The “Problem” of L2 Writers in College Composition Placement: Identity, Outcomes, and the Future of Directed Self Placement

In response to the rapidly growing number of international and multilingual students on U.S. college campuses, many colleges’ first year composition (FYC) courses have expanded to include classes designated for “ESL” or “International” students, with increasing scholarship on the best pedagogical practices for such classes.  Despite increasing scholarship on the best pedagogical practices for such classes, the implications of placing students into them remains “the thorniest of issues” (Crusan, 2011), with mounting debate as to how to measure L2 students’ suitability for either “ESL” or “mainstream” writing classes, as well as the role students should play in labelling themselves “ESL” writers. Directed Self-Placement (DSP) is emerging as a more equitable and anti-racist alternative to test-based placement; however, there are concerns about its suitability for L2 writers specifically (Crusan, 2011; Ferris, 2017). This literature review therefore aims to address two questions: (1) what are the unique challenges of placing L2 writers in FYC courses? Specifically, what are the implications of the identity labelling inherent in placing L2 students in courses designated as “ESL” or for “International Students” with regard to student investment and learning outcomes?  (2) Might DSP offer a viable alternative to traditional L2 placement testing that addresses such implications

The Distribution of Macroalgae in Furman Lake

A three page summary by four Furman students describing their research on macroalge in the Furman Lake. The goal is to test whether or not the restoration efforts have significantly changed the algae cover in the lake.https://scholarexchange.furman.edu/lake-documents/1014/thumbnail.jp

Hypervariability of Ascidian Mitochondrial Gene Order: Exposing the Myth of Deuterostome Organelle Genome Stability

The few sequenced mitochondrial (mt) genomes of the class Ascidiacea (Chordata, Tunicata), mostly belonging to congeneric species of the Phlebobranchia order, show extraordinary gene order rearrangements. In order to assess if this hypervariability in gene order is a general feature of Ascidiacea, we report here the gene arrangement of five ascidians belonging to the Aplousobranchia and Stolidobranchia orders. Our data show that Ascidiacea are characterized by: 1) extensive gene order rearrangements both within and between the three major lineages; 2) lack of significant similarities to the gene order of other deuterostomes; and 3) an extent of rearrangements comparable with that of Mollusca (especially the Gastropoda, Bivalvia, and Scaphopoda classes), a phylum with highly rearranged mtDNAs. The only conserved feature is the location of all genes on the same strand, which suggests that selective constraints are related to the mt transcription. Finally, a higher mobility of the tRNA genes is undetectable because of saturation effect, and only the partially conserved cox2-cob gene block seems to retain some phylogenetic signals

A constituição do Sujeito-Mãe nos livros didáticos de matemática da Educação do Campo

This article describes the constitution of what was named as mother-subject from the analysis of ten mathematics textbooks produced to primary countryside schools in Brazil. This material composes two collections approved in the National Textbook Program, the PNLD Campo. Foucauldian theorizations about discourse analyses support the description and analysis of a set of sent that affect a body as female cultural performance. The excerpts images, activities and exercises brought replicate stylized practices that inscribe the mother-subject through discursivities directed to a body with a specific gender target: the female. Thus, the data showed that the mathematics curriculum materializes well elaborated narratives that use the contents of this school discipline in order to replicate and constitute a set of values and moralities with a substantial status of truth that guide the modes of being and acting of the body that is seen and seen as female.Este artigo descreve a constituição do que foi aqui denominado ‘sujeito-mãe’ a partir da análise de dez livros didáticos de matemática, produzidos para os anos iniciais de escolas do campo no Brasil. Esse material compõe duas coleções aprovadas no Programa Nacional do Livro Didático Campo, o PNLD Campo. As teorizações foucaultianas acerca da análise do discurso amparam a descrição e análise de um conjunto de endereçamentos que incidem sobre um corpo como performance cultural do feminino. Os excertos, imagens, atividades e exercícios trazidos replicam práticas estilizadas que inscrevem o sujeito-mãe por meio de discursividades direcionadas a um corpo com marcas de gênero específicas: o feminino. Desse modo, os dados mostraram que o currículo de matemática materializa narrativas bem elaboradas que se valem dos conteúdos dessa disciplina escolar, a fim de replicar e constituir um conjunto de valores e moralidades, com substancial status de verdade, que acabam por orientar os modos de ser e agir desse corpo que se vê e é visto como feminino

PROCESSOS DE SUBJETIVAÇÃO MOVIMENTADOS EM LIVROS DIDÁTICOS DE MATEMÁTICA PARA A EDUCAÇÃO DO CAMPO: DESCREVENDO E ANALISANDO O HABITANTE DESEJÁVEL DO CAMPO

Este artigo apresenta resultados de uma investigação de doutorado que perquiriu dez livros de matemática produzidos para os anos iniciais do Ensino Fundamental da Educação do Campo que fizeram parte do Programa Nacional do Livro Didático (PNLD) na versão do PNLD Campo, entre os anos de 2013 e 2018. A pesquisa mapeou, descreveu e analisou os processos de subjetivação movimentados e produzidos nesses materiais. O currículo de matemática escolar, como política cultural, opera esses processos para validar, justificar e potencializar a construção de noções bem elaboradas acerca do tipo de habitante desejável para o campo. Por meio de um entendimento do livro didático como dispositivo de poder que governa a população por meio de específicas ordens temporais e discursivas, foram identificadas quatro dimensões que comportam enunciados para o governo dessa população, a saber: Estudos de Gênero, Estudos Animais, Cidadania e Trabalho. Os resultados mostram que os livros didáticos são uma eficiente ferramenta na produção e propagação de subjetividades que interessam a uma sociedade bem organizada do ponto de vista da eficiência e produtividade, ou seja, de uma racionalidade neoliberal

Somatic mutations of thymic epithelial tumors with myasthenia gravis

BackgroundThymic epithelial tumors are rare malignant neoplasms that are frequently associated with paraneoplastic syndromes, especially myasthenia gravis. GTF2I is an oncogene mutated in a subgroup of thymomas that is reputed to drive their growth. However, for GTF2I wild-type tumors, the relevant mutations remain to be identified.MethodsWe performed a meta-analysis and identified 4,208 mutations in 339 patients. We defined a panel of 63 genes frequently mutated in thymic epithelial tumors, which we used to design a custom assay for next-generation sequencing. We sequenced tumor DNA from 67 thymomas of patients with myasthenia gravis who underwent resection in our institution.ResultsAmong the 67 thymomas, there were 238 mutations, 83 of which were in coding sequences. There were 14 GTF2I mutations in 6 A, 5 AB, 2 B2 thymomas, and one in a thymoma with unspecified histology. No other oncogenes showed recurrent mutations, while sixteen tumor suppressor genes were predicted to be inactivated. Even with a dedicated assay for the identification of specific somatic mutations in thymic epithelial tumors, only GTF2I mutations were found to be significantly recurrent.ConclusionOur evaluation provides insights into the mutational landscape of thymic epithelial tumors, identifies recurrent mutations in different histotypes, and describes the design and implementation of a custom panel for targeted resequencing. These findings contribute to a better understanding of the genetic basis of thymic epithelial tumors and may have implications for future research and treatment strategies

Undiagnosed diseases: Needs and opportunities in 20 countries participating in the Undiagnosed Diseases Network International

Introduction: Rare diseases (RD) are a health priority worldwide, overall affecting hundreds of millions of people globally. Early and accurate diagnosis is essential to support clinical care but remains challenging in many countries, especially the low- and medium-income ones. Hence, undiagnosed RD (URD) account for a significant portion of the overall RD burden. Methods: In October 2020, the Developing Nations Working Group of the Undiagnosed Diseases Network International (DNWG-UDNI) launched a survey among its members, belonging to 20 countries across all continents, to map unmet needs and opportunities for patients with URD. The survey was based on questions with open answers and included eight different domains. Conflicting interpretations were resolved in contact with the partners involved. Results: All members responded to the survey. The results indicated that the scientific and medical centers make substantial efforts to respond to the unmet needs of patients. In most countries, there is a high awareness of RD issues. Scarcity of resources was highlighted as a major problem, leading to reduced availability of diagnostic expertise and research. Serious equity in accessibility to services were highlighted both within and between participating countries. Regulatory problems, including securing informed consent, difficulties in sending DNA to foreign laboratories, protection of intellectual property, and conflicts of interest on the part of service providers, remain issues of concern. Finally, most respondents stressed the need to strengthen international cooperation in terms of data sharing, clinical research, and diagnostic expertise for URD patients in low and medium income countries. Discussion: The survey highlighted that many countries experienced a discrepancy between the growing expertise and scientific value, the level of awareness and commitment on the part of relevant parties, and funding bodies. Country-tailored public health actions, including general syllabus of medical schools and of the education of other health professionals, are needed to reduce such gaps.VSh is supported by Health Systems Research Institute of Thailand (65-040). SJ is supported by National Medical Research Council, Singapore (Grants ID CSAINV21jun-0003 and CIRG22jul-0003).S

Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM study on COVID-19.

Objectives To evaluate the strength of association between maternal and pregnancy characteristics and the risk of adverse perinatal outcomes in pregnancies with laboratory confirmed COVID-19. Methods Secondary analysis of a multinational, cohort study on all consecutive pregnant women with laboratory-confirmed COVID-19 from February 1, 2020 to April 30, 2020 from 73 centers from 22 different countries. A confirmed case of COVID-19 was defined as a positive result on real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay of nasal and pharyngeal swab specimens. The primary outcome was a composite adverse fetal outcome, defined as the presence of either abortion (pregnancy loss before 22 weeks of gestations), stillbirth (intrauterine fetal death after 22 weeks of gestation), neonatal death (death of a live-born infant within the first 28 days of life), and perinatal death (either stillbirth or neonatal death). Logistic regression analysis was performed to evaluate parameters independently associated with the primary outcome. Logistic regression was reported as odds ratio (OR) with 95% confidence interval (CI). Results Mean gestational age at diagnosis was 30.6+/-9.5 weeks, with 8.0% of women being diagnosed in the first, 22.2% in the second and 69.8% in the third trimester of pregnancy. There were six miscarriage (2.3%), six intrauterine device (IUD) (2.3) and 5 (2.0%) neonatal deaths, with an overall rate of perinatal death of 4.2% (11/265), thus resulting into 17 cases experiencing and 226 not experiencing composite adverse fetal outcome. Neither stillbirths nor neonatal deaths had congenital anomalies found at antenatal or postnatal evaluation. Furthermore, none of the cases experiencing IUD had signs of impending demise at arterial or venous Doppler. Neonatal deaths were all considered as prematurity-related adverse events. Of the 250 live-born neonates, one (0.4%) was found positive at RT-PCR pharyngeal swabs performed after delivery. The mother was tested positive during the third trimester of pregnancy. The newborn was asymptomatic and had negative RT-PCR test after 14 days of life. At logistic regression analysis, gestational age at diagnosis (OR: 0.85, 95% CI 0.8-0.9 per week increase; pPeer reviewe

Unmet needs in countries participating in the undiagnosed diseases network international: an international survey considering national health care and economic indicators

BackgroundPatients, families, the healthcare system, and society as a whole are all significantly impacted by rare diseases (RDs). According to various classifications, there are currently up to 9,000 different rare diseases that have been recognized, and new diseases are discovered every month. Although very few people are affected by each uncommon disease individually, millions of people are thought to be impacted globally when all these conditions are considered. Therefore, RDs represent an important public health concern. Although crucial for clinical care, early and correct diagnosis is still difficult to achieve in many nations, especially those with low and middle incomes. Consequently, a sizeable amount of the overall burden of RD is attributable to undiagnosed RD (URD). Existing barriers and policy aspects impacting the care of patients with RD and URD remain to be investigated.MethodsTo identify unmet needs and opportunities for patients with URD, the Developing Nations Working Group of the Undiagnosed Diseases Network International (DNWG-UDNI) conducted a survey among its members, who were from 20 different nations. The survey used a mix of multiple choice and dedicated open questions covering a variety of topics. To explore reported needs and analyze them in relation to national healthcare economical aspects, publicly available data on (a) World Bank ranking; (b) Current health expenditure per capita; (c) GDP per capita; (d) Domestic general government health expenditure (% of GDP); and (e) Life expectancy at birth, total (years) were incorporated in our study.ResultsThis study provides an in-depth evaluation of the unmet needs for 20 countries: low-income (3), middle-income (10), and high-income (7). When analyzing reported unmet needs, almost all countries (N = 19) indicated that major barriers still exist when attempting to improve the care of patients with UR and/or URD; most countries report unmet needs related to the availability of specialized care and dedicated facilities. However, while the countries ranked as low income by the World Bank showed the highest prevalence of referred unmet needs across the different domains, no specific trend appeared when comparing the high, upper, and low-middle income nations. No overt trend was observed when separating countries by current health expenditure per capita, GDP per capita, domestic general government health expenditure (% of GDP) and life expectancy at birth, total (years). Conversely, both the GDP and domestic general government health expenditure for each country impacted the presence of ongoing research.ConclusionWe found that policy characteristics varied greatly with the type of health system and country. No overall pattern in terms of referral for unmet needs when separating countries by main economic or health indicators were observed. Our findings highlight the importance of identifying actionable points (e.g., implemented orphan drug acts or registries where not available) in order to improve the care and diagnosis of RDs and URDs on a global scale