88 research outputs found
Persistence length of a polyelectrolyte in salty water: a Monte-Carlo study
We address the long standing problem of the dependence of the electrostatic
persistence length of a flexible polyelectrolyte (PE) on the screening
length of the solution within the linear Debye-Huckel theory. The
standard Odijk, Skolnick and Fixman (OSF) theory suggests ,
while some variational theories and computer simulations suggest . In this paper, we use Monte-Carlo simulations to study the conformation
of a simple polyelectrolyte. Using four times longer PEs than in previous
simulations and refined methods for the treatment of the simulation data, we
show that the results are consistent with the OSF dependence . The linear charge density of the PE which enters in the coefficient of
this dependence is properly renormalized to take into account local
fluctuations.Comment: 7 pages, 6 figures. Various corrections in text and reference
Doubly stochastic coherence via noise-induced symmetry in bistable neural models
The generation of coherent dynamics due to noise in an activator-inhibitor system describing bistable neural dynamics is investigated. We show that coherence can be induced in deterministically asymmetric regimes via symmetry restoration by multiplicative noise, together with the action of additive noise which induces jumps between the two stable steady states. The phenomenon is thus doubly stochastic, because both noise sources are necessary. This effect can be understood analytically in the frame of a small-noise expansion and is confirmed experimentally in a nonlinear electronic circuit. Finally, we show that spatial coupling enhances this coherent behavior in a form of system-size coherence resonance
Noise-induced inhibitory suppression of malfunction neural oscillators
Motivated by the aim to find new medical strategies to suppress undesirable
neural synchronization we study the control of oscillations in a system of
inhibitory coupled noisy oscillators. Using dynamical properties of inhibition,
we find regimes when the malfunction oscillations can be suppressed but the
information signal of a certain frequency can be transmitted through the
system. The mechanism of this phenomenon is a resonant interplay of noise and
the transmission signal provided by certain value of inhibitory coupling.
Analyzing a system of three or four oscillators representing neural clusters,
we show that this suppression can be effectively controlled by coupling and
noise amplitudes.Comment: 10 pages, 14 figure
Variational theory for a single polyelectrolyte chain revisited
We reconsider the electrostatic contribution to the persistence length,
, of a single, infinitely long charged polymer in the presence of
screening. A Gaussian variational method is employed, taking as the
only variational parameter. For weakly charged and flexible chains, crumpling
occurs at small length scales because conformational fluctuations overcome
electrostatic repulsion. The electrostatic persistence length depends on the
square of the screening length, , as first argued by
Khokhlov and Khachaturian by applying the Odijk-Skolnick-Fixman (OSF) theory to
a string of crumpled blobs. We compare our approach to previous theoretical
works (including variational formulations) and show that the result
found by several authors comes from the improper use of
a cutoff at small length scales. For highly charged and stiff chains, crumpling
does not occur; here we recover the OSF result and validate the perturbative
calculation for slightly bent rods.Comment: 11 pages, 6 figure
The transition between stochastic and deterministic behavior in an excitable gene circuit
We explore the connection between a stochastic simulation model and an
ordinary differential equations (ODEs) model of the dynamics of an excitable
gene circuit that exhibits noise-induced oscillations. Near a bifurcation point
in the ODE model, the stochastic simulation model yields behavior dramatically
different from that predicted by the ODE model. We analyze how that behavior
depends on the gene copy number and find very slow convergence to the large
number limit near the bifurcation point. The implications for understanding the
dynamics of gene circuits and other birth-death dynamical systems with small
numbers of constituents are discussed.Comment: PLoS ONE: Research Article, published 11 Apr 201
Complex and unexpected dynamics in simple genetic regulatory networks
Peer reviewedPublisher PD
Optimizing end-labeled free-solution electrophoresis by increasing the hydrodynamic friction of the drag-tag
We study the electrophoretic separation of polyelectrolytes of varying
lengths by means of end-labeled free-solution electrophoresis (ELFSE). A
coarse-grained molecular dynamics simulation model, using full electrostatic
interactions and a mesoscopic Lattice Boltzmann fluid to account for
hydrodynamic interactions, is used to characterize the drag coefficients of
different label types: linear and branched polymeric labels, as well as
transiently bound micelles.
It is specifically shown that the label's drag coefficient is determined by
its hydrodynamic size, and that the drag per label monomer is largest for
linear labels. However, the addition of side chains to a linear label offers
the possibility to increase the hydrodynamic size, and therefore the label
efficiency, without having to increase the linear length of the label, thereby
simplifying synthesis. The third class of labels investigated, transiently
bound micelles, seems very promising for the usage in ELFSE, as they provide a
significant higher hydrodynamic drag than the other label types.
The results are compared to theoretical predictions, and we investigate how
the efficiency of the ELFSE method can be improved by using smartly designed
drag-tags.Comment: 32 pages, 11 figures, submitted to Macromolecule
Neutral and Charged Polymers at Interfaces
Chain-like macromolecules (polymers) show characteristic adsorption
properties due to their flexibility and internal degrees of freedom, when
attracted to surfaces and interfaces. In this review we discuss concepts and
features that are relevant to the adsorption of neutral and charged polymers at
equilibrium, including the type of polymer/surface interaction, the solvent
quality, the characteristics of the surface, and the polymer structure. We pay
special attention to the case of charged polymers (polyelectrolytes) that have
a special importance due to their water solubility. We present a summary of
recent progress in this rapidly evolving field. Because many experimental
studies are performed with rather stiff biopolymers, we discuss in detail the
case of semi-flexible polymers in addition to flexible ones. We first review
the behavior of neutral and charged chains in solution. Then, the adsorption of
a single polymer chain is considered. Next, the adsorption and depletion
processes in the many-chain case are reviewed. Profiles, changes in the surface
tension and polymer surface excess are presented. Mean-field and corrections
due to fluctuations and lateral correlations are discussed. The force of
interaction between two adsorbed layers, which is important in understanding
colloidal stability, is characterized. The behavior of grafted polymers is also
reviewed, both for neutral and charged polymer brushes.Comment: a review: 130 pages, 30 ps figures; final form, added reference
Effect of Network Architecture on Synchronization and Entrainment Properties of the Circadian Oscillations in the Suprachiasmatic Nucleus
In mammals, the suprachiasmatic nucleus (SCN) of the hypothalamus constitutes the central circadian pacemaker. The SCN receives light signals from the retina and controls peripheral circadian clocks (located in the cortex, the pineal gland, the liver, the kidney, the heart, etc.). This hierarchical organization of the circadian system ensures the proper timing of physiological processes. In each SCN neuron, interconnected transcriptional and translational feedback loops enable the circadian expression of the clock genes. Although all the neurons have the same genotype, the oscillations of individual cells are highly heterogeneous in dispersed cell culture: many cells present damped oscillations and the period of the oscillations varies from cell to cell. In addition, the neurotransmitters that ensure the intercellular coupling, and thereby the synchronization of the cellular rhythms, differ between the two main regions of the SCN. In this work, a mathematical model that accounts for this heterogeneous organization of the SCN is presented and used to study the implication of the SCN network topology on synchronization and entrainment properties. The results show that oscillations with larger amplitude can be obtained with scale-free networks, in contrast to random and local connections. Networks with the small-world property such as the scale-free networks used in this work can adapt faster to a delay or advance in the light/dark cycle (jet lag). Interestingly a certain level of cellular heterogeneity is not detrimental to synchronization performances, but on the contrary helps resynchronization after jet lag. When coupling two networks with different topologies that mimic the two regions of the SCN, efficient filtering of pulse-like perturbations in the entrainment pattern is observed. These results suggest that the complex and heterogeneous architecture of the SCN decreases the sensitivity of the network to short entrainment perturbations while, at the same time, improving its adaptation abilities to long term changes
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