Paediatric non-alcoholic fatty liver disease: impact on patients and mothers' quality of life

Background: Non-alcoholic fatty liver disease (NAFLD) is one of the causes of fatty liver in adults and is currently the primary form of chronic liver disease in children and adolescents. However, the psychological outcome (i.e. the behavioural problems that can in turn be related to psychiatric conditions, like anxiety and mood disorders, or lower quality of life) in children and adolescents suffering of NAFLD has not been extensively explored in the literature. Objectives: The present study aims at evaluating the emotional and behavioural profile in children suffering from NAFLD and the quality of life in their mothers. Patients and Methods: A total of 57 children (18 females/39 males) with NAFLD were compared to 39 age-matched control children (25 females/14 males). All participants were submitted to the following psychological tools to assess behavior, mood, and anxiety: the Multidimensional Anxiety Scale for Children (MASC), the Child Behavior Checklist (CBCL), and the Children's Depression Inventory (CDI). Moreover, the mothers of 40 NAFLD and 39 control children completed the World Health Organization Quality of Life-BREF (WHOQOL-BREF) questionnaire. Results: NAFLD children scored significantly higher as compared to control children in MASC (P = 0.001) and CDI total (P < 0.001) scales. The CBCL also revealed significantly higher scores for NAFLD children in total problems (P = 0.046), internalizing symptoms (P = 0.000) and somatic complaints (P < 0.001). The WHOQOL-BREF revealed significantly lower scores for the mothers of NAFLD children in the overall perception of the quality of life (P < 0.001), and in the "relationships" domain (P = 0.023). Conclusions: Increased emotional and behavioural problems were detected in children with NAFLD as compared to healthy control children, together with an overall decrease in their mothers' quality of life. These results support the idea that these patients may benefit from a psychological intervention, ideally involving both children and parents, whose quality of life is likely negatively affected by this disease

Micro RNA facilitated chemoresistance in gastric cancer: a novel biomarkers and potential therapeutics

Introduction: In spite of the substantial advances in clinical practice, Gastric cancer (GC) remains the third leading cause of cancer death worldwide. The incidence of drug resistance remains a hindrance to effective treatment for GC. Although the molecular mechanisms of chemoresistance have broadly studied, the gene regulation and expression mechanisms of miRNA have not entirely understood. Methods: Online databases of PubMed, Scopus, Google Scholar, and Embase databases were searched to retrieve relevant publications. The following keywords were used: MicroRNA, Noncoding RNA, miRNA, Gastric cancer, drug resistance, and chemoresistance. Results: miRNAs play a pivotal role in the initiation, progression of tumor and metastasis, as well as in the development of pathways mediating resistance to chemotherapy in GC. Unluckily, to date, there is no consistent, reliable biomarker available to predict the response of chemotherapy before the start of the treatment. Discussion: In this review, we would like to provide an overview of the miRNAs and miRNA facilitated chemoresistance machinery in GC to develop a personalized treatment to overcome GC drug resistance

Resurfacing Capitate Pyrocarbon Implant for the treatment of advanced wrist arthritis in the elderly: a retrospective study

OBJECTIVE: Advanced forms of wrist osteoarthritis in the elderly are quite common and often under-treated, preferring a conservative management of the condition due to the age of the patient. However, in elderly people who are still active, sporty and physically demanding, surgical management of wrist osteoarthritis should be considered. Proximal Row Carpectomy associated with a Resurfacing Capitate Pyrocarbon Implant (RCPI), allows the management of a wide range of wrist arthrosis, involving both the radio-carpal and the mid-carpal joints. This treatment has been already reported as a solution in younger people affected by degenerative pathologies of the wrist, giving overall good results. Authors aimed at verifying how this technique could be useful in elderly patients, resolving the severe pain often related to this pathology and letting them recover strength and motion. PATIENTS AND METHODS: This is a retrospective analysis involving 7 cases of elderly men (mean age = 68 y.o.), suffering from severe wrist arthritis and treated with RCPI between 2016 and 2021. RESULTS: All patients reported a return to manual activities between 6 and 12 months after surgery, significantly improving pain. Two patients complained moderate pain under strain at follow-up, with residual difficulty in performing manual tasks. In all cases, an increase of strength and improvement in terms of stiffness was registered. No cases of infections or implant mobilization were reported. CONCLUSIONS: RCPI combined with proximal row carpectomy shows satisfying results in all published studies and it has been confirmed in our series as well. Indications for this procedure should be widened to elderly people, as useful alternatives to more aggressive salvage procedures, such as total prosthesis or arthrodesis

Perfect secrecy cryptography via mixing of chaotic waves in irreversible time-varying silicon chips

A.D.F. acknowledges support from EPSRC (EP/L017008/1). A.F. acknowledges support from KAUST (OSR-2016-CRG5-2995). The research data underpinning this publication can be accessed at https://doi.org/10.17630/19156fc3-cc1f-4ee3-b553-f02042cf89a0.Protecting confidential data is a major worldwide challenge. Classical cryptography is fast and scalable, but its broken by quantum algorithms. Quantum cryptography is unclonable, but requires quantum installations that are more expensive, slower, and less scalable than classical optical networks. Here we show a perfect secrecy cryptography in classical optical channels. The system exploits correlated chaotic wavepackets, which are mixed in inexpensive and CMOS compatible silicon chips. The chips can generate 0:1 Tbit of different keys for every mm of length of the input channel, and require the transmission of an amount of data that can be as small as 1/1000 of the message’s length. We discuss the security of this protocol for an attacker with unlimited technological power, and who can access the system copying any of its part, including the chips. The second law of thermodynamics and the exponential sensitivity of chaos unconditionally protect this scheme against any possible attack.Publisher PDFPeer reviewe

EU-DEMO divertor: Cassette design and PFCs integration at pre-conceptual stage

The pre-conceptual design of the DEMO divertor cassette with a novelty, alternative path of the main cooling pipes inside cassette body is presented in this paper, focusing on cassette design and Plasma Facing Components (PFC) integration. The divertor cassette design is reviewed, considering recent updates in the DEMO configuration model as presented by the Programme Management Unit (PMU) in 2018. The new configuration requires the cooling pipes to be integrated inside the cassette body. The components affected by these changes and the impact on the divertor design are analyzed. The study focuses on a new integration system between cassette and cooling pipes. The paper describes the integration on the new cassette geometry and the divertor sub-systems. The design activities related to this system are discussed in detail in terms of CAD modeling and considerations with respect to manufacturing such as welding technologies and non-destructive testing

Shape Transition of Nanostructures created on Si(100) surfaces after MeV Implantation

We have studied the modification in the Surface morphology of the Si(100) surfaces after 1.5 MeV Sb implantation. Scanning Probe Microscopy has been utilized to investigate the ion implanted surfaces. We observe the formation of nano-sized defect features on the Si surfaces for various fluences. These nanostructures are elliptical in shape and inflate in sizefor higher fluences. Furthermore, these nanostructures undergo a shape transition from an elliptical shape to a circular-like at a high fluence. We will also discuss the modification in surface roughness as a function of Sb fluence.Comment: 9 pages, 4 figure

Insulated fixation system of plasma facing components to the divertor cassette in Eurofusion-DEMO

The design activities of an insulated Plasma Facing Components-Cassette Body (PFCs-CB) support has been carried out under the pre-conceptual design phase for Eurofusion-DEMO Work Package DIV-1 \u201cDivertor Cassette Design and Integration\u201d - Eurofusion Power Plant Physics & Technology (PPPT) program. The Eurofusion-DEMO divertor is a key in-vessel component with PFCs which directly interact with the plasma scrape-off layer. The PFCs have to cope with high heat loads, neutron irradiation and electromagnetic loads. The mechanical integrity of the PFCs and water cooling pipes can be jeopardized by high heat loads and by electromagnetic loads generated in a disruption event. In European-DEMO the possibility to estimate the heat load by measuring the relative thermocurrents is under investigation. In order to allow thermocurrents measurements, a divertor design option provides that PFCs are electrically insulated from CB. In this work authors aim to analyze the opportunity that the PFC-CB fixing system incorporates an electrical insulation system, thus acquiring also an important diagnostic role in the measurement of the thermocurrents and in the management of the current flows. The possible use of ceramic material (e.g. alumina) as the insulating layer between the support components is investigated