Integrating data from heterogeneous DNA microarray platforms

DNA microarrays are one of the most used technologies for gene expression measurement. However, there are several distinct microarray platforms, from different manufacturers, each with its own measurement protocol, resulting in data that can hardly be compared or directly integrated. Data integration from multiple sources aims to improve the assertiveness of statistical tests, reducing the data dimensionality problem. The integration of heterogeneous DNA microarray platforms comprehends a set of tasks that range from the re-annotation of the features used on gene expression, to data normalization and batch effect elimination. In this work, a complete methodology for gene expression data integration and application is proposed, which comprehends a transcript-based re-annotation process and several methods for batch effect attenuation. The integrated data will be used to select the best feature set and learning algorithm for a brain tumor classification case study. The integration will consider data from heterogeneous Agilent and Affymetrix platforms, collected from public gene expression databases, such as The Cancer Genome Atlas and Gene Expression Omnibus.The authors thank the FCT Strategic Project of UID/BIO/04469/2013 unit, the project RECI/BBBEBI/0179/2012 (FCOMP-01-0124-FEDER-027462) and the project BioInd - Biotechnology and Bioengineering for improved Industrial and Agro-Foodprocesses”, REF.NORTE-07-0124FEDER-000028 Co-funded by the Programa Operacional Regional do Norte (ON.2 O Novo Norte), QREN, FEDER

External brand extensions impact on Diesel's brand image

A Work Project, presented as part of the requirements for the Award of a Masters Degree in Management from the NOVA – School of Business and EconomicsDiesel is a global urban brand that privileges individuality and irreverence. This project measures Diesel brand image within the different types of Portuguese consumers; the objective is to understand the main buying drivers and analyze the impact of brand licensing. It was concluded that Diesel global brand image is consensual among the consumers of each product category, but the purchasing drivers differ among them; Clothing and Time Frames consumers refer the brand itself as the main driver, while Shades and Fragrances consumers refer product attributes as the main driver. Additionally, Time Frames consumers reacted negatively when informed about the brand licensing, while Shades and Fragrances consumers tended to react positively

Data quality and dependability of IOT Platform for buildings energy assessment

Tese de mestrado, Informática, Universidade de Lisboa, Faculdade de Ciências, 2022In the domain of IoT(Internet of Things), there is a correlation between the efficiency and effectiveness of a platform, and the quality of the data available for processing and decision making. When a scenario of data collection from different types of sensors, integrated into several devices that are distributed alongside the building, is presented. And, considering that data is essential to monitor and control the level of actuation in the building, the process becomes a matter of extreme importance. To achieve this, ANNODE’s methodology is adopted for quality verification of each measurement that arrives to the framework. The construction and utilization of neural net works are crucial points of this project, as well as, the correct application of dependability concepts, and notions of efficiency in processes of outlier detection and fault mitigation

Modelling fed-batch fermentation processes: An approach based on artificial neural networks

Publicado em "2nd International Workshop on Practical Applications of Computational Biology and Bioinformatics (IWPACBB 2008)", ISBN 978-3-540-85860-7Artificial Neural Networks (ANNs) have shown to be powerful tools for solving several problems which, due to their complexity, are extremely difficult to unravel with other methods. Their capabilities of massive parallel processing and learning from the environment make these structures ideal for prediction of nonlinear events. In this work, a set of computational tools are proposed, allowing researchers in Biotechnology to use ANNs for the modelling of fed-batch fermentation processes. The main task is to predict the values of kinetics parameters from the values of a set of state variables. The tools were validated with two case studies, showing the main functionalities of the application.This work was supported by the Portuguese FCT under project POSC/EIA/59899/2004

The impacts of bus lanes on urban traffic environment

Tese de mestrado. Transportes. Faculdade de Engenharia. Universidade do Porto. 200

Ties between business model innovation and entrepreneurial finance: A case in the employer branding industry

CEMSThis report describes a business project conducted by a team of CEMS students at Nova SBE, where they were tasked with redefining an employer branding consultant’s product portfolio as part of a larger strategic change. The company is benchmarked against other B2B business models and a study is conducted into customer needs and ideal segmentation. The final recommendation of a modular offering built on a subscription-based online platform is derived from the identified customer needs and sector best practices. Finally, ties are found between the project and entrepreneurial finance theory, and future research ideas are presented

Integração de ferramentas de desenvolvimento no eclipse

Trabalho de projecto de mestrado em Engenharia Informática, apresentado à Universidade de Lisboa, através da Faculdade de Ciências, 2007Nos tempos que correm, são cada vez mais utilizadas ferramentas que facilitam o trabalho a quem desenvolve software. Isto acontece por razões óbvias, sendo a mais determinante a de permitir ao programador preocupar-se o menos possível, compormenores irrelevantes ao processo de criação de software, sejam eles inerentes à linguagem, o memorizar da totalidade das bibliotecas disponíveis ou o descobrir a localização de erros de sintaxe. O aparecimento deste tipo de ferramentas tem vindo a rentabilizar bastante o trabalho de quem as usa, não só em termos de velocidade mas, também de criatividade já que, menos interrupções ao raciocínio permitem ir mais longe em termos de abstracção e complexidade. Neste contexto, a plataforma de desenvolvimento Eclipse tem tomado uma posição dianteira face a outras por várias razões. Destacam-se a facilidade de utilização, o excelente apoio à linguagem Java, e talvez a mais relevante para o contexto deste projecto, a possibilidade de alterar funcionalidades já existentes e até a de criar outras novas, integrando-as na plataforma. Esta mais valia tem proporcionado, nos últimos tempos, uma adaptação da plataforma original aos objectivos, gostos e preferências dos elementos de várias empresas sendo mesmo, muitas vezes criada uma nova versão do Eclipse à medida de cada um. Este projecto tem como objectivo a integração de novas funcionalidades no Eclipse, entre as quais, um construtor específico para uma linguagem usada internamente, acompanhado de todas as funcionalidades que permitam e maximizem o seu uso. Tendo como objectivo principal o de rentabilizar e facilitar o desenvolvimento de software da empresa EF Tecnologias de Software, SA, este projecto foi elaborado no âmbito da disciplina de Projecto em Engenharia Informàtica, com uma duração de nove meses e com o objectivo de obter o grau de Mestre em Engenharia Informática.Nowadays we are witnessing a growing use of software development tools. The main objective of these tools is to allow the programmer to waste, as little time as possible, with irrelevant details to the process of software creation. Like errors inherent to the language nature, memorizing all of the available libraries or discovering the exact lines where syntax errors occur. The growing use of this type of tools has improved dramatically the work of whom uses them, not only at the level of creativity but also the development speed. This advantage allows the developer to focus on the real issue, reaching higher levels of abstraction and complexity. In this context, the development platform Eclipse has taken a lead position, among other platforms. It´s easy to use, it as excellent Java language support, and perhaps the most important feature for this project, the possibility to modify existing features and even to create new ones, integrating them in the platform. These features have allowed, in the last years, an evolution of the original platform to meet the users goals, tastes and preferences, sometimes even originating a new version of the Eclipse, built to meet specific needs. This project’s goal is the integration of new functionalities in the Eclipse platform. Among these tools, a builder for an internally used language, along with all the features that allow and maximize its use. To increase the productivity and ease up the work of the elements of the company EF Tecnologias de Software, SA is this application’s main goal. It was developed in the scope of project of Engineering Computer Sciences, with a duration of nine months and the goal of achieving the degree of Master in Engineering Computer Sciences