Splice variants in apoptotic pathway

Elimination of superfluous or mutated somatic cells is provided by various mechanisms including apoptosis, and deregulation of apoptotic signaling pathways contributes to oncogenesis. 40 years have passed since the term “apoptosis” was introduced by Kerr et al. in 1972; among the programmed cell death, a variety of therapeutic strategies especially targeting apoptotic pathways have been investigated. Alternative precursor messenger RNA splicing, by which the process the exons of pre-mRNA are spliced in different arrangements to produce structurally and functionally distinct mRNA and proteins, is another field in progress, and it has been recognized as one of the most important mechanisms that maintains genomic and functional diversity. A variety of apoptotic genes are regulated through alternative pre-mRNA splicing as well, some of which have important functions as pro-apoptotic and anti-apoptotic factors. In this article we summarized splice variants of some of the apoptotic genes including BCL2L1, BIRC5, CFLAR, and MADD, as well as the regulatory mechanisms of alternative splicing of these genes. If the information of the apoptosis and aberrant splicing in each of malignancies is integrated, it will become possible to target proper variants for apoptosis, and the trans-elements themselves can become specific targets of cancer therapy as well. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”

Oscillations of rapidly rotating relativistic stars

Non-axisymmetric oscillations of rapidly rotating relativistic stars are studied using the Cowling approximation. The oscillation spectra have been estimated by Fourier transforming the evolution equations describing the perturbations. This is the first study of its kind and provides information on the effect of fast rotation on the oscillation spectra while it offers the possibility in studying the complete problem by including spacetime perturbations. Our study includes both axisymmetric and non-axisymmetric perturbations and provides limits for the onset of the secular bar mode rotational instability. We also present approximate formulae for the dependence of the oscillation spectrum from rotation. The results suggest that it is possible to extract the relativistic star's parameters from the observed gravitational wave spectrum.Comment: this article will be published in Physical Review

The chaotic behavior of the black hole system GRS 1915+105

A modified non-linear time series analysis technique, which computes the correlation dimension $D_2$, is used to analyze the X-ray light curves of the black hole system GRS 1915+105 in all twelve temporal classes. For four of these temporal classes $D_2$ saturates to $\approx 4-5$ which indicates that the underlying dynamical mechanism is a low dimensional chaotic system. Of the other eight classes, three show stochastic behavior while five show deviation from randomness. The light curves for four classes which depict chaotic behavior have the smallest ratio of the expected Poisson noise to the variability ($< 0.05$) while those for the three classes which depict stochastic behavior is the highest ($> 0.2$). This suggests that the temporal behavior of the black hole system is governed by a low dimensional chaotic system, whose nature is detectable only when the Poisson fluctuations are much smaller than the variability.Comment: Accepted for publication in Astrophysical Journa

Crustal Oscillations of Slowly Rotating Relativistic Stars

We study low-amplitude crustal oscillations of slowly rotating relativistic stars consisting of a central fluid core and an outer thin solid crust. We estimate the effect of rotation on the torsional toroidal modes and on the interfacial and shear spheroidal modes. The results compared against the Newtonian ones for wide range of neutron star models and equations of state.Comment: 15 page

Global Twist of Sunspot Magnetic Fields Obtained from High Resolution Vector Magnetograms

The presence of fine structures in the sunspot vector magnetic fields has been confirmed from Hinode as well as other earlier observations. We studied 43 sunspots based on the data sets taken from ASP/DLSP, Hinode (SOT/SP) and SVM (USO). In this \emph{Letter}, (i) We introduce the concept of signed shear angle (SSA) for sunspots and establish its importance for non force-free fields. (ii) We find that the sign of global $\alpha$ (force-free parameter) is well correlated with the global SSA and the photospheric chirality of sunspots. (iii) Local $\alpha$ patches of opposite signs are present in the umbra of each sunspot. The amplitude of the spatial variation of local $\alpha$ in the umbra is typically of the order of the global $\alpha$ of the sunspot. (iv) We find that the local $\alpha$ is distributed as alternately positive and negative filaments in the penumbra. The amplitude of azimuthal variation of the local $\alpha$ in the penumbra is approximately an order of magnitude larger than that in the umbra. The contributions of the local positive and negative currents and $\alpha$ in the penumbra cancel each other giving almost no contribution for their global values for whole sunspot. (v) Arc-like structures (partial rings) with a sign opposite to that of the dominant sign of $\alpha$ of the umbral region are seen at the umbral-penumbral boundaries of some sunspots. (vi) Most of the sunspots studied, belong to the minimum epoch of the 23$^{rd}$ solar cycle and do not follow the so-called hemispheric helicity rule.Comment: 15 pages, 3 figures, 1 table; Accepted for publication in the ApJ Letter

Nonlinear force-free modelling: influence of inaccuracies in the measured magnetic vector

Context: Solar magnetic fields are regularly extrapolated into the corona starting from photospheric magnetic measurements that can suffer from significant uncertainties. Aims: Here we study how inaccuracies introduced into the maps of the photospheric magnetic vector from the inversion of ideal and noisy Stokes parameters influence the extrapolation of nonlinear force-free magnetic fields. Methods: We compute nonlinear force-free magnetic fields based on simulated vector magnetograms, which have been produced by the inversion of Stokes profiles, computed froma 3-D radiation MHD simulation snapshot. These extrapolations are compared with extrapolations starting directly from the field in the MHD simulations, which is our reference. We investigate how line formation and instrumental effects such as noise, limited spatial resolution and the effect of employing a filter instrument influence the resulting magnetic field structure. The comparison is done qualitatively by visual inspection of the magnetic field distribution and quantitatively by different metrics. Results: The reconstructed field is most accurate if ideal Stokes data are inverted and becomes less accurate if instrumental effects and noise are included. The results demonstrate that the non-linear force-free field extrapolation method tested here is relatively insensitive to the effects of noise in measured polarization spectra at levels consistent with present-day instruments. Conclusions heading: Our results show that we can reconstruct the coronal magnetic field as a nonlinear force-free field from realistic photospheric measurements with an accuracy of a few percent, at least in the absence of sunspots.Comment: A&A, accepted, 9 Pages, 4 Figure

The underlying physical meaning of the νmax−νc\nu_{\rm max}-\nu_{\rm c} relation

Asteroseismology of stars that exhibit solar-like oscillations are enjoying a growing interest with the wealth of observational results obtained with the CoRoT and Kepler missions. In this framework, scaling laws between asteroseismic quantities and stellar parameters are becoming essential tools to study a rich variety of stars. However, the physical underlying mechanisms of those scaling laws are still poorly known. Our objective is to provide a theoretical basis for the scaling between the frequency of the maximum in the power spectrum ($\nu_{\rm max}$) of solar-like oscillations and the cut-off frequency ($\nu_{\rm c}$). Using the SoHO GOLF observations together with theoretical considerations, we first confirm that the maximum of the height in oscillation power spectrum is determined by the so-called \emph{plateau} of the damping rates. The physical origin of the plateau can be traced to the destabilizing effect of the Lagrangian perturbation of entropy in the upper-most layers which becomes important when the modal period and the local thermal relaxation time-scale are comparable. Based on this analysis, we then find a linear relation between $\nu_{\rm max}$ and $\nu_{\rm c}$, with a coefficient that depends on the ratio of the Mach number of the exciting turbulence to the third power to the mixing-length parameter.Comment: 8 pages, 11 figures. Accepted in A&

Rapid X-Ray Variability of Neutron Stars in Low-Mass Binary Systems

The dramatic discovery with the Rossi X-Ray Timing Explorer satellite of remarkably coherent $\sim$300--1200 Hz oscillations in the X-ray brightness of some sixteen neutron stars in low-mass binary systems has spurred theoretical modeling of these oscillations and investigation of their implications for the neutron stars and accretion flows in these systems. High-frequency oscillations are observed both during thermonuclear X-ray bursts and during intervals of accretion-powered emission and appear to be a characteristic feature of disk-accreting neutron stars with weak magnetic fields. In this review we focus on the high-frequency quasi-periodic oscillations (QPOs) seen in the accretion-powered emission. We first summarize the key properties of these kilohertz QPOs and then describe briefly the models that have been proposed to explain them. The existing evidence strongly favors beat-frequency models. We mention several of the difficulties encountered in applying the magnetospheric beat-frequency model to the kilohertz QPOs. The most fully developed and successful model is the sonic-point beat-frequency model. We describe the work on this model in some detail. We then discuss observations that could help to distinguish between models. We conclude by noting some of the ways in which study of the kilohertz QPOs may advance our understanding of dense matter and strong gravitational fields.Comment: 10 pages LaTeX including six figures, uses espcrc2.sty (included), invited talk at "The Active X-Ray Sky", eds. L. Scarsi, H. Bradt, P. Giommi, and F. Fior

On the Doppler Shift and Asymmetry of Stokes Profiles of Photospheric FeI and Chromospheric MgI Lines

We analyzed the full Stokes spectra using simultaneous measurements of the photospheric (FeI 630.15 and 630.25 nm) and chromospheric (MgI b2 517.27 nm) lines. The data were obtained with the HAO/NSO Advanced Stokes Polarimeter, about a near disc center sunspot region, NOAA AR 9661. We compare the characteristics of Stokes profiles in terms of Doppler shifts and asymmetries among the three spectral lines, which helps us to better understand the chromospheric lines and the magnetic and flow fields in different magnetic regions. The main results are: (1) For penumbral area observed by the photospheric FeI lines, Doppler velocities derived from Stokes I (Vi) are very close to those derived from linear polarization profiles (Vlp) but significantly different from those derived from Stokes V profiles (Vzc), which provides direct and strong evidence that the penumbral Evershed flows are magnetized and mainly carried by the horizontal magnetic component. (2) The rudimentary inverse Evershed effect observed by the MgI b2 line provides a qualitative evidence on its formation height that is around or just above the temperature minimum region. (3) Vzc and Vlp in penumbrae and Vzc in pores generally approach their Vi observed by the chromospheric MgI line, which is not the case for the photospheric FeI lines. (4) Outer penumbrae and pores show similar behavior of the Stokes V asymmetries that tend to change from positive values in the photosphere (FeI lines) to negative values in the low chromosphere (MgI line). (5) The Stokes V profiles in plage regions are highly asymmetric in the photosphere and more symmetric in the low chromosphere. (6) Strong red shifts and large asymmetries are found around the magnetic polarity inversion line within the common penumbra of the Delta spot. This study thus emphasizes the importance of spectro-polarimetry using chromospheric lines.Comment: 10 pages, 7 figures, accepted to The Astrophysical Journa