Grado de concordancia diagnóstica de los métodos cefalométricos de Madsen-Paniagua y Schwarz para la determinación del perfil facial en pacientes chilenos con dentición mixta

Tesis (Cirujano Dentista)El análisis del perfil facial y su relación con los tejidos blandos, las estructuras óseas y el sistema dentario, permite identificar el tipo de crecimiento que el individuo pueda presentar, así como de las discrepancias esqueletales desde un punto de vista clínico, y la necesidad de realizar un tratamiento ortodóntico. Dicho análisis puede realizarse utilizando el método de Madsen-Paniagua o de Schwarz, ambos ampliamente investigados y validados, sin embargo, no existen estudios que justifiquen el uso de uno por sobre el otro

Road safety improvement on the Pacín river bridge, at OU-1212 PK 22+800, in O Casal (municipality of Entrimo)

[Resumen:] La carretera OU-1212, entre los PK 22+762 y 22+804, en O Casal, término municipal de Entrimo, sufre una importante reducción en el ancho de calzada, pasando de un ancho de carril de 3.5m y 0.5 de arcén a apenas 2.65m de ancho por carril y con un arcén inexistente. Esta circunstancia genera una situación de inseguridad en la vía que debe resolverse. Por ello, mediante la ampliación de la sección de tablero sobre el puente existente, y con el fin de la mejora de la seguridad vial en la OU-1212 a su paso sobre el río Pacín se proyecta una losa continua de hormigón armado, que permita adaptar la calzada a las características de la vía antes y después de la estructura. A su vez, la estructura que sostiene la actual plataforma es un puente de fábrica de mampostería de valor histórico y que, aunque no se encuentre catalogado actualmente, se pretende su completa conservación y mínima afección. Por tanto, se plantea que la cimentación y en definitiva la transmisión de cargas, se ejecute con una cimentación profunda mediante micropilotes, que permitan transmitir las nuevas sobrecargas de uso, directamente al sustrato competente bajo la actual estructura, sin que esta se vea afectada y en ningún caso soporte más cargas que las que actualmente soporta. Así mismo, la asociación de vecinos de la zona reclama la construcción de una pasarela peatonal, pues en el año 2018, el gestor de la vía, La diputación de Ourense, sustituyo la barandilla del puente, tras varios accidentes con salida de vía. La nueva barrera, un pretil con nivel de contención alto, ocupa por completo, lo que en su momento se proyectó como un estrecho paso para los viandantes, de apenas 60cm, con lo que en la actualidad, además de la propia accidentalidad de la vía, los peatones circulan sobre la calzada, con los elevados riesgos que ello conlleva. Si bien no se plantea una sección de tablero mixta, para que los peatones puedan mejorar su situación se propone la mejora y adecuación de un sendero anexo al puente, que transcurre apenas unos metros al suroeste del mismo, y que salva el cauce cruzando a la rivera norte a través de un pontón que sí se encuentra catalogado como bien patrimonial. Se trataría de realizar una pavimentación adecuada y la iluminación de la senda, y dar continuidad a esta en ambas márgenes hasta los núcleos de O Casal y Feiravella. Esta actuación no se desarrolla ya que el objetivo fundamental del presente proyecto es la ampliación de la sección del tablero del puente y la ejecución de esta senda requeriría en si misma de un proyecto propio. En cuanto al proceso constructivo, este se ha definido de forma que tampoco haya afectación directa al entorno o esta sea la menor posible.Traballo fin de grao (UDC.ETSECCP). Enxeñaría de Obras Públicas. Curso 2021/202

DMN for Data Quality Measurement and Assessment

Data Quality assessment is aimed at evaluating the suitability of a dataset for an intended task. The extensive literature on data quality describes the various methodologies for assessing data quality by means of data profiling techniques of the whole datasets. Our investigations are aimed to provide solutions to the need of automatically assessing the level of quality of the records of a dataset, where data profiling tools do not provide an adequate level of information. As most of the times, it is easier to describe when a record has quality enough than calculating a qualitative indicator, we propose a semi-automatically business rule-guided data quality assessment methodology for every record. This involves first listing the business rules that describe the data (data requirements), then those describing how to produce measures (business rules for data quality measurements), and finally, those defining how to assess the level of data quality of a data set (business rules for data quality assessment). The main contribution of this paper is the adoption of the OMG standard DMN (Decision Model and Notation) to support the data quality requirement description and their automatic assessment by using the existing DMN engines.Ministerio de Ciencia y Tecnología RTI2018-094283-B-C33Ministerio de Ciencia y Tecnología RTI2018-094283-B-C31European Regional Development Fund SBPLY/17/180501/00029

Oral administration of heat-killed mycobacterium manresensis delays progression toward active tuberculosis in C3HeB/FeJ mice

Altres ajuts: MS 13/00174Low-dose tolerance using heat-killed mycobacteria has been tested as a means of stopping progression toward active tuberculosis (TB) lesions in a human-like murine model using C3HeB/FeJ mice. In the present study, we studied the effect of different treatment schedules with heat-killed non-tuberculous-mycobacteria (NTM) species when given orally, based on the hypothesis of generating oral tolerance. This study included M. manresensis, a new species belonging to the fortuitum group, present in drinking water. Oral treatment with M. manresensis for 2 weeks was able to induce a PPD-specific Tregs population, which has been related to a decrease in the neutrophilic infiltration found in TB lesions. Further mechanistic analysis using PPD-stimulated splenocytes links this 2-week treatment with heat-killed M. manresensis to IL-10 production and memory PPD-specific Tregs, and also to a weak PPD-specific global immune response stimulation, increasing IL-6, TNF, and IFN-γ production. In lungs, this treatment decreased the bacillary load, granulomatous infiltration and pro-inflammatory cytokines (TNF, IFN-γ, IL-6, and IL-17). Oral administration of M. manresensis during standard treatment for TB also significantly reduced the relapse of active TB after ending the treatment. Overall the data suggest that the use of heat-killed M. manresensis could be a new and promising tool for avoiding active TB induction and as adjunctive to TB treatment. This supports the usefulness of generating a new kind of protection based on a complex balanced immune response focused on both destroying the bacilli and including control of an excessive inflammatory response

Disseminated tuberculosis and hemophagocytic syndrome although TB prophylaxis in patients with inflammatory bowel disease treated with Infliximab

Purpose: We present de case of a 27-year-old woman admitted to ICU after scheduled splenectomy to study her short course of fever, leukopenia and splenic space-occupying lesions and splenomegaly. She has been previously treated with Infliximab due to indeterminate colitis and completed correct tuberculosis prophylaxis. Materials and methods: We reviewed our case in our regional Electronic Health DataBase IANUS and compared it with other case reports in literature, found in PubMed, with keywords tuberculosis, inflammatory disease and hemophagocytic lymphohistiocytosis. Results: After splenectomy, she needed intensive care due to acute respiratory failure, alveolar-interstitial pulmonary infiltrates, right pleural effusion and fever. Bone marrow aspirate resulted in hemophagocytic lymphohistiocytosis. Only multidisciplinary management in ICU and combined treatment with chemotherapy for hemophagocytic syndrome and tuberculostatics achieved her curation. Conclusion: Tuberculosis must always be considered in the differential diagnosis of hemophagocytic lymphohistiocytosis and acute respiratory failure despite correct prior prophylaxi

Hacia una agenda de investigación sobre la relación entre capital social y turismo

  The present study conducts a reflective analysis of academic production about the relationship between tourism and social capital, with the aim of responding to the question: What are the themes, variables and paths that the study of social capital ought to follow in the tourism sphere? It became clear that although there is relevant academic production regarding the relationship between tourism and social capital, the entire range of the possibilities for its study and understanding has still not been covered, which in addition limits its academic knowledge, the possibility of designing intervention actions that could have an impact on the improvement of tourism or of social capital in societies where they participate, or in both. The elements to be considered when approaching a research agenda are presented, in order to delve into the knowledge of the relationship between tourism and social capital as theoretical-conceptual framework, that is, stemming from the type of relationship between the themes, the scenarios to be considered, the scales to approach the studies, the actors to be included, and the dimensions, categories, themes or variables to be considered. Finally, reflections are made about what has been researched until today, and the different scientific academic work lines that can be pursued in the future.  El presente ensayo, realiza un análisis reflexivo de la producción académica sobre la relación entre turismo y capital social, con la finalidad de responder a la interrogante ¿cuáles son las temáticas, variables y rumbos que ha de seguir el estudio del capital social en el ámbito turístico? Se encontró que, si bien existe producción académica importante respecto a la relación entre turismo y capital social, aún no se ha cubierto toda la gama de posibilidades para su estudio y comprensión, lo cual limita además de su conocimiento académico, la posibilidad de diseñar acciones de intervención que incidan en la mejora de la propia actividad turística o del capital social en las sociedades que en él participan o en ambos. Se presentan los elementos a considerar al abordar una agenda de investigación para profundizar en el conocimiento de la relación entre turismo y capital social como marco teórico-conceptual, a saber, desde el tipo de relación entre las temáticas, los escenarios a considerar, las escalas para abordar los estudios, los actores a incluir y las dimensiones, categorías, temáticas o variables a considerar. Finalmente se hacen reflexiones sobre lo que hasta el momento se ha investigado y las distintas líneas de trabajo académico científico que pueden seguirse en el futuro

Microalgae as potential sources of bioactive compounds for functional foods and pharmaceuticals

Microalgae are an untapped source of bioactive compounds with various biotechnological applications. Several species are industrially produced and commercialized for the feed or cosmetic industries, however, other applications in the functional food and pharmaceutical markets can be foreseen. In this study, nine industrial/commercial species were evaluated for in vitro antioxidant, calcium-chelating, anti-tumoral, and anti-inflammatory activities. The most promising extracts were fractionated yielding several promising fractions namely, of Tetraselmis striata CTP4 with anti-inflammatory activity (99.0 ± 0.8% reduction in TNF-α production in LPS stimulated human macrophages at 50 µg/mL), of Phaeodactylum Tricornutum with cytotoxicity towards cancerous cell lines (IC50 = 22.3 ± 1.8 µg/mL and 27.5 ± 1.6 µg/mL for THP-1 and HepG2, respectively) and of Porphyridium sp. and Skeletonema sp. with good chelating activity for iron, copper and calcium (IC50 = 0.047, 0.272, 0.0663 mg/mL and IC50 = 0.055, 0.240, 0.0850 mg/mL, respectively). These fractions were chemically characterized by GC–MS after derivatization and in all, fatty acids at various degrees of unsaturation were the most abundant compounds. Some of the species under study proved to be potentially valuable sources of antioxidant, metal chelators, anti-tumoral and anti-inflammatory compounds with possible application in the functional food and pharmaceutical industries.info:eu-repo/semantics/publishedVersio

A global customer experience management architecture

Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. A. Cuadra-Sanchez, M. Cutanda-Rodriguez, I. Perez-Mateos, A. Aurelius, K. Brunnstrom, J. Laulajainen, M. Varela, and J. E. López de Vergara, "A global customer experience management architecture", in Future Network and Mobile Summit, 2012, 1-8The quality of experience (QoE) is one of the main research lines in ITC industry, which seeks to manage quality as perceived by users. This document analyzes and describes requirements of a QoE driven management system architecture, which has been designed in the Celtic IPNQSIS project. The architecture is grouped into different levels: Data acquisition level, Monitoring level and Control Level. Each level comprises a specific set of capacities, such as Data collector, or Traffic Monitor amongst others. The architecture described in this paper constitutes the guidelines of the IPNQSIS project in terms of a QoE ecosystem that will settle the basis of global customer experience management architecture.This work is carried out in the framework of the Celtic and EUREKA initiative IPNQSIS (IP Network Monitoring for Quality of Service Intelligent Support) and has been partially funded by CDTI under Spanish PRINCE (PRoducto INdustrial para la gestión de la Calidad de Experiencia) project, meanwhile the Swedish part of the project is co funded by VINNOVA and the work of Finnish partners has been partially funded by Tekes

High Prevalence of Systemic Autoimmune Diseases in Patients with Menière's Disease

BACKGROUND: Autoimmunity appears to be associated with the pathophysiology of Meniere's disease (MD), an inner ear disorder characterized by episodes of vertigo associated with hearing loss and tinnitus. However, the prevalence of autoimmune diseases (AD) in patients with MD has not been studied in individuals with uni or bilateral sensorineural hearing loss (SNHL). METHODS AND FINDINGS: We estimated the prevalence of AD in 690 outpatients with MD with uni or bilateral SNHL from otoneurology clinics at six tertiary referral hospitals by using clinica criteria and an immune panel (lymphocyte populations, antinuclear antibodies, C3, C4 and proinflammatory cytokines TNFα, INFγ). The observed prevalence of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and ankylosing spondylitis (AS) was higher than expected for the general population (1.39 for RA, 0.87 for SLE and 0.70 for AS, respectively). Systemic AD were more frequently observed in patients with MD and diagnostic criteria for migraine than cases with MD and tension-type headache (p = 0.007). There were clinical differences between patients with uni or bilateral SNHL, but no differences were found in the immune profile. Multiple linear regression showed that changes in lymphocytes subpopulations were associated with hearing loss and persistence of vertigo, suggesting a role for the immune response in MD. CONCLUSIONS: Despite some limitations, MD displays an elevated prevalence of systemic AD such as RA, SLE and AS. This finding, which suggests an autoimmune background in a subset of patients with MD, has important implications for the treatment of MD

Burden of rare variants in synaptic genes in patients with severe tinnitus: An exome based extreme phenotype study

Background: tinnitus is a heterogeneous condition associated with audiological and/or mental disorders. Chronic, severe tinnitus is reported in 1% of the population and it shows a relevant heritability, according to twins, adoptees and familial aggregation studies. The genetic contribution to severe tinnitus is unknown since large genomic studies include individuals with self-reported tinnitus and large heterogeneity in the phenotype. The aim of this study was to identify genes for severe tinnitus in patients with extreme phenotype. Methods: for this extreme phenotype study, we used three different cohorts with European ancestry (Spanish with Meniere disease (MD), Swedes tinnitus and European generalized epilepsy). In addition, four independent control datasets were also used for comparisons. Whole-exome sequencing was performed for the MD and epilepsy cohorts and whole-genome sequencing was carried out in Swedes with tinnitus. Findings: we found an enrichment of rare missense variants in 24 synaptic genes in a Spanish cohort, the most significant being PRUNE2, AKAP9, SORBS1, ITGAX, ANK2, KIF20B and TSC2 (p < 2E 04), when they were compared with reference datasets. This burden was replicated for ANK2 gene in a Swedish cohort with 97 tinnitus individuals, and in a subset of 34 Swedish patients with severe tinnitus for ANK2, AKAP9 and TSC2 genes (p < 2E 02). However, these associations were not significant in a third cohort of 701 generalized epilepsy individuals without tinnitus. Gene ontology (GO) and gene-set enrichment analyses revealed several pathways and biological processes involved in severe tinnitus, including membrane trafficking and cytoskeletal protein binding in neurons. Interpretation: a burden of rare variants in ANK2, AKAP9 and TSC2 is associated with severe tinnitus. ANK2, encodes a cytoskeleton scaffolding protein that coordinates the assembly of several proteins, drives axonal branching and influences connectivity in neurons