Thermal quantitative sensory testing in healthy Dutch children and adolescents standardized test paradigm and Dutch reference values

Background: Quantitative sensory testing (QST) is often used to measure children's and adults' detection- and pain thresholds in a quantitative manner. In children especially the Thermal Sensory Analyzer (TSA-II) is often applied to determine thermal detection and pain thresholds. As comparisons between studies are hampered by the different testing protocols used, we aimed to present a standard protocol and reference values for thermal detection- and pain thresholds in children. Methods: Our standard testing protocol includes reaction time dependent and independent tests and takes about 14-18 min to complete. Reference values were obtained from a sample of 69 healthy term born children and adolescents with a median age of 11.2 years (range 8.2 to 17.9 years old). Seventy-one children were recruited and data of 28 males and 41 females was obtained correctly. We studied possible age and sex differences. Results: This study provides Dutch reference values and presents a standard quantitative sensory testing protocol for children with an age from 8 years onwards. This protocol appeared to be feasible, since only two out of 71 participants were not able to correctly complete the protocol due to attention deficits and were therefore excluded. We found some significant age and sex differences: females were statistically significantly more sensitive for both cold and heat pain compared to males, and the youngest children (8-9 years old) were less sensitive to detect a warm stimulus. The youngest children tend to be more sensitive to heat pain in comparison to older participants, although the difference was not statistically significant. Conclusions: We present a feasible thermal quantitative sensory testing protocol for children and reference values that are easy to interpret and may serve as normative values for future studies

Report of a Pest Risk Analysis for Hydrocotyle ranunculoides

Hydrocotyle ranunculoides originates from the American continent and was introduced into the EPPO region as an ornamental plant for tropical aquaria and garden ponds, where it is still sold under its correct name, sometimes under other names (H. vulgaris, H. leucocephala, and H. natans which is a synonym of H. ranunculoides). The plant was first recorded as naturalised in the south-east of the UK in the 1980s (Newman, 2003). Naturalisation in the Netherlands and in Belgium was recorded in the last decade of the twentieth century (Baas & Duistermaat, 1999; Baas & Holverda, 1996; Krabben & Rotteveel, 2003; Verloove 2006, Invasive Species in Belgium Website). Deleterious impacts have been reported in these three countries. The species is also recorded in France, Ireland, Italy, Germany (see EPPO, 2009) but several EPPO countries are still free from H. ranunculoides and there are concerns that it may be able to enter and establish in further countries. This PRA assesses the risks of its further introduction into other EPPO countries and its current and predicted impact. An initial EPPO PRA was performed and approved in 2005. After the proposal of listing this species in the Directive 2000/29, the European Food Safety Authority reviewed the initial PRA and made some comments. The initial PRA is therefore revised in the view of the EFSA comments and of information having become available after the initial PRA (EFSA, 2007)

Pain in Intellectually Disabled Children: Towards Evidence-Based Pharmacotherapy?

This critical opinion article deals with the challenges of finding the most effective pharmacotherapeutic options for the management of pain in intellectually disabled children and provides recommendations for clinical practice and research. Intellectual disability can be caused by a wide variety of underlying diseases and may be associated with congenital anomalies such as cardiac defects, small-bowel obstructions or limb abnormalities as well as with comorbidities such as scoliosis, gastro-esophageal reflux disease, spasticity, and epilepsy. These conditions themselves or any necessary surgical interventions are sources of pain. Epilepsy often requires chronic pharmacological treatment with antiepileptic drugs. These antiepileptic drugs can potentially cause drug–drug interactions with analgesic drugs. It is unfortunate that children with intellectual disabilities often cannot communicate pain to caregivers. Although these children are at high risk of experiencing pain, researchers nevertheless often have to exclude them from trials on pain management because of ethical considerations. We therefore make a plea for prescribers, researchers, patient organizations, pharmaceutical companies, and policy makers to study evidence-based, safe and effective pharmacotherapy in these children through properly designed studies. In the meantime, parents and clinicians must resort to validated pain assessment tools such as the revised FLACC scale

Low-speed impact craters in loose granular media

We report on craters formed by balls dropped into dry, non-cohesive, granular media. By explicit variation of ball density $\rho_{b}$, diameter $D_{b}$, and drop height $H$, the crater diameter is confirmed to scale as the 1/4 power of the energy of the ball at impact: $D_{c}\sim(\rho_{b}{D_{b}}^{3}H)^{1/4}$. Against expectation, a different scaling law is discovered for the crater depth: $d\sim({\rho_{b}}^{3/2}{D_{b}}^{2}H)^{1/3}$. The scaling with properties of the medium is also established. The crater depth has significance for granular mechanics in that it relates to the stopping force on the ball.Comment: experiment; 4 pages, 3 figure

Clinical characterization of 66 patients with congenital retinal disease due to the deep-intronic c.2991+1655A>G mutation in CEP290

Purpose: To describe the phenotypic spectrum of retinal disease caused by the c.2991+1655A>G mutation in CEP290 and to compare disease severity between homozygous and compound heterozygous patients. Methods: Medical records were reviewed for best-corrected visual acuity (BCVA), age of onset, fundoscopy descriptions. Foveal outer nuclear layer (ONL) and ellipsoid zone (EZ) presence was assessed using spectral-domain optical coherence tomography (SD-OCT). Differences between compound heterozygous and homozygous patients were analyzed based on visual performance and visual development. Results: A total of 66 patients were included. The majority of patients had either light perception or no light perception. In the remaining group of 14 patients, median BCVA was 20/195 Snellen (0.99 LogMAR; range 0.12-1.90) for the right eye, and 20/148 Snellen (0.87 LogMAR; range 0.22-1.90) for the left. Homozygous patients tended to be more likely to develop light perception compared to more severely affected compound heterozygous patients (P = 0.080) and are more likely to improve from no light perception to light perception (P = 0.022) before the age of 6 years. OCT data were available in 12 patients, 11 of whom had retained foveal ONL and EZ integrity up to 48 years (median 23 years) of age. Conclusions: Homozygous patients seem less severely affected compared to their compound-heterozygous peers. Improvement of visual function may occur in the early years of life, suggesting a time window for therapeutic intervention up to the approximate age of 17 years. This period may be extended by an intact foveal ONL and EZ on OCT

De ontwikkeling van een informatiesysteem voor invasieve plantensoorten

De laatste decennia kent de Nederlandse flora een sterke toename van exoten. Soorten die door een sterke uitbreiding of verdichting van hun areaal overlast veroorzaken, worden invasieve soorten genoemd. De overlast van invasieve soorten (vaak kortweg invasieven genoemd) kan bestaan uit economische schade en gezondheids- en/of veiligheidsproblemen. Het Ministerie van Landbouw, Natuur en Voedselkwaliteit heeft daarom het Uitvoeringsconsortium Invasieve Plantensoorten een FES‑subsidie verleend om in vier jaar tijd een informatiesysteem over potentieel invasieve exotische plantensoorten op te zetten. Doel is informatie aan te leveren op basis waarvan ingeschat kan worden hoe groot de kans is dat exotische soorten zich bij introductie in Nederland invasief zullen gaan gedragen. Daarnaast is het doel hulp te bieden bij het herkennen van zulke soorten als ze worden geïmporteerd. Het informatiesysteem is ondergebracht in Q-bank

Gradient and Passive Circuit Structure in a Class of Non-linear Dynamics on a Graph

We consider a class of non-linear dynamics on a graph that contains and generalizes various models from network systems and control and study convergence to uniform agreement states using gradient methods. In particular, under the assumption of detailed balance, we provide a method to formulate the governing ODE system in gradient descent form of sum-separable energy functions, which thus represent a class of Lyapunov functions; this class coincides with Csisz\'{a}r's information divergences. Our approach bases on a transformation of the original problem to a mass-preserving transport problem and it reflects a little-noticed general structure result for passive network synthesis obtained by B.D.O. Anderson and P.J. Moylan in 1975. The proposed gradient formulation extends known gradient results in dynamical systems obtained recently by M. Erbar and J. Maas in the context of porous medium equations. Furthermore, we exhibit a novel relationship between inhomogeneous Markov chains and passive non-linear circuits through gradient systems, and show that passivity of resistor elements is equivalent to strict convexity of sum-separable stored energy. Eventually, we discuss our results at the intersection of Markov chains and network systems under sinusoidal coupling

#Sleepyteens: social media use in adolescence is associated with poor sleep quality, anxiety, depression and low self-esteem

This study examined how social media use related to sleep quality, self-esteem, anxiety and depression in 467 Scottish adolescents. We measured overall social media use, nighttime-specific social media use, emotional investment in social media, sleep quality, self-esteem and levels of anxiety and depression. Adolescents who used social media more – both overall and at night – and those who were more emotionally invested in social media experienced poorer sleep quality, lower self-esteem and higher levels of anxiety and depression. Nighttime-specific social media use predicted poorer sleep quality after controlling for anxiety, depression and self-esteem. These findings contribute to the growing body of evidence that social media use is related to various aspects of wellbeing in adolescents. In addition, our results indicate that nighttime-specific social media use and emotional investment in social media are two important factors that merit further investigation in relation to adolescent sleep and wellbeing

Опыт применения криохирургии в гинекологии

Приведены результаты применения низких температур для лечения ряда гинекологических заболеваний и обоснована необходимость широкого внедрения криогенного метода лечения в клиническую практику.The results of low temperature application in treatment of a number of gynecological diseases are presented, the necessity of wide introduction of cryogenic treatment into clinical practice is substantiated

Pest risk analysis for Myriophyllum heterophyllum

Myriophyllum heterophyllum presents an overall high phytosanitary risk for the EPPO region with a low uncertainty rating. The overall likelihood of M. heterophyllum continuing to enter the EPPO region is high. The plant is imported into the EPPO region as a misidentified aquatic species for aquaria and ponds and is already established in Austria, Belgium, France, Germany, Hungary, the Netherlands, Spain and Switzerland. The risk of entry into other EPPO countries through import is considered high. The risk of the species establishing in additional countries is high as movement through irrigation and river systems acts to connect countries, facilitating spread regionally. Spread may be accelerated by recreational activities in water bodies invaded by the weed. Impacts of the species within the EPPO region are likely to be severe (high score rating), including aquatic plant species displacement, habitat dominance and effects on other aquatic organisms