Evaluation of residue levels of imidacloprid and thiamethoxam after foliar application to the citrus varieties Lane Late, Valencia Late, Rohde Summer, and Nules

Neonicotinoids are used to protect citrus trees against pests. Dissipation and persistence of neonicotinoids in pollen and nectar of citrus trees after foliar applications and their potential exposure to pollinators have not been well characterized. Field studies were conducted using three orange and one mandarin varieties to compare the imidacloprid and thiamethoxam residue levels and their decline in pollen and nectar after treatments in pre-bloom close to flowering period and their persistence 1 yr after treatment. The possible risk to honeybees was assessed. In nectar, thiamethoxam and imidacloprid residues were between 61 and 99% lower than in pollen, depending on the citrus variety or/and the days after treatment when applied close to blooming. At the end of the flowering period, imidacloprid in pollen and nectar was not detected in the mandarin variety after treatment in pre-bloom, whereas for thiamethoxam, no residues were detected in nectar but 10 ng/g was detected in pollen. There were no quantifiable levels of residues for either neonicotinoids in pollen or nectar during the flowering period of the following year. Neonicotinoid residue levels and their decline in nectar and pollen in citrus depended on the timing of applications relative to flowering and on the citrus variety. The absence of neonicotinoid residues 1 yr out after foliar applications in all varieties assayed demonstrated that none of the neonicotinoids tested were persistent. The results could be different in other citrus varieties, and therefore, also the exposure assessment for managed pollinators.info:eu-repo/semantics/acceptedVersio

La Montaña Palentina

Producción CientíficaEstudio del medio físico, población, poblamiento, economía y nivel de vida de la Montaña Palentina, analizando los problemas existentes, potencialidades y propuestas de actuación.GeografíaEstudio realizado en el marco del Convenio firmado entre la Consejería de Economía y Hacienda de la Junta de Castilla y León y la Universidad de Valladolid con fecha 26 de febrero de 1999

Los procedimientos en los Diseños Curriculares Base de primaria: Un análisis critico

Una nueva etapa de Reforma de la educación se inicia en España que afecta tanto a su estructura (determinación de las diferentes etapas y duración de las mismas), como a los contenidos y a metodología. Este trabajo sobre los procedimientos, está dirigido a una parte de este proceso de cambio relacionado con el modo propuesto en los Diseños Curriculares Base (DCB) de abordar los contenidos de la enseñanza

Innovaciones y mejoras en el proyecto tutoría entre compañeros. Curso 2015-2016

Memoria ID-0137. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2015-2016

Efficacy of Budesonide Orodispersible Tablets as Induction Therapy for Eosinophilic Esophagitis in a Randomized Placebo-Controlled Trial.

BACKGROUND & AIMS: Swallowed topical-acting corticosteroids are recommended as first-line therapy for eosinophilic esophagitis (EoE). Asthma medications not optimized for esophageal delivery are sometimes effective, although given off-label. We performed a randomized, placebo-controlled trial to assess the effectiveness and tolerability of a budesonide orodispersible tablet (BOT), which allows the drug to be delivered to the esophagus in adults with active EoE. METHODS: We performed a double-blind, parallel study of 88 adults with active EoE in Europe. Patients were randomly assigned to groups that received BOT (1 mg twice daily; n = 59) or placebo (n = 29) for 6 weeks. The primary end point was complete remission, based on clinical and histologic factors, including dysphagia and odynophagia severity ≤2 on a scale of 0-10 on each of the 7 days before the end of the double-blind phase and a peak eosinophil count <5 eosinophils/high power field. Patients who did not achieve complete remission at the end of the 6-week double-blind phase were offered 6 weeks of open-label treatment with BOT (1 mg twice daily). RESULTS: At 6 weeks, 58% of patients given BOT were in complete remission compared with no patients given placebo (P < .0001). The secondary end point of histologic remission was achieved by 93% of patients given BOT vs no patients given placebo (P < .0001). After 12 weeks, 85% of patients had achieved remission. Six-week and 12-week BOT administration were safe and well tolerated; 5% of patients who received BOT developed symptomatic, mild candida, which was easily treated with an oral antifungal agent. CONCLUSIONS: In a randomized trial of adults with active EoE, we found that budesonide oral tablets were significantly more effective than placebo in inducing clinical and histologic remission. Eudra-CT number 2014-001485-99; ClinicalTrials.gov ID NCT02434029

Neonicotinoid contamination in wildflowers collected from citrus orchards in a northwestern Mediterranean Region (Spain) after tree foliar treatments

Ground-cover vegetation attracts and harbors beneficial insects to the agrosystem, playing an important role in conservation biological control. Integrated pest management (IPM) program guidelines recommend the implantation of sowed or resident wild covers in perennial crops. Given the high-quality fruit requirements, even in IPM programs, insecticides can be required in citrus crops. This study presents, over a year, the levels of neonicotinoids (thiamethoxam and imidacloprid) in not-target ground-cover wildflowers growing spontaneously in citrus orchards after foliar treatment of citrus trees. The presence and persistence of these neonicotinoids in different wildflower species were studied. Concentrations of thiamethoxam and imidacloprid in whole wildflowers ranged from < method quantification limit (MQL) to 52.9 ng g−1 and from < MQL to 98.6 ng g−1, respectively. Thiamethoxam was more frequently detected than imidacloprid. Thiamethoxam and imidacloprid were detected up to 336 and 230 days after treatment, respectively. The highest detection frequencies (100%) and highest thiamethoxam and imidacloprid mean concentrations (26.0 ± 7.3 ng g−1 and 11.0 ± 10.6 ng g−1, respectively) occurred in wildflowers collected 9 days after the treatments. Since application, a clear decrease in the concentration of both compounds and differences in the accumulation depending on wildflower species were observed. Cross contamination was detected, indicating a transport from adjacent treated plots. Maintaining a cover crop in citrus orchards may lead to detrimental effects on non-target arthropods if these neonicotinoid compounds are used for pest control since they can entail a chronic exposure during at least 230 days for imidacloprid and 336 days for thiamethoxam.info:eu-repo/semantics/publishedVersio

A review of glacial geomorphology and chronology in northern Spain: Timing and regional variability during the last glacial cycle

In this paper we synthesize the research in glacial geomorphology and geochronology in northern Spain, with special attention to the evidence of local glacier maximum extent earlier than the global LGM of MIS 2 (18-21. ka BP). More accurate models of glacier evolution have been defined based on limnogeological, geochronological and geomorphological data. In the Pyrenees, OSL (Optically Stimulated Luminescence), surface exposure and radiocarbon dating techniques have identified end moraines and fluvial terraces corresponding to MIS 6 (about 170. ka) and even to MIS 8 (about 260. ka), and also established the timing of the last local glacial maxima as prior to global LGM (MIS 4, ca. 50-70. ka). During the global LGM a smaller re-advance occurred but glaciers reached different extents in the Central and the Eastern Pyrenees. In NW Iberia, radiocarbon and OSL techniques point to local glacial maximum prior to ca 26. ka-38. ka and probably synchronous with 45. ka. Although some bias might have been introduced by the dating procedures, this review demonstrates that in both regions the local maximum extent occurred prior to the global LGM. The asynchronies between the glacial maxima chronologies in the different mountain ranges of northern Spain suggest that local climate factors exert a strong control on mountain glacier dynamics. © 2012 Elsevier B.V.This research has been funded through the projects LIMNOCAL (CGL2006-13327-C04-01) and GRACCIE (CONSOLIDER Program, CSD2007-00067) provided by the Spanish Inter-Ministry Commission of Science and Technology (CICYT). Additional funding was provided by the Spanish National Parks Agency (OAPN) through the Project 53/2006 and the Fundación Patrimonio Natural de Castilla y León (Sanabria project); and by the Project PC 10‐14 (Geoarchaeology and Global Change in Asturias) provided by FICYT-RIOGLASS. The authors thank Dr. Cendrero, Dr. Woodward and another anonymous reviewer for their comments and suggestions that contributed to improve the original manuscript. L. Rodríguez-Rodríguez has developed her research under a Severo Ochoa Programme fellowship (FICYT- Asturias).Peer Reviewe

Effects of usual yoga practice on the diaphragmatic contractility: A cross-sectional controlled study

Objectives: The aim of this study is to observe and compare the effects of regular yoga practice on the main inspiratory muscle, the diaphragm, by analyzing its thickness, excursion, velocity and contraction time, using ultrasound. Design: A Cross-Sectional Controlled Study. Participants: 80 healthy subjects (40 habitual yoga practitioners and 40 non-practitioners), without previous respiratory pathology participated in this study. During maximum diaphragmatic breathing, the diaphragmatic thickness (at rest and after maximum inspiration), excursion, velocity and contraction time were measured by ultrasound. Results: in the experimental group, practicing yoga, statistically significant differences (p < 0.001) were observed compared to the control group, not practicing, in the thickness of the diaphragm at rest (0.26 ± 0.02 vs 0.22 ± 0.01 cm); the diaphragmatic thickness in maximum inspiration (0.34 ± 0.03 vs 0.28 ± 0.03 cm); contraction velocity (1.54 ± 0.54 vs 2.23 ± 0.86 cm/s), contraction time (3.28 ± 0.45 vs 2.58 ± 0.49 s) and Borg scale of perceived exertion (1.05 ± 1.6 vs 1.70 ± 1.34), p = 0.05. However, the diaphragmatic excursion was greater in the control group (5.45 ± 1.42 vs 4.87 ± 1.33 cm) with no statistically significant differences (p = 0.06). Conclusions: the regular practice of yoga improves the parameters of diaphragm thickness, speed and contraction time measured in ultrasound and the sensation of perceived exertion during a maximum inspiration. So it can be considered as another method for training the inspiratory muscles in clinical practice

Los procedimientos en los Diseños Curriculares Base de primaria: Un análisis critico

El actual proceso de Reforma del Sistema Educativo introduce nuevas perspectivas, una de ellas son los «contenidos procedimentales». En este breve trabajo pretendemos fundamentar esa propuesta en un contexto más amplio que el de los contenidos, proponer una alternativa global y analizar desde ésta, el desarrollo realizado por el Ministerio de Educación y Ciencia en los Diseños Curriculares Base de Primaria