1,777 research outputs found
Older people and preventive home visits
In 1996, national preventive efforts for the elderly were introduced in Denmark with a general offer of home visits by preventive staff.The focal point of the preventive home visits has been the functional decline and the corresponding early and coordinated follow-up activities. This has proved an extremely suitable instrument in activities aimed at maintaining elderly people's autonomy, independence, and functional ability, in allowing them to continue taking care of themselves
A systematic review of pedagogies that support, engage and improve the educational outcomes of Aboriginal students
This review analyses studies that identify pedagogies to support, engage and improve Aboriginal and Torres Strait Islander student outcomes. Some studies focus on pedagogies to support and engage, while others describe pedagogies that are designed to improve engagement, attendance and academic skills. The role of context emerges as a key theme, particularly in remote areas. In larger studies, Aboriginal students are often a subset of a larger student group, included because of socio-economic status and achievement levels. Key findings indicate a disconnect between practice and outcomes where links to improved outcomes are by implication rather than evidence. Further, definitions and detail about pedagogies are mostly absent, relying on ‘common understandings’ of what pedagogy means. This review highlights that most of the research identifies effective pedagogies to engage and support Aboriginal students rather than to improve their educational outcomes
Multi-color Cavity Metrology
Long baseline laser interferometers used for gravitational wave detection
have proven to be very complicated to control. In order to have sufficient
sensitivity to astrophysical gravitational waves, a set of multiple coupled
optical cavities comprising the interferometer must be brought into resonance
with the laser field. A set of multi-input, multi-output servos then lock these
cavities into place via feedback control. This procedure, known as lock
acquisition, has proven to be a vexing problem and has reduced greatly the
reliability and duty factor of the past generation of laser interferometers. In
this article, we describe a technique for bringing the interferometer from an
uncontrolled state into resonance by using harmonically related external fields
to provide a deterministic hierarchical control. This technique reduces the
effect of the external seismic disturbances by four orders of magnitude and
promises to greatly enhance the stability and reliability of the current
generation of gravitational wave detector. The possibility for using
multi-color techniques to overcome current quantum and thermal noise limits is
also discussed
Phenotyping shows improved physiological traits and seed yield of transgenic wheat plants expressing the alfalfa aldose reductase under permanent drought stress
Members of the aldo-keto reductase family including aldose reductases are involved in antioxidant defense by metabolizing a wide range of lipid peroxidation-derived cytotoxic compounds. Therefore, we produced transgenic wheat genotypes over-expressing the cDNA of alfalfa aldose reductase gene. These plants consequently exhibit 1.5-4.3 times higher detoxification activity for the aldehyde substrate. Permanent drought stress was generated in the greenhouse by growing wheat plants in soil with 20 % water capacity. The control and stressed plants were monitored by a semi automatic phenotyping platform providing computer-controlled watering, digital and thermal imaging. Calculation of biomass values was based on the correlation (R2 = 0.7556) between fresh weight and green pixel-based shoot surface area. The green biomass production by plants of the three transgenic lines was 12-26-41 % higher than the non-transgenic plants' grown under water limitation. Thermal imaging of stressed non-transgenic plants indicated an elevation in the leaf temperature. The thermal status of transformants was similar at both normal and suboptimal water regime. In drought, the transgenic plants used more water during the growing season. The described phenotyping platform provided a comprehensive data set demonstrating the improved physiological condition of the drought stressed transgenic wheat plants in the vegetative growth phase. In soil with reduced water capacity two transgenic genotypes showed higher seed weight per plant than the control non-transgenic one. Limitation of greenhouse-based phenotyping in analysis of yield potential is discussed. © 2013 The Author(s)
Phase-space structures II: Hierarchical Structure Finder
A new multi-dimensional Hierarchical Structure Finder (HSF) to study the
phase-space structure of dark matter in N-body cosmological simulations is
presented. The algorithm depends mainly on two parameters, which control the
level of connectivity of the detected structures and their significance
compared to Poisson noise. By working in 6D phase-space, where contrasts are
much more pronounced than in 3D position space, our HSF algorithm is capable of
detecting subhaloes including their tidal tails, and can recognise other
phase-space structures such as pure streams and candidate caustics. If an
additional unbinding criterion is added, the algorithm can be used as a
self-consistent halo and subhalo finder. As a test, we apply it to a large halo
of the Millennium Simulation, where 19 % of the halo mass are found to belong
to bound substructures, which is more than what is detected with conventional
3D substructure finders, and an additional 23-36 % of the total mass belongs to
unbound HSF structures. The distribution of identified phase-space density
peaks is clearly bimodal: high peaks are dominated by the bound structures and
low peaks belong mostly to tidal streams. In order to better understand what
HSF provides, we examine the time evolution of structures, based on the merger
tree history. Bound structures typically make only up to 6 orbits inside the
main halo. Still, HSF can identify at the present time at least 80 % of the
original content of structures with a redshift of infall as high as z <= 0.3,
which illustrates the significant power of this tool to perform dynamical
analyses in phase-space.Comment: Submitted to MNRAS, 24 pages, 18 figure
Time sequence of the damage to the acceptor and donor sides of photosystem II by UV-B radiation as evaluated by chlorophyll a fluorescence
The effects of ultraviolet-B (UV-B) radiation on photosystem II (PS II) were studied in leaves of Chenopodium album. After the treatment with UV-B the damage was estimated using chlorophyll a fluorescence techniques. Measurements of modulated fluorescence using a pulse amplitude modulated fluorometer revealed that the efficiency of photosystem II decreased both with increasing time of UV-B radiation and with increasing intensity of the UV-B. Fluorescence induction rise curves were analyzed using a mechanistic model of energy trapping. It appears that the damage by UV-B radiation occurs first at the acceptor side of photosystem II, and only later at the donor side
Simultaneous non-negative matrix factorization for multiple large scale gene expression datasets in toxicology
Non-negative matrix factorization is a useful tool for reducing the dimension of large datasets. This work considers simultaneous non-negative matrix factorization of multiple sources of data. In particular, we perform the first study that involves more than two datasets. We discuss the algorithmic issues required to convert the approach into a practical computational tool and apply the technique to new gene expression data quantifying the molecular changes in four tissue types due to different dosages of an experimental panPPAR agonist in mouse. This study is of interest in toxicology because, whilst PPARs form potential therapeutic targets for diabetes, it is known that they can induce serious side-effects. Our results show that the practical simultaneous non-negative matrix factorization developed here can add value to the data analysis. In particular, we find that factorizing the data as a single object allows us to distinguish between the four tissue types, but does not correctly reproduce the known dosage level groups. Applying our new approach, which treats the four tissue types as providing distinct, but related, datasets, we find that the dosage level groups are respected. The new algorithm then provides separate gene list orderings that can be studied for each tissue type, and compared with the ordering arising from the single factorization. We find that many of our conclusions can be corroborated with known biological behaviour, and others offer new insights into the toxicological effects. Overall, the algorithm shows promise for early detection of toxicity in the drug discovery process
Human hippocampal theta power indicates movement onset and distance travelled
Theta frequency oscillations in the 6- to 10-Hz range dominate the rodent hippocampal local field potential during translational movement, suggesting that theta encodes self-motion. Increases in theta power have also been identified in the human hippocampus during both real and virtual movement but appear as transient bursts in distinct high- and low-frequency bands, and it is not yet clear how these bursts relate to the sustained oscillation observed in rodents. Here, we examine depth electrode recordings from the temporal lobe of 13 presurgical epilepsy patients performing a selfpaced spatial memory task in a virtual environment. In contrast to previous studies, we focus on movement-onset periods that incorporate both initial acceleration and an immediately preceding stationary interval associated with prominent theta oscillations in the rodent hippocampal formation. We demonstrate that movementonset periods are associated with a significant increase in both low (2–5 Hz)- and high (6–9 Hz)-frequency theta power in the human hippocampus. Similar increases in low- and high-frequency theta power are seen across lateral temporal lobe recording sites and persist throughout the remainder of movement in both regions. In addition, we show that movement-related theta power is greater both before and during longer paths, directly implicating human hippocampal theta in the encoding of translational movement. These findings strengthen the connection between studies of theta-band activity in rodents and humans and offer additional insight into the neural mechanisms of spatial navigation
- …