319 research outputs found
Outcome in patients perceived as receiving excessive care across different ethical climates : a prospective study in 68 intensive care units in Europe and the USA
Whether the quality of the ethical climate in the intensive care unit (ICU) improves the identification of patients receiving excessive care and affects patient outcomes is unknown.
In this prospective observational study, perceptions of excessive care (PECs) by clinicians working in 68 ICUs in Europe and the USA were collected daily during a 28-day period. The quality of the ethical climate in the ICUs was assessed via a validated questionnaire. We compared the combined endpoint (death, not at home or poor quality of life at 1 year) of patients with PECs and the time from PECs until written treatment-limitation decisions (TLDs) and death across the four climates defined via cluster analysis.
Of the 4747 eligible clinicians, 2992 (63%) evaluated the ethical climate in their ICU. Of the 321 and 623 patients not admitted for monitoring only in ICUs with a good (n = 12, 18%) and poor (n = 24, 35%) climate, 36 (11%) and 74 (12%), respectively were identified with PECs by at least two clinicians. Of the 35 and 71 identified patients with an available combined endpoint, 100% (95% CI 90.0-1.00) and 85.9% (75.4-92.0) (P = 0.02) attained that endpoint. The risk of death (HR 1.88, 95% CI 1.20-2.92) or receiving a written TLD (HR 2.32, CI 1.11-4.85) in patients with PECs by at least two clinicians was higher in ICUs with a good climate than in those with a poor one. The differences between ICUs with an average climate, with (n = 12, 18%) or without (n = 20, 29%) nursing involvement at the end of life, and ICUs with a poor climate were less obvious but still in favour of the former.
Enhancing the quality of the ethical climate in the ICU may improve both the identification of patients receiving excessive care and the decision-making process at the end of life
The search for transient astrophysical neutrino emission with IceCube-DeepCore
We present the results of a search for astrophysical sources of brief transient neutrino emission using IceCube and DeepCore data acquired between 2012 May 15 and 2013 April 30. While the search methods employed in this analysis are similar to those used in previous IceCube point source searches, the data set being examined consists of a sample of predominantly sub-TeV muon-neutrinos from the Northern Sky (-5 degrees < delta < 90 degrees) obtained through a novel event selection method. This search represents a first attempt by IceCube to identify astrophysical neutrino sources in this relatively unexplored energy range. The reconstructed direction and time of arrival of neutrino events are used to search for any significant self-correlation in the data set. The data revealed no significant source of transient neutrino emission. This result has been used to construct limits at timescales ranging from roughly 1 s to 10 days for generic soft-spectra transients. We also present limits on a specific model of neutrino emission from soft jets in core-collapse supernovae
Search for transient optical counterparts to high-energy IceCube neutrinos with Pan-STARRS1
In order to identify the sources of the observed diffuse high-energy neutrino
flux, it is crucial to discover their electromagnetic counterparts. IceCube
began releasing alerts for single high-energy ( TeV) neutrino
detections with sky localisation regions of order 1 deg radius in 2016. We used
Pan-STARRS1 to follow-up five of these alerts during 2016-2017 to search for
any optical transients that may be related to the neutrinos. Typically 10-20
faint ( mag) extragalactic transients are found within the
Pan-STARRS1 footprints and are generally consistent with being unrelated field
supernovae (SNe) and AGN. We looked for unusual properties of the detected
transients, such as temporal coincidence of explosion epoch with the IceCube
timestamp. We found only one transient that had properties worthy of a specific
follow-up. In the Pan-STARRS1 imaging for IceCube-160427A (probability to be of
astrophysical origin of 50 %), we found a SN PS16cgx, located at 10.0'
from the nominal IceCube direction. Spectroscopic observations of PS16cgx
showed that it was an H-poor SN at z = 0.2895. The spectra and light curve
resemble some high-energy Type Ic SNe, raising the possibility of a jet driven
SN with an explosion epoch temporally coincident with the neutrino detection.
However, distinguishing Type Ia and Type Ic SNe at this redshift is notoriously
difficult. Based on all available data we conclude that the transient is more
likely to be a Type Ia with relatively weak SiII absorption and a fairly normal
rest-frame r-band light curve. If, as predicted, there is no high-energy
neutrino emission from Type Ia SNe, then PS16cgx must be a random coincidence,
and unrelated to the IceCube-160427A. We find no other plausible optical
transient for any of the five IceCube events observed down to a 5
limiting magnitude of mag, between 1 day and 25 days after
detection.Comment: 20 pages, 6 figures, accepted to A&
Outcome in patients perceived as receiving excessive care across different ethical climates: a prospective study in 68 intensive care units in Europe and the USA.
PURPOSE: Whether the quality of the ethical climate in the intensive care unit (ICU) improves the identification of patients receiving excessive care and affects patient outcomes is unknown. METHODS: In this prospective observational study, perceptions of excessive care (PECs) by clinicians working in 68 ICUs in Europe and the USA were collected daily during a 28-day period. The quality of the ethical climate in the ICUs was assessed via a validated questionnaire. We compared the combined endpoint (death, not at home or poor quality of life at 1 year) of patients with PECs and the time from PECs until written treatment-limitation decisions (TLDs) and death across the four climates defined via cluster analysis. RESULTS: Of the 4747 eligible clinicians, 2992 (63%) evaluated the ethical climate in their ICU. Of the 321 and 623 patients not admitted for monitoring only in ICUs with a good (n = 12, 18%) and poor (n = 24, 35%) climate, 36 (11%) and 74 (12%), respectively were identified with PECs by at least two clinicians. Of the 35 and 71 identified patients with an available combined endpoint, 100% (95% CI 90.0-1.00) and 85.9% (75.4-92.0) (P = 0.02) attained that endpoint. The risk of death (HR 1.88, 95% CI 1.20-2.92) or receiving a written TLD (HR 2.32, CI 1.11-4.85) in patients with PECs by at least two clinicians was higher in ICUs with a good climate than in those with a poor one. The differences between ICUs with an average climate, with (n = 12, 18%) or without (n = 20, 29%) nursing involvement at the end of life, and ICUs with a poor climate were less obvious but still in favour of the former. CONCLUSION: Enhancing the quality of the ethical climate in the ICU may improve both the identification of patients receiving excessive care and the decision-making process at the end of life
All-sky search for time-integrated neutrino emission from astrophysical sources with 7 years of IceCube data
Since the recent detection of an astrophysical flux of high energy neutrinos,
the question of its origin has not yet fully been answered. Much of what is
known about this flux comes from a small event sample of high neutrino purity,
good energy resolution, but large angular uncertainties. In searches for
point-like sources, on the other hand, the best performance is given by using
large statistics and good angular reconstructions. Track-like muon events
produced in neutrino interactions satisfy these requirements. We present here
the results of searches for point-like sources with neutrinos using data
acquired by the IceCube detector over seven years from 2008--2015. The
discovery potential of the analysis in the northern sky is now significantly
below , on average
lower than the sensitivity of the previously published analysis of four
years exposure. No significant clustering of neutrinos above background
expectation was observed, and implications for prominent neutrino source
candidates are discussed.Comment: 19 pages, 17 figures, 3 tables; ; submitted to The Astrophysical
Journa
Neutrinos and Cosmic Rays Observed by IceCube
The core mission of the IceCube Neutrino observatory is to study the origin
and propagation of cosmic rays. IceCube, with its surface component IceTop,
observes multiple signatures to accomplish this mission. Most important are the
astrophysical neutrinos that are produced in interactions of cosmic rays, close
to their sources and in interstellar space. IceCube is the first instrument
that measures the properties of this astrophysical neutrino flux, and
constrains its origin. In addition, the spectrum, composition and anisotropy of
the local cosmic-ray flux are obtained from measurements of atmospheric muons
and showers. Here we provide an overview of recent findings from the analysis
of IceCube data, and their implications on our understanding of cosmic rays.Comment: Review article, to appear in Advances in Space Research, special
issue "Origins of Cosmic Rays
Characterization of the Atmospheric Muon Flux in IceCube
Muons produced in atmospheric cosmic ray showers account for the by far
dominant part of the event yield in large-volume underground particle
detectors. The IceCube detector, with an instrumented volume of about a cubic
kilometer, has the potential to conduct unique investigations on atmospheric
muons by exploiting the large collection area and the possibility to track
particles over a long distance. Through detailed reconstruction of energy
deposition along the tracks, the characteristics of muon bundles can be
quantified, and individual particles of exceptionally high energy identified.
The data can then be used to constrain the cosmic ray primary flux and the
contribution to atmospheric lepton fluxes from prompt decays of short-lived
hadrons.
In this paper, techniques for the extraction of physical measurements from
atmospheric muon events are described and first results are presented. The
multiplicity spectrum of TeV muons in cosmic ray air showers for primaries in
the energy range from the knee to the ankle is derived and found to be
consistent with recent results from surface detectors. The single muon energy
spectrum is determined up to PeV energies and shows a clear indication for the
emergence of a distinct spectral component from prompt decays of short-lived
hadrons. The magnitude of the prompt flux, which should include a substantial
contribution from light vector meson di-muon decays, is consistent with current
theoretical predictions.Comment: 36 pages, 39 figure
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