Proyecto "La casa de tod@s" utilización del medio audiovisual para exponer problemáticas de género en comunidades minoritarias en las zonas con necesidad de transformación social

Proyecto de integración de la población inmigrante en el distrito de PalmaPalmilla (Málaga) en el entorno de una asociación gitana durante los años posteriores a la crisis del 2007/2008 fomentando la participación activa y la difusión de la figura del voluntariado con tres ejes fundamentales: la educación, la visibilidad y la igualdad. Metodología: Tomamos dos modelos teóricos de trabajo: La mediación entre iguales. La educación a través de Mediadores Sociales (educación inter pares) como estrategia para el cambio del comportamiento se basa, entre otras, en la Teoría del aprendizaje social (Bandura, 1986), o en la Teoría de la acción razonada (Fishbein & Ajzen, 1975), y que se importa a través del conocimiento que se tiene del “Proyecto Bola de Nieve. Guía para la formación de usuarios de la droga como agentes de salud” (García, Gutiérrez y Morante, 2004) que lo sintetiza previamente. Iniciación de un proceso de empoderamiento de mujeres gitanas, inmigrantes y ex presidiarias. Este proyecto tiene algún remoto precedente teórico en el movimiento de mujeres musulmanas francesas “Ni putas ni sumisas". Se actúa desde la matriculación de niñas musulmanas en institutos, la intervención en foros de participación del barrio posicionándose en temas de maltrato, machismo, racismo o derecho al trabajo, y atribuyendo sonoridad a las nuevas lideresas Ani Cortés (gitana), Yuli Fajardo (ex presidiaria), Cristiana (subsahariana), Fati ElHachimi(marroquí) y otras surgidas en hábitats patriarcales. Conclusiones: se inicia un proyecto audiovisual para intentar plasmar lo que allí está ocurriendo difundiéndolo a través de las redes sociales y de una trilogía de cortometrajes (2008-2015) www.la trilogiadelapalmilla.blogspot.com: * Ruta del cole 2009 (tema la educación) * El edificio fantasma 2010 (la visibilidad) * Vida desatenta 2015 (la superación

Preliminary study on the performance of biomorphic silicon carbide as substrate for diesel particulate filters

This paper presents the results of a preliminary experimental study to assess the performance of biomorphic silicon carbide when used for the abatement of soot particles in the exhaust of Diesel engines. Given its optimal thermal and mechanical properties, silicon carbide is one of the most popular substrates in commercial diesel particulate filters. Biomorphic silicon carbide is known for having, besides, a hierarchical porous microstructure and the possibility of tailoring that microstructure through the selection of a suitable wood precursor. An experimental rig was designed and built to be integrated within an engine test bench that allowed to characterizing small lab-scale biomorphic silicon carbide filter samples. A particle counter was used to measure the particles distribution before and after the samples, while a differential pressure sensor was used to measure their pressure drop during the soot loading process. The experimental campaign yielded promising results: for the flow rate conditions that the measuring devices imposed (1 litre per minute; space velocity = 42,000 L/h), the samples showed initial efficiencies above 80%, pressure drops below 20 mbar, and a low increase in the pressure drop with the soot load which allows to reach almost 100% efficiency with an increase in pressure drop lower than 15%, when the soot load is still less than 0.01 g/L. It shows the potential of this material and the interest for advancing in more complex diesel particle filter designs based on the results of this workMinisterio de Economía y Competitividad (España) MAT2013-41233-R DPI2013-46485-C3-3-RFondos FEDER MAT2013-41233-R DPI2013-46485-C3-3-RUniversidad de Sevilla VI Plan Propio I.3B - C.I. 24/05/2017 MAT2016-76526-

InnoVar - Portal Regional de Innovación

En el contexto de Sistemas Regionales de Innovación (SRI) débilmente desarrollados, proyectos de elaboración de un Portal de promoción y asistencia a la innovación puede resultar una herramienta interesante de soporte a la construcción de Entornos favorables para la innovación. El Portal Regional de Innovación-InnoVar (InnoVar-PRI) de la Facultad de Ingeniería de la Universidad Nacional de Lomas de Zamora (FI-UNLZ) plantea como objetivo, la generación de un “Nuevo Punto de Encuentro”, un “Nuevo Espacio de Interacción” entre los actores esenciales del SRI. Los resultados del PRI se pueden visualizar como la creación de un espacio real/virtual, capaz de generar, clasificar, acumular y difundir conocimiento relacionado con el desarrollo efectivo de la innovación, basando su potencialidad en las posibilidades de incrementar las “Capacidades Tecnológicas” del territorio en la modalidad específica de “Capacidad de Encuentro”, más que en una lógica de “Depósito o Biblioteca Tecnológica”, persiguiendo finalmente una mejoría en la “Capacidad Relacional” y la “Capacidad de Eslabonamiento” del SRI. El InnoVar-PRI impacta en factores de Macro-Innovación (sobre el SRI) y Micro-Innovación regional (sobre actores individuales del SRI). Macro-Innovación: instalación social de la temática innovación; definición/dinamización Actores-Estructuras-Instrumentos SRI; incremento Capital Social regional, Capacidad Eslabonamiento-innovación. Micro-Innovación: Empresas, diseño de estrategias y toma de decisiones tecnológicas, herramientas para la mejora continua, los aprendizajes y consecuentemente los niveles de innovación; Instituciones de Gobierno, en el desarrollo de políticas e instrumentos de actuación; Universidad, para el enfoque de sus líneas de investigación, formación, extensión, vinculación y transferencia

The eukaryote-specific N-terminal extension of ribosomal protein S31 contributes to the assembly and function of 40S ribosomal subunits

The archaea-/eukaryote-specific 40S-ribosomal-subunit protein S31 is expressed as an ubiquitin fusion protein in eukaryotes and consists of a conserved body and a eukaryote-specific N-terminal extension. In yeast, S31 is a practically essential protein, which is required for cytoplasmic 20S pre-rRNA maturation. Here, we have studied the role of the N-terminal extension of the yeast S31 protein. We show that deletion of this extension partially impairs cell growth and 40S subunit biogenesis and confers hypersensitivity to aminoglycoside antibiotics. Moreover, the extension harbours a nuclear localization signal that promotes active nuclear import of S31, which associates with pre-ribosomal particles in the nucleus. In the absence of the extension, truncated S31 inefficiently assembles into pre-40S particles and two subpopulations of mature small subunits, one lacking and another one containing truncated S31, can be identified. Plasmid-driven overexpression of truncated S31 partially suppresses the growth and ribosome biogenesis defects but, conversely, slightly enhances the hypersensitivity to aminoglycosides. Altogether, these results indicate that the N- terminal extension facilitates the assembly of S31 into pre-40S particles and contributes to the optimal translational activity of mature 40S subunits but has only a minor role in cytoplasmic cleavage of 20S pre-rRNA at site D

Permeability and mechanical integrity of porous biomorphic SiC ceramics for application as hot-gas filters

Biomorphic SiC is a biotemplated material fabricated by Si melt-infiltration of carbon preforms from wood pyrolysis. In this work, porous bioSiC ceramics from five different wood precursors, with porosities between 45 and 72% were studied for their feasibility in filtering applications.Gas permeability and mechanical stability were investigated as a function of the microstructure of the starting wood precursor. Air-permeation performance at room temperature was measured for a range of flow rates, and the permeability constants were assessed by fitting of Forchheimer's equation to the experimental data. Darcian permeabilities were achieved in the range 10-10 m, while inertial terms were in the range 10-10 m, showing a correlation with the average pore size and orientation of the larger channels. Regarding the mechanical stability, maximum compressive strength values were reached in the range of 3-115 MPa.These results improve our understanding of the ways in which the microstructure influences permeability and mechanical robustness, enabling the device requirements to be tailored by selecting the wood precursor. It was also shown that these materials are promising for hot-gas filtering applications.Ministerio de Economía y Competitividad MAT2013-41233-

Trunk Control Measurement Scale (TCMS): Psychometric Properties of Cross-Cultural Adaptation and Validation of the Spanish Version

The aim of this study was to develop a Spanish Version of the Trunk Measurement Scale (TCMS-S) to analyze its validity and reliability and determine the Standard Error of Measurement (SEM) and Minimal Detectable Change (MDC) in children with Cerebral Palsy (CP). Participants were assessed twice 7–15 days apart with the TCMS-S and once with the Gross Motor Function Measurement-88 (GMFM-88), Pediatric Disability Inventory-Computer Adaptive Test (PEDI-CAT), Cerebral Palsy Quality of Life (CPQoL), and Gross Motor Classification System (GMFCS). Internal consistency was evaluated using Cronbach’s alpha, and the intraclass correlation (ICC) and kappa coefficients were used to investigate the agreement between the assessments. Finally, 96 participants with CP were included. The TCMS-S showed excellent internal consistency (Cronbach’s alpha = 0.95 [0.93 to 0.96]); was highly correlated with the GMFM-88 (rho = 0.816) and the “mobility” subscale of the PEDI-CAT (rho = 0.760); showed a moderate correlation with the “feeling about functioning” CPQoL subscale (rho = 0.576); and differentiated between the GMFCS levels. Excellent test–retest agreement was found for the total and subscale scores (ICC � 0.94 [0.89 to 0.97). For the total TCMS-S score, an SEM of 1.86 and an MDC of 5.15 were found. The TCMS-S is a valid and reliable tool for assessing trunk control in children with CP.Sección Deptal. de Radiología, Rehabilitación y Fisioterapia (Enfermería)Fac. de Enfermería, Fisioterapia y PodologíaTRUEUniversidad Europea de Madridpu

Medidor multicota para piezas producidas por máquinas-herramienta

Referencia OEPM: P9600748.-- Fecha de solicitud: 28/03/1996.-- Titular: Consejo Superior de Investigaciones Científicas (CSIC).El medidor multicota para piezas producidas por máquinas-herramienta es un sistema que permite medir simultáneamente hasta 16 cotas en piezas producidas por máquinas-herramienta, visualizando sobre una pantalla de ordenador los resultados en forma analógica sobre una columna, con indicación de límites de tendencia y tolerancia, y digital sobre un indicador numérico. Consta de un multiplexor analógico (1, ver figura en archivo de texto completo) cuya salida se entrega a un amplificador (6) que junto con el divisor programable (8) y el conversor analógico/digital (7), proporciona la medida del canal seleccionado (5). Un circuito temporizador (10 y 11) facilita la realización de medidas promediadas y a intervalos regulares. Dispone de salidas de control (22) indicadoras de: pieza fuera de tolerancia, corrección paralela o cónica, positiva o negativa, cambio o regeneración de herramienta y situación de alarma (15 a 21). La presencia de pieza puede detectarse automáticamente o bajo comando (14). Dispone de amplias facilidades de programación y calibrado, para ser utilizado con una gran diversidad de sensores y aplicaciones.Peer reviewe

The ubiquitin moiety of ubi1 is required for productive expression of ribosomal protein el40 in saccharomyces cerevisiae

Ubiquitin is a highly conserved small eukaryotic protein. It is generated by proteolytic cleavage of precursor proteins in which it is fused either to itself, constituting a polyubiquitin precursor of head-to-tail monomers, or as a single N-terminal moiety to ribosomal proteins. Understanding the role of the ubiquitin fused to ribosomal proteins becomes relevant, as these proteins are practically invariably eS31 and eL40 in the different eukaryotes. Herein, we used the amenable yeast Saccharomyces cerevisiae to study whether ubiquitin facilitates the expression of the fused eL40 (Ubi1 and Ubi2 precursors) and eS31 (Ubi3 precursor) ribosomal proteins. We have analyzed the phenotypic effects of a genomic ubi1∆ub-HA ubi2∆ mutant, which expresses a ubiquitin-free HA-tagged eL40A protein as the sole source of cellular eL40. This mutant shows a severe slow-growth phenotype, which could be fully suppressed by increased dosage of the ubi1∆ub-HA allele, or partially by the replacement of ubiquitin by the ubiquitin-like Smt3 protein. While expression levels of eL40A-HA from ubi1∆ub- HA are low, eL40A is produced practically at normal levels from the Smt3-S-eL40A- HA precursor. Finally, we observed enhanced aggregation of eS31-HA when derived from a Ubi3∆ub-HA precursor and reduced aggregation of eL40A-HA when expressed from a Smt3-S-eL40A-HA precursor. We conclude that ubiquitin might serve as a cis- acting molecular chaperone that assists in the folding and synthesis of the fused eL40 and eS31 ribosomal proteins

Extracellular vesicles in parasitic diseases

Parasitic diseases affect billions of people and are considered a major public health issue. Close to 400 species are estimated to parasitize humans, of which around 90 are responsible for great clinical burden and mortality rates. Unfortunately, they are largely neglected as they are mainly endemic to poor regions. Of relevance to this review, there is accumulating evidence of the release of extracellular vesicles (EVs) in parasitic diseases, acting both in parasite–parasite inter-communication as well as in parasite–host interactions. EVs participate in the dissemination of the pathogen and play a role in the regulation of the host immune systems. Production of EVs from parasites or parasitized cells has been described for a number of parasitic infections. In this review, we provide the most relevant findings of the involvement of EVs in intercellular communication, modulation of immune responses, involvement in pathology, and their potential as new diagnostic tools and therapeutic agents in some of the major human parasitic pathogens

The Lysholm score: Cross cultural validation and evaluation of psychometric properties of the Spanish version

This study aims at assessing the validity and reliability of the Spanish version of the Lysholm score, a widely used instrument for assessing knee function and activity level after ligament injuries. Ninety-five participants (67.4% male, 22±5 years) completed the questionnaire twice within 7 days and a subsample of 42 participants completed a test-retest reliability. Reliability, validity and feasibility psychometric properties were studied. The validity of the questionnaire was analysed using ceiling and floor effects. Factor structure and construct validity were analysed with the SF-36, the Hip and Knee Questionnaire (HKQ) and one leg jump test (OLJT). Criterion validity with the SF-36 Physical State was moderate (r = 0.50 and p<0.01), poor and inverse relationship (r = -0.31, p<0.01) with HKQ and positive moderate (r = 0.59, p<0.01) with OLJT. Measurement error from MDC90 was 3.9%. Exploratory factor analysis demonstrated a one-factor solution explaining 51.5% of total variance. The x2 test for the one-factor model was significant (x2 = 29.58, df = 20, p < 0.08). Test-retest reliability level was high (ICC2.1 = 0.92, p<0.01) and also the internal consistency (α = 0.77). The Spanish Lysholm score demonstrated that it is a reliable and valid instrument that can be used to assess knee function after ligament injuries.This study takes place thanks to the additional funding from the University of Granada, Plan Propio de Investigación 2016, Excellence actions: Units of Excellence; Unit of Excellence on Exercise and Health (UCEES)