MUSAS FITNESS E A TRÍADE CORPO-CONSUMO-FELICIDADE

We analyze how Fitness Muses are produced and produce themselves by mapping their strategies to engage with followers and by understanding the relationships established between bodily architectures and consumption. In this virtual ethnography, we extracted photos and texts from Instagram profiles of nine women for three months. The results point to: different investments in producing bodily architectures by means of consumption focused on the body exposure; public display of intimacy; and the relationship between goods, services, and products as a condition of happiness. The performatic images of their spectacular lives encourage their obsession about an irreproachable life whose noises and seductions support the never-ending promise that consumption of the products advertised is key to reach that lifestyle. Thus, by adding likes, accumulating followers, participation in events, marketing products, Fitness Muses constantly underscore the triad body-consumption-happiness.Analizamos cómo son producidas y se producen las Musas Fitness, haciendo un mapeo de sus estrategias para interpelar seguidores/as, comprendiendo las relaciones establecidas entre las arquitecturas corporales y el consumo. En esta etnografía virtual, seguimos a nueve mujeres en Instagram por tres meses, utilizando la observación y la captura de fotografías y textos. Los resultados apuntan hacia diferentes inversiones en la producción de arquitecturas corporales por la vía del consumo dirigido a la exposición de los cuerpos; la exhibición pública de la intimidad; la relación entre bienes, servicios y productos como condición para la felicidad. Las imágenes performáticas de sus vidas espectaculares alimentan la obsesión por un cotidiano impecable, cuyos ruidos y seducciones afianzan la promesa infinita de que el consumo de los productos anunciados representa el acceso a aquel celebrado estilo de vida. Así, sumando likes, acumulando seguidores/as, participando en eventos, comercializando productos, las Musas Fitness reiteran constantemente el imperativo de la tríada cuerpo-consumo-felicidad. Analisamos como são produzidas e se produzem as Musas Fitness, mapeando suas estratégias para interpelar seguidores/as, entendendo as relações estabelecidas entre as arquiteturas corporais e o consumo. Nesta etnografia virtual, acompanhamos nove mulheres no Instagram por três meses, utilizando a observação e a captura de fotografias e textos. Os resultados apontam para diferentes investimentos na produção de arquiteturas corporais pela via do consumo direcionada à exposição dos corpos; a exibição pública da intimidade; a relação entre bens, serviços, produtos como condição à felicidade. As imagens performáticas de suas vidas espetaculares alimentam a obsessão por um cotidiano irretocável, cujos ruídos e seduções ancoram a promessa infinda de que o consumo dos produtos anunciados envolve o acesso aquele festejado estilo de vida. Assim, somando likes, acumulando seguidores/as, participando de eventos, comercializando produtos, as Musas Fitness reiteram constantemente o imperativo da tríade corpo-consumo-felicidade. 

Infectious diseases and reproductive status in european hare (Lepus europaeus) in La Pampa province (Argentina)

El objetivo de este trabajo fue determinar la prevalencia a Neospora caninum (Nc) y Toxoplasma gondii (Tg) y conocer el periodo reproductivo de la liebre europea (Lepus europaeus) en la provincia de La Pampa (Argentina). Para ello se muestrearon 106 liebres procedentes de acopiadores de la provincia de La Pampa. Los sueros fueron analizados por un ensayo inmunoenzimático de competición para determinar anticuerpos a Nc y para Tg se realizó una prueba de hemaglutinación indirecta. Se encontraron 66 hembras, de las cuales 13 estaban preñadas, y 40 machos (p=0,01). Sobre un total de 44 sueros analizados para Nc, 5 (11,4%) dieron positivo. De los 106 sueros estudiados para Tg ninguno fue positivo.The objective of this study was to determine the prevalence of these diseases and to know the reproductive season of the European hare (Lepus europaeus) in the Province of La Pampa (Argentina). To that aim, 106 hares coming from different places from La Pampa province were sampled. Nc antibody diagnosis was performed by means of a competitive enzimoimmunoassay (ELISA-c), and an hemo-agglutination indirect assay (HAI) for Tg were carried out to know the disease status. From the total of hares sampled, 40 were male, 66 female (p=0.01) and 13 (19.7%) of them were detected as pregnant. Nc sero-prevalence was 11.4% over a total of 44. From 106 sera analyzed by HAI no one was positive for Tg.Facultad de Ciencias Veterinaria

Immune response to Neospora caninum live tachyzoites in prepubertal female calves

The aim of the present study was to characterize the specific immune response in prepubertal female calves inoculated with Neospora caninum. Forty-eight N. caninum-seronegative 6-month-old Angus female calves were randomly allocated into two groups: group A calves were inoculated subcutaneously (sc) with 1 × 106 tachyzoites of the low virulence NC-Argentina LP1 isolate in sterile phosphate-buffered saline (PBS); group B calves were mock inoculated sc with sterile PBS. Calves from group A developed a specific immune response characterized by the production of IgG antibodies and the expression of IFN-γ and TNF-α cytokines. Animals did not present any febrile reaction or reactions at the site of inoculation. Although chronic N. caninum infection was developed in 50% of calves of group A after inoculation, according to the presence of antibodies against rNc-SAG4, antigen characteristic of bradyzoites, N. caninum antibodies dropped below the cut-off of ELISA from day 210 post-inoculation onwards. Future trials using the same group of inoculated animals will allow the characterization of the evolution of the immune response during pregnancy and to determine whether the immunization with the local isolate is able to prevent congenital transmission and to protect against heterologous challenges.Facultad de Ciencias Veterinaria

Molecular profiles and urinary biomarkers of upper tract urothelial carcinomas associated with aristolochic acid exposure

Recurrent upper tract urothelial carcinomas (UTUCs) arise in the context of nephropathy linked to exposure to the herbal carcinogen aristolochic acid (AA). Here we delineated the molecular programs underlying UTUC tumorigenesis in patients from endemic aristolochic acid nephropathy (AAN) regions in Southern Europe. We applied an integrative multiomics analysis of UTUCs, corresponding unaffected tissues and of patient urines. Quantitative microRNA (miRNA) and messenger ribonucleic acid (mRNA) expression profiling, immunohistochemical analysis by tissue microarrays and exome and transcriptome sequencing were performed in UTUC and nontumor tissues. Urinary miRNAs of cases undergoing surgery were profiled before and after tumor resection. Ribonucleic acid (RNA) and protein levels were analyzed using appropriate statistical tests and trend assessment. Dedicated bioinformatic tools were used for analysis of pathways, mutational signatures and result visualization. The results delineate UTUC-specific miRNA:mRNA networks comprising 89 miRNAs associated with 1,862 target mRNAs, involving deregulation of cell cycle, deoxyribonucleic acid (DNA) damage response, DNA repair, bladder cancer, oncogenes, tumor suppressors, chromatin structure regulators and developmental signaling pathways. Key UTUC-specific transcripts were confirmed at the protein level. Exome and transcriptome sequencing of UTUCs revealed AA-specific mutational signature SBS22, with 68% to 76% AA-specific, deleterious mutations propagated at the transcript level, a possible basis for neoantigen formation and immunotherapy targeting. We next identified a signature of UTUC-specific miRNAs consistently more abundant in the patients' urine prior to tumor resection, thereby defining biomarkers of tumor presence. The complex gene regulation programs of AAN-associated UTUC tumors involve regulatory miRNAs prospectively applicable to noninvasive urine-based screening of AAN patients for cancer presence and recurrence

Vera Cartonera, entre Gilda y Derrida

El capítulo recupera la historia y el recorrido de Vera Cartonera, una editorial universitaria cartonera que se inscribe en la Universidad Nacional del Litoral y el Instituto de Humanidades y Ciencias del Litoral, dependiente de Conicet.Fil: Pérez Aguilar, Anahí Lucía. No especifíca;Fil: Airaldi, Candela. No especifíca;Fil: Ariel, Federico. No especifíca;Fil: Balangero, Julián. No especifíca;Fil: Baldini, Virginia. No especifíca;Fil: Bitar, Francisco Miguel. Universidad Nacional del Litoral. Instituto de Humanidades y Ciencias Sociales del Litoral. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Humanidades y Ciencias Sociales del Litoral; ArgentinaFil: Bonetti, Carola. No especifíca;Fil: Bórtoli, Pamela. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Carrio, Cintia Valeria. Universidad Nacional del Litoral. Instituto de Humanidades y Ciencias Sociales del Litoral. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Humanidades y Ciencias Sociales del Litoral; ArgentinaFil: Coutaz, Federico. No especifíca;Fil: Cumin, Larisa Belén. No especifíca;Fil: Chávez, Félix. No especifíca;Fil: Cherri, Guillermina. No especifíca;Fil: Chialva, Ivana Selene. Universidad Nacional del Litoral. Instituto de Humanidades y Ciencias Sociales del Litoral. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Humanidades y Ciencias Sociales del Litoral; ArgentinaFil: Dolzani, Sofía Macarena. Universidad Nacional del Litoral. Instituto de Humanidades y Ciencias Sociales del Litoral. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Humanidades y Ciencias Sociales del Litoral; ArgentinaFil: Ferrante, Enzo. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gauna, Daniela Fernanda. Universidad Nacional del Litoral. Instituto de Humanidades y Ciencias Sociales del Litoral. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Humanidades y Ciencias Sociales del Litoral; ArgentinaFil: Gerbaudo, Analía Isabel. Universidad Nacional del Litoral. Instituto de Humanidades y Ciencias Sociales del Litoral. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Humanidades y Ciencias Sociales del Litoral; ArgentinaFil: Gómez Anziani, Guillermina. No especifíca;Fil: Gudiño, Micaela. No especifíca;Fil: Ibáñez, Susana. No especifíca;Fil: Kiener, Laura. No especifíca;Fil: Larker, Vera. No especifíca;Fil: Molinas, Isabel Sabina. No especifíca;Fil: Miglioli, Valentina. No especifíca;Fil: Mihal, Ivana Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Nudelman, Ianina. No especifíca;Fil: Perticará, Mariana Andrea. No especifíca;Fil: Ramírez, Cristian. No especifíca;Fil: Sabena, María Julia. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sanseverinatt, Zoe. No especifíca;Fil: Santomero, Lucila. Universidad Nacional del Litoral. Instituto de Humanidades y Ciencias Sociales del Litoral. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Humanidades y Ciencias Sociales del Litoral; ArgentinaFil: Sierra, Gabriela. Universidad Nacional del Litoral. Instituto de Humanidades y Ciencias Sociales del Litoral. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Humanidades y Ciencias Sociales del Litoral; ArgentinaFil: Sobré, Amalia. No especifíca;Fil: Sterli, Laura. No especifíca;Fil: Szpilbarg, Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Torres, Patricia. No especifíca;Fil: Tosti, Ivana. No especifíca;Fil: Venturini, Santiago. Universidad Nacional del Litoral. Instituto de Humanidades y Ciencias Sociales del Litoral. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Humanidades y Ciencias Sociales del Litoral; ArgentinaFil: Yódice, Paula. No especifíca

Multicentre Italian study of SARS-CoV-2 infection in children and adolescents, preliminary data as at 10 April 2020

Data on features of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in children and adolescents are scarce. We report preliminary results of an Italian multicentre study comprising 168 laboratory-confirmed paediatric cases (median: 2.3 years, range: 1 day-17.7 years, 55.9% males), of which 67.9% were hospitalised and 19.6% had comorbidities. Fever was the most common symptom, gastrointestinal manifestations were frequent; two children required intensive care, five had seizures, 49 received experimental treatments and all recovered

Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology

Circulating levels of adiponectin, an adipocyte-secreted protein associated with cardiovascular and metabolic risk, are highly heritable. To gain insights into the biology that regulates adiponectin levels, we performed an exome array meta-analysis of 265,780 genetic variants in 67,739 individuals of European, Hispanic, African American, and East Asian ancestry. We identified 20 loci associated with adiponectin, including 11 that had been reported previously (p .60) spanning as much as 900 kb. To identify potential genes and mechanisms through which the previously unreported association signals act to affect adiponectin levels, we assessed cross-trait associations, expression quantitative trait loci in subcutaneous adipose, and biological pathways of nearby genes. Eight of the nine loci were also associated (p <1 x 10(-4)) with at least one obesity or lipid trait. Candidate genes include PRKAR2A, PTH1R, and HDAC9, which have been suggested to play roles in adipocyte differentiation or bone marrow adipose tissue. Taken together, these findings provide further insights into the processes that influence circulating adiponectin levels.Peer reviewe

Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity.

Leptin influences food intake by informing the brain about the status of body fat stores. Rare LEP mutations associated with congenital leptin deficiency cause severe early-onset obesity that can be mitigated by administering leptin. However, the role of genetic regulation of leptin in polygenic obesity remains poorly understood. We performed an exome-based analysis in up to 57,232 individuals of diverse ancestries to identify genetic variants that influence adiposity-adjusted leptin concentrations. We identify five novel variants, including four missense variants, in LEP, ZNF800, KLHL31, and ACTL9, and one intergenic variant near KLF14. The missense variant Val94Met (rs17151919) in LEP was common in individuals of African ancestry only, and its association with lower leptin concentrations was specific to this ancestry (P = 2 × 10-16, n = 3,901). Using in vitro analyses, we show that the Met94 allele decreases leptin secretion. We also show that the Met94 allele is associated with higher BMI in young African-ancestry children but not in adults, suggesting that leptin regulates early adiposity

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, height, weight, waist and hip circumference, waist-to-hip ratio). The first four AvPCs explain >99% of the variability, are heritable, and associate with cardiometabolic outcomes. We performed genome-wide association analyses for each body shape composite phenotype across 65 studies and meta-analysed summary statistics. We identify six novel loci: LEMD2 and CD47 for AvPC1, RPS6KA5/C14orf159 and GANAB for AvPC3, and ARL15 and ANP32 for AvPC4. Our findings highlight the value of using multiple traits to define complex phenotypes for discovery, which are not captured by single-trait analyses, and may shed light onto new pathways

Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals

We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 12-16% of EA variance and contributes to risk prediction for ten diseases. Direct effects (i.e., controlling for parental PGIs) explain roughly half the PGI's magnitude of association with EA and other phenotypes. The correlation between mate-pair PGIs is far too large to be consistent with phenotypic assortment alone, implying additional assortment on PGI-associated factors. In an additional GWAS of dominance deviations from the additive model, we identify no genome-wide-significant SNPs, and a separate X-chromosome additive GWAS identifies 57