Can videogames be used to develop the infant stage educational curriculum?

The utilization of videogames is not too common due to their consideration as an element that interferes with the educational and learning process. Thus, few teachers are ready to include videogames as didactic tools. Nevertheless, some educators who consider that they have a potential to become didactic tools are progressively adopting videogames as part of their teaching strategies. This paper presents the result of an academic experiment conducted with university students from the degree of Primary Education. The initial step in this experience consisted in determining whether videogames could be seen as another of the many tools employed to develop the infant stage educational curriculum. A survey was developed in order to achieve this goal. The interviewees answered this survey in two different stages, providing as a result that these future teachers would definitely be willing to incorporate videogames in their classrooms once they have been trained to do so

Análisis de la saliva de Ornithodoros moubata y producción de antígenos recombinantes para el desarrollo de test serológicos y vacunas anti-garrapata

[ES]Ornithodoros moubata es un argásido africano que actúa como reservorio y vector de la Fiebre recurrente humana y de la Peste porcina africana en ese continente. Con el fin de localizar con precisión las poblaciones de esta garrapata en el medio sinantrópico y de desarrollar métodos de control de las mismas, en la presente tesis doctoral se persiguieron dos objetivos generales: por una parte, el desarrollo de una herramienta para el diagnóstico serológico de los parasitismos por O. moubata aplicable en la identificación de los lugares colonizados por el argásido y, por otra, la identificación de antígenos salivales protectores para el desarrollo de vacunas anti-O. moubata

University Virtual Learning in Covid Times

Online training is demanded in the ubiquitous society we live in, and this is especially true if we consider the current situation at universities due to the Government issuing a state of alarm decree which requests all citizens to remain at home. The goal of this study is to determine the opinion of university students from different Spanish campuses on e-learning platforms, by the means of a descriptive and correlational study design, with N = 431. The results reveal that there is still a long road ahead to ensure that these tools work optimally to enable professors to fully exert their teaching profession. We can conclude that the online teaching system needs to be improved regarding the technical service that the university offers

Non-catecholaminergic vasopressors in the management of shock: a narrative review and meta-analysis of randomized clinical trials

Martín Díaz: Estudiante de Facultad de Medicina, Universidad de la República. Montevideo, Uruguay.-- Mariana Funes: Estudiante de Facultad de Medicina, Universidad de la República. Montevideo, Uruguay.-- Verónica Hermida: Estudiante de Facultad de Medicina, Universidad de la República. Montevideo, Uruguay.-- Catalina Kavedjian: Estudiante de Facultad de Medicina, Universidad de la República. Montevideo, Uruguay.-- Martín Kavedjian: Estudiante de Facultad de Medicina, Universidad de la República. Montevideo, Uruguay.-- José Gorrasi: Docente supervisor, Prof. Agr. Departamento de Emergencia, Facultad de Medicina, Universidad de la República, Uruguay. Contacto: José Gorrasi - [email protected]; Martín Kavedjian – [email protected] refractariedad a catecolaminas es un final hemodinámico común a los diferentes tipos de shock, que deriva en la administración de altas dosis de estos, situación asociada a resultados clínicos desfavorables. Es de interés el uso de vasopresores no catecolaminérgicos, que actúan en diferentes vías de la contracción muscular lisa vascular, aportando un efecto vasopresor sinérgico. El objetivo es evaluar la respuesta a vasopresores no catecolaminérgicos en shock asociado al postoperatorio de cirugía cardíaca (POCC), sepsis y grandes quemados. Se realizó una búsqueda en las bases PubMed, LILACS, Embase y Cochrane Central Register de estudios clínicos y revisiones en pacientes adultos con shock séptico, POCC o asociado a grandes quemados y administración de al menos uno de los siguientes vasopresores: azul de metileno (AM), angiotensina II (AII), vasopresina (VP), terlipresina (TP). Se realizó una revisión narrativa y un metaanálisis de ensayos clínicos aleatorizados (ECA) para el análisis estadístico de variables hemodinámicas, efecto ahorrador de catecolaminas y mortalidad. Se incluyeron 137 artículos, 31 ECA se utilizaron para el metaanálisis. Del análisis cualitativo se observó un aumento de la presión arterial media (PAM) y resistencias vasculares sistémicas (RVS) con efecto ahorrador de catecolaminas para los 4 fármacos. El metaanálisis evidenció una disminución significativa de la mortalidad con AM (RR: 0,12 IC95%: 0,02;0,95) en pacientes con shock en el POCC. No hubo cambios en la mortalidad en shock séptico. Todos los fármacos aumentan la PAM y tienen efecto ahorrador de catecolaminas preservando la función cardíaca. Sus efectos sobre la mortalidad son menos claros.Refractoriness to catecholamines is a final potential hemodynamic state for all types of circulatory shock leading to the administration of high doses of catecholamines, which is associated with poor clinical outcomes. The pathophysiology of systemic vasodilation is complex, in this sense, there is a rising interest in non-catecholaminergic vasopressors which target different vasoconstriction pathways, potentially resulting in a synergistic vasopressor effect. The purpose is to assess the hemodynamic and clinical response of patients with shock associated with sepsis, post cardiac surgery (POCC) and burns to non-catecholaminergic vasopressors. PubMed, LILACS, Embase and the Cochrane Central Register were searched. Clinical studies and reviews in adult patients with septic, postcardiac surgery and burns shock with the administration of at least one of the following non adrenergic vasopressors: methylene blue (MB), angiotensin II (AII), vasopressin (VP), terlipressin (TP) were included. A literature review and a meta-analysis of randomized clinical trials was done to analyze hemodynamic variables, catecholaminergic sparing effect and mortality 137 articles were included, 31 clinical trials for the metanalysis. The qualitative revision showed an increase in mean arterial pressure (MAP), systemic vascular resistance (SVR) and a catecholamine sparing effect for all vasopressors. Metanalysis results evidenced a significant decrease in mortality in shock postcardiac surgery with MB (RR: 0,12 IC95%: 0,02;0,95). Non-significant effects were shown for mortality in septic shock. All included vasopressors increase MAP resulting in a catecholamine sparing effect with no decrease in cardiac output. Effects on mortality are less precise

Proteoma de la saliva de Ornithodoros moubata: comparativa entre machos y hembras

Comunicaciones a congreso

Construcción de microarrays de proteínas a partir de genotecas de expresión para el estudio de la interfase molecular garrapata-hospedador

Comunicaciones a congreso

Physiologic Responses to Infrarenal Aortic Cross-Clamping during Laparoscopic or Conventional Vascular Surgery in Experimental Animal Model: Comparative Study

The aim of this study was to compare the hemodynamic and ventilatory effects of prolonged infrarenal aortic cross-clamping in pigs undergoing either laparotomy or laparoscopy. 18 pigs were used for this study. Infrarenal aortic crossclamping was performed for 60 minutes in groups I (laparotomy, n = 6) and II (laparoscopy, n = 6). Group III (laparoscopy, n = 6) underwent a 120-minute long pneumoperitoneum in absence of aortic clamping (sham group). Ventilatory and hemodynamic parameters and renal function were serially determined in all groups. A significant decrease in pH and significant increase in PaCO2 were observed in group II, whereas no changes in these parameters were seen in group I and III. All variables returned to values similar to baseline in groups I and II 60 minutes after declamping. A significant increase in renal resistive index was evidenced during laparoscopy, with significantly higher values seen in Group II. Thus a synergic effect of pneumoperitoneum and aortic cross-clamping was seen in this study. These two factors together cause decreased renal perfusion and acidosis, thus negatively affecting the patient's general state during this type of surgery

Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF enhances neovascularization but moderately improves cardiac regeneration in a porcine model

(A) Lentiviral vectors used for IGF-1 and HGF forced expression in paMSC. (B) Fluorescence of cultures at distinct viral concentrations after transduction with the pRRL-sin-IGF-1-IRES-GFP vector. Images for paMSC-IGF-1-GFP, 5 days post-transduction, at distinct multiplicity of infection (MOI, 1–50). (C) Cell sorting after paMSC transduction. Four subpopulations resulting from sorting. Top panels, results for a subpopulation cultured at 3 % O2; bottom, transduced paMSC cultured in 20 % O2 conditions. An un-transduced cell population was used as a negative control. Purity of sorted GFP-positive paMSC was 95 % and 91.1 % for cells cultured at 3 % and 20 % O2, respectively. (TIF 447 kb

Nutrient Removal and Membrane Performance of an Algae Membrane Photobioreactor in Urban Wastewater Regeneration

The increase in industry and population, together with the need for wastewater reuse, makes it necessary to implement new technologies in the circular economy framework. The aim of this research was to evaluate the quality of the effluent of an algae membrane photobioreactor for the treatment of the effluent of an urban wastewater treatment plant, to characterise the ultrafiltration membranes, to study the effectiveness of a proposed cleaning protocol, and to analyse the performance of the photobioreactor. The photobioreactor operated under two days of hydraulic retention times feed with the effluent from the Los Vados wastewater treatment plant (WWTP) (Granada, Spain). The microalgae community in the photobioreactor grew according to the pseudo-second-order model. The effluent obtained could be reused for different uses of diverse quality with the removal of total nitrogen and phosphorus of 56.3% and 64.27%, respectively. The fouling of the polyvinylidene difluoride ultrafiltration membrane after 80 days of operation was slight, increasing the total membrane resistance by approximately 22%. Moreover, the higher temperature of the medium was, the lower intrinsic resistance of the membrane. A total of 100% recovery of the membrane was obtained in the two-phase cleaning protocol, with 42% and 58%, respectively.Junta de Andalucia European Commission P18-TP-473