Recurrent pregnancy loss and metabolic syndrome

Objectives: The aim of this study was to evaluate the frequency of metabolic syndrome (MetS) and its components inpatients with unexplained recurrent pregnancy loss (RPL).Material and methods: A cross-sectional study was held including 115 patients with unexplained RPL who were referredto a tertiary center between December 2018 and December 2019. In the study, MetS was classified according to TheNational Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III) criteria on the basis of metabolic riskfactors. Frequency of MetS in the patients with unexplained RPL was investigated. The relationship between miscarriagerate and metabolic risk factors was also evaluated.Results: According to our study the percentage of MetS in patients with unexplained RPL was 24.4%. When evaluated accordingto different age groups, it was 18.4% in patients aged 20–29 years, and it was 27.8% in patients aged 30–39 years. Atleast having one of its components were high (82.6%) in all patients with unexplained RPL.Conclusions: The percentage of MetS or of at least having one of its components were high in patients with unexplainedRPL. Increased number of having MetS components were associated with increased miscarriage rate

Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142904/1/hep29800.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142904/2/hep29800_am.pd

Quality of life in patients with melasma in Turkish women

The aim of this study was to determine the impact of melasma on quality of life (QoL) using the dermatology life quality index (DLQI) questionnaire in a group of outpatients. This study is questionnairebased. A total of 101 Turkish women suffering from melasma, who themselves were able to understand and complete the Turkish version of the DLQI questionnaire, were enrolled. This questionnaire included 10 questions; each of each was scored on a scale of 0-3, with a maximum score of 30. The data were analyzed after the results had been collated and the higher the DLQI score, the poorer the QoL. The participants’ mean age was 29.53±6.87 years, and mean DLQI score was 6.02±4.94. When we divided the participants into two subgroups according to age, the DLQI scores for younger and older individuals were 7.44±4.99 and 4.33±4.36, respectively (P=0.001). When the melasma area and severity index (MASI) score was used, participants with mild and moderate disease had mean DLQI scores of 5.80±4.72 and 7.11±5.90, respectively. No patient had severe disease. Melasma might affect the participants’ QoL, especially that of the younger individuals, in our study population

Evaluation of intoxication cases

Subject: The purpose of this study was to evaluate demographics, etiologies and prognostic findings in intoxicated patients in Vakif Gureba Training Hospital Emergency Unit between January-December 200

A New Risk-Scoring System for Colorectal Cancer and Polyp Screening by Turkish Colorectal Cancer and Polyp Study Group

Background: Colorectal cancer is one of the most commonly diagnosed types of cancer worldwide. An early diagnosis and detection of colon cancer and polyp can reduce mortality and morbidity from colorectal cancer. Even though there are a variety of options in screening tests, the question remains on which test is the most effective for the early detection of colorectal cancer. In this prospective study, we aimed to develop a simple, useful, effective, and reliable scoring system to detect colon polyp and colorectal cancer. Methods: We enrolled 6508 subjects over the age of 18 from 16 centers, with colonoscopy screening. The age, smoking status, alcohol consumption, body mass index polyp incidence, polyp size, number and localization, and pathologic findings were recorded. Results: The age, male gender, obesity, smoking, and family history were found as independent risk factors for adenomatous polyp. We have developed a new scoring system which can be used for these factors. With a score of 4 or above, we found the following: sensitivity 81%, specificity 40%, positive predictive value 25.68%, and negative predictive value 89.84%, for adenomatous polyp detection; and sensitivity 96%, specificity 39%, positive predictive value 3.35%, negative predictive value 99.29%, for colorectal cancer detection. Conclusion: Even though the first colorectal cancer screening worldwide is generally performed for individuals over 50 years of age, we recommend that screening for colorectal cancer might begin for those under 50 years of age as well. Individuals with a score >= 4 must be included in the screening tests for colorectal cancer

Melatonin may have a role in the pathogenesis of functional dyspepsia in males

OBJECTIVE: Pathogenesis of functional dyspepsia (FD) is complex. Melatonin is synthesized in enterochromaffin cells (EC) of the digestive system. It may influence gut function. The aim of this study is to evaluate the serum melatonin levels in FD patients