1,518 research outputs found
Stroke in Patients with Schistosomiasis: Review of Cases in Literature
Introduction. Cerebral vascular comorbidities may occur in patients with schistosomiasis, as described in case reports. Aim and Methods. We have summarized general clinical and neurological features in patients with stroke associated with schistosomiasis, through a review of case reports in the literature. Investigation Outcomes. A total of eight case reports were retrieved. The mean age of patients was 36.42 +/- 16.7 (19 to 56 years), four females, three males, and one anonymous sex. Eosinophilia was the most frequent feature at presentation, followed by cardiac abnormalities, confusion, fever, ataxia, hemiplegia, headache, urticaria, dysphasia, and memory impairment. Patients usually present with watershed infarction or intracranial vasculitis. In one case, extracranial carotid arteries presented with inflammation and stenosis. The patient's serology was positive on admission in five cases. Full neurological recovery was reported in three cases, and partial improvement in another three. In two cases, information on neurological outcomes was incomplete. Stroke in schistosomiasis can be caused by haemodynamic impairment, direct lesion to the arterial wall, vasa vasorum obliterative endarteritis, contiguity with a focus of inflamed tissue, or inflammatory intimal damage. Schistosomiasis needs to be included in the differential diagnosis of stroke in people living or coming back from endemic areas. Conclusions. Further studies addressing the noncommunicable comorbidity issues related to this condition are needed
Inhibition of dengue virus replication by novel inhibitors of RNA-dependent RNA polymerase and protease activities
Dengue virus (DENV) is the leading mosquito-transmitted viral infection in the world. With more than 390 million new infections annually, and up to 1 million clinical cases with severe disease manifestations, there continues to be a need to develop new antiviral agents against dengue infection. In addition, there is no approved anti-DENV agents for treating DENV-infected patients. In the present study, we identified new compounds with anti-DENV replication activity by targeting viral replication enzymes – NS5, RNA-dependent RNA polymerase (RdRp) and NS3 protease, using cell-based reporter assay. Subsequently, we performed an enzyme-based assay to clarify the action of these compounds against DENV RdRp or NS3 protease activity. Moreover, these compounds exhibited anti-DENV activity in vivo in the ICR-suckling DENV-infected mouse model. Combination drug treatment exhibited a synergistic inhibition of DENV replication. These results describe novel prototypical small anti-DENV molecules for further development through compound modification and provide potential antivirals for treating DENV infection and DENV-related diseases
Extra galactic sources of high energy neutrinos
The main goal of the construction of large volume, high energy neutrino
telescopes is the detection of extra-Galactic neutrino sources. The existence
of such sources is implied by observations of ultra-high energy, >10^{19} eV,
cosmic-rays (UHECRs), the origin of which is a mystery. The observed UHECR flux
sets an upper bound to the extra-Galactic high energy neutrino intensity, which
implies that the detector size required to detect the signal in the energy
range of 1 TeV to 1 PeV is >=1 giga-ton, and much larger at higher energy.
Optical Cerenkov neutrino detectors, currently being constructed under ice and
water, are expected to achieve 1 giga-ton effective volume for 1 TeV to 1 PeV
neutrinos. Coherent radio Cerenkov detectors (and possibly large air-shower
detectors) will provide the >> 1 giga-ton effective volume required for
detection at ~10^{19} eV. Detection of high energy neutrinos associated with
electromagnetically identified sources will allow to identify the sources of
UHECRs, will provide a unique probe of the sources, which may allow to resolve
open questions related to the underlying physics of models describing these
powerful accelerators, and will provide information on fundamental neutrino
properties.Comment: 8 pages, 4 figures; Summary of talk presented at the Nobel Symposium
129: Neutrino Physics, Sweden 200
The Chromospheric Activity and Ages of M Dwarf Stars in Wide Binary Systems
We investigate the relationship between age and chromospheric activity for
139 M dwarf stars in wide binary systems with white dwarf companions. The age
of each system is determined from the cooling age of its white dwarf component.
The current limit for activity-age relations found for M dwarfs in open
clusters is 4 Gyr. Our unique approach to finding ages for M stars allows for
the exploration of this relationship at ages older than 4 Gyr. The general
trend of stars remaining active for a longer time at later spectral type is
confirmed. However, our larger sample and greater age range reveals additional
complexity in assigning age based on activity alone. We find that M dwarfs in
wide binaries older than 4 Gyr depart from the log-linear relation for clusters
and are found to have activity at magnitudes, colors and masses which are
brighter, bluer and more massive than predicted by the cluster relation. In
addition to our activity-age results, we present the measured radial velocities
and complete space motions for 161 white dwarf stars in wide binaries.Comment: 22 pages including 9 figures and 5 tables. Accepted for publication
in The Astronomical Journa
Development status of a Laue lens project for gamma-ray astronomy
We report the status of the HAXTEL project, devoted to perform a design study
and the development of a Laue lens prototype. After a summary of the major
results of the design study, the approach adopted to develop a Demonstration
Model of a Laue lens is discussed, the set up described, and some results
presented.Comment: 11 pages, 11 figures, 2007 SPIE Conference on Optics for EUV, X-Ray,
and Gamma-Ray Astronomy II
Dark halo baryons not in ancient halo white dwarfs
Having ruled out the possibility that stellar objects are the main
contributor of the dark matter embedding galaxies, microlensing experiments
cannot exclude the hypothesis that a significant fraction of the Milky Way dark
halo might be made of MACHOs with masses in the range 0.5-0.8 \msun. Ancient
white dwarfs are generally considered the most plausible candidates for such
MACHOs. We report the results of a search for such white dwarfs in a proper
motion survey covering a 0.16 sqd field at three epochs at high galactic
latitude, and 0.938 sqd at two epochs at intermediate galactic latitude (VIRMOS
survey), using the CFH telescope. Both surveys are complete to I = 23, with
detection efficiency fading to 0 at I = 24.2. Proper motion data are suitable
to separate unambiguously halo white dwarfs identified by belonging to a non
rotating system. No candidates were found within the colour-magnitude-proper
motion volume where such objects can be safely discriminated from any standard
population as well as from possible artefacts. In the same volume, we estimate
the maximum white dwarf halo fraction compatible with this observation at
different significance levels if the halo is at least 14 gigayears old and
under different ad hoc initial mass functions. Our data alone rules out a halo
fraction greater than 14% at 95% confidence level. Combined with two previous
investigations exploring comparable volumes pushes the limit below 4 % (95%
confidence level) or below 1.3% (64% confidence), this implies that if baryonic
dark matter is present in galaxy halos, it is not, or it is only marginally in
the form of faint hydrogen white dwarfs.Comment: accepted in Astronomy and Astrophysics (19-05-2004
The Big Trip and Wheeler-DeWitt equation
Of all the possible ways to describe the behavior of the universe that has
undergone a big trip the Wheeler-DeWitt equation should be the most accurate --
provided, of course, that we employ the correct formulation. In this article we
start by discussing the standard formulation introduced by Gonz\'alez-D\'iaz
and Jimenez-Madrid, and show that it allows for a simple yet efficient method
of the solution's generation, which is based on the Moutard transformation.
Next, by shedding the unnecessary restrictions, imposed on aforementioned
standard formulation we introduce a more general form of the Wheeler-DeWitt
equation. One immediate prediction of this new formula is that for the universe
the probability to emerge right after the big trip in a state with will
be maximal if and only if .Comment: accepted in Astrophysics and Space Scienc
Phantom scalar emission in the Kerr black hole spacetime
We study the absorption probability and Hawking radiation spectra of a
phantom scalar field in the Kerr black hole spacetime. We find that the
presence of the negative kinetic energy terms modifies the standard results in
the greybody factor, super-radiance and Hawking radiation. Comparing with the
usual scalar particle, the phantom scalar emission is enhanced in the black
hole spacetime.Comment: 11 pages, 6 figures, a revised version accepted for publication in
CQ
Planck-LFI radiometers' spectral response
The Low Frequency Instrument (LFI) is an array of pseudo-correlation
radiometers on board the Planck satellite, the ESA mission dedicated to
precision measurements of the Cosmic Microwave Background. The LFI covers three
bands centred at 30, 44 and 70 GHz, with a goal bandwidth of 20% of the central
frequency.
The characterization of the broadband frequency response of each radiometer
is necessary to understand and correct for systematic effects, particularly
those related to foreground residuals and polarization measurements. In this
paper we present the measured band shape of all the LFI channels and discuss
the methods adopted for their estimation. The spectral characterization of each
radiometer was obtained by combining the measured spectral response of
individual units through a dedicated RF model of the LFI receiver scheme.
As a consistency check, we also attempted end-to-end spectral measurements of
the integrated radiometer chain in a cryogenic chamber. However, due to
systematic effects in the measurement setup, only qualitative results were
obtained from these tests. The measured LFI bandpasses exhibit a moderate level
of ripple, compatible with the instrument scientific requirements.Comment: 16 pages, 9 figures, this paper is part of the Prelaunch status LFI
papers published on JINST:
http://www.iop.org/EJ/journal/-page=extra.proc5/jins
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