Global-scale evidence for the refractory nature of riverine black carbon

Author Posting. © The Author(s), 2018. This is the author's version of the work. It is posted here under a nonexclusive, irrevocable, paid-up, worldwide license granted to WHOI. It is made available for personal use, not for redistribution. The definitive version was published in Nature Geoscience 11 (2018): 584-588, doi:10.1038/s41561-018-0159-8.Wildfires and incomplete combustion of fossil fuel produce large amounts of black carbon. Black carbon production and transport are essential components of the carbon cycle. Constraining estimates of black carbon exported from land to ocean is critical, given ongoing changes in land use and climate, which affect fire occurrence and black carbon dynamics. Here, we present an inventory of the concentration and radiocarbon content (∆14C) of particulate black carbon for 18 rivers around the globe. We find that particulate black carbon accounts for about 15.8 ± 0.9% of river particulate organic carbon, and that fluxes of particulate black carbon co-vary with river-suspended sediment, indicating that particulate black carbon export is primarily controlled by erosion. River particulate black carbon is not exclusively from modern sources but is also aged in intermediate terrestrial carbon pools in several high-latitude rivers, with ages of up to 17,000 14C years. The flux-weighted 14C average age of particulate black carbon exported to oceans is 3,700 ± 400 14C years. We estimate that the annual global flux of particulate black carbon to the ocean is 0.017 to 0.037 Pg, accounting for 4 to 32% of the annually produced black carbon. When buried in marine sediments, particulate black carbon is sequestered to form a long-term sink for CO2.A.C. acknowledges financial support from the University of Zurich Forschungskredit Fellowship and the University of Zurich (grant No. STWF-18-026). M.R., S.A. and M.S. acknowledge support from the University Research Priority Projection Global Change and Biodiversity (URPP-GCB). M.Z. acknowledges support from the National Natural Science Foundation of China (No. 41521064). T.E. acknowledges support from the Swiss National Science Foundation (“CAPS-LOCK” and “CAPS-LOCK2” #200021_140850). V.G. acknowledges financial support from an Independent Study Award from the Woods Hole Oceanographic Institution

Macrophage origin limits functional plasticity in helminth-bacterial co-infection

Rapid reprogramming of the macrophage activation phenotype is considered important in the defense against consecutive infection with diverse infectious agents. However, in the setting of persistent, chronic infection the functional importance of macrophage-intrinsic adaptation to changing environments vs. recruitment of new macrophages remains unclear. Here we show that resident peritoneal macrophages expanded by infection with the nematode Heligmosomoides polygyrus bakeri altered their activation phenotype in response to infection with Salmonella enterica ser. Typhimurium in vitro and in vivo. The nematode-expanded resident F4/80high macrophages efficiently upregulated bacterial induced effector molecules (e.g. MHC-II, NOS2) similarly to newly recruited monocyte-derived macrophages. Nonetheless, recruitment of blood monocyte-derived macrophages to Salmonella infection occurred with equal magnitude in co-infected animals and caused displacement of the nematode-expanded, tissue resident-derived macrophages from the peritoneal cavity. Global gene expression analysis revealed that although nematode-expanded resident F4/80high macrophages made an anti-bacterial response, this was muted as compared to newly recruited F4/80low macrophages. However, the F4/80high macrophages adopted unique functional characteristics that included enhanced neutrophil-stimulating chemokine production. Thus, our data provide important evidence that plastic adaptation of MΦ activation does occur in vivo, but that cellular plasticity is outweighed by functional capabilities specific to the tissue origin of the cell

Channels of Small Log-Ratio Leakage and Characterization of Two-Party Differentially Private Computation

Consider a PPT two-party protocol $\Pi=(A,B)$ in which the parties get no private inputs and obtain outputs $O^A,O^B\in \{0,1\}$, and let $V^A$ and $V^B$ denote the parties\u27 individual views. Protocol $\Pi$ has $\alpha$-agreement if $Pr[O^A=O^B]=1/2+\alpha$. The leakage of $\epsilon$ is the amount of information a party obtains about the event $\{O^A=O^B\}$; that is, the leakage $\epsilon$ is the maximum, over $P\in \{A,B\}$, of the distance between $V^P|_{O^A=O^B}$ and $V^P|_{O^A\neq O^B}$. Typically, this distance is measured in statistical distance, or, in the computational setting, in computational indistinguishability. For this choice, Wullschleger [TCC \u2709] showed that if $\epsilon<<\alpha$ then the protocol can be transformed into an OT protocol. We consider measuring the protocol leakage by the log-ratio distance (which was popularized by its use in the differential privacy framework). The log-ratio distance between $X,Y$ over domain $\Omega$ is the minimal $\epsilon\geq 0$ for which, for every $v\in\Omega, \log(Pr[X=v]/Pr[Y=v])\in [-\epsilon,\epsilon]$. In the computational setting, we use computational indistinguishability from having log-ratio distance $\epsilon$. We show that a protocol with (noticeable) accuracy $\alpha\in\Omega(\epsilon^2)$ can be transformed into an OT protocol (note that this allows $\epsilon>>\alpha$). We complete the picture, in this respect, showing that a protocol with $\alpha\in o(\epsilon^2)$ does not necessarily imply OT. Our results hold for both the information theoretic and the computational settings, and can be viewed as a ``fine grained\u27\u27 approach to ``weak OT amplification\u27\u27. We then use the above result to fully characterize the complexity of differentially private two-party computation for the XOR function, answering the open question put by Goyal, Khurana, Mironov, Pandey, and Sahai [ICALP \u2716] and Haitner, Nissim, Omri, Shaltiel, and Silbak [FOCS \u2718]. Specifically, we show that for any (noticeable) $\alpha\in\Omega(\epsilon^2)$, a two-party protocol that computes the XOR function with $\alpha$-accuracy and $\epsilon$-differential privacy can be transformed into an OT protocol. This improves upon Goyal et al. that only handle $\alpha\in\Omega(\epsilon)$, and upon Haitner et al. who showed that such a protocol implies (infinitely-often) key agreement (and not OT). Our characterization is tight since OT does not follow from protocols in which $\alpha\in o(\epsilon^2)$, and extends to functions (over many bits) that ``contain\u27\u27 an ``embedded copy\u27\u27 of the XOR function

Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.

BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700