500 research outputs found
Behaviour of the potentials due to strangeness degree of freedom in He hypernucleus
Fully correlated study of He hypernucleus has been
performed with two- and three- baryon potentials. For the S=-2 sector, various
simulations of Nijmegen potential models have been used. We
investigate the role of every strength of the strange sector potentials on the
energy breakdown and present a crystal clear understanding of their interplay.
Consistency between He and He depends on the
space-exchange strength only. Investigation limits the strength of
simulated Nijmegen potential models. The study is a step
forward to determine all the strengths, to reslove A=5 anomaly and to search
for H in an authentic way.Comment: 4 pages, 1 figur
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B-cell maturation antigen (BCMA) in multiple myeloma: rationale for targeting and current therapeutic approaches.
Despite considerable advances in the treatment of multiple myeloma (MM) in the last decade, a substantial proportion of patients do not respond to current therapies or have a short duration of response. Furthermore, these treatments can have notable morbidity and are not uniformly tolerated in all patients. As there is no cure for MM, patients eventually become resistant to therapies, leading to development of relapsed/refractory MM. Therefore, an unmet need exists for MM treatments with novel mechanisms of action that can provide durable responses, evade resistance to prior therapies, and/or are better tolerated. B-cell maturation antigen (BCMA) is preferentially expressed by mature B lymphocytes, and its overexpression and activation are associated with MM in preclinical models and humans, supporting its potential utility as a therapeutic target for MM. Moreover, the use of BCMA as a biomarker for MM is supported by its prognostic value, correlation with clinical status, and its ability to be used in traditionally difficult-to-monitor patient populations. Here, we review three common treatment modalities used to target BCMA in the treatment of MM: bispecific antibody constructs, antibody-drug conjugates, and chimeric antigen receptor (CAR)-modified T-cell therapy. We provide an overview of preliminary clinical data from trials using these therapies, including the BiTEÂź (bispecific T-cell engager) immuno-oncology therapy AMG 420, the antibody-drug conjugate GSK2857916, and several CAR T-cell therapeutic agents including bb2121, NIH CAR-BCMA, and LCAR-B38M. Notable antimyeloma activity and high minimal residual disease negativity rates have been observed with several of these treatments. These clinical data outline the potential for BCMA-targeted therapies to improve the treatment landscape for MM. Importantly, clinical results to date suggest that these therapies may hold promise for deep and durable responses and support further investigation in earlier lines of treatment, including newly diagnosed MM
Charged gravastars admitting conformal motion
We propose a new model of a {\it gravastar} admitting conformal motion. While
retaining the framework of the Mazur-Mottola model, the gravastar is assumed to
be internally charged, with an exterior defined by a Reissner-Nordstr{\"o}m
rather than a Schwarzschild line element. The solutions obtained involve (i)
the interior region, (ii) the shell, and (iii) the exterior region of the
sphere. Of these three cases the first case is of primary interest since the
total gravitational mass vanishes for vanishing charge and turns the total
gravitational mass into an {\it electromagnetic mass} under certain conditions.
This suggests that the interior de Sitter vacuum of a charged gravastar is
essentially an electromagnetic mass model that must generate the gravitational
mass. We have also analyzed various other aspects such as the stress energy
tensor in the thin shell and the entropy of the system.Comment: Minor addition, Accepted in Phys. Lett.
Cellulose an ageless renewable green nanomaterial for medical applications: an overview of ionic liquids in extraction, separation and dissolution of cellulose
Cellulose is a renewable natural fiber, which has gained enormous and significant research interest and evolved as the prime and promising candidate for replacing synthetic fibers. The various sources of cellulose, which is one of the world's most ubiquitous and renewable biopolymer resources, include trees, plants, tunicate and bacteria. The renewable biomaterial in the form of nanocellulose and its composites have been included in this review having the broad range of medical applications, viz.; tissue engineering, cardiovascular surgery, dental, pharmaceuticals, veterinary, adhesion barriers and skin therapy. These grafts are being fabricated from biodegradable materials. Bacterial cellulose is also an emerging renewable biomaterial with immense potential in biomedical field. The fabrication methods, characteristic properties and various overwhelming applications of cellulosic composites are explicitly elucidated in this review. The crux of this review is to exhibit the latest state of art, development in the field of cellulosic nanocomposite science and technology research and their applications towards biomedical field. Among the fourteen principle of green chemistry the two key principles i.e. using environmentally preferable solvents and bio-renewable feed-stocks covers in dissolution of cellulose in ionic liquids (ILs). In addition, this review covers about the comprehensive extraction and dissolution of cellulose and nanocellulose using ILs.publishe
d-dimensional non-asymptotically flat thin-shell wormholes in Einstein-Yang-Mills-Dilaton gravity
Thin-shell wormholes in Einstein-Yang-Mills-dilaton (EYMD) gravity are
considered. We show that a non-asymptotically flat (NAF) black hole solution of
the d-dimensional EYMD theory provides stable thin-shell wormholes which are
supported entirely by exotic matter. The presence of dilaton makes the
spacetime naturally NAF, and with our conclusion it remains still open to
construct wormholes supported by normal matter between two such spacetimes.Comment: 6 pages, 5 figures. Title changed, the first version has been
generalized to d-dimensions. The EYMGB part was removed and was considered in
a more general form separately in arXiv:1007.462
Heralded quantum entanglement between two crystals
Quantum networks require the crucial ability to entangle quantum nodes. A
prominent example is the quantum repeater which allows overcoming the distance
barrier of direct transmission of single photons, provided remote quantum
memories can be entangled in a heralded fashion. Here we report the observation
of heralded entanglement between two ensembles of rare-earth-ions doped into
separate crystals. A heralded single photon is sent through a 50/50
beamsplitter, creating a single-photon entangled state delocalized between two
spatial modes. The quantum state of each mode is subsequently mapped onto a
crystal, leading to an entangled state consisting of a single collective
excitation delocalized between two crystals. This entanglement is revealed by
mapping it back to optical modes and by estimating the concurrence of the
retrieved light state. Our results highlight the potential of rare-earth-ions
doped crystals for entangled quantum nodes and bring quantum networks based on
solid-state resources one step closer.Comment: 10 pages, 5 figure
Extramedullary disease in multiple myeloma: a systematic literature review
Extramedullary involvement (or extramedullary disease, EMD) represents an aggressive form of multiple myeloma (MM), characterized by the ability of a clone and/or subclone to thrive and grow independent of the bone marrow microenvironment. Several different definitions of EMD have been used in the published literature. We advocate that true EMD is restricted to soft-tissue plasmacytomas that arise due to hematogenous spread and have no contact with bony structures. Typical sites of EMD vary according to the phase of MM. At diagnosis, EMD is typically found in skin and soft tissues; at relapse, typical sites involved include liver, kidneys, lymph nodes, central nervous system (CNS), breast, pleura, and pericardium. The reported incidence of EMD varies considerably, and differences in diagnostic approach between studies are likely to contribute to this variability. In patients with newly diagnosed MM, the reported incidence ranges from 0.5% to 4.8%, while in relapsed/refractory MM the reported incidence is 3.4 to 14%. Available data demonstrate that the prognosis is poor, and considerably worse than for MM without soft-tissue plasmacytomas. Among patients with plasmacytomas, those with EMD have poorer outcomes than those with paraskeletal involvement. CNS involvement is rare, but prognosis is even more dismal than for EMD in other locations, particularly if there is leptomeningeal involvement. Available data on treatment outcomes for EMD are derived almost entirely from retrospective studies. Some agents and combinations have shown a degree of efficacy but, as would be expected, this is less than in MM patients with no extramedullary involvement. The paucity of prospective studies makes it difficult to justify strong recommendations for any treatment approach. Prospective data from patients with clearly defined EMD are important for the optimal evaluation of treatment outcomes
Islamic labeled firms: Revisiting Dow Jones measure of compliance
Billions of dollars, across 131 countries, are invested in Islamic lawâcompliant funds that are often promoted as consistent with the spirit and overall objectives of Islam (Maqasid AlâSharia), thereby indicating they are more socially responsible, less risky, and less prone to failure. The empirical results of this study indicate that Shariahâcompliant firms identified by the Dow Jones do not have higher corporate social responsibility (CSR) scores, lower risk, or lower likelihood of failure than nonâcompliant firms. We address endogeneity using the instrumental variable (IV) approach and selection bias using propensity score matching (PSM). Our results are similar when using the Dow Jones Islamic Market World, the Financial Times Stock Exchange Islamic Index, and the Hong Kong and Shanghai Banking Corporation indices and when using CSR scores provided by multiple databases. We create an index to measure compliance with Islamic law that overcomes several flaws in the binary measures currently employed in the industry. This index can help Shariahâcompliant funds to fulfill their promise by constructing portfolios that are both compliant with Islamic rulings and consistent with the spirit and objectives of Islam in being more socially responsible, less risky, and less prone to failure
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