Review of the safety of octocrylene used as an ultraviolet filter in cosmetics

Octocrylene or octocrilene is an organic ultraviolet (UV) filter which absorbs mainly UVB radiation and short UVA wavelengths. It is used in various cosmetic products to either provide an appropriate sun protection factor in sunscreen products or to protect cosmetic formulations from UV radiation. There is no discussion that UV filters are beneficial ingredients in cosmetics since they protect from skin cancer, but octocrylene has been recently incriminated to potentially induce adverse effects on the endocrine system in addition to having allergic and/or photoallergic potential. However, the substance has the advantage to work synergistically with other filters allowing a beneficial broad photoprotection, e.g. it stabilizes the UVA filter avobenzone (i.e. butylmethoxydibenzoylmethane). Like all chemicals used in cosmetics, the safety profile of octocrylene is constantly under assessment by the European Chemical Agency (ECHA) since it has been registered according to the European regulation Registration, Evaluation, Authorisation and Restriction of Chemicals. Summaries of safety data of octocrylene are publicly available on the ECHA website. This review aims to present the main safety data from the ECHA website, as well as those reported in scientific articles from peer-reviewed journals. The available data show that octocrylene does not have any endocrine disruption potential. It is a rare sensitizer, photocontact allergy is more frequent and it is considered consecutive to photosensitization to ketoprofen. Based on these results, octocrylene can be considered as safe when used as a UV filter in cosmetic products at a concentration up to 10%

Evaluasi Sistem Informasi Manajemen Puskesmas Guna Mendukung Penerapan Sikda Generik Menggunakan Metode Hot Fit Di Kabupaten Purworejo

Dinas Kesehatan Kabupaten Purworejo telah mengembangkan Sistem Informasi Manajemen Puskesmas (SIMPUS) demi tersedianya informasi yang cepat, tepat dan akurat guna mendukung pengambilan keputusan dan kebijakan pelayanan Puskesmas, namun pada Kenyataannya ada pelaporan yang kosong dan puskesmas yang tidak menggunakan SIMPUS. Untuk standarisasi SIK Kementerian Kesehatan mengeluarkan konsep SIKDA Generik. Untuk itu SIMPUS DKK Purworejo perlu dievaluasi, evaluasi yang diterapkan pada penelitian ini menggunakan model HOT fit. Jenis penelitian ini adalah penelitian kualitatif dengan menggunakan wawancara mendalam dan observasi langsung. Informan utama dalam penelitian ini adalah Sembilan petugas operator data dan enam informan triangulasi Puskesmas serta lima informan triangulasi Dinas kesehatan. Teknik analisis data dengan analisis konten. Hasil penelitian ini menunjukan bahwa SIMPUS DKK Purworejo dari sisi aplikasi yang digunakan telah setara dengan SIKDA Generik. SIMPUS telah digunakan secara rutin namun belum didukung dengan adanya prosedur penggunaan dan pelatihan. Personil telah mencukupi dalam jumlah, namun secara operasional perlu dibentuk TIM Pengelola SIK sesuai kompetensi. Belum ada monitoring yang rutin dan terjadwal, dan anggaran yang ada belum dapat mengatasi kebutuhan pemeliharaan perangkat pendukung SIMPUS. Kualitas SIMPUS yang digunakan baik, mudah digunakan dan tersedia menu untuk mengkomunikasikan data. Kualitas informasi yang dihasilkan belum akurat dan tidak lengkap karena tidak memuat data pelayanan di PUSTU dan PKD. Kuallitas layanan lambat berkaitan dengan prosedur pendanaan. SIMPUS DKK Purworejo telah setara dengan SIKDA Generik namun belum dapat dimanfaatkan untuk pengambilan keputusan. Disarankan agar Dinas Kesehatan meningkatkan pelatihan, monitoring, pengadaan perangkat keras dan jaringan, serta bagi Puskesmas diperlukan komitmen untuk menerapkan SIMPUS secara maksimal oleh PUSTU dan PKD. Purworejo District Health Office (DHO) has developed Health Center Management Information System (HCMIS) to provide quick, precise, and accurate information for supporting the process of decision making and the policy of services at Health Center. However, there was still any empty forms and did not use the system. To standardize Health Information System, Ministry of Health has released a concept of Generic SIKDA. Therefore, the system applied by Purworejo DHO needs to be evaluated using the method of HOT fit. This was qualitative research using indepth interview and direct observation. Main informants were nine data operators and informants for triangulation purpose was six persons from health centers and five persons from DHO. Furthermore, data were analyzed using content analysis. The result of this research revealed that the application of HCMIS at Purworejo DHO was equal to Generic SIKDA. The system had been applied routinely but there was no a guidance book and training. Number of human resources was sufficient. However, there needed to make an implementer team of Health Information System in accordance with competency. There was no routine monitoring and current budget was not sufficient to maintain hardware to support the system. Quality of the system used was good, easy to use, and available of menu to communicate data. Unfortunately, quality of resulted information had still been inaccurate and incomplete because it did not cover data of services at Subsidiary Health Centers (SHC) and Village Health Posts (VHP). The lateness of services was related to a funding procedure. HCMIS at Purworejo DHO was equal to Generic SIKDA but it had not been used to make a decision. As a suggestion, DHO needs to conduct training, monitor, and provide hardware and a network. Meanwhile, Health Centers needs to make a commitment for applying the HCMIS maximally by SHC and VHP

Assessment of motor coordination in primary education of Barcelona and province

El presente estudio tiene por objetivo valorar la coordinación motora de estudiantes de primaria de Barcelona y provincia. Para la evaluación se ha utilizado el test KTK en el que participaron 1254 personas, 670 niños y 584 niñas, de edades entre 7 y 10 años. Se realizó el análisis descriptivo y la comparación entre género y edad. Los resultados indican que más del 40% de la población estudiada presenta una coordinación por debajo de la normalidad, cerca de un 57% de la muestra fue clasificado con coordinación normal y solamente el 4,6% lo ha sido por encima de esta clasificación. Los chicos han presentado resultados significativamente mejores que las chicas. Los datos del estudio no permiten generalizar los resultados, sin embargo como es una muestra representativa, nos lleva a creer que la población de alumnos en educación primaria de Barcelona y su provincia tiene un nivel coordinativo por debajo del esperado para su edadThe present study aims to assess motor coordination of primary-school students of Barcelona and its province. For evaluation we used the KTK test. 1254 people, 670 boys and 584 girls with ages between 7 and 10 years participated in the study. Descriptive analysis and the comparison between gender and age were performed. The results indicate that about 40% of the population studied presents results below normal, around 57% were classified with normal coordination and only 4.6% has been above this rating. The boys have presented significantly better results than girls. The study data do not permit to generalize the results, however as a representative sample, it leads us to believe that the student population in elementary education from Barcelona and its province has a coordinative level below expected for their ageAgrupació de Recerca en Ciències de l’Educació. U

A Benchmark Study on Sentiment Analysis for Software Engineering Research

A recent research trend has emerged to identify developers' emotions, by applying sentiment analysis to the content of communication traces left in collaborative development environments. Trying to overcome the limitations posed by using off-the-shelf sentiment analysis tools, researchers recently started to develop their own tools for the software engineering domain. In this paper, we report a benchmark study to assess the performance and reliability of three sentiment analysis tools specifically customized for software engineering. Furthermore, we offer a reflection on the open challenges, as they emerge from a qualitative analysis of misclassified texts.Comment: Proceedings of 15th International Conference on Mining Software Repositories (MSR 2018

Signature of chaos in gravitational waves from a spinning particle

A spinning test particle around a Schwarzschild black hole shows a chaotic behavior, if its spin is larger than a critical value. We discuss whether or not some peculiar signature of chaos appears in the gravitational waves emitted from such a system. Calculating the emitted gravitational waves by use of the quadrupole formula, we find that the energy emission rate of gravitational waves for a chaotic orbit is about 10 times larger than that for a circular orbit, but the same enhancement is also obtained by a regular "elliptic" orbit. A chaotic motion is not always enhance the energy emission rate maximally. As for the energy spectra of the gravitational waves, we find some characteristic feature for a chaotic orbit. It may tell us how to find out a chaotic behavior of the system. Such a peculiar behavior, if it will be found, may also provide us some additional informations to determine parameters of a system such as a spin.Comment: 14 pages, LaTeX, to appear in Phys. Rev.

Learnersourcing Personalized Hints

Personalized support for students is a gold standard in education, but it scales poorly with the number of students. Prior work on learnersourcing presented an approach for learners to engage in human computation tasks while trying to learn a new skill. Our key insight is that students, through their own experience struggling with a particular problem, can become experts on the particular optimizations they implement or bugs they resolve. These students can then generate hints for fellow students based on their new expertise. We present workflows that harvest and organize studentsâ collective knowledge and advice for helping fellow novices through design problems in engineering. Systems embodying each workflow were evaluated in the context of a college-level computer architecture class with an enrollment of more than two hundred students each semester. We show that, given our design choices, students can create helpful hints for their peers that augment or even replace teachersâ personalized assistance, when that assistance is not available

Rates, amounts, and determinants of ambulatory blood pressure monitoring claim reimbursements among Medicare beneficiaries

Ambulatory blood pressure monitoring (ABPM) can be used to identify white coat hypertension and guide hypertensive treatment. We determined the percentage of ABPM claims submitted between 2007 and 2010 that were reimbursed. Among 1970 Medicare beneficiaries with submitted claims, ABPM was reimbursed for 93.8% of claims that had an International Classification of Diseases, Ninth Revision, diagnosis code of 796.2 (“elevated blood pressure reading without diagnosis of hypertension”) versus 28.5% of claims without this code. Among claims without an International Classification of Diseases, Ninth Revision, diagnosis code of 796.2 listed, those for the component (eg, recording, scanning analysis, physician review, reporting) versus full ABPM procedures and performed by institutional versus non–institutional providers were each more than two times as likely to be successfully reimbursed. Of the claims reimbursed, the median payment was $52.01 (25th–75th percentiles,$32.95–$64.98). In conclusion, educating providers on the ABPM claims reimbursement process and evaluation of Medicare reimbursement may increase the appropriate use of ABPM and improve patient care

Condensin I Reveals New Insights on Mouse Meiotic Chromosome Structure and Dynamics

Chromosome shaping and individualization are necessary requisites to warrant the correct segregation of genomes in either mitotic or meiotic cell divisions. These processes are mainly prompted in vertebrates by three multiprotein complexes termed cohesin and condensin I and II. In the present study we have analyzed by immunostaining the appearance and subcellular distribution of condensin I in mouse mitotic and meiotic chromosomes. Our results demonstrate that in either mitotically or meiotically dividing cells, condensin I is loaded onto chromosomes by prometaphase. Condensin I is detectable as a fuzzy axial structure running inside chromatids of condensed chromosomes. The distribution of condensin I along the chromosome length is not uniform, since it preferentially accumulates close to the chromosome ends. Interestingly, these round accumulations found at the condensin I axes termini colocalized with telomere complexes. Additionally, we present the relative distribution of the condensin I and cohesin complexes in metaphase I bivalents. All these new data have allowed us to propose a comprehensive model for meiotic chromosome structure

Circulation and Oxygen Distribution in the Tropical Atlantic Cruise No. 80, Leg 1; October 26 to November 23, 2009 Mindelo (Cape Verde) to Mindelo (Cape Verde)

METEOR cruise 80/1 was a contribution to the SFB 754 “Climate-Biogeochemistry Interactions in the Tropical Ocean”. Shipboard, glider and moored observations are used to study the temporal and spatial variability of physical and biogeochemical parameters within the oxygen minimum zone (OMZ) of the tropical North Atlantic. As part of the BMBF “Nordatlantik” project, it further focuses on the equatorial current system including the Equatorial Undercurrent (EUC) and intermediate currents below. During the cruise, hydrographic station observations were performed using a CTD/O2 rosette, including water sampling for salinity, oxygen, nutrients and other biogeochemical tracers. Underway current measurements were successfully carried out with the 75 kHz ADCP borrowed from R/V POSEIDON during the first part of the cruise, and R/V METEOR’s 38 kHz ADCP during the second part. During M80/1, an intensive mooring program was carried out with 8 mooring recoveries and 8 mooring deployments. Right at the beginning of the cruise, a multidisciplinary mooring near the Cape Verde Islands was recovered and redeployed. Within the framework of SFB 754, two moorings with CTD/O2 profilers were recovered and redeployed with other instrumentation in the center and at the southern rim of the OMZ of the tropical North Atlantic. The equatorial mooring array as part of BMBF “North Atlantic” project consists of 5 current meter moorings along 23°W between 2°S and 2°N. It is aimed at quantifying the variability of the thermocline water supply toward the equatorial cold tongue which develops east of 10°W during boreal summer. Several glider missions were performed during the cruise. One glider was recovered that was deployed two months earlier. Another glider was deployed for two short term missions, near the equator for about 8 days and near 8°N for one day. This glider was equipped with a new microstructure probe in addition to standard sensors, i.e. CTD/O2, chlorophyll and turbidity