BIM Roles and Responsibilities in Developing Countries: A Dedicated Matrix for Design-Bid-Build Projects

Building information modeling (BIM) through data-rich digital representation has revolutionized the architecture, engineering, and construction (AEC) industry. BIM implementation in the AEC industry has noticeably increased over the last decade. Various BIM roles have been discussed in the literature to ease the process of BIM implementation, but the BIM roles related to project delivery methods have not been standardized. Stimulated by this need, this study develops a BIM roles and responsibilities matrix (BIM-R&R) in the context of the design−bid−build (DBB) projects for developing countries. A comprehensive literature review has been conducted, followed by a questionnaire survey comprising 105 responses. The results were analyzed to formulate a BIM-R&R matrix, on which the expert opinion was obtained from the BIM experts. The proposed BIM-R&R matrix describes all the roles and their corresponding responsibilities required along the project life cycle phases of DBB projects. The incorporation of BIM roles in the DBB procurement process will aid in the efficient management of all information and data that may be lost due to the fragmented nature of DBB. BIM roles with enhanced communication and coordination will also help in reducing time and cost overruns while maintaining a high-quality product. This study helps the associated construction industry in its efforts to implement BIM on their projects by providing a method by which to assess which BIM roles are necessary. Moreover, it will provide project and construction managers with a clear understanding of the BIM roles in DBB projects

Fulminant necrotizing fasciitis following the use of herbal concoction: a case report

<p>Abstract</p> <p>Introduction</p> <p>Necrotizing fasciitis is a rare and life-threatening rapidly progressive soft tissue infection. A fulminant case could involve muscle and bone. Necrotizing fasciitis after corticosteroid therapy and intramuscular injection of non-steroidal anti-inflammatory drugs has been reported. We present a case of fulminant necrotizing fasciitis occurring in a patient who used a herbal concoction to treat a chronic leg ulcer.</p> <p>Case presentation</p> <p>A 20-year-old Ibo woman from Nigeria presented with a three-year history of recurrent chronic ulcer of the right leg. She started applying a herbal concoction to dress the wound two weeks prior to presentation. This resulted in rapidly progressive soft tissue necrosis that spread from the soft tissue to the bone, despite aggressive emergency debridement. As a result she underwent above-knee amputation.</p> <p>Conclusion</p> <p>The herbal concoction used is toxic, and can initiate and exacerbate necrotizing fasciitis. Its use for wound dressing should be discouraged.</p

A redox switch in angiotensinogen modulates angiotensin release.

Blood pressure is critically controlled by angiotensins, which are vasopressor peptides specifically released by the enzyme renin from the tail of angiotensinogen-a non-inhibitory member of the serpin family of protease inhibitors. Although angiotensinogen has long been regarded as a passive substrate, the crystal structures solved here to 2.1 Å resolution show that the angiotensin cleavage site is inaccessibly buried in its amino-terminal tail. The conformational rearrangement that makes this site accessible for proteolysis is revealed in our 4.4 Å structure of the complex of human angiotensinogen with renin. The co-ordinated changes involved are seen to be critically linked by a conserved but labile disulphide bridge. Here we show that the reduced unbridged form of angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized sulphydryl-bridged form, which preferentially interacts with receptor-bound renin. We propose that this redox-responsive transition of angiotensinogen to a form that will more effectively release angiotensin at a cellular level contributes to the modulation of blood pressure. Specifically, we demonstrate the oxidative switch of angiotensinogen to its more active sulphydryl-bridged form in the maternal circulation in pre-eclampsia-the hypertensive crisis of pregnancy that threatens the health and survival of both mother and child

Evaluation of Absolute Oral Bioavailability Of Thorium using Female Sprague Dawley Rats and Comparison with Unified BARGE Bioaccessibility Method in IAEA-312 Standard Reference Soil

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Effect of Wet Aging on Color Stability, Tenderness, and Sensory Attributes of Longissimus lumborum and Gluteus medius Muscles from Water Buffalo Bulls

The present study aimed to investigate the effect of wet aging on meat quality characteristics of Longissimus lumborum (LL) and Gluteus medius (GM) muscles of buffalo bulls. Meat samples from six aging periods, i.e., 0 day (d) = control, 7 d, 14 d, 21 d, 28 d, and 35 d, were evaluated for pH, color, metmyoglobin content (MetMb%), cooking loss, water holding capacity (WHC), myofibrillar fragmentation index (MFI), Warner–Bratzler shear force (WBSF), and sensory evaluation. The pH, instrumental color redness (a *), yellowness (b *), chroma (C *), and MetMb% values were increased, while the lightness (L *) and hue angle (h *) values showed non-significant (p &gt; 0.05) differences in both LL and GM muscles in all aging periods. The cooking loss increased while WHC decreased till 35 days of aging. MFI values significantly (p &lt; 0.05) increased, while WBSF values decreased; in addition, sensory characteristics were improved with the increase in the aging period. Overall, the color, tenderness, and sensory characteristics were improved in LL and GM muscles until 28 and 21 days of aging, respectively. Based on the evaluated meat characteristics, 28 days of aging is required to improve the meat quality characteristics of LL, whereas 21 days of aging is suitable for GM muscle