Relationships between Dimensions of Religiosity and Internalizing and Externalizing Psychiatric Disorders: A Twin Study

The present study estimated the genetic and environmental effects on different dimensions of religiosity, explored how genetic and environmental effects covary across different dimensions of religiosity, and decomposed the covariance of genetic and environmental effects between different dimensions of religiosity and internalizing and externalizing psychiatric disorders. Dimensions of religiosity were found to be largely influenced by additive genetic and unique environmental effects, with little influence observed from common enviromental effects. Multidimensional analyses found that the seven religiosity factors observed in the present study were influenced by one common additive genetic factor, three common unique environmental factors, and unique environmental effects specific to each religiosity factor. Bivariate analyses of the seven religiosity factors and four psychiatric disorders found that the negative correlation between alcohol dependence and six of the seven religiosity factors could be accounted for by additive genetic effects. Similar results were obtained for nicotine dependence and one religiosity factor, Social Religiosity and for phobia and the religiosity factor Unvengefulness with shared genetic factors accounting for the observed correlation. For phobia and the religiosity factor God as Judge , the correlation due to additive genetic factors was positive while that due to common environmental effects was negative. Analysis of a subset of religiosity items showed that for one religiosity factor, additive genetic effects increased over time while common environmental effects decreased. The results of the present study point to the complexity of the religiosity construct and suggest that various dimensions of religiosity are differentially related to various psychiatric disorders

Spherical Mechanism Synthesis in Virtual Reality

This paper presents a new approach to using virtual reality (VR) to design spherical mechanisms. VR provides a three dimensional design space where a designer can input design positions using a combination of hand gestures and motions and view the resultant mechanism in stereo using natural head movement to change the viewpoint. Because of the three dimensional nature of the design and verification of spherical mechanisms, VR is examined as a new design interface in this research. In addition to providing a VR environment for design, the research presented in this paper has focused on developing a “design in context” approach to spherical mechanism design. Previous design methods have involved placing coordinate frames along the surface of a constraint sphere. The new “design in context” approach allows a designer to freely place geometric models of movable objects inside an environment consisting of fixed objects. The fixed objects could either act as a base for a mechanism or be potential sources of interference with the motion of the mechanism. This approach allows a designer to perform kinematic synthesis of a mechanism while giving consideration to the interaction of that mechanism with its application environment

Geophysical tests for habitability in ice-covered ocean worlds

Geophysical measurements can reveal the structure of icy ocean worlds and cycling of volatiles. The associated density, temperature, sound speed, and electrical conductivity of such worlds thus characterizes their habitability. To explore the variability and correlation of these parameters, and to provide tools for planning and data analyses, we develop 1-D calculations of internal structure, which use available constraints on the thermodynamics of aqueous MgSO$_4$, NaCl (as seawater), and NH$_3$, water ices, and silicate content. Limits in available thermodynamic data narrow the parameter space that can be explored: insufficient coverage in pressure, temperature, and composition for end-member salinities of MgSO$_4$ and NaCl, and for relevant water ices; and a dearth of suitable data for aqueous mixtures of Na-Mg-Cl-SO$_4$-NH$_3$. For Europa, ocean compositions that are oxidized and dominated by MgSO$_4$, vs reduced (NaCl), illustrate these gaps, but also show the potential for diagnostic and measurable combinations of geophysical parameters. The low-density rocky core of Enceladus may comprise hydrated minerals, or anydrous minerals with high porosity comparable to Earth's upper mantle. Titan's ocean must be dense, but not necessarily saline, as previously noted, and may have little or no high-pressure ice at its base. Ganymede's silicious interior is deepest among all known ocean worlds, and may contain multiple phases of high-pressure ice, which will become buoyant if the ocean is sufficiently salty. Callisto's likely near-eutectic ocean cannot be adequately modeled using available data. Callisto may also lack high-pressure ices, but this cannot be confirmed due to uncertainty in its moment of inertia

A Rare Novel Deletion of the Tyrosine Hydroxylase Gene in Parkinson Disease

Tyrosine hydroxylase (TH) enzyme is a rate limiting enzyme in dopamine biosynthesis. Missense mutation in both alleles of the TH gene is known to cause dopamine-related phenotypes, including dystonia and infantile Parkinsonism. However, it is not clear if single allele mutation in TH modifies the susceptibility to the adult form of Parkinson disease (PD). We reported a novel deletion of entire TH gene in an adult with PD. The deletion was first identified by copy number variation (CNV) analysis in a genome-wide association study using Illumina Infinium BeadChips. After screening 635 cases and 642 controls, the deletion was found in one PD case but not in any control. The deletion was confirmed by multiple quantitative PCR (qPCR) assays. There is no additional exonic single nucleotide variant in the one copy of TH gene of the patient. The patient has an age-at-onset of 54 years, no evidence for dystonia, and was responsive to L-DOPA. This case supports the importance of the TH gene in PD pathogenesis and raises more attention to rare variants in candidate genes being a risk factor for Parkinson disease. © 2010 Wiley-Liss, Inc

The Otterbein Miscellany - May 1967

https://digitalcommons.otterbein.edu/miscellany/1008/thumbnail.jp

Whole Genome Sequencing of a Methicillin-Resistant Staphylococcus aureus Pseudo-Outbreak in a Professional Football Team.

Two American football players on the same team were diagnosed with methicillin-resistant Staphylococcus aureus (MRSA) skin and soft tissue infections on the same day. Our investigation, including whole genome sequencing, confirmed that players did not transmit MRSA to one another nor did they acquire the MRSA from a single source within the training facility

LACTB is a tumour suppressor that modulates lipid metabolism and cell state

Post-mitotic, differentiated cells exhibit a variety of characteristics that contrast with those of actively growing neoplastic cells, such as the expression of cell-cycle inhibitors and differentiation factors. We hypothesized that the gene expression profiles of these differentiated cells could reveal the identities of genes that may function as tumour suppressors. Here we show, using in vitro and in vivo studies in mice and humans, that the mitochondrial protein LACTB potently inhibits the proliferation of breast cancer cells. Its mechanism of action involves alteration of mitochondrial lipid metabolism and differentiation of breast cancer cells. This is achieved, at least in part, through reduction of the levels of mitochondrial phosphatidylserine decarboxylase, which is involved in the synthesis of mitochondrial phosphatidylethanolamine. These observations uncover a novel mitochondrial tumour suppressor and demonstrate a connection between mitochondrial lipid metabolism and the differentiation program of breast cancer cells, thereby revealing a previously undescribed mechanism of tumour suppression

LACTB is a tumour suppressor that modulates lipid metabolism and cell state

Post-mitotic, differentiated cells exhibit a variety of characteristics that contrast with those of actively growing neoplastic cells, such as the expression of cell-cycle inhibitors and differentiation factors. We hypothesized that the gene expression profiles of these differentiated cells could reveal the identities of genes that may function as tumour suppressors. Here we show, using in vitro and in vivo studies in mice and humans, that the mitochondrial protein LACTB potently inhibits the proliferation of breast cancer cells. Its mechanism of action involves alteration of mitochondrial lipid metabolism and differentiation of breast cancer cells. This is achieved, at least in part, through reduction of the levels of mitochondrial phosphatidylserine decarboxylase, which is involved in the synthesis of mitochondrial phosphatidylethanolamine. These observations uncover a novel mitochondrial tumour suppressor and demonstrate a connection between mitochondrial lipid metabolism and the differentiation program of breast cancer cells, thereby revealing a previously undescribed mechanism of tumour suppression