178 research outputs found
An Analytical and Experimental Investigation of the Skin Friction of the Turbulent Boundary Layer on a Flat Plate at Supersonic Speeds
A summary of available knowledge concerning skin friction and heat transfer and its application to the design of high-speed missiles
Corrigendum to “Respiratory syncytial virus nonstructural protein 2 specifically inhibits type I interferon signal transduction” [Virology 344 (2006) 328–339]
Borromean Binding of Three or Four Bosons
We estimate the ratio of the critical coupling constants
and which are required to achieve binding of 2 or 3 bosons,
respectively, with a short-range interaction, and examine how this ratio
depends on the shape of the potential. Simple monotonous potentials give
. A wide repulsive core pushes this ratio close to R=1. On the
other hand, for an attractive well protected by an external repulsive barrier,
the ratio approaches the rigorous lower bound . We also present results
for N=4 bosons, sketch the extension to , and discuss various
consequences.Comment: 12 pages, RevTeX, 5 Figures in tex include
Benchmark Test Calculation of a Four-Nucleon Bound State
In the past, several efficient methods have been developed to solve the
Schroedinger equation for four-nucleon bound states accurately. These are the
Faddeev-Yakubovsky, the coupled-rearrangement-channel Gaussian-basis
variational, the stochastic variational, the hyperspherical variational, the
Green's function Monte Carlo, the no-core shell model and the effective
interaction hyperspherical harmonic methods. In this article we compare the
energy eigenvalue results and some wave function properties using the realistic
AV8' NN interaction. The results of all schemes agree very well showing the
high accuracy of our present ability to calculate the four-nucleon bound state.Comment: 17 pages, 1 figure
Monte Carlo integration in Glauber model analysis of reactions of halo nuclei
Reaction and elastic differential cross sections are calculated for light
nuclei in the framework of the Glauber theory. The optical phase-shift function
is evaluated by Monte Carlo integration. This enables us to use the most
accurate wave functions and calculate the phase-shift functions without
approximation. Examples of proton nucleus (e.g. p-He, p-Li) and
nucleus-nucleus (e.g. HeC) scatterings illustrate the effectiveness
of the method. This approach gives us a possibility of a more stringent
analysis of the high-energy reactions of halo nuclei.Comment: 20 pages, 8 figure
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<i>HLA</i> and autoantibodies define scleroderma subtypes and risk in African and European Americans and suggest a role for molecular mimicry
Systemic sclerosis (SSc) is a clinically heterogeneous autoimmune disease characterized by mutually exclusive autoantibodies directed against distinct nuclear antigens. We examined HLA associations in SSc and its autoantibody subsets in a large, newly recruited African American (AA) cohort and among European Americans (EA). In the AA population, the African ancestry-predominant HLA-DRB1*08:04 and HLA-DRB1*11:02 alleles were associated with overall SSc risk, and the HLA-DRB1*08:04 allele was strongly associated with the severe antifibrillarin (AFA) antibody subset of SSc (odds ratio = 7.4). These African ancestry-predominant alleles may help explain the increased frequency and severity of SSc among the AA population. In the EA population, the HLA-DPB1*13:01 and HLA-DRB1*07:01 alleles were more strongly associated with antitopoisomerase (ATA) and anticentromere antibody-positive subsets of SSc, respectively, than with overall SSc risk, emphasizing the importance of HLA in defining autoantibody subtypes. The association of the HLA-DPB1*13:01 allele with the ATA+ subset of SSc in both AA and EA patients demonstrated a transancestry effect. A direct correlation between SSc prevalence and HLA-DPB1*13:01 allele frequency in multiple populations was observed (r = 0.98, P = 3 × 10−6). Conditional analysis in the autoantibody subsets of SSc revealed several associated amino acid residues, mostly in the peptide-binding groove of the class II HLA molecules. Using HLA α / β allelic heterodimers, we bioinformatically predicted immunodominant peptides of topoisomerase 1, fibrillarin, and centromere protein A and discovered that they are homologous to viral protein sequences from the Mimiviridae and Phycodnaviridae families. Taken together, these data suggest a possible link between HLA alleles, autoantibodies, and environmental triggers in the pathogenesis of SSc
Emericella quadrilineata as Cause of Invasive Aspergillosis
This opportunistic fungus is frequently misidentified because of its morphologic similarity to E. nidulans
Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice
Abstract: The accumulation of adenosine is strongly correlated with the need for sleep and the detection of sleep pressure is antagonised by caffeine. Caffeine also affects the circadian timing system directly and independently of sleep physiology, but how caffeine mediates these effects upon the circadian clock is unclear. Here we identify an adenosine-based regulatory mechanism that allows sleep and circadian processes to interact for the optimisation of sleep/wake timing in mice. Adenosine encodes sleep history and this signal modulates circadian entrainment by light. Pharmacological and genetic approaches demonstrate that adenosine acts upon the circadian clockwork via adenosine A1/A2A receptor signalling through the activation of the Ca2+ -ERK-AP-1 and CREB/CRTC1-CRE pathways to regulate the clock genes Per1 and Per2. We show that these signalling pathways converge upon and inhibit the same pathways activated by light. Thus, circadian entrainment by light is systematically modulated on a daily basis by sleep history. These findings contribute to our understanding of how adenosine integrates signalling from both light and sleep to regulate circadian timing in mice
Selective Targeting of TRPV1 Expressing Sensory Nerve Terminals in the Spinal Cord for Long Lasting Analgesia
Chronic pain is a major clinical problem and opiates are often the only treatment, but they cause significant problems ranging from sedation to deadly respiratory depression. Resiniferatoxin (RTX), a potent agonist of Transient Receptor Potential Vanilloid 1 (TRPV1), causes a slow, sustained and irreversible activation of TRPV1 and increases the frequency of spontaneous excitatory postsynaptic currents, but causes significant depression of evoked EPSCs due to nerve terminal depolarization block. Intrathecal administration of RTX to rats in the short-term inhibits nociceptive synaptic transmission, and in the long-term causes a localized, selective ablation of TRPV1-expressing central sensory nerve terminals leading to long lasting analgesia in behavioral models. Since RTX actions are selective for central sensory nerve terminals, other efferent functions of dorsal root ganglion neurons can be preserved. Preventing nociceptive transmission at the level of the spinal cord can be a useful strategy to treat chronic, debilitating and intractable pain
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