Performance-based university funding and the drive towards ‘institutional meritocracy’ in Italy

Many countries, including Italy, are increasingly managing their public higher education systems in accordance with the New Public Management principle that private-sector management practices improve efficiency and quality. A key mechanism has been the introduction of performance-based funding systems designed to reward ‘high-performing’ institutions and incentivise ‘lesser-performing’ institutions to improve. Instead of improving efficiency and quality across the board, however, we argue that performance-based funding systems naturalise longstanding structurally determined inequalities between institutions by recasting national higher education systems as competitive institutional meritocracies in which institutional inequalities are redefined as objective indicators of intrinsic ‘merit’ or worth. We illustrate how performance-based university funding systems naturalise pre-existing inequalities between universities drawing on the case of Italy, a country characterised by longstanding inequalities between its northern and southern regions which demonstrably impact on the apparent ‘performance’ of universities. The concept of institutional meritocracy captures the illusory nature of this performance game

Constructing networks of defects with scalar fields

We propose a new way to build networks of defects. The idea takes advantage of the deformation procedure recently employed to describe defect structures, which we use to construct networks, spread from small rudimentary networks that appear in simple models of scalar fields.Comment: 5 pages, 4 figures, version with new title, motivations and references, to appear in PL

A critical developmental window for ELAV/Hu-dependent mRNA signatures at the onset of neuronal differentiation

Cell-type-specific gene regulatory programs are essential for cell differentiation and function. In animal neurons, the highly conserved ELAV/Hu family of proteins promotes alternative splicing and polyadenylation of mRNA precursors to create unique neuronal transcript isoforms. Here, we assess transcriptome profiles and neurogenesis success in Drosophila models engineered to express differing levels of ELAV activity in the course of development. We show that the ELAV-mediated establishment of a subset of neuronal mRNA isoforms at the onset of neuron differentiation constitutes a developmental bottleneck that cannot be overcome later by the nuclear activation of the paralog found in neurons (FNE). Loss of ELAV function outside of that critical time window results in neurological defects. We find that FNE, when activated early enough, can restore ELAV-dependent neuronal mRNA isoforms and fully rescue development. Our findings demonstrate the essential role of robust cellular strategies to maintain ELAV activity and intact neuronal signatures in neurogenesis and neuronal function

Spherically Symmetric and Rotating Wormholes Produced by Lightlike Branes

Lightlike p-branes (LL-branes) with dynamical (variable) tension allow simple and elegant Polyakov-type and dual to it Nambu-Goto-like world-volume action formulations. Here we first briefly describe the dynamics of LL-branes as test objects in various physically interesting gravitational backgrounds of black hole type, including rotating ones. Next we show that LL-branes are the appropriate gravitational sources that provide proper matter energy momentum tensors in the Einstein equations of motion needed to generate traversable wormhole solutions, in particular, self-consistent cylindrical rotating wormholes, with the LL-branes occupying their throats. Here a major role is being played by the dynamical LL-brane tension which turns out to be negative but may be of arbitrary small magnitude. As a particular solution we obtain traversable wormhole with Schwarzschild geometry generated by a LL-brane positioned at the wormhole throat, which represents the correct consistent realization of the original Einstein-Rosen "bridge" manifold.Comment: 27 pages; important clarifications regarding the meaning of the original Einstein-Rosen "bridge" construction; an important addition to the Appendix; acknowledgments adde

«Orthopteroidea» españoles con estatus de protección estricta.

Apteromands aptera (Fuente, 1893) es el único mántido endémico español incluido en el Apéndice II del Convenio de Berna y en los Anexos U y IV de la Directiva Habitats, y ratificado por la Legislación española como especie estrictamente protegida desde 1988. Este trabajo recoge, en relación con la consulta realizada a uno de los autores por la European Invertebrate Survey, los datos conocidos hasta el momento sobre esta especie, aportando, además, imágenes y mapas de distribución.Apteromands aptera (Fuente, 1893) es el único mántido endémico español incluido en el Apéndice II del Convenio de Berna y en los Anexos U y IV de la Directiva Habitats, y ratificado por la Legislación española como especie estrictamente protegida desde 1988. Este trabajo recoge, en relación con la consulta realizada a uno de los autores por la European Invertebrate Survey, los datos conocidos hasta el momento sobre esta especie, aportando, además, imágenes y mapas de distribución

Treatment of patients with multiple myeloma progressing on frontline-therapy with lenalidomide

Over the last years, there has been great progress in the treatment of multiple myeloma with many new agents and combinations having been approved and being now routinely incorporated into treatment strategies. As a result, patients are experiencing benefits in terms of survival and better tolerance. However, the multitude of treatment options also presents a challenge to select the best options tailored to the specific patient situation. Lenalidomide is increasingly being used as part of frontline therapy in newly diagnosed multiple myeloma. This agent is typically administered until disease progression. It is currently unclear, how to best manage patients, who relapse while receiving lenalidomide as part of their frontline treatment. We conducted a review to summarize the available evidence in this setting. Our summary shows that there are very few data from current trials testing new combinations based on carfilzomib, pomalidomide, or daratumumab that address this specific patient population. Our review is aimed to summarize the available evidence to assist treatment decision making and to raise awareness of this lack of data to encourage further analyses and the incorporation of sequencing questions in future trial designs

Holographic collisions in confining theories

We study the gravitational dual of a high-energy collision in a confining gauge theory. We consider a linearized approach in which two point particles traveling in an AdS-soliton background suddenly collide to form an object at rest (presumably a black hole for large enough center-of-mass energies). The resulting radiation exhibits the features expected in a theory with a mass gap: late-time power law tails of the form t −3/2, the failure of Huygens" principle and distortion of the wave pattern as it propagates. The energy spectrum is exponentially suppressed for frequencies smaller than the gauge theory mass gap. Consequently, we observe no memory effect in the gravitational waveforms. At larger frequencies the spectrum has an upward-stairway structure, which corresponds to the excitation of the tower of massive states in the confining gauge theory. We discuss the importance of phenomenological cutoffs to regularize the divergent spectrum, and the aspects of the full non-linear collision that are expected to be captured by our approach