How ripples turn into dots: modeling ion-beam erosion under oblique incidence

Pattern formation on semiconductor surfaces induced by low energetic ion-beam erosion under normal and oblique incidence is theoretically investigated using a continuum model in form of a stochastic, nonlocal, anisotropic Kuramoto-Sivashinsky equation. Depending on the size of the parameters this model exhibits hexagonally ordered dot, ripple, less regular and even rather smooth patterns. We investigate the transitional behavior between such states and suggest how transitions can be experimentally detected.Comment: 11 pages, 4 figures, submitted for publication, revised versio

Far-infrared photometric observations of the outer planets and satellites with Herschel-PACS

We present all Herschel PACS photometer observations of Mars, Saturn, Uranus, Neptune, Callisto, Ganymede, and Titan. All measurements were carefully inspected for quality problems, were reduced in a (semi-)standard way, and were calibrated. The derived flux densities are tied to the standard PACS photometer response calibration, which is based on repeated measurements of five fiducial stars. The overall absolute flux uncertainty is dominated by the estimated 5% model uncertainty of the stellar models in the PACS wavelength range between 60 and 210 micron. A comparison with the corresponding planet and satellite models shows excellent agreement for Uranus, Neptune, and Titan, well within the specified 5%. Callisto is brighter than our model predictions by about 4-8%, Ganymede by about 14-21%. We discuss possible reasons for the model offsets. The measurements of these very bright point-like sources, together with observations of stars and asteroids, show the high reliability of the PACS photometer observations and the linear behavior of the PACS bolometer source fluxes over more than four orders of magnitude (from mJy levels up to more than 1000 Jy). Our results show the great potential of using the observed solar system targets for cross-calibration purposes with other ground-based, airborne, and space-based instruments and projects. At the same time, the PACS results will lead to improved model solutions for future calibration applications.Comment: 25 pages, 11 figures, 11 table

Herschel-PACS photometry of Uranus' five major moons

Aims. We aim to determine far-infrared fluxes at 70, 100, and 160$\mu$m of the five major Uranus satellites Titania, Oberon, Umbriel, Ariel and Miranda, based on observations with the photometer PACS-P aboard the Herschel Space Observatory. Methods. The bright image of Uranus is subtracted using a scaled Uranus point spread function (PSF) reference established from all maps of each wavelength in an iterative process removing the superimposed moons. Photometry of the satellites is performed by PSF photometry. Thermophysical models of the icy moons are fitted to the photometry of each measurement epoch and auxilliary data at shorter wavelengths. Results. The best fitting thermophysical models provide constraints for important thermal properties of the moons like surface roughness and thermal inertia. We present the first thermal infrared radiometry longward of 50$\mu$m of the four largest Uranian moons, Titania, Oberon, Umbriel and Ariel, at epochs with equator-on illumination. Due to this inclination geometry there was heat transport to the night side so that thermal inertia played a role, allowing us to constrain that parameter. Also some indication for differences in the thermal properties of leading and trailing hemispheres is found. We specify precisely the systematic error of the Uranus flux by its moons, when using Uranus as a far-infrared prime flux calibrator. Conclusions. We have successfully demonstrated an image processing technique for PACS photometer data allowing to remove a bright central source. We have established improved thermophysical models of the five major Uranus satellites. Derived thermal inertia values resemble more those of TNO dwarf planets Pluto and Haumea than those of smaller TNOs and Centaurs.Comment: 25 pages, 10 figures, 7 tables, plus appendices. Accepted for publication on A&

Herschel-PACS photometry of the five major moons of Uranus

Aims: We aim to determine far-infrared fluxes at 70, 100, and 160 μm for the five major Uranus satellites, Titania, Oberon, Umbriel, Ariel, and Miranda. Our study is based on the available calibration observations at wavelengths taken with the PACS photometer aboard the Herschel Space Observatory. Methods: The bright image of Uranus was subtracted using a scaled Uranus point spread function (PSF) reference established from all maps of each wavelength in an iterative process removing the superimposed moons. The photometry of the satellites was performed using PSF photometry. Thermophysical models of the icy moons were fitted to the photometry of each measurement epoch and auxiliary data at shorter wavelengths. Results: The best-fit thermophysical models provide constraints for important properties of the moons, such as surface roughness and thermal inertia. We present the first thermal infrared radiometry longward of 50 μm for the four largest Uranian moons, Titania, Oberon, Umbriel, and Ariel, at epochs with equator-on illumination. Due to this inclination geometry, heat transport took place to the night side so that thermal inertia played a role, allowing us to constrain that parameter. Also, we found some indication for differences in the thermal properties of leading and trailing hemispheres. The total combined flux contribution of the four major moons relative to Uranus is 5.7 × 10-3, 4.8 × 10-3, and 3.4 × 10-3 at 70, 100, and 160 μm, respectively. We therefore precisely specify the systematic error of the Uranus flux by its moons when Uranus is used as a far-infrared prime flux calibrator. Miranda is considerably fainter and always close to Uranus, impeding reliable photometry. Conclusions: We successfully demonstrate an image processing technique for PACS photometer data that allows us to remove a bright central source and reconstruct point source fluxes on the order of 10-3 of the central source as close as ≈3 × the half width at half maximum of the PSF. We established improved thermophysical models of the five major Uranus satellites. Our derived thermal inertia values resemble those of trans-neptunian object (TNO) dwarf planets, Pluto and Haumea, more than those of smaller TNOs and Centaurs at heliocentric distances of about 30 AU. Herschel is an ESA space observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from NASA

Non-perturbative measurement of low-intensity charged particle beams

Non-perturbative measurements of low-intensity charged particle beams are particularly challenging to beam diagnostics due to the low amplitude of the induced electromagnetic fields. In the low-energy antiproton decelerator (AD) and the future extra low energy antiproton rings at CERN, an absolute measurement of the beam intensity is essential to monitor the operation efficiency. Superconducting quantum interference device (SQUID) based cryogenic current comparators (CCC) have been used for measuring slow charged beams in the nA range, showing a very good current resolution. But these were unable to measure fast bunched beams, due to the slew-rate limitation of SQUID devices and presented a strong susceptibility to external perturbations. Here, we present a CCC system developed for the AD machine, which was optimised in terms of its current resolution, system stability, ability to cope with short bunched beams, and immunity to mechanical vibrations. This paper presents the monitor design and the first results from measurements with a low energy antiproton beam obtained in the AD in 2015. These are the first CCC beam current measurements ever performed in a synchrotron machine with both coasting and short bunched beams. It is shown that the system is able to stably measure the AD beam throughout the entire cycle, with a current resolution of $30\,\mathrm{nA}$

Microevolution of Helicobacter pylori during prolonged infection of single hosts and within families

Our understanding of basic evolutionary processes in bacteria is still very limited. For example, multiple recent dating estimates are based on a universal inter-species molecular clock rate, but that rate was calibrated using estimates of geological dates that are no longer accepted. We therefore estimated the short-term rates of mutation and recombination in Helicobacter pylori by sequencing an average of 39,300 bp in 78 gene fragments from 97 isolates. These isolates included 34 pairs of sequential samples, which were sampled at intervals of 0.25 to 10.2 years. They also included single isolates from 29 individuals (average age: 45 years) from 10 families. The accumulation of sequence diversity increased with time of separation in a clock-like manner in the sequential isolates. We used Approximate Bayesian Computation to estimate the rates of mutation, recombination, mean length of recombination tracts, and average diversity in those tracts. The estimates indicate that the short-term mutation rate is 1.4×10−6 (serial isolates) to 4.5×10−6 (family isolates) per nucleotide per year and that three times as many substitutions are introduced by recombination as by mutation. The long-term mutation rate over millennia is 5–17-fold lower, partly due to the removal of non-synonymous mutations due to purifying selection. Comparisons with the recent literature show that short-term mutation rates vary dramatically in different bacterial species and can span a range of several orders of magnitude

Cardioprotective effects of lixisenatide in rat myocardial ischemia-reperfusion injury studies

BACKGROUND: Lixisenatide is a glucagon-like peptide-1 analog which stimulates insulin secretion and inhibits glucagon secretion and gastric emptying. We investigated cardioprotective effects of lixisenatide in rodent models reflecting the clinical situation. METHODS: The acute cardiac effects of lixisenatide were investigated in isolated rat hearts subjected to brief ischemia and reperfusion. Effects of chronic treatment with lixisenatide on cardiac function were assessed in a modified rat heart failure model after only transient coronary occlusion followed by long-term reperfusion. Freshly isolated cardiomyocytes were used to investigate cell-type specific mechanisms of lixisenatide action. RESULTS: In the acute setting of ischemia-reperfusion, lixisenatide reduced the infarct-size/area at risk by 36% ratio without changes on coronary flow, left-ventricular pressure and heart rate. Treatment with lixisenatide for 10 weeks, starting after cardiac ischemia and reperfusion, improved left ventricular end-diastolic pressure and relaxation time and prevented lung congestion in comparison to placebo. No anti-fibrotic effect was observed. Gene expression analysis revealed a change in remodeling genes comparable to the ACE inhibitor ramipril. In isolated cardiomyocytes lixisenatide reduced apoptosis and increased fractional shortening. Glucagon-like peptide-1 receptor (GLP1R) mRNA expression could not be detected in rat heart samples or isolated cardiomyocytes. Surprisingly, cardiomyocytes isolated from GLP-1 receptor knockout mice still responded to lixisenatide. CONCLUSIONS: In rodent models, lixisenatide reduced in an acute setting infarct-size and improved cardiac function when administered long-term after ischemia-reperfusion injury. GLP-1 receptor independent mechanisms contribute to the described cardioprotective effect of lixisenatide. Based in part on these preclinical findings patients with cardiac dysfunction are currently being recruited for a randomized, double-blind, placebo-controlled, multicenter study with lixisenatide. TRIAL REGISTRATION: (ELIXA, ClinicalTrials.gov Identifier: NCT01147250

MATISSE, perspective of imaging in the mid-infrared at the VLTI

International audienceMATISSE is foreseen as a mid-infrared spectro-interferometer combining the beams of up to four UTs/ATs of the Very Large Telescope Interferometer (VLTI) of the European Southern Observatory. The related science case study demonstrates the enormous capability of a new generation mid-infrared beam combiner. MATISSE will constitute an evolution of the two-beam interferometric instrument MIDI. MIDI is a very successful instrument which offers a perfect combination of spectral and angular resolution. New characteristics present in MATISSE will give access to the mapping and the distribution of the material (typically dust) in the circumstellar environments by using a wide mid-infrared band coverage extended to L, M and N spectral bands. The four beam combination of MATISSE provides an efficient UV-coverage : 6 visibility points are measured in one set and 4 closure phase relations which can provide aperture synthesis images in the mid-infrared spectral regime

Nightly sleep apnea severity in patients with atrial fibrillation: Potential applications of long-term sleep apnea monitoring

In patients with atrial fibrillation (AF), the prevalence of moderate-to-severe sleep-disordered breathing (SDB) ranges between 21% and 72% and observational studies have demonstrated that SDB reduces the efficacy of rhythm control strategies, while treatment with continuous positive airway pressure lowers the rate of AF recurrence. Currently, the number of apneas and hypopneas per hour (apnea-hypopnea-index, AHI) determined during a single overnight sleep study is clinically used to assess the severity of SDB. However, recent studies suggest that SDB-severity in an individual patient is not stable over time but exhibits a considerable night-to-night variability which cannot be detected by only one overnight sleep assessment. Nightly SDB-severity assessment rather than the single-night diagnosis by one overnight sleep study may better reflect the exposure to SDB-related factors and yield a superior metric to determine SDB-severity in the management of AF. In this review we discuss mechanisms of night-to-night SDB variability, arrhythmogenic consequences of night-to-night SDB variability, strategies for longitudinal assessment of nightly SDB-severity and clinical implications for screening and management of SDB in AF patients

A Global Overview of the Genetic and Functional Diversity in the Helicobacter pylori cag Pathogenicity Island

The Helicobacter pylori cag pathogenicity island (cagPAI) encodes a type IV secretion system. Humans infected with cagPAI–carrying H. pylori are at increased risk for sequelae such as gastric cancer. Housekeeping genes in H. pylori show considerable genetic diversity; but the diversity of virulence factors such as the cagPAI, which transports the bacterial oncogene CagA into host cells, has not been systematically investigated. Here we compared the complete cagPAI sequences for 38 representative isolates from all known H. pylori biogeographic populations. Their gene content and gene order were highly conserved. The phylogeny of most cagPAI genes was similar to that of housekeeping genes, indicating that the cagPAI was probably acquired only once by H. pylori, and its genetic diversity reflects the isolation by distance that has shaped this bacterial species since modern humans migrated out of Africa. Most isolates induced IL-8 release in gastric epithelial cells, indicating that the function of the Cag secretion system has been conserved despite some genetic rearrangements. More than one third of cagPAI genes, in particular those encoding cell-surface exposed proteins, showed signatures of diversifying (Darwinian) selection at more than 5% of codons. Several unknown gene products predicted to be under Darwinian selection are also likely to be secreted proteins (e.g. HP0522, HP0535). One of these, HP0535, is predicted to code for either a new secreted candidate effector protein or a protein which interacts with CagA because it contains two genetic lineages, similar to cagA. Our study provides a resource that can guide future research on the biological roles and host interactions of cagPAI proteins, including several whose function is still unknown