of a portfolio of companies with high GSCORE is significantly greater than the return of a portfolio of firms with low GSCORE.Key words: profitability, shares, pricing, winners, losers.Este trabalho combina dados utilizados na análise fundamentalista tradicional, como lucro líquido e ROA, com medidas desenvolvidas para avaliar empresas com baixa razão book-to-market (LBM), como estabilidade dos lucros, gastos com pesquisa e desenvolvimento e estabilidade no crescimento das vendas, de forma a separar winners e losers entre empresas LBM listadas na BOVESPA, a partir de dados do período 1994-2006. O modelo utilizado foi o proposto por Mohanram (2005) adaptado à realidade brasileira. Os resultados encontrados para o mercado brasileiro são semelhantes aos achados por Mohanram (2005) para o mercado norte-americano, ou seja, que o retorno anormal para os períodos de 12 e 24 meses da carteira composta por empresas com alto GSCORE é significativamente superior ao retorno da carteira composta por empresas com baixo GSCORE.Palavras-chave: lucratividade, ações, precificação, winners, losers

Análise fundamentalista para seleção de uma carteira de investimento em ações com baixa razão book-to-market

This study combines the data utilized in traditional fundamentalist analysis, such as net income and ROA, with measures developed to evaluate companies with low book-to-market ratios (LBM), such as stable earnings, research and development spending and stable sales growth, in an attempt to separate the winners from the losers among LBM companies listed on the São Paulo Stock Exchange (Bovespa) in the period from 1994 to 2006. We used the model proposed by Mohanram (2005), adapted to Brazilian reality. The results for the Brazilian market are similar to Mohanram’s findings (2005) for the American market: the abnormal return for 12 and 24 months of a portfolio of companies with high GSCORE is significantly greater than the return of a portfolio of firms with low GSCORE.Key words: profitability, shares, pricing, winners, losers.Este trabalho combina dados utilizados na análise fundamentalista tradicional, como lucro líquido e ROA, com medidas desenvolvidas para avaliar empresas com baixa razão book-to-market (LBM), como estabilidade dos lucros, gastos com pesquisa e desenvolvimento e estabilidade no crescimento das vendas, de forma a separar winners e losers entre empresas LBM listadas na BOVESPA, a partir de dados do período 1994-2006. O modelo utilizado foi o proposto por Mohanram (2005) adaptado à realidade brasileira. Os resultados encontrados para o mercado brasileiro são semelhantes aos achados por Mohanram (2005) para o mercado norte-americano, ou seja, que o retorno anormal para os períodos de 12 e 24 meses da carteira composta por empresas com alto GSCORE é significativamente superior ao retorno da carteira composta por empresas com baixo GSCORE.Palavras-chave: lucratividade, ações, precificação, winners, losers

Intimal smooth muscle cells are a source but not a sensor of anti-inflammatory CYP450 derived oxylipins

AbstractVascular pathologies are associated with changes in the presence and expression of morphologically distinct vascular smooth muscle cells. In particular, in complex human vascular lesions and models of disease in pigs and rodents, an intimal smooth muscle cell (iSMC) which exhibits a stable epithelioid or rhomboid phenotype in culture is often found to be present in high numbers, and may represent the reemergence of a distinct developmental vascular smooth muscle cell phenotype. The CYP450-oxylipin - soluble epoxide hydrolase (sEH) pathway is currently of great interest in targeting for cardiovascular disease. sEH inhibitors limit the development of hypertension, diabetes, atherosclerosis and aneurysm formation in animal models. We have investigated the expression of CYP450-oxylipin-sEH pathway enzymes and their metabolites in paired intimal (iSMC) and medial (mSMC) cells isolated from rat aorta. iSMC basally released significantly larger amounts of epoxy-oxylipin CYP450 products from eicosapentaenoic acid > docosahexaenoic acid > arachidonic acid > linoleic acid, and expressed higher levels of CYP2C12, CYP2B1, but not CYP2J mRNA compared to mSMC. When stimulated with the pro-inflammatory TLR4 ligand LPS, epoxy-oxylipin production did not change greatly in iSMC. In contrast, LPS induced epoxy-oxylipin products in mSMC and induced CYP2J4. iSMC and mSMC express sEH which metabolizes primary epoxy-oxylipins to their dihydroxy-counterparts. The sEH inhibitors TPPU or AUDA inhibited LPS-induced NFκB activation and iNOS induction in mSMC, but had no effect on NFκB nuclear localization or inducible nitric oxide synthase in iSMC; effects which were recapitulated in part by addition of authentic epoxy-oxylipins. iSMCs are a rich source but not a sensor of anti-inflammatory epoxy-oxylipins. Complex lesions that contain high levels of iSMCs may be more resistant to the protective effects of sEH inhibitors