Radical prostatectomy after vascular-targeted photodynamic therapy (VTP) with TOOKAD® : feasibility, early and intermediate results

Purpose: Vascular targeted photodynamic therapy with TOOKAD® is a new therapeutic option for localized prostate cancer management. The objectives of this study were to assess the feasibility of radical prostatectomy after vascular targeted photodynamic therapy and describe functional and oncologic outcomes. Materials and Methods: We retrospectively included in study 45 patients who underwent salvage radical prostatectomy after vascular targeted photodynamic therapy for recurrent prostate cancer at a total of 14 surgical centers in Europe between October 2008 and March 2017. Of the 42 radical prostatectomies performed 16 were robot-assisted, 6 were laparoscopic and 20 were open surgery. Primary end points were morbidity and technical difficulties. Secondary end points were early and intermediate postoperative functional and oncologic outcomes. Results: Median operative time was 180 minutes (IQR 150-223). Median blood loss was 200 ml (IQR 155-363). According to the surgeons the surgery was easy in 29 patients (69%) and difficult in 13 (31%). Nerve sparing was feasible in 14 patients (33%). Five postoperative complications (12%) were found, including 2 Clavien I, 2 Clavien II and 1 Clavien IIIB complications. Of the cases 13 (31%) were pT3 and 21 (50%) were pT2c. Surgical margins were positive in 13 patients (31%). Prostate specific antigen was undetectable at 6 to 12 months in 37 patients (88%). Nine patients underwent complementary radiotherapy. Four patients had final prostate specific antigen greater than 0.2 ng/ml at a median followup of 23 months (IQR 12-36). At 1 year 27 patients (64%) were completely continent (no pads) and 10 (24%) had low incontinence (1 pad). Four patients (11%) recovered potency without treatment and 23 (64%) recovered potency with appropriate treatment. Conclusions: Salvage radical prostatectomy after vascular targeted photodynamic therapy treatment was feasible and safe without difficulty for most of the surgeons

Energy Resolution Performance of the CMS Electromagnetic Calorimeter

The energy resolution performance of the CMS lead tungstate crystal electromagnetic calorimeter is presented. Measurements were made with an electron beam using a fully equipped supermodule of the calorimeter barrel. Results are given both for electrons incident on the centre of crystals and for electrons distributed uniformly over the calorimeter surface. The electron energy is reconstructed in matrices of 3 times 3 or 5 times 5 crystals centred on the crystal containing the maximum energy. Corrections for variations in the shower containment are applied in the case of uniform incidence. The resolution measured is consistent with the design goals

European consensus statement on diagnosis and treatment of adult ADHD: The European Network Adult ADHD.

BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is among the most common psychiatric disorders of childhood that persists into adulthood in the majority of cases. The evidence on persistence poses several difficulties for adult psychiatry considering the lack of expertise for diagnostic assessment, limited treatment options and patient facilities across Europe. METHODS: The European Network Adult ADHD, founded in 2003, aims to increase awareness of this disorder and improve knowledge and patient care for adults with ADHD across Europe. This Consensus Statement is one of the actions taken by the European Network Adult ADHD in order to support the clinician with research evidence and clinical experience from 18 European countries in which ADHD in adults is recognised and treated. RESULTS: Besides information on the genetics and neurobiology of ADHD, three major questions are addressed in this statement: (1) What is the clinical picture of ADHD in adults? (2) How can ADHD in adults be properly diagnosed? (3) How should ADHD in adults be effectively treated? CONCLUSIONS: ADHD often presents as an impairing lifelong condition in adults, yet it is currently underdiagnosed and treated in many European countries, leading to ineffective treatment and higher costs of illness. Expertise in diagnostic assessment and treatment of ADHD in adults must increase in psychiatry. Instruments for screening and diagnosis of ADHD in adults are available and appropriate treatments exist, although more research is needed in this age group

RECTO : REcommandation diminuant la Congestion par Transport Optimal

National audienceThe matching setting, a particular case of recommendation problem, focuses on applications where a so-called item can be attributed to at most one user, with the job market and the matrimonial market as chief examples. In such cases, recommending the items preferred by each user might contribute to a congestion issue as users aiming at the same item cannot be all satisfied. While some state of art approaches proceed by repairing the recommendationpolicy to account for the congestion issue, other approaches take inspiration from the optimal transport (OT) framework, and aim to map the user population onto the item population in order to minimize some global transportation cost. In OT-based recommendation state-of-art approaches,the collaborative matrix (reporting the user-item matches) is interpreted as if it were the result of an OT plan ; the underlying transport cost is inferred and used e.g. to propose new congestion-avoiding recommendation policies. In this paper, another OT-based recommendation strategy is defined, noting that the collaborative matrix reflecting the individual decisions can hardly be considered as the result of a (centralized) OT plan. Accordingly, the proposed algorithm first learns a recommendation score from the data and then defines a cost matrix, with the transportation cost decreasing depending on the matching relevance. The optimal transport plan is thereafter used for the recommendation. The experimental validation of the approach presents com-parative results on benchmark data on the matrimonial market, and proprietary real-world data on the job market, illustrating the trade-off between the recall and the congestion indicators. The discussion focuses on the integration of individual and collective criteria.La recommandation de biens rivaux (sur le marché du travail ou des rencontres) fait face au danger majeur de la congestion. Pour concevoir un système de recommandation évitant la congestion, une approche possible repose sur le transport optimal, cherchant un appariement global entre l'ensemble des utilisateurs et l'ensemble des items selon un coût de transport à définir. L'originalité de l'approche RECTO (REcommandation diminuant la Congestion parTransport Optimal) est de construire le coût de transport en fonction du score de recommandation, et de définir la politique de recommandation en fonction du plan de transport entre utilisateurs et items. Une validation expérimentale comparative, menée sur une base de données publiquerelative au marché matrimonial et une base de données propriétaire relative au marché du travail, illustre le compromis entre précision et congestion. La discussion porte sur l’intégration de critères individuels et collectifs

RECTO : REcommandation diminuant la Congestion par Transport Optimal

National audienceThe matching setting, a particular case of recommendation problem, focuses on applications where a so-called item can be attributed to at most one user, with the job market and the matrimonial market as chief examples. In such cases, recommending the items preferred by each user might contribute to a congestion issue as users aiming at the same item cannot be all satisfied. While some state of art approaches proceed by repairing the recommendationpolicy to account for the congestion issue, other approaches take inspiration from the optimal transport (OT) framework, and aim to map the user population onto the item population in order to minimize some global transportation cost. In OT-based recommendation state-of-art approaches,the collaborative matrix (reporting the user-item matches) is interpreted as if it were the result of an OT plan ; the underlying transport cost is inferred and used e.g. to propose new congestion-avoiding recommendation policies. In this paper, another OT-based recommendation strategy is defined, noting that the collaborative matrix reflecting the individual decisions can hardly be considered as the result of a (centralized) OT plan. Accordingly, the proposed algorithm first learns a recommendation score from the data and then defines a cost matrix, with the transportation cost decreasing depending on the matching relevance. The optimal transport plan is thereafter used for the recommendation. The experimental validation of the approach presents com-parative results on benchmark data on the matrimonial market, and proprietary real-world data on the job market, illustrating the trade-off between the recall and the congestion indicators. The discussion focuses on the integration of individual and collective criteria.La recommandation de biens rivaux (sur le marché du travail ou des rencontres) fait face au danger majeur de la congestion. Pour concevoir un système de recommandation évitant la congestion, une approche possible repose sur le transport optimal, cherchant un appariement global entre l'ensemble des utilisateurs et l'ensemble des items selon un coût de transport à définir. L'originalité de l'approche RECTO (REcommandation diminuant la Congestion parTransport Optimal) est de construire le coût de transport en fonction du score de recommandation, et de définir la politique de recommandation en fonction du plan de transport entre utilisateurs et items. Une validation expérimentale comparative, menée sur une base de données publiquerelative au marché matrimonial et une base de données propriétaire relative au marché du travail, illustre le compromis entre précision et congestion. La discussion porte sur l’intégration de critères individuels et collectifs

RECTO : REcommandation diminuant la Congestion par Transport Optimal

National audienceThe matching setting, a particular case of recommendation problem, focuses on applications where a so-called item can be attributed to at most one user, with the job market and the matrimonial market as chief examples. In such cases, recommending the items preferred by each user might contribute to a congestion issue as users aiming at the same item cannot be all satisfied. While some state of art approaches proceed by repairing the recommendationpolicy to account for the congestion issue, other approaches take inspiration from the optimal transport (OT) framework, and aim to map the user population onto the item population in order to minimize some global transportation cost. In OT-based recommendation state-of-art approaches,the collaborative matrix (reporting the user-item matches) is interpreted as if it were the result of an OT plan ; the underlying transport cost is inferred and used e.g. to propose new congestion-avoiding recommendation policies. In this paper, another OT-based recommendation strategy is defined, noting that the collaborative matrix reflecting the individual decisions can hardly be considered as the result of a (centralized) OT plan. Accordingly, the proposed algorithm first learns a recommendation score from the data and then defines a cost matrix, with the transportation cost decreasing depending on the matching relevance. The optimal transport plan is thereafter used for the recommendation. The experimental validation of the approach presents com-parative results on benchmark data on the matrimonial market, and proprietary real-world data on the job market, illustrating the trade-off between the recall and the congestion indicators. The discussion focuses on the integration of individual and collective criteria.La recommandation de biens rivaux (sur le marché du travail ou des rencontres) fait face au danger majeur de la congestion. Pour concevoir un système de recommandation évitant la congestion, une approche possible repose sur le transport optimal, cherchant un appariement global entre l'ensemble des utilisateurs et l'ensemble des items selon un coût de transport à définir. L'originalité de l'approche RECTO (REcommandation diminuant la Congestion parTransport Optimal) est de construire le coût de transport en fonction du score de recommandation, et de définir la politique de recommandation en fonction du plan de transport entre utilisateurs et items. Une validation expérimentale comparative, menée sur une base de données publiquerelative au marché matrimonial et une base de données propriétaire relative au marché du travail, illustre le compromis entre précision et congestion. La discussion porte sur l’intégration de critères individuels et collectifs

European consensus statement on diagnosis and treatment of adult ADHD: The European Network Adult ADHD

Background: Attention deficit hyperactivity disorder (ADHD) is among the most common psychiatric disorders of childhood that persists into adulthood in the majority of cases. The evidence on persistence poses several difficulties for adult psychiatry considering the lack of expertise for diagnostic assessment, limited treatment options and patient facilities across Europe.Methods: The European Network Adult ADHD, founded in 2003, aims to increase awareness of this disorder and improve knowledge and patient care for adults with ADHD across Europe. This Consensus Statement is one of the actions taken by the European Network Adult ADHD in order to support the clinician with research evidence and clinical experience from 18 European countries in which ADHD in adults is recognised and treated.Results: Besides information on the genetics and neurobiology of ADHD, three major questions are addressed in this statement: (1) What is the clinical picture of ADHD in adults? (2) How can ADHD in adults be properly diagnosed? (3) How should ADHD in adults be effectively treated?Conclusions: ADHD often presents as an impairing lifelong condition in adults, yet it is currently underdiagnosed and treated in many European countries, leading to ineffective treatment and higher costs of illness. Expertise in diagnostic assessment and treatment of ADHD in adults must increase in psychiatry. Instruments for screening and diagnosis of ADHD in adults are available and appropriate treatments exist, although more research is needed in this age group. © 2010 Kooij et al; licensee BioMed Central Ltd