A Study to Validate a Self-Reported Version of the ONS Drug Dependence Questionnaire

Aim: A prospective study to establish the reliability of a self-completion version of the Office for National Statistics (ONS) questionnaire for assessing drug dependence of substance misuse clients. Method: A total of 47 treatment seeking opioid-dependent clients completed the self-complete version of the ONS questionnaire (ONS-sc) followed by the interviewer-administered ONS questionnaire (ONS-ia) at a single clinic appointment. Scores for four Class A drugs (heroin, methadone, speed and crack/cocaine) from both formats were compared. Results: The observed agreement was 87% or more and Cohen's kappa was 0.7 (p < 0.001) or more for all four Class A drugs. Sensitivity for each Class A drugs was 56% or higher and specificity was 87% or higher. Sensitivity for severe heroin dependency was 98% (CI 89–100%). There was a 100% correlation between the ONS-sc and positive urine analysis for heroin use. However, methadone and crack/cocaine drug use appeared under reported. Conclusion: ONS-sc is a feasible, practical and time-saving alternative to a detailed interview on drug dependence. Further research with a larger sample size and non-opiate-dependent clients are needed, as this could prove a useful tool for monitoring clients in everyday practice, or for survey purposes where interviews are impractical

A proposal and a theoretical analysis of an enhanced surface plasmon coupled emission structure for single molecule detection

We propose a structure that can be used for enhanced single molecule detection using surface plasmon coupled emission (SPCE). In the proposed structure, instead of a single metal layer on the glass prism of a typical SPCE structure for fluorescence microscopy, a metal-dielectric-metal structure is used. We theoretically show that the proposed structure significantly decreases the excitation volume of the fluorescently labeled sample, and simultaneously increases the peak SPCE intensity and SPCE power. Therefore, the signal-to-noise ratio and sensitivity of an SPCE based fluorescence microscopy system can be significantly increased using the proposed structure, which will be helpful for enhanced single molecule detection, especially, in a less pure biological sample

Accelerating universe from F(T) gravity

It is shown that the acceleration of the universe can be understood by considering a F(T) gravity models. For these F(T) gravity models, a variant of the accelerating cosmology reconstruction program is developed. Some explicit examples of F(T) are reconstructed from the background FRW expansion history.Comment: 13 pages, references adde

Multiple early introductions of SARS-CoV-2 into a global travel hub in the Middle East

International travel played a significant role in the early global spread of SARS-CoV-2. Understanding transmission patterns from different regions of the world will further inform global dynamics of the pandemic. Using data from Dubai in the United Arab Emirates (UAE), a major international travel hub in the Middle East, we establish SARS-CoV-2 full genome sequences from the index and early COVID-19 patients in the UAE. The genome sequences are analysed in the context of virus introductions, chain of transmissions, and possible links to earlier strains from other regions of the world. Phylogenetic analysis showed multiple spatiotemporal introductions of SARS-CoV-2 into the UAE from Asia, Europe, and the Middle East during the early phase of the pandemic. We also provide evidence for early community-based transmission and catalogue new mutations in SARS-CoV-2 strains in the UAE. Our findings contribute to the understanding of the global transmission network of SARS-CoV-2

Multi-wavelength observations of an unusual impulsive flare associated with CME

We present the results of a detailed analysis of multi-wavelength observations of a very impulsive solar flare 1B/M6.7, which occurred on 10 March, 2001 in NOAA AR 9368 (N27 W42). The observations show that the flare is very impulsive with very hard spectrum in HXR that reveal non-thermal emission was most dominant. On the other hand this flare also produced type II radio burst and coronal mass ejections (CME), which are not general characteristics for impulsive flares. In H$\alpha$ we observed the bright mass ejecta (BME) followed by drak mass ejecta (DME). Based on the consistence of the onset times and direction of BME and CME, we conclude that these two phenomena are closely associated. It is inferred that the energy build-up took place due to photospheric reconnection between emerging positive parasitic polarity and predominant negative polarity, which resulted as a consequence of flux cancellation. The shear increased to $>80^o$ due to further emergence of positive parasitic polarity causing strongly enhanced cancellation of flux. It appears that such enhanced magnetic flux cancellation in a strongly sheared region triggered the impulsive flare.Comment: 14 pages, 8 Figures, Accepted for the publication in Solar Physic

Carnegie Supernova Project-II: The Near-infrared Spectroscopy Program

Shifting the focus of Type Ia supernova (SN Ia) cosmology to the near-infrared (NIR) is a promising way to significantly reduce the systematic errors, as the strategy minimizes our reliance on the empirical width-luminosity relation and uncertain dust laws. Observations in the NIR are also crucial for our understanding of the origins and evolution of these events, further improving their cosmological utility. Any future experiments in the rest-frame NIR will require knowledge of the SN Ia NIR spectroscopic diversity, which is currently based on a small sample of observed spectra. Along with the accompanying paper, Phillips et al. (2018), we introduce the Carnegie Supernova Project-II (CSP-II), to follow up nearby SNe Ia in both the optical and the NIR. In particular, this paper focuses on the CSP-II NIR spectroscopy program, describing the survey strategy, instrumental setups, data reduction, sample characteristics, and future analyses on the data set. In collaboration with the Harvard-Smithsonian Center for Astrophysics (CfA) Supernova Group, we obtained 661 NIR spectra of 157 SNe Ia. Within this sample, 451 NIR spectra of 90 SNe Ia have corresponding CSP-II follow-up light curves. Such a sample will allow detailed studies of the NIR spectroscopic properties of SNe Ia, providing a different perspective on the properties of the unburned material, radioactive and stable nickel produced, progenitor magnetic fields, and searches for possible signatures of companion stars.Comment: 20 pages, 7 figures, accepted for publication in PAS

Oscillation mode frequencies of 61 main sequence and subgiant stars observed by Kepler

Solar-like oscillations have been observed by Kepler and CoRoT in several solar-type stars, thereby providing a way to probe the stars using asteroseismology. We provide the mode frequencies of the oscillations of various stars required to perform a comparison with those obtained from stellar modelling. We used a time series of nine months of data for each star. The 61 stars observed were categorised in three groups: simple, F-like and mixed-mode. The simple group includes stars for which the identification of the mode degree is obvious. The F-like group includes stars for which the identification of the degree is ambiguous. The mixed-mode group includes evolved stars for which the modes do not follow the asymptotic relation of low-degree frequencies. Following this categorisation, the power spectra of the 61 main sequence and subgiant stars were analysed using both maximum likelihood estimators and Bayesian estimators, providing individual mode characteristics such as frequencies, linewidths, and mode heights. We developed and describe a methodology for extracting a single set of mode frequencies from multiple sets derived by different methods and individual scientists. We report on how one can assess the quality of the fitted parameters using the likelihood ratio test and the posterior probabilities. We provide the mode frequencies of 61 stars (with their 1-sigma error bars), as well as their associated echelle diagrams.Comment: 83 pages, 17 figures, 61 tables, paper accepted by Astronomy and Astrophysic