393 research outputs found
Representation of Nelson Algebras by Rough Sets Determined by Quasiorders
In this paper, we show that every quasiorder induces a Nelson algebra
such that the underlying rough set lattice is algebraic. We
note that is a three-valued {\L}ukasiewicz algebra if and only if
is an equivalence. Our main result says that if is a Nelson
algebra defined on an algebraic lattice, then there exists a set and a
quasiorder on such that .Comment: 16 page
Le tuberculome intra medullaire : une cause rare de paraparesie
Le tuberculome intra-mĂ©dullaire (TIM) est une localisation de la tuberculose du systĂšme nerveux central. Nous rapportons un cas de TIM, chez un patient de 48 ans, sans antĂ©cĂ©dents particuliers, qui a consultĂ©pour un dĂ©ficit moteur des 2 membres infĂ©rieurs dâinstallation progressive. Lâexamen clinque a permis dâobjectiver un syndrome de compression mĂ©dullaire thoracique. La dĂ©couverte dâune masse intra mĂ©dullaire, aprĂšs les explorations neuroradiologiques (myĂ©loscanner et IRM), nous a fait poser lâindication dâune exĂ©rĂšse micro-chirurgicale. Le diagnostique de TIM a Ă©tĂ© affirmĂ© par lâexamen anatomo-pathologique de la piĂšce opĂ©ratoire. Lâassociation dâune chimiothĂ©rapie anti-tuberculeuse au delĂ de 6 mois aprĂšs lâexĂ©rĂšse chirurgicale, Ă permis une guĂ©rison complĂšte aprĂšs un recul de 18 mois
Un cas dâhematome extradural cervical non traumatique
LâhĂ©matome extradural cervical spontanĂ© est une pathologie rare mais une sĂ©vĂšre cause de compression mĂ©dullaire. Il requiert un diagnostic et une prise en charge urgents. Nous en rapportons un cas chez une patiente de 20 ans sans antĂ©cĂ©dent pathologique, rĂ©vĂ©lĂ© par un syndrome de compression mĂ©dullaire cervical sĂ©vĂšre (grade A de Frankel). Une dĂ©compression neurochirurgicale est intervenue avec un dĂ©lai de48H avec comme corollaire de lourdes sĂ©quelles. Les auteurs insistent sur lâintĂ©rĂȘt dâun diagnostic et dâune prise en charge prĂ©coces pour en minimiser les sĂ©quelles neurologiques
Sonocrystallisation of ZIF-8 in water with high excess of ligand: Effects of frequency, power and sonication time
A systematic study on the sonocrystallisation of ZIF-8 (zeolitic imidazolate framework-8) in a water-based system was investigated under different mixing speeds, ultrasound frequencies, calorimetric powers and sonication time. Regardless of the synthesis technique, pure crystals of ZIF-8 with high BET (Brunauer, Emmett and Teller) specific surface area (SSA) can be obtained in water after only 5 s. Furthermore, 5 s sonication produced even smaller crystals (~0.08 ”m). The type of technique applied for producing the ZIF-8 crystals did not have any significant impact on crystallinity, purity and yield. Crystal morphology and size were affected by the use of ultrasound and mixing, obtaining nanoparticles with a more spherical shape than in silent condition (no ultrasound and mixing). However, no specific trends were observed with varying frequency, calorimetric power and mixing speed. Ultrasound and mixing may have an effect on the nucleation step, causing the fast production of nucleation centres. Furthermore, the BET SSA increased with increasing mixing speed. With ultrasound, the BET SSA is between the values obtained under silent condition and with mixing. A competition between micromixing and shockwaves has been proposed when sonication is used for ZIF-8 production. The former increases the BET SSA, while the latter could be responsible for porosity damage, causing a decrease of the surface area. © 2021 The Author(s
Hydrogen sulfide measurement by headspace-gas chromatography-mass spectrometry (HS-GC-MS): application to gaseous samples and gas dissolved in muscle.
The aim of our study was to present a new headspace-gas chromatography-mass spectrometry (HS-GC-MS) method applicable to the routine determination of hydrogen sulfide (H(2)S) concentrations in biological and gaseous samples. The primary analytical drawback of the GC/MS methods for H(2)S measurement discussed in the literature was the absence of a specific H(2)S internal standard required to perform quantification. Although a deuterated hydrogen sulfide (D(2)S) standard is currently available, this standard is not often used because this standard is expensive and is only available in the gas phase. As an alternative approach, D(2)S can be generated in situ by reacting deuterated chloride with sodium sulfide; however, this technique can lead to low recovery yield and potential isotopic fractionation. Therefore, N(2)O was chosen for use as an internal standard. This method allows precise measurements of H(2)S concentrations in biological and gaseous samples. Therefore, a full validation using accuracy profile based on the ÎČ-expectation tolerance interval is presented. Finally, this method was applied to quantify H(2)S in an actual case of H(2)S fatal intoxication
Ballistic Josephson junctions in edge-contacted graphene
Hybrid graphene-superconductor devices have attracted much attention since
the early days of graphene research. So far, these studies have been limited to
the case of diffusive transport through graphene with poorly defined and modest
quality graphene-superconductor interfaces, usually combined with small
critical magnetic fields of the superconducting electrodes. Here we report
graphene based Josephson junctions with one-dimensional edge contacts of
Molybdenum Rhenium. The contacts exhibit a well defined, transparent interface
to the graphene, have a critical magnetic field of 8 Tesla at 4 Kelvin and the
graphene has a high quality due to its encapsulation in hexagonal boron
nitride. This allows us to study and exploit graphene Josephson junctions in a
new regime, characterized by ballistic transport. We find that the critical
current oscillates with the carrier density due to phase coherent interference
of the electrons and holes that carry the supercurrent caused by the formation
of a Fabry-P\'{e}rot cavity. Furthermore, relatively large supercurrents are
observed over unprecedented long distances of up to 1.5 m. Finally, in the
quantum Hall regime we observe broken symmetry states while the contacts remain
superconducting. These achievements open up new avenues to exploit the Dirac
nature of graphene in interaction with the superconducting state.Comment: Updated version after peer review. Includes supplementary material
and ancillary file with source code for tight binding simulation
Biomarker prevalence study and phase I trial of afatinib in children with malignant tumours
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Deletion of Nkx2-5 in trabecular myocardium reveals the developmental origins of pathological heterogeneity associated with ventricular non-compaction cardiomyopathy.
Left ventricular non-compaction (LVNC) is a rare cardiomyopathy associated with a hypertrabeculated phenotype and a large spectrum of symptoms. It is still unclear whether LVNC results from a defect of ventricular trabeculae development and the mechanistic basis that underlies the varying severity of this pathology is unknown. To investigate these issues, we inactivated the cardiac transcription factor Nkx2-5 in trabecular myocardium at different stages of trabecular morphogenesis using an inducible Cx40-creERT2 allele. Conditional deletion of Nkx2-5 at embryonic stages, during trabecular formation, provokes a severe hypertrabeculated phenotype associated with subendocardial fibrosis and Purkinje fiber hypoplasia. A milder phenotype was observed after Nkx2-5 deletion at fetal stages, during trabecular compaction. A longitudinal study of cardiac function in adult Nkx2-5 conditional mutant mice demonstrates that excessive trabeculation is associated with complex ventricular conduction defects, progressively leading to strain defects, and, in 50% of mutant mice, to heart failure. Progressive impaired cardiac function correlates with conduction and strain defects independently of the degree of hypertrabeculation. Transcriptomic analysis of molecular pathways reflects myocardial remodeling with a larger number of differentially expressed genes in the severe versus mild phenotype and identifies Six1 as being upregulated in hypertrabeculated hearts. Our results provide insights into the etiology of LVNC and link its pathogenicity with compromised trabecular development including compaction defects and ventricular conduction system hypoplasia
Clinical, radiologic, pathologic, and molecular characteristics of long-term survivors of diffuse intrinsic pontine glioma (DIPG): a collaborative report from the International and European Society for Pediatric Oncology DIPG registries
Purpose Diffuse intrinsic pontine glioma (DIPG) is a brainstem malignancy with a median survival of < 1 year. The International and European Society for Pediatric Oncology DIPG Registries collaborated to compare clinical, radiologic, and histomolecular characteristics between short-term survivors (STSs) and long-term survivors (LTSs). Materials and Methods Data abstracted from registry databases included patients from North America, Australia, Germany, Austria, Switzerland, the Netherlands, Italy, France, the United Kingdom, and Croatia. Results Among 1,130 pediatric and young adults with radiographically confirmed DIPG, 122 (11%) were excluded. Of the 1,008 remaining patients, 101 (10%) were LTSs (survival â„ 2 years). Median survival time was 11 months (interquartile range, 7.5 to 16 months), and 1-, 2-, 3-, 4-, and 5-year survival rates were 42.3% (95% CI, 38.1% to 44.1%), 9.6% (95% CI, 7.8% to 11.3%), 4.3% (95% CI, 3.2% to 5.8%), 3.2% (95% CI, 2.4% to 4.6%), and 2.2% (95% CI, 1.4% to 3.4%), respectively. LTSs, compared with STSs, more commonly presented at age < 3 or > 10 years (11% v 3% and 33% v 23%, respectively; P < .001) and with longer symptom duration ( P < .001). STSs, compared with LTSs, more commonly presented with cranial nerve palsy (83% v 73%, respectively; P = .008), ring enhancement (38% v 23%, respectively; P = .007), necrosis (42% v 26%, respectively; P = .009), and extrapontine extension (92% v 86%, respectively; P = .04). LTSs more commonly received systemic therapy at diagnosis (88% v 75% for STSs; P = .005). Biopsies and autopsies were performed in 299 patients (30%) and 77 patients (10%), respectively; 181 tumors (48%) were molecularly characterized. LTSs were more likely to harbor a HIST1H3B mutation (odds ratio, 1.28; 95% CI, 1.1 to 1.5; P = .002). Conclusion We report clinical, radiologic, and molecular factors that correlate with survival in children and young adults with DIPG, which are important for risk stratification in future clinical trials
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