Toy story: homophily, transmission and the use of simple models in assessing variability in the archaeological record

The interpretation of spatial and temporal patterns in the archaeological record remains a long-standing issue in the discipline. Amongst many methods and interpretations, modelling of ‘biased transmission’ has proved a successful strategy to tackle this problem. Here, we investigate a type of biased transmission, homophily, that is the tendency of individuals to associate and bond with similar others. In contrast to other social sciences, homophily remains underused in archaeology. In order to fill this gap, we develop six distinct variants of a well-established modelling framework borrowed from social science, Axelrod’s Cultural Dissemination Model. These so-called toy models are abstract models used for theory-building and aim at exploring the interplay between homophily and various factors (e.g. addition of spatial features such as mountains and coastlines, diffusion of innovations and population spread). The relevance and implications of each ‘toy model’ for archaeological reasoning are then discussed

Characterization of the bacteriophage-derived endolysins PlySs2 and PlySs9 with in vitro lytic activity against bovine mastitis streptococcus uberis

Bovine mastitis, an infection of the cow’s mammary gland, is frequently caused by Streptococcus uberis and causes major economic losses in the dairy industry. The intramammary administration of antibiotics currently remains the predominant preventive and therapeutic measure. These antimicrobial compounds, ofwhich some are consideredcritical in human health care, are frequently applied as dry therapy resulting in their consistent overuse. Therefore, the use of antibiotics in the dairy sector is being questioned. We here identified two endolysins, i.e., PlySs2 and PlySs9, respectively derived from Streptococcus suis serotype-2 and -9 prophages, with lytic activity against S. uberis in an in vitro setting. Both endolysins gave clear lysis zones in spot-on-plate assays and caused a reduction of the optical density in a turbidity reduction assay. In depth characterization identified PlySs9 as the more potent endolysin over PlySs2 with a lower MIC value and about one additional log of killing. PlySs2 and PlySs9 were challenged to a panel of subclinical and clinical S. uberis milk isolates and were both able to lyse all strains tested. Molecular dissection of these endolysins in catalytic and cell wall binding subdomains resulted in major loss of killing and binding activity, respectively. Taken together, we here propose PlySs2 and PlySs9 as candidate compounds to the current antimicrobial arsenal known against bovine mastitis-causing S. uberis as future add-on or replacement strategy to the currently used intramammary antibiotics

Modelling diffusion of innovation curves using radiocarbon data

Archaeological data provide a potential to investigate the diffusion of technological and cultural traits. However, much of this research agenda currently needs more formal quantitative methods to address small sample sizes and chronological uncertainty. This paper introduces a novel Bayesian framework for inferring the shape of diffusion curves using radiocarbon data associated with the presence/absence of a particular innovation. We developed two distinct approaches: 1) a hierarchical model that enables the fitting of an s-shaped diffusion curve whilst accounting for inter-site variations in the probability of sampling the innovation itself, and 2) a non-parametric model that can estimate the changing proportion of the innovation across user-defined time-blocks. The robustness of the two approaches was first tested against simulated datasets and then applied to investigate three case studies, the first pair on the diffusion of farming in prehistoric Japan and Britain and the third on cycles of changes in the burial practices of later prehistoric Britain

Catalog of Galactic Beta Cephei Stars

We present an extensive and up-to-date catalog of Galactic Beta Cephei stars. This catalog is intended to give a comprehensive overview of observational characteristics of all known Beta Cephei stars. 93 stars could be confirmed to be Beta Cephei stars. For some stars we re-analyzed published data or conducted our own analyses. 61 stars were rejected from the final Beta Cephei list, and 77 stars are suspected to be Beta Cephei stars. A list of critically selected pulsation frequencies for confirmed Beta Cephei stars is also presented. We analyze the Beta Cephei stars as a group, such as the distributions of their spectral types, projected rotational velocities, radial velocities, pulsation periods, and Galactic coordinates. We confirm that the majority of these stars are multiperiodic pulsators. We show that, besides two exceptions, the Beta Cephei stars with high pulsation amplitudes are slow rotators. We construct a theoretical HR diagram that suggests that almost all 93 Beta Cephei stars are MS objects. We discuss the observational boundaries of Beta Cephei pulsation and their physical parameters. We corroborate that the excited pulsation modes are near to the radial fundamental mode in frequency and we show that the mass distribution of the stars peaks at 12 solar masses. We point out that the theoretical instability strip of the Beta Cephei stars is filled neither at the cool nor at the hot end and attempt to explain this observation

Abundance analysis of prime B-type targets for asteroseismology I. Nitrogen excess in slowly-rotating beta Cephei stars

We present the results of a detailed NLTE abundance study of nine beta Cephei stars, all of them being prime targets for theoretical modelling: gamma Peg, delta Cet, nu Eri, beta CMa, xi1 CMa, V836 Cen, V2052 Oph, beta Cep and DD (12) Lac. The following chemical elements are considered: He, C, N, O, Mg, Al, Si, S and Fe. Our abundance analysis is based on a large number of time-resolved, high-resolution optical spectra covering in most cases the entire oscillation cycle of the stars. Nitrogen is found to be enhanced by up to 0.6 dex in four stars, three of which have severe constraints on their equatorial rotational velocity, \Omega R, from seismic or line-profile variation studies: beta Cep (\Omega R~26 km/s), V2052 Oph (\Omega R~56 km/s), delta Cet (\Omega R < 28 km/s) and xi1 CMa (\Omega R sin i < 10 km/s). The existence of core-processed material at the surface of such largely unevolved, slowly-rotating objects is not predicted by current evolutionary models including rotation. We draw attention to the fact that three stars in this subsample have a detected magnetic field and briefly discuss recent theoretical work pointing to the occurrence of diffusion effects in beta Cephei stars possibly capable of altering the nitrogen surface abundance. On the other hand, the abundances of all the other chemical elements considered are, within the errors, indistinguishable from the values found for OB dwarfs in the solar neighbourhood. Despite the mild nitrogen excess observed in some objects, we thus find no evidence for a significantly higher photospheric metal content in the studied beta Cephei stars compared to non-pulsating B-type stars of similar characteristics.Comment: Accepted for publication in A&A, 21 pages, 7 figure

Three-dimensional analysis of a lofted instep kick by male and female footballers

There is a paucity of data describing the lofted instep kick and little information on the kinematic differences between male and female footballers. This study provides a preliminary investigation into the differences in motion patterns between the sexes. A four-camera motion analysis system videoed 13 amateur footballers (7 female and 6 male) attempting a standardised task that represented a lofted instep kick of approximately 35 m. Footballers performed 20 kicks, with the three trials categorised closest to the standardised distance retained for statistical analysis. Three-dimensional motion patterns for kicks of 35 m illustrated that female footballers produced greater fluctuation in movement patterns for pelvic, hip joint and thoracolumbar spine motion in the frontal plane; thorax and hip joint transverse rotation; and ankle dorsiflexion/plantarflexion motion. Peak hip extension (P = 0.018), impact hip abduction (P = 0.032), impact ankle plantar flexion (P = 0.030) and resultant ball velocity (P = 0.004) differed significantly between sexes. Principle component analysis highlighted associations between kinematic variables related to ball velocity and sex including a reduced hip abduction and increased internal rotation approaching impact, and greater peak knee flexion, respectively. In summary, increased variation in direction of segment motion, increased backswing and formation of a tension arc by females compared to males, may be related to anthropometric, strength and muscle activation differences. Specifically, this exploratory study indicates future research would benefit from exploring trunk, pelvis and hip kinematics and kinetics, and whether training the trunk, pelvis and hip musculature assists female footballers.Published versio

Measurement of the t(t)over-bar production cross section in the dilepton channel in pp collisions at √s=8 TeV

The top-antitop quark (t (t) over bar) production cross section is measured in proton-proton collisions at root s = 8 TeV with the CMS experiment at the LHC, using a data sample corresponding to an integrated luminosity of 5.3 fb(-1). The measurement is performed by analysing events with a pair of electrons or muons, or one electron and one muon, and at least two jets, one of which is identified as originating from hadronisation of a bottom quark. The measured cross section is 239 +/- 2 (stat.) +/- 11 (syst.) +/- 6 (lum.) pb, for an assumed top-quark mass of 172.5 GeV, in agreement with the prediction of the standard model

Evidence for Significant Overlap between Common Risk Variants for Crohn's Disease and Ankylosing Spondylitis

BACKGROUND: A multicenter genome-wide association scan for Crohn's Disease (CD) has recently reported 40 CD susceptibility loci, including 29 novel ones (19 significant and 10 putative). To gain insight into the genetic overlap between CD and ankylosing spondylitis (AS), these markers were tested for association in AS patients. PRINCIPAL FINDINGS: Two previously established associations, namely with the MHC and IL23R loci, were confirmed. In addition, rs2872507, which maps to a locus associated with asthma and influences the expression of the ORMDL3 gene in lymphoblastoid cells, showed a significant association with AS (p = 0.03). In gut biopsies of AS and CD patients, ORMDL3 expression was not significantly different from controls and no correlation was found with the rs2872507 genotype (Spearman's rho: -0.067). The distribution of p-values for the remaining 36 SNPs was significantly skewed towards low p-values unless the top 5 ranked SNPs (ORMDL3, NKX2-3, PTPN2, ICOSLG and MST1) were excluded from the analysis. CONCLUSIONS: Association analysis using risk variants for CD led to the identification of a new risk variant associated with AS (ORMDL3), underscoring a role for ER stress in AS. In addition, two known and five potentially relevant associations were detected, contributing to common susceptibility of CD and AS